| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danning Tong, Enshuang Xu, Ruidong Ge, Mengxin Hu, Shengzi Jin, Jing Mu, Yun Li. Aspirin alleviates cisplatin-induced acute kidney injury through the AMPK-PGC-1α signaling pathway. Chemico-biological interactions. 2023-05-13. PMID:37179038. |
furthermore, aspirin was observed to down-regulate the expression of pro-inflammatory factors tnf-α, nf-κb, il-1β, and il-6 mrna and proteins, increase the expression of bax and caspase3 as indicators of apoptosis, decrease the expression of bcl-2, and improve the reduced expression of mtdna, atp content, atpase activity and mitochondrial respiratory chain complex enzyme-related genes nd1, atp5b, and sdhd. |
2023-05-13 |
2023-08-14 |
mouse |
| Pengcheng Pang, Xing Zhang, Jingping Yuan, Hong Yan, Dandan Ya. Acrylamide interferes with autophagy and induces apoptosis in Neuro-2a cells by interfering with TFEB-regulated lysosomal function. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-05-12. PMID:37172712. |
in addition, acr increased cellular apoptosis via decreasing bcl-2 expression, increasing bax and cleaved caspase-3 expression, and raising the apoptotic rate. |
2023-05-12 |
2023-08-14 |
human |
| Kallesh D Jayappa, Brian Tran, Vicki L Gordon, Christopher G Morris, Shekhar Saha, Caroline C Farrington, Caitlin M O'Connor, Kaitin P Zawacki, Krista M Isaac, Mark Kester, Timothy P Bender, Michael E Williams, Craig A Portell, Michael J Weber, Goutham Narl. PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis. The Journal of clinical investigation. 2023-05-11. PMID:37166997. |
here, we demonstrated that multidrug resistant cll cells in vivo exhibit apoptosis restriction at a premitochondrial level due to insufficient activation of the bax and bak proteins. |
2023-05-11 |
2023-08-14 |
mouse |
| Sheng-Yuan Chen, Chien-Chih Chiu, Chun-Tzu Hung, Wen-Hsiung Pan, Yen-Chun Chen, Yung-Ding Bow, Wan-Ju Li, Sheng-Kai Hsu, I-Ling Lin, Zhi-Hong Wen, Chang-Yi W. Diphenyl disulfide potentiates the apoptosis of breast cancer cells through Bax proteolytic activation with accompanying autophagy. Environmental toxicology. 2023-05-10. PMID:37163415. |
diphenyl disulfide potentiates the apoptosis of breast cancer cells through bax proteolytic activation with accompanying autophagy. |
2023-05-10 |
2023-08-14 |
Not clear |
| Sheng-Yuan Chen, Chien-Chih Chiu, Chun-Tzu Hung, Wen-Hsiung Pan, Yen-Chun Chen, Yung-Ding Bow, Wan-Ju Li, Sheng-Kai Hsu, I-Ling Lin, Zhi-Hong Wen, Chang-Yi W. Diphenyl disulfide potentiates the apoptosis of breast cancer cells through Bax proteolytic activation with accompanying autophagy. Environmental toxicology. 2023-05-10. PMID:37163415. |
western blotting of the expression of bax p21 and its cleaved form p18 suggested the activation of p18 bax-induced apoptosis. |
2023-05-10 |
2023-08-14 |
Not clear |
| Ni-Na Song, Ying Zhao, Chuang Sun, Jun Zhang, Guang-Jun Lin, Xiao-Wei Yin, Chun-Ye M. DUSP10 alleviates ischemic stroke-induced neuronal damage by restricting p38/JNK pathway. Behavioural brain research. 2023-05-10. PMID:37164190. |
the results showed that dusp10 overexpression improved survival and reduced apoptosis in neurons subjected to ogd/r, which was manifested by decreased apoptotic proteins (cleaved caspase 3 and bax) and tunel+ cells, as well as increased the anti-apoptotic protein (bcl-2). |
2023-05-10 |
2023-08-14 |
mouse |
| Jin-Tao Liu, Zhen-Xuan Sun, Rui Zhong, Yi-Dan Zhang, Teng Wang, Yu-Dong Hou, Jian-Heng Bao, Lei Zhang, Bo Che. ZNRF2 as an oncogene is transcriptionally regulated by CREB1 in breast cancer models. Human cell. 2023-05-10. PMID:37165255. |
flow cytometry and hoechst staining showed that knockdown of znrf2 induced cell apoptosis, which was verified by the upregulation of apoptosis genes such as bax, cleaved parp and bim. |
2023-05-10 |
2023-08-14 |
Not clear |
| A V Sirotkin, Z Fabova, W Aldahmash, A Alshamrani, A H Harrat. Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH. Physiological research. vol 72. issue 2. 2023-05-09. PMID:37159860. |
the expression of intracellular proliferation (pcna, cyclin b1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. |
2023-05-09 |
2023-08-14 |
human |
| Alaa Elmetwalli, Shimaa Mustafa Hashish, Mervat G Hassan, Mohammed Abu El-Magd, Sabry Ali El-Naggar, Amina M Tolba, Afrah Fatthi Salam. Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-09. PMID:37160480. |
the upregulation of tnf-α, il1β, and bcl-2 genes suggests that the clt was able to initiate an inflammatory response to combat the tumor, while the downregulation of the bax and beclin1 genes indicates that the clt was able to reduce the risk of apoptosis in the liver. |
2023-05-09 |
2023-08-14 |
mouse |
| Fatemeh Hosseini, Masoumeh Mirzaei Chegeni, Ali Bidaki, Mohammad Zaer, Hossein Abolhassani, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Arezoo Ashrafnia Menarbazari, Alaa Moeinzadeh, Ahmad Reza Farmani, Mohammad Tavakkoli Yarak. 3D-printing-assisted synthesis of paclitaxel-loaded niosomes functionalized by cross-linked gelatin/alginate composite: Large-scale synthesis and in-vitro anti-cancer evaluation. International journal of biological macromolecules. 2023-05-08. PMID:37156313. |
the anticancer effect of the designed nanocarrier could be attributed to gene expression regulation, where a significant increase in the expression and activity of genes promoting apoptosis (casp-3, casp-8, and casp-9) and inhibiting metastasis (bax, and p53) and a remarkable decrease in metastasis-enhancing genes (bcl2, mmp-2, and mmp-9) were observed. |
2023-05-08 |
2023-08-14 |
Not clear |
| Guanglu Wang, Yong Sun, Qiankun Yang, Dapeng Dai, Le Zhang, Hui Fan, Wei Zhang, Jingquan Dong, Panpan Zha. Liensinine, a alkaloid from lotus plumule, mitigates lipopolysaccharide-induced sepsis-associated encephalopathy through modulation of nuclear factor erythroid 2-related factor-mediated inflammatory biomarkers and mitochondria apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-05-07. PMID:37150347. |
tunel staining combined with transmission electron microscope indicated that lipopolysaccharide induced cerebrum apoptosis, whereas liensinine blocked apoptosis through decreasing b-cell lymphoma-2 associated x (bax) expression and cytochrome c (cyto-c) release, increasing b-cell lymphoma-2 (bcl-2) expression, blocking apoptosome assembly, inhibiting caspase-3 activation, thereby suppressing intrinsic mitochondria apoptosis. |
2023-05-07 |
2023-08-14 |
mouse |
| Ercan Ozdemir, Onur Avcı, Zeynep Deniz Sahin Inan, Ahmet Sevki Taskiran, Handan Gunes, Sinan Gurso. Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia. Metabolic brain disease. 2023-05-06. PMID:37148432. |
to evaluate apoptosis, elisa kits were used to measure caspase-3, bax and bcl-2 levels. |
2023-05-06 |
2023-08-14 |
rat |
| Sana Zafar, Yong Luo, Li Zhang, Chang Hu Li, Adnan Khan, Muhammad Ibrar Khan, Kifayatullah Shah, Eun Kyoung Seo, Feng Wang, Salman Kha. Daidzein attenuated paclitaxel-induced neuropathic pain via the down-regulation of TRPV1/P2Y and up-regulation of Nrf2/HO-1 signaling. Inflammopharmacology. 2023-05-05. PMID:37145202. |
dz also decreased neuronal apoptosis by decreasing caspase-3 and bcl2-associated x-protein (bax), while simultaneously, increasing bcl-2. |
2023-05-05 |
2023-08-14 |
Not clear |
| Xuehua Zhang, Leilei Zhao, Jinlong Xiao, Yudi Wang, Yunmeng Li, Chaoqun Zhu, He Zhang, Yurui Zhang, Xiao Zhu, Yucui Don. 5-Demethylnobiletin mediates cell cycle arrest and apoptosis Frontiers in oncology. vol 13. 2023-05-04. PMID:37139163. |
furthermore, 5-demethylnobiletin significantly induced glioblastoma cells apoptosis by upregulating the protein levels of bax and downregulating the protein level of bcl-2, subsequently increasing the expression of cleaved caspase-3 and cleaved caspase-9. |
2023-05-04 |
2023-08-14 |
Not clear |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Yangyang Xu, Jie Zhang, Fei Gao, Wenna Cheng, Ye Zhang, Chuanmei Wei, Shuping Zhang, Xinfu Ga. Engeletin alleviates cerebral ischemia reperfusion-induced neuroinflammation via the HMGB1/TLR4/NF-κB network. Journal of cellular and molecular medicine. 2023-05-03. PMID:37132060. |
furthermore, engeletin treatment markedly reduced neuronal apoptosis, which, in turn, elevated bcl-2 protein levels, while suppressing bax and cleaved caspase-3 protein levels. |
2023-05-03 |
2023-08-14 |
rat |
| Zheng Zheng, Xiang Wang, Donglei Che. Proteasome inhibitor MG132 enhances the sensitivity of human OSCC cells to cisplatin via a ROS/DNA damage/p53 axis. Experimental and therapeutic medicine. vol 25. issue 5. 2023-05-01. PMID:37123203. |
finally, in cells co-treated with mg132 and cddp, the expression of p53 was markedly elevated and the p53-mediated apoptotic pathway was further activated compared with cells treated with mg132 or cddp alone, as shown by the enhanced cell apoptosis, bax upregulation, and bcl-2 downregulation. |
2023-05-01 |
2023-08-14 |
human |
| Shuang Liu, Han Zhou, Yang Shi, Simeng Yi, Xinyu Wang, Jingyan Li, Bin Liao, Jimin Cao, Guang L. Zinc Oxide Nanoparticles Induce Renal Injury by Initiating Oxidative Stress, Mitochondrial Damage and Apoptosis in Renal Tubular Epithelial Cells. Biological trace element research. 2023-04-29. PMID:37119342. |
mechanistically, zno nps promoted oxidative stress and mitochondrial damage by generating ros and induced apoptosis in hk-2 cells, as evidenced by the upregulation of bax and caspase 3 and downregulation of beclin 1. |
2023-04-29 |
2023-08-14 |
mouse |
| Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlack. Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108135. |
the 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction bax, forming a channel in momp and releasing cytochrome c for the activation of caspases 9 and 3. |
2023-04-28 |
2023-08-14 |
Not clear |
| Patrycja Szczepańska, Magdalena Rychlicka, Sylwia Groborz, Angelika Kruszyńska, Rodrigo Ledesma-Amaro, Andrzej Rapak, Anna Gliszczyńska, Zbigniew Laza. Studies on the Anticancer and Antioxidant Activities of Resveratrol and Long-Chain Fatty Acid Esters. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108328. |
the above-mentioned resveratrol derivatives similarly increased the tumor cells' apoptosis by modifying their caspase activity of pro-apoptotic pathways (p21, p53, and bax). |
2023-04-28 |
2023-08-14 |
human |