| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei Zhang, Jiazhen Xu, Qianfei Cui, Guoqiang Lin, Feiyun Wang, Xinyue Ding, Suxin You, Nina Sang, Junchao Tan, Wenwen Xu, Changsen Zhan, Yuying Zhu, Jiange Zhan. Multi-pathway neuroprotective effects of a novel salidroside derivative SHPL-49 against acute cerebral ischemic injury. European journal of pharmacology. 2023-04-14. PMID:37059375. |
furthermore, shpl-49 could reduce cell apoptosis by increasing protein expression ratio of anti-apoptotic factor bcl-2 to pro-apoptotic factor bax in vitro. |
2023-04-14 |
2023-08-14 |
rat |
| Judith Morawietz, Hanna Körber, Eva-Maria Packeiser, Andreas Beineke, Sandra Goericke-Pesc. Insights into Canine Infertility: Apoptosis in Chronic Asymptomatic Orchitis. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047053. |
to understand the impact and mode of action of apoptosis, we investigated tunel, bax, bcl-2, fas/fa |
2023-04-13 |
2023-08-14 |
Not clear |
| Qingyu Zhou, James D Quirk, Ying Hu, Huimin Yan, Joseph P Gaut, Christine T N Pham, Samuel A Wickline, Hua Pa. Rapamycin Perfluorocarbon Nanoparticle Mitigates Cisplatin-Induced Acute Kidney Injury. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047059. |
using western blotting and immunofluorescence staining, mechanistic studies revealed that rapamycin pfc np significantly enhanced autophagy in the kidney, reduced the expression of intercellular adhesion molecule 1 (icam-1) and vascular cell adhesion molecule 1 (vcam-1), as well as decreased the expression of the apoptotic protein bax, all of which contributed to the suppression of apoptosis that was confirmed with tunel staining. |
2023-04-13 |
2023-08-14 |
Not clear |
| Hui Song Cui, So Young Joo, Seung Yeol Lee, Yoon Soo Cho, Dong Hyun Kim, Cheong Hoon Se. Effect of Hypertrophic Scar Fibroblast-Derived Exosomes on Keratinocytes of Normal Human Skin. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047109. |
the expression of proliferation markers (ki-67 and keratin 14), activation markers (keratins 6, 16, and 17), differentiation markers (keratins 1 and 10), apoptosis factors (bax, bcl2, caspase 14, and ask1), proliferation/differentiation regulators (p21 and p27), and epithelial-mesenchymal transition (emt) markers (e-cadherin, n-cadherin, and vimentin) was investigated. |
2023-04-13 |
2023-08-14 |
human |
| Alaleh Mohammadi, Souzan Najafi, Mohammad Amini, Behzad Baradaran, Masoumeh Firouzamand. B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma. Melanoma research. 2023-04-13. PMID:37053079. |
apoptosis induction by dacarbazine was enhanced after b7h6 knockdown through modulating caspase-3, bax, and bcl-2 mrna levels. |
2023-04-13 |
2023-08-14 |
Not clear |
| Xiaoxiang Xu, Juan Chang, Ping Wang, Chaoqi Liu, Mengjie Liu, Ting Zhou, Qingqiang Yin, Guorong Ya. Combination of glycyrrhizic acid and compound probiotics alleviates deoxynivalenol-induced damage to weaned piglets. Ecotoxicology and environmental safety. vol 256. 2023-04-13. PMID:37054475. |
moreover, gap could significantly decrease the expressions of inflammation and apoptosis genes and proteins (il-8, il-10, tnf-α, cox-2, bax, bcl-2 and caspase 3), and increase the expressions of tight-junction proteins and nutrient transport factor genes and proteins (zo-1, occludin, claudin-1, asct2 and pept1). |
2023-04-13 |
2023-08-14 |
Not clear |
| Alexandra L Pourzia, Michael L Olson, Stefanie R Bailey, Angela C Boroughs, Aditi Aryal, Jeremy Ryan, Marcela V Maus, Anthony Leta. Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells. Cell death & disease. vol 14. issue 4. 2023-04-13. PMID:37055388. |
impairing mitochondrial apoptosis via knockout of bak and bax, forced bcl-2 and bcl-xl expression, or caspase inhibition protected several tumor models from car t killing. |
2023-04-13 |
2023-08-14 |
Not clear |
| Ping Yan, Yong C Jia, Xue L Zhang, Yuan Y Zhou, Ying Guo, Rong L Yin, Jing Yuan, Lin X Wang, Zhong B Guo, Jing Y Wang, Xin Wang, Rong H Yi. Virulence assessment of four Glaesserella parasuis strains isolated in Liaoning province of China. Research in veterinary science. vol 158. 2023-04-09. PMID:37031471. |
through testing the expression of apoptosis-related genes bcl-2 and bax, we found highly virulent strains induced apoptosis by inhibiting the expression of bcl-2. |
2023-04-09 |
2023-08-14 |
Not clear |
| John S H Danial, Andreas Jenner, Ana J Garcia-Saez, Katia Cosentin. Real-Time Growth Kinetics Analysis of Macromolecular Assemblies in Cells with Single Molecule Resolution. The journal of physical chemistry. A. 2023-04-06. PMID:37023388. |
we validated our method with simulated ground-truth data and time-lapse images of diffraction-limited oligomeric assemblies of bax and bak proteins on mitochondria of cells undergoing apoptosis. |
2023-04-06 |
2023-08-14 |
Not clear |
| Xun Chen, Qian Zhang, Tao Song, Wentao Zhang, Yan Yang, Ning Duan, Fei Con. Vitamin D deficiency triggers intrinsic apoptosis by impairing SPP1-dependent antiapoptotic signaling in chronic hematogenous osteomyelitis. Gene. 2023-04-06. PMID:37024063. |
foxo3a then upregulates the expression of the apoptotic genes bax (bcl2-associated x-protein), bid (bh3 interacting death domain), and bim (bcl2-interacting mediator of cell death), to induce apoptosis. |
2023-04-06 |
2023-08-14 |
mouse |
| Xue Jiang, Jie Wang, Jin Liu, Haiyan Zhu, Jian Hu, Xingzhen Sun, Wendi Zho. Resveratrol ameliorates penconazole-induced cardiotoxicity by inhibition of oxidative stress and apoptosis in zebrafish larvae. Ecotoxicology and environmental safety. vol 256. 2023-04-05. PMID:37018857. |
in addition, pen elevated oxidative stress via reactive oxygen species (ros) accumulation and triggered cardiomyocytic apoptosis by upregulation of p53, bcl-2, bax and caspase 3. |
2023-04-05 |
2023-08-14 |
zebrafish |
| Lulu Liu, Danting Li, Chuan Peng, Rufei Gao, Xuan Li, Linkun Zhang, Qiong Lv, Xiaoqiu Xiao, Qifu L. MicroRNA-27a, downregulated in human obesity, exerts an antiapoptotic function in adipocytes. Endocrine journal. 2023-04-05. PMID:37019667. |
notably, tnf-α induced cell apoptosis in both preadipocytes and mature adipocytes, as evidenced by the upregulation of cleaved caspase 3 and cleaved caspase 8 and the ratio of bax to bcl-2, while these effects were partly diminished by mir-27a overexpression. |
2023-04-05 |
2023-08-14 |
mouse |
| Yanchun Wang, Yilong Dong, Wenbo Zhang, Yanmei Wang, Yang Jao, Jianjun Liu, Mingzhu Zhang, Hongbing H. AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad Apoptosis : an international journal on programmed cell death. 2023-04-04. PMID:37014579. |
subsequently, apoptosis was detected using flow cytometry, and expression and activity of bcl-2, bad, bax, pi3k, akt, ampk, mtor, and p70s6k proteins were analyzed using western blotting. |
2023-04-04 |
2023-08-14 |
human |
| Peihao Sun, Xinzhe Zhao, Mingxiao Liu, Hanxiao Wu, Ce Lv, Shuo Zhou, Zhiming Ding, Lijun Huo, Liguo Yang, Aixin Lian. Lactational exposure to Deoxynivalenol causes mammary gland injury via inducing inflammatory response and impairing blood-milk barrier integrity in mice. Ecotoxicology and environmental safety. vol 255. 2023-04-01. PMID:37003064. |
furthermore, lactational don exposure increased blood-milk barrier permeability by reducing the expression of zo-1 and occludin, promoted cell apoptosis by upregulating the expression of bax and cleaved caspase-3 and downregulating the expression of bcl-2 and pcna. |
2023-04-01 |
2023-08-14 |
mouse |
| Guiying Xiao, Fang Yuan, Yang Deng, Debiao Xiang, Liguang Xiong, Xin Li, Yuan L. Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway-mediated antioxidant response. Journal of biochemical and molecular toxicology. 2023-03-30. PMID:36992629. |
finally, the expressions of genes and proteins (bax, bcl-2, caspase-3, caspase-9) related to apoptosis were evaluated through quantitative polymerase chain reaction and western blot assay. |
2023-03-30 |
2023-08-14 |
mouse |
| Jovana Jeremic, Natalia Govoruskina, Jovana Bradic, Isidora Milosavljevic, Ivan Srejovic, Vladimir Zivkovic, Nevena Jeremic, Tamara Nikolic Turnic, Irena Tanaskovic, Stefani Bolevich, Vladimir Jakovljevic, Sergey Bolevich, Marko N Zivanovic, Nduka Okwose, Dragana Seklic, Nevena Milivojevic, Jelena Grujic, Lazar Velicki, Guy MacGowan, Djordje G Jakovljevic, Nenad Filipovi. Sacubitril/valsartan reverses cardiac structure and function in experimental model of hypertension-induced hypertrophic cardiomyopathy. Molecular and cellular biochemistry. 2023-03-30. PMID:36997815. |
moreover, sacubitril/valsartan treatment reduced oxidative stress and apoptosis (reduced expression of bax and cas9 genes) compared to untreated rats. |
2023-03-30 |
2023-08-14 |
rat |
| Xue Zheng, Lu Chen, Tong Chen, Maosheng Cao, Boqi Zhang, Chenfeng Yuan, Zijiao Zhao, Chunjin Li, Xu Zho. The Mechanisms of BDNF Promoting the Proliferation of Porcine Follicular Granulosa Cells: Role of miR-127 and Involvement of the MAPK-ERK1/2 Pathway. Animals : an open access journal from MDPI. vol 13. issue 6. 2023-03-29. PMID:36978655. |
however, bdnf knockdown in gcs decreased cell viability and s-phase cells proportion-and bdnf simultaneously regulated the expression of genes linked with cell proliferation (ccnd1, p21 and bcl2) and apoptosis (bax). |
2023-03-29 |
2023-08-14 |
Not clear |
| Vanesa Sánchez-Martín, Paloma Morales, Amaia Iriondo-DeHond, Xavier F Hospital, Manuela Fernández, Eva Hierro, Ana I Haz. Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978864. |
the cytotoxic effects of samples were analyzed using the mtt (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay (0-250 mg/ml) and the effects on apoptosis were analyzed using cell cycle analysis, tdt-dutp terminal nick-end labeling (tunel) assay, dr5 (death receptor 5) and bax (bcl-2-associated x) activation, and caspases 8, 9, and 3 activities. |
2023-03-29 |
2023-08-14 |
bee |
| Aisha Kafoud, Zoya Salahuddin, Raghad Sabaawi Ibrahim, Reem Al-Janahi, Alena Mazurakova, Peter Kubatka, Dietrich Büsselber. Potential Treatment Options for Neuroblastoma with Polyphenols through Anti-Proliferative and Apoptotic Mechanisms. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979499. |
the mechanisms of the therapeutic effects include calpain-dependent pathways, receptor-mediated apoptosis, and, notably, and most frequently, mitochondrial apoptosis pathways, including the mitochondrial proteins bax and bcl-2. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ann-Kathrin Berg, Elisabeth M Hahn, Fiona Speichinger-Hillenberg, Annemaria Silvana Grube, Nina A Hering, Ani K Stoyanova, Katharina Beye. The Impact of TRAIL on the Immunological Milieu during the Early Stage of Abdominal Sepsis. Cancers. vol 15. issue 6. 2023-03-29. PMID:36980658. |
neutrophils of the bone marrow and spleen showed enhanced protein expression of anti-apoptotic flip, c-iap1, and mcl-1 and reduced expression levels of pro-apoptotic bax in neutrophils, which might correlate with apoptosis inhibition in these cells. |
2023-03-29 |
2023-08-14 |
mouse |