| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chiara Baggio, Roberto Luisetto, Carlotta Boscaro, Anna Scanu, Roberta Ramonda, Mattia Albiero, Paolo Sfriso, Francesca Olivier. Leucocyte Abnormalities in Synovial Fluid of Degenerative and Inflammatory Arthropathies. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982526. |
the study of the apoptosis process revealed an increased bax expression in cia and ra compared to oa and psa, while bcl-2 was higher in cia. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ziyang Huang, Qiuling Huang, Kai Xu, Lina Liang, Yamin Li, Wei Zhou, Na Ning, Jiewen Zhou, Jiajia Hu, Shanshan Liu, Lei Dan. Protective effect of ZYMT, a traditional Chinese patent medicine in a mouse model of retinitis pigmentosa. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-03-29. PMID:36989720. |
tunel, immunofluorescence and qpcr were used to evaluate cell apoptosis and expressions of sirt1, iba1, bcl-2, bax and caspase-3. |
2023-03-29 |
2023-08-14 |
mouse |
| Xu-Dong Jiang, Yu Liu, Jian-Fei Wu, San-Ni Gong, Yao Ma, Xiang-Dong Z. Regulation of proliferation, apoptosis, hormone secretion and gene expression by acetyl-L-carnitine in yak (Bos grunniens) granulosa cells. Theriogenology. vol 203. 2023-03-27. PMID:36972666. |
rt‒qpcr results verified that gcs treated with 1 mm alc for 48 h significantly increased the expression of genes related to anti-apoptosis and the cell cycle (bcl-2, pcna, ccnd1 and ccnb1), antioxidants (cat, sod2 and gpx1), and e2 and p4 secretion (star, cyp19a1 and hsd3b1) (p < 0.05), but it significantly decreased the expression of apoptosis genes (bax and p53) (p < 0.05). |
2023-03-27 |
2023-08-14 |
cat |
| Fumihiko Nakao, Kiyoko Setoguchi, Yuichiro Semba, Takuji Yamauchi, Jumpei Nogami, Kensuke Sasaki, Hiroshi Imanaga, Tatsuya Terasaki, Manaka Miyazaki, Shigeki Hirabayashi, Kohta Miyawaki, Yoshikane Kikushige, Takeshi Masuda, Koichi Akashi, Takahiro Maed. Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance. Leukemia. 2023-03-27. PMID:36973350. |
mechanistically, bax released from bcl2 upon ven treatment was entrapped by mcl1 and bcl-xl and failed to induce apoptosis in march5 intact aml cells. |
2023-03-27 |
2023-08-14 |
mouse |
| Fumihiko Nakao, Kiyoko Setoguchi, Yuichiro Semba, Takuji Yamauchi, Jumpei Nogami, Kensuke Sasaki, Hiroshi Imanaga, Tatsuya Terasaki, Manaka Miyazaki, Shigeki Hirabayashi, Kohta Miyawaki, Yoshikane Kikushige, Takeshi Masuda, Koichi Akashi, Takahiro Maed. Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance. Leukemia. 2023-03-27. PMID:36973350. |
by contrast, in march5 knockout cells, liberated bax did not bind to mcl1, as noxa likely occupied mcl1 bh3-binding grooves and efficiently induced mitochondrial apoptosis. |
2023-03-27 |
2023-08-14 |
mouse |
| Yudong Jia, Fenglin Wang, Yuntao Gao, Hongyu Qin, Changtao Gua. Hypoxia stress induces hepatic antioxidant activity and apoptosis, but stimulates immune response and immune-related gene expression in black rockfish Sebastes schlegelii. Aquatic toxicology (Amsterdam, Netherlands). vol 258. 2023-03-25. PMID:36965427. |
in this study, hepatic anti-oxidant enzymes (superoxide dismutase [sod], catalase [cat], glutathione peroxidase [gsh-px]), aminotransferase (ast) and alanine aminotransferase (alt) activities, lipid peroxidation (lpo), malondialdehyde (mda) and glutathione (gsh) content, immunological parameters and the expression of apoptosis (bax, bcl2, p53, caspase3, xiap) and immune-related genes (c3, il-1β, ccl25, saa, hap, isg15) of black rockfish were determined during hypoxia and reoxygenation to illustrate the underlying defense response mechanisms. |
2023-03-25 |
2023-08-14 |
human |
| Huimiao Feng, Huizhen Chen, Jingchao Qiang, Baoshi Xu, Xinyu Wu, Enzhuang Pan, Haitao Yang, Xueqing Li, Jian Zhang, Jingquan Don. Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole. Pesticide biochemistry and physiology. vol 191. 2023-03-24. PMID:36963925. |
in addition, difenoconazole exposure further activated the mitochondrial pathway of apoptosis by upregulating cytochrome c, bax, cleaved-caspase 9, and downregulating bcl-2. |
2023-03-24 |
2023-08-14 |
cat |
| Khalid M Mohany, Abo Bakr Abdel Shakour, Sara Ibrahim Mohamed, Randa Samir Hanna, Ahmed Y Nassa. Cytotoxic n-Hexane Fraction of the Egyptian Pteris vittata Functions as Anti-breast Cancer Through Coordinated Actions on Apoptotic and Autophagic Pathways. Applied biochemistry and biotechnology. 2023-03-23. PMID:36951939. |
treated cell lines showed significant concentration and time-dependent reductions in cell viability in response to pv-n-hexane extract and also exhibited a concomitant induction of apoptosis [increased chromatin condensation, nuclear fragmentation, and pro-apoptotic bax, and cleaved caspase-7 levels while decreased bcl-2 levels] and autophagy [increased autophagosomes vacuoles, and lc3b ii levels while decreased p62/sqstm1 levels]. |
2023-03-23 |
2023-08-14 |
Not clear |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
results compared with control group, activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein decreased in lps group while apoptosis rate, expressions of c-caspase-3 and bax proteins, and levels of tnf-α, il-1β and il-6 mrna were increased, along with the increased mir-155-5p level and ratios of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk. |
2023-03-22 |
2023-08-14 |
human |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
the activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein increased in mir-155-5p inhibitor group, compared with lps group, whereas decreased mir-155-5p level, apoptosis rate, expressions of c-caspase-3 and bax proteins, levels of tnf-α, il-1β and il-6 mrna, and expressions of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk proteins were observed. |
2023-03-22 |
2023-08-14 |
human |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
compared with lps group, activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein were decreased in mir-155-5p mimic group, while mir-155-5p level, apoptosis rate, expressions of c-caspase-3 and bax proteins, levels of tnf-α, il-1β and il-6 mrna, and ratios of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk proteins were increased. |
2023-03-22 |
2023-08-14 |
human |
| Yu-Jing Lan, Chu-Chun Cheng, Shu-Chi Chu, Yun-Wei Chian. A gating mechanism of the BsYetJ calcium channel revealed in an endoplasmic reticulum lipid environment. Biochimica et biophysica acta. Biomembranes. 2023-03-22. PMID:36948481. |
the transmembrane bax inhibitor-1-containing motif 6 (tmbim6) is suggested to modulate apoptosis by regulating calcium homeostasis in the endoplasmic reticulum (er). |
2023-03-22 |
2023-08-14 |
Not clear |
| Ali Akar, Rahime Özlem Öztopuz, Başak Büyük, Mehmet Akif Ovali, Damla Aykora, Ümit Ali Malço. Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage. Molecular neurobiology. 2023-03-18. PMID:36933146. |
in this study, we aimed to investigate the potential therapeutic effects of pic on ob injury following sah at molecular mechanism based on sirt1, inflammatory (tnf-α, il1-β, nf-κb, il-6, tlr4), and apoptosis (p53, bax, bcl-2, caspase-3)-related gene expression markers and histopathology level; 27 male wistar albino rats were used in a pre-chiasmatic subarachnoid hemorrhage model. |
2023-03-18 |
2023-08-14 |
rat |
| Roua Chaabani, Mohamed Bejaoui, Ikram Ben Jeddou, Mohamed Amine Zaouali, Zohra Haouas, Sameh Belgacem, Carmen Peralta, Hassen Ben Abdenneb. Effect of the Non-steroidal Anti-inflammatory Drug Diclofenac on Ischemia-Reperfusion Injury in Rat Liver: A Nitric Oxide-Dependent Mechanism. Inflammation. 2023-03-18. PMID:36933163. |
finally, the gene expression levels of inflammatory (cox-2, il-6, il-1β, il-18, tnf-α, hmgb-1, and tlr-4) and apoptosis (bcl-2 and bax) markers were measured. |
2023-03-18 |
2023-08-14 |
rat |
| Ting Zhang, Jie Lu, Ying Yao, Yanting Pang, Xiaomeng Ding, Meng Tan. MPA-capped CdTequantum dots induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human liver normal cell and liver tumor cell. Environmental pollution (Barking, Essex : 1987). 2023-03-18. PMID:36933817. |
the subsequent autophagosome accumulation eventually triggers apoptosis by activating proapoptotic signaling pathways and the expression of proapoptotic bax. |
2023-03-18 |
2023-08-14 |
human |
| Ting Zhang, Jie Lu, Ying Yao, Yanting Pang, Xiaomeng Ding, Meng Tan. MPA-capped CdTequantum dots induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human liver normal cell and liver tumor cell. Environmental pollution (Barking, Essex : 1987). 2023-03-18. PMID:36933817. |
in contrast, in human liver cancer cells (hepg2 cells), expression of upr restrains proapoptotic signaling and downregulates bax, and activated protective cellular autophagy, as a result of protecting these liver cancer cells from cdte qds-induced apoptosis. |
2023-03-18 |
2023-08-14 |
human |
| Liu Qiang, Li Hong, Xu Jian, Zhou Zhanli. HUVECs affect HuT-78 cell apoptosis and cytokine production via the HIF-1α-PD-L1/PD-1 pathway under hypoxia. International immunopharmacology. vol 118. 2023-03-16. PMID:36924563. |
in hut-78 cells, hypoxic monoculture significantly increased the expression of hif-1α, pd-1, il-2, il-4, il-6, il-8, il-10, tnf-α, ifn-α, and bax, decreased the expression of bcl-2, and resulted in increased apoptosis. |
2023-03-16 |
2023-08-14 |
human |
| Liu Qiang, Li Hong, Xu Jian, Zhou Zhanli. HUVECs affect HuT-78 cell apoptosis and cytokine production via the HIF-1α-PD-L1/PD-1 pathway under hypoxia. International immunopharmacology. vol 118. 2023-03-16. PMID:36924563. |
meanwhile, bax expression was significantly increased with elevated apoptosis in hut-78 cells. |
2023-03-16 |
2023-08-14 |
human |
| Jiawen Cui, Minna Qiu, Yuhang Liu, Yuhao Liu, You Tang, Xiaohua Teng, Shu L. Nano-selenium protects grass carp hepatocytes against 4-tert-butylphenol-induced mitochondrial apoptosis and necroptosis via suppressing ROS-PARP1 axis. Fish & shellfish immunology. 2023-03-16. PMID:36924910. |
in this experiment, l8824 displayed hallmark phenotypes of apoptosis and necroptosis after 4-tbp exposure, as evidenced by changes in cell morphology, increased rates of apoptosis and necrosis, the loss of mmp, the accumulation of ros, and changes in associated factors (parp1, jnk, bid, bcl-2, bax, aifm1, cytc, caspase 9, apaf1, caspase 3, tnf-α, tnfr1, ripk1, ripk3, and mlkl). |
2023-03-16 |
2023-08-14 |
Not clear |
| Mengna Wu, Boyue Huang, Ling Hu, Tao Zhang, Binyu Zhang, Xi Zhao, Ruijin Lu, Wei Xiong, Shengyao Zhang, Jing Li, Dilong Chen, Baoxue Yang, Guoli Li, Jianhua Ra. Ganoderma lucidum polysaccharides ameliorates D-galactose-induced aging salivary secretion disorders by upregulating the rhythm and aquaporins. Experimental gerontology. 2023-03-16. PMID:36925084. |
the results showed that glp effectively promoted the expression of aqp5, aqp4, and aqp1, inhibited the release of tnf-α, il-6, and bax, and reduced inflammation and apoptosis. |
2023-03-16 |
2023-08-14 |
mouse |