| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xufan Zhao, Yaqin Chen, Wenrui Zhang, Hui Zhang, Yilong Hu, Fengyu Yang, Yingying Zhang, Xu Son. Dihydromyricetin Inhibits Pseudorabies Virus Multiplication In Vitro by Regulating NF-κB Signaling Pathway and Apoptosis. Veterinary sciences. vol 10. issue 2. 2023-02-28. PMID:36851415. |
furthermore, dmy promoted the apoptosis of prv-infected cells through the regulation of the expressions of bax and bcl-xl and the transcriptional levels of caspase-3, bax, bcl-2 and bcl-xl, thereby limiting the production of progeny virus. |
2023-02-28 |
2023-08-14 |
human |
| Guanghua Xiong, Hongmei Hu, Haiyan Zhang, Jun'e Zhang, Zigang Cao, Huiqiang Lu, Xinjun Lia. Cyhalofop-butyl exposure induces the severe hepatotoxicity and immunotoxicity in zebrafish embryos. Fish & shellfish immunology. 2023-02-26. PMID:36842639. |
moreover, cyb induced zebrafish liver injury and increased hepatocyte apoptosis, which increased the protein expression levels of bax, tlr4, nf-kb p65 and stat3 in zebrafish. |
2023-02-26 |
2023-08-14 |
cat |
| Kwang-Youn Kim, Jae Dong Son, Su-Jin Hwang, Jong Kwang Lee, Jae Young Park, Kwang Il Park, Tae Woo O. Fermented Glutinous Rice Extract Mitigates DSS-Induced Ulcerative Colitis by Alleviating Intestinal Barrier Function and Improving Gut Microbiota and Inflammation. Antioxidants (Basel, Switzerland). vol 12. issue 2. 2023-02-25. PMID:36829894. |
furthermore, fgr treatment inhibited apoptosis by reducing the activity of caspase-3 and the ratio of bcl-2 associated x (bax)/b-cell lymphoma 2 (bcl-2). |
2023-02-25 |
2023-08-14 |
mouse |
| Chang-Sheng Yang, Xiao-Shuang Guo, Ying-Ying Yue, Yu Wang, Xiao-Lei Ji. Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835263. |
additionally, axt alleviated apoptosis by inhibiting bcl-2-associated x protein (bax)/caspase 3 signaling and improving the mitochondrial membrane potential (mmp), which could also be abolished by ml385. |
2023-02-25 |
2023-08-14 |
Not clear |
| Ghedeir M Alshammari, Mohammed S Al-Ayed, Mohamed Anwar Abdelhalim, Laila Naif Al-Harbi, Mohammed Abdo Yahy. Effects of Antioxidant Combinations on the Renal Toxicity Induced Rats by Gold Nanoparticles. Molecules (Basel, Switzerland). vol 28. issue 4. 2023-02-25. PMID:36838869. |
in addition, aunps induced renal inflammation and apoptosis, as evidenced by the increase in the total mrna and the cytoplasmic and nuclear levels of nf-κb, mrna levels of bax and caspase-3, and levels of tumor necrosis factor-α (tnf-α) and interleukin-6 (il-6). |
2023-02-25 |
2023-08-14 |
rat |
| Gautam Sethi, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Renuka Choudhary, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Isha Rani, Hardeep Singh Tul. Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements. Pharmaceutics. vol 15. issue 2. 2023-02-25. PMID:36840034. |
quercetin targets apoptosis, by upregulating bax, caspase-3, and p21 while downregulating akt, plk-1, cyclin-b1, cyclin-a, cdc-2, cdk-2, and bcl-2. |
2023-02-25 |
2023-08-14 |
Not clear |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Hoo Young Lee, Suk-Young Song, Jihye Hwang, Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jung Hyun Park, Sungchul Choi, Soonil Pyo, Sung-Rae Ch. Very early environmental enrichment protects against apoptosis and improves functional recovery from hypoxic-ischemic brain injury. Frontiers in molecular neuroscience. vol 15. 2023-02-24. PMID:36824441. |
very early exposure to ee significantly downregulated fas/fasl-mediated apoptosis, decreased expression of fas, fas-associated death domain, cleaved caspase-8/caspase-8, cleaved caspase-3/caspase-3, as well as bax and bcl-2, in the cerebral cortex and the hippocampus. |
2023-02-24 |
2023-08-14 |
mouse |
| Angelos Yfantis, Ilias Mylonis, George Simo. Direct interaction between mortalin and HIF-1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax. The FEBS journal. 2023-02-24. PMID:36825991. |
direct interaction between mortalin and hif-1α at the mitochondria inhibits apoptosis by blocking recruitment of bax. |
2023-02-24 |
2023-08-14 |
Not clear |
| Angelos Yfantis, Ilias Mylonis, George Simo. Direct interaction between mortalin and HIF-1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax. The FEBS journal. 2023-02-24. PMID:36825991. |
mitochondrial dissociation of hif-1α, either by embelin or overexpression of a hif-1α peptide harboring the mortalin binding site, under stress conditions leads to mitochondrial localization of the pro-apoptotic protein bax and induction of apoptosis. |
2023-02-24 |
2023-08-14 |
Not clear |
| Mohammad Keyvaloo Shahrestanaki, Abdollah Mirjani, Mustafa Ghanadian, Mahmoud Aghae. Cycloartane triterpenoid from Euphorbia macrostegia modulates ER stress signaling pathways to induce apoptosis in MDA-MB231 and MCF-7 breast cancer cell lines. Naunyn-Schmiedeberg's archives of pharmacology. 2023-02-24. PMID:36826495. |
apoptosis was assayed by annexin v/propidium iodide (pi), immunoblotting of anti- and proapoptotic, bcl-2 and bax proteins, and mitochondrial transmembrane potential (ΔΨm) changes. |
2023-02-24 |
2023-08-14 |
Not clear |
| Masoumeh Dolati, Farzaneh Tafvizi, Masoud Salehipour, Tahereh Komeili Movahed, Parvaneh Jafar. Biogenic copper oxide nanoparticles from Bacillus coagulans induced reactive oxygen species generation and apoptotic and anti-metastatic activities in breast cancer cells. Scientific reports. vol 13. issue 1. 2023-02-24. PMID:36828883. |
the up-regulation of bcl2-associated x (bax), cyclin dependent kinase inhibitor 1a (p21), caspase 3 (casp3), and caspase 9 (casp9), the down-regulation of bcl2 apoptosis regulator (bcl2), annexin v-fitc/propidium iodide, and reactive oxygen species (ros) generation results suggested that bc-cuonps had a significant apoptotic impact when compared to the control. |
2023-02-24 |
2023-08-14 |
human |
| Ling Wu, Guodong Xu, Ni Li, Linwen Zhu, Guofeng Sha. Curcumin Analog, HO-3867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild-Type p53. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-02-23. PMID:36814470. |
mechanically, ho-3867-induced apoptosis relied on the inhibition of mcl-1 and bcl-2 and the upregulation of bax. |
2023-02-23 |
2023-08-14 |
Not clear |
| Juanyun Li, Jialu Zheng, Baohang Lin, Hao Sun, Shan Lu, Dandan Wang, Hongjun Hu. Knockdown of NCAPG promotes the apoptosis and inhibits the invasion and migration of triple‑negative breast cancer MDA‑MB‑231 cells via regulation of EGFR/JAK/STAT3 signaling. Experimental and therapeutic medicine. vol 25. issue 3. 2023-02-23. PMID:36815969. |
the expression of ncapg was knocked down, and cell viability was then detected using a cck-8 assay, apoptosis was detected using a tunel assay, and the expression of the apoptosis-related proteins bcl-2, bax and bad were detected by western blotting. |
2023-02-23 |
2023-08-14 |
Not clear |
| Hanyu Zhou, Xiao Yun, Yongqian Shu, Kequn X. Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition. Oncology letters. vol 25. issue 3. 2023-02-23. PMID:36817049. |
in addition, cell apoptosis was evaluated via flow cytometry with annexin v-fitc/pi and the western blotting of bax and bcl-2. |
2023-02-23 |
2023-08-14 |
human |
| b' Hamit Emre K\\xc4\\xb1z\\xc4\\xb1l, Cihan G\\xc3\\xbcr, Adnan Ayna, Ekrem Darendelio\\xc4\\x9flu, Sefa K\\xc3\\xbc\\xc3\\xa7\\xc3\\xbckler, Sevda Sa\\xc4\\x9. Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF-induced Testicular Toxicity. Chemistry & biodiversity. 2023-02-22. PMID:36808882.' |
naf supplementation caused apoptosis in the testes by upregulating p53, nfkb, caspase-3 , caspase-6, caspase-9, and bax and downregulating bcl-2. |
2023-02-22 |
2023-08-14 |
rat |
| Yin Yang, Chen Mei, Hong Xian, Xue Zhang, Jun Li, Zhi-Xuan Liang, Yan Zhi, Yue Ma, Hong-Jun Wan. Toosendanin-induced apoptosis in canine mammary tumor CMT-U27 cells is mediated through the mitochondrial apoptotic pathway. Veterinary and comparative oncology. 2023-02-22. PMID:36809669. |
tsn induced cell apoptosis by upregulating bax, cleaved caspase-3, cleaved caspase-9, p53, and cytochrome c (cytosolic) protein expression, and downregulating bcl-2 and cytochrome c (mitochondrial) expression. |
2023-02-22 |
2023-08-14 |
human |
| Xinglin Yu, Yuan Luo, Liping Yang, Pu Chen, Xiaohua Dua. P‑hydroxybenzyl alcohol ameliorates neuronal cerebral ischemia‑reperfusion injury by activating mitochondrial autophagy through SIRT1. Molecular medicine reports. vol 27. issue 3. 2023-02-17. PMID:36799156. |
finally, apoptosis was analyzed by tunel staining and the expression of apoptosis‑related proteins (bax, bcl‑2 and caspase‑3) by western blotting. |
2023-02-17 |
2023-08-14 |
rat |
| Nasrin Ziamajidi, Sajedeh Daei, Maryam Khajvand-Abedini, Roghayeh Abbasalipourkabir, Alireza Nouria. Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles. Chonnam medical journal. vol 59. issue 1. 2023-02-16. PMID:36794239. |
to this aim, a population of 54 healthy, male wistar rats were used in this work and then assigned into nine groups of 6 rats as g1: control 1 (water); g2: control 2 (olive oil); g3: va (1000 iu/kg), g4: vc (200 mg/kg), g5: ve (100 iu/kg), g6: zno nps exposed animals (200 mg/kg); and g7, 8 and 9: zno nps-exposed animals that were pre-treated with either va, c, or e. apoptosis rates were estimated by measuring the level of apoptotic regulatory markers including bcl-2-associated x (bax) and b-cell lymphoma protein 2 (bcl-2) using western blotting and qrt-pcr assays. |
2023-02-16 |
2023-08-14 |
rat |
| Sheng Fang, Hao Tang, Ming-Zhi Li, Jian-Jun Chu, Zong-Sheng Yin, Qi-Yu Ji. Identification of the CCL2 PI3K/Akt axis involved in autophagy and apoptosis after spinal cord injury. Metabolic brain disease. 2023-02-16. PMID:36795287. |
we found that when pi3k inhibitors were activated, apoptosis decreased, the levels of autophagy-positive proteins lc3-i/lc3-ii and bcl-1 increased, the levels of autophagy-negative protein p62 decreased, the levels of pro-apoptotic proteins bax and caspase-3 decreased, the levels of the apoptosis-inhibiting protein bcl-2 increased. |
2023-02-16 |
2023-08-14 |
Not clear |