| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahran Mohamed Abd El-Emam, Manobendro Nath Ray, Mizune Ozono, Kentaro Kogur. Heat stress disrupts spermatogenesis via modulation of sperm-specific calcium channels in rats. Journal of thermal biology. vol 112. 2023-02-16. PMID:36796910. |
heat treatment also upregulated the expression of the apoptosis regulator, bcl2-associated x protein (bax), decreased testicular weight, and altered testicular histology. |
2023-02-16 |
2023-08-14 |
rat |
| Eman T Mohammed, Ghada M Safwat, Esraa A Bahnasawy, Abdel-Razik H Abdel-Razik, Doaa Sh Mohame. Zinc Oxide Nanoparticles and Vitamin C Ameliorate Atrazine-Induced Hepatic Apoptosis in Rat via CYP450s/ROS Pathway and Immunomodulation. Biological trace element research. 2023-02-15. PMID:36790584. |
atrazine induced inflammation accompanied by apoptosis via upregulation of hepatic gene expression levels of nf-κb, tnf-α, bax, and caspase-3 and downregulation of bcl-2 gene expression levels. |
2023-02-15 |
2023-08-14 |
human |
| Francesca R Di Cristofano, Mara W Fong, Kelsey E Huntington, Benedito A Carneiro, Lanlan Zhou, Wafik S El-Deir. Synergistic activity of ABT-263 and ONC201/TIC10 against solid tumor cell lines is associated with suppression of anti-apoptotic Mcl-1, BAG3, pAkt, and upregulation of pro-apoptotic Noxa and Bax cleavage during apoptosis. American journal of cancer research. vol 13. issue 1. 2023-02-13. PMID:36777502. |
synergistic activity of abt-263 and onc201/tic10 against solid tumor cell lines is associated with suppression of anti-apoptotic mcl-1, bag3, pakt, and upregulation of pro-apoptotic noxa and bax cleavage during apoptosis. |
2023-02-13 |
2023-08-14 |
human |
| Francesca R Di Cristofano, Mara W Fong, Kelsey E Huntington, Benedito A Carneiro, Lanlan Zhou, Wafik S El-Deir. Synergistic activity of ABT-263 and ONC201/TIC10 against solid tumor cell lines is associated with suppression of anti-apoptotic Mcl-1, BAG3, pAkt, and upregulation of pro-apoptotic Noxa and Bax cleavage during apoptosis. American journal of cancer research. vol 13. issue 1. 2023-02-13. PMID:36777502. |
combination therapy-induced cell death correlated with decreased levels of mcl-1, bag3, pakt, and upregulation of noxa along with bax cleavage during apoptosis at 48 hours, and atf4, trail, and dr5 induction at 24 hours. |
2023-02-13 |
2023-08-14 |
human |
| Liguo Xie, Lifangyu Cheng, Yunlin We. Mitomycin C enhanced the antitumor efficacy of Rocaglamide in colorectal cancer. Pathology, research and practice. vol 243. 2023-02-13. PMID:36780842. |
the results showed that low concentration of mmc combined with roc significantly promoted hct116 and ht29 cell apoptosis and inhibited cell proliferation by downregulating the expression of bcl-2 and c-flip, upregulating the expression of bax, activating the caspase cascade (involving the mitochondrial apoptosis pathway), arresting cell cycle in g1 phase, and increasing the level of reactive oxygen species (ros). |
2023-02-13 |
2023-08-14 |
Not clear |
| Jun-Min Liu, Min Li, Wei Luo, Hong-Bo Su. Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 10. 2023-02-12. PMID:36775429. |
overexpression of hotair reversed the regulatory effect of curcumin on apoptosis and migration and restored the effect of curcumin on inducing the expression of cleaved caspase3, bax, and p27. |
2023-02-12 |
2023-08-14 |
human |
| Mona Hafez Hafez, Sara El-Sayed El-Kazaz, Heba I Ghamry, Mustafa Shukr. Coenzyme Q10 enhances testicular functions and sexual behavior through regulating steroidogenic-related gene expression and inflammatory pathways of Japanese quail (Coturnix japonica) aganist cadmium. Poultry science. vol 102. issue 4. 2023-02-11. PMID:36773446. |
in addition, testicular apoptosis was assessed by monitoring the alterations in the local expression of stress-induced (hsp70), proteins of anti-apoptotic marker (bcl-2), and pro-apoptotic markers (caspase-3 and bax). |
2023-02-11 |
2023-08-14 |
Not clear |
| Laxmidhar Da. Epigenetic alterations impede epithelial-mesenchymal transition by modulating centrosome amplification and Myc/RAS axis in triple negative breast cancer cells. Scientific reports. vol 13. issue 1. 2023-02-11. PMID:36774386. |
in addition, induction of apoptosis was observed by downregulation of bcl2, upregulation of bax and activation of parp cleavage. |
2023-02-11 |
2023-08-14 |
human |
| Osama Y Althunibat, Mohammad H Abukhalil, Muthana M Jghef, Manal A Alfwuaires, Abdulmohsen I Algefare, Bader Alsuwayt, Reem Alazragi, Mohammed A S Abourehab, Afaf F Almuqati, Shaik Karimulla, Saleem H Aladaile. Hepatoprotective effect of taxifolin on cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in mice: Involvement of Nrf2/HO-1 signaling. Biomolecules and biomedicine. 2023-02-10. PMID:36762432. |
livers of cp-injected mice also showed increased inflammatory response (nf-κb p65 activation, increased levels of proinflammatory cytokines tumor necrosis factor alpha [tnf-α], interleukin 1 beta [il-1β] and il-6) and apoptosis (decreased bcl-2 and increased bax and caspase-3 expression levels). |
2023-02-10 |
2023-08-14 |
mouse |
| Chenxi Wang, Chenyang Huang, Jiali Wang, Jianfeng Ye, Zhiqiang Xue, Jian Zhang, Yuke Re. Ginsenoside Rg5 attenuates hypoxia-induced cardiomyocyte apoptosis via regulating theAkt pathway. Chemical biology & drug design. 2023-02-10. PMID:36762503. |
finally, the experimental results shown that ginsenoside rg5 significantly inhibited hypoxia-induced nrms apoptosis, decreased the expression pro-apoptotic protein bax, increased the expression of anti-apoptotic protein bcl-2 ratio and the level of cleaved caspase 3. |
2023-02-10 |
2023-08-14 |
rat |
| Runfang Wang, Jing Zhao, Cuilian Liu, Shengxian Li, Weifang Liu, Qinying Ca. Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p. Reproductive biology. vol 23. issue 1. 2023-02-08. PMID:36753931. |
downregulation of aggf1 promoted cell proliferation, invasion and migration, inhibited apoptosis in vitro, decreased p53 and bax expression, and simultaneously increased bcl-2 expression, whereas overexpression of aggf1 had the opposite results. |
2023-02-08 |
2023-08-14 |
Not clear |
| Tahmineh Mokhtari, Lu-Peng Yue, Li H. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36747075. |
np upregulated bax, downregulated bcl2, and increased cell apoptosis in the hc and pfc. |
2023-02-07 |
2023-08-14 |
rat |
| Tahmineh Mokhtari, Lu-Peng Yue, Li H. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36747075. |
mlt could promote cell survival from apoptosis by modulating bax and bcl2. |
2023-02-07 |
2023-08-14 |
rat |
| Nilesh Rai, Priyamvada Gupta, Ashish Verma, Santosh Kumar Singh, Vibhav Gauta. Isolation and characterization of N-(2-Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis-inducing potential in breast cancer cells. BioFactors (Oxford, England). 2023-02-06. PMID:36744732. |
further validation was done using in vitro study that showed pea inhibitsthe proliferation, alters nuclear morphology and attenuates the wound closure ability of mda-mb-231 and mcf-7 cells. pea induces apoptosis via upregulating cell-cycle arrest (p21), tumor suppression (p53), pro-apoptotic (bax, caspase-8, and fadd) genes, and downregulating anti-apoptotic gene bcl-2. |
2023-02-06 |
2023-08-14 |
human |
| Priyanka, Medha, Parul Bhatt, Hemant Joshi, Sadhna Sharma, Monika Sharm. Late stage specific Rv0109 (PE_PGRS1) protein of Mycobacterium tuberculosis induces mitochondria mediated macrophage apoptosis. Microbial pathogenesis. 2023-02-05. PMID:36739922. |
this mitochondrial stress in response to rv0109 was observed to culminate in increased expression of pro-apoptotic bax and bim factors and caspase activation leading to macrophage apoptosis. |
2023-02-05 |
2023-08-14 |
Not clear |
| Yanhe Zhang, Shuang Xu, Kan Li, Xueying Li, Hang Yin, Shu Li, Xue-Jiao Ga. TBBPA induced ROS overproduction promotes apoptosis and inflammation by inhibiting autophagy in mice lung. Ecotoxicology and environmental safety. vol 252. 2023-02-04. PMID:36738613. |
the expression of bax, caspase3, caspase7, caspase 9 increase, the expression of bcl-2 decreased, and the apoptosis pathway activated. |
2023-02-04 |
2023-08-14 |
mouse |
| Mohamed A Tantawy, Aziza B Shalby, Ibrhim El-Bernawy, Shahad W Kattan, Ahmed A Abd-Rabou, Gamal A Elmegee. Anti-cancer Activity, and Molecular Docking of Novel Hybrid Heterocyclic Steroids Revealed Promising Anti-hepatocellular Carcinoma Agent: Implication of Cyclin Dependent kinase-2 Pathway. Steroids. 2023-02-03. PMID:36736802. |
moreover, compound 7 induced apoptosis via upregulating the expression of caspase-3, -8, -9, p53, bax and inhibiting the expression of bcl2, and cdk2 genes. |
2023-02-03 |
2023-08-14 |
human |
| Wei-Ping He, Jin-Cheng Li, Gao-Ming Wan. [Effect of total flavonoids of buckwheat flower and leaf on myocardial cell apoptosis and Wnt/β-catenin/PPARγ pathway in arrhythmic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 1. 2023-02-01. PMID:36725274. |
as compared with the control group, the arrhythmia score, the number of ventricular premature beats, ventricular fibrillation duration, myocardial cell apoptosis rate, mda levels in myocardial tissues, serum il-6 and pge2 levels, bax in myocardial tissues, and wnt1 and β-catenin protein expression levels increased significantly in the model group, whereas the gsh-px and cat levels, and bcl-2 and pparγ protein expression levels in myocardial tissues reduced significantly. |
2023-02-01 |
2023-08-14 |
rat |
| Wei-Ping He, Jin-Cheng Li, Gao-Ming Wan. [Effect of total flavonoids of buckwheat flower and leaf on myocardial cell apoptosis and Wnt/β-catenin/PPARγ pathway in arrhythmic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 1. 2023-02-01. PMID:36725274. |
as compared with the model group, the arrhythmia score, the number of ventricular premature beats, ventricular fibrillation duration, myocardial cell apoptosis rate, mda leve in myocardial tissues, serum il-6 and pge2 levels, bax in myocardial tissues, and wnt1 and β-catenin protein expression levels reduced in the drug intervention groups, whereas the gsh-px and cat levels and bcl-2 and pparγ protein expression levels in myocardial tissues increased. |
2023-02-01 |
2023-08-14 |
rat |
| Nan Chen, Yushuang Liu, Hongyi Yu, Sihan Liu, Peng Xiao, Zhongyi Jia, Zhongling Zhan. The role of CUL3 in cerebral ischemia-reperfusion injury. Neuroscience. 2023-01-31. PMID:36720302. |
cul3 silencing reduced tunel-positive cells, down-regulated pro-apoptotic factor (bax and cleaved caspase 3) levels and increased the anti-apoptotic factor (bcl-2) level in vitro and in vivo, suggesting that cul3 repression alleviated neuronal apoptosis. |
2023-01-31 |
2023-08-14 |
rat |