| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ni Zeng, Zaijin Jian, Wenxin Zhu, Junmei Xu, Yongmei Fan, Feng Xia. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced cellular inflammation and apoptosis. International journal of experimental pathology. 2022-12-30. PMID:36583453. |
pro-apoptotic cleaved-caspase3/caspase3 and bax levels and anti-apoptotic bcl2 level, inflammatory cytokines (il-1β, tnf-α, il-8 and mcp-1) production and iκb-α protein level and p65 phosphorylation in septic mice and lps-induced cells were detected to evaluate cardiomyocyte apoptosis, inflammatory response and nf-κb pathway activation. |
2022-12-30 |
2023-08-14 |
mouse |
| Ni Zeng, Zaijin Jian, Wenxin Zhu, Junmei Xu, Yongmei Fan, Feng Xia. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced cellular inflammation and apoptosis. International journal of experimental pathology. 2022-12-30. PMID:36583453. |
septic heart and lps-induced cell model showed abnormally increased cardiomyocyte apoptosis (increased cleaved-caspase3/caspase and bax protein levels and decreased bcl2 level), elevated inflammation (increased production of inflammatory cytokines) and the activated nf-κb pathway (increased p65 phosphorylation and decreased iκb-α protein level). |
2022-12-30 |
2023-08-14 |
mouse |
| Ke Zhang, Hailing Zhang, Shanshan Gao, Caiping Sun, Bing Wan. Effect and mechanism of microRNA-515-5p in proliferation and apoptosis of trophoblast cells in preeclampsia via manipulating histone deacetylase 2. Molecular reproduction and development. 2022-12-29. PMID:36580437. |
overexpressed mir-515-5p impeded proliferation and stimulated apoptosis of htr-8/svneo cells, and decreased levels of cleaved caspase-3 and bax and elevated bcl-2, whilst opposite results were observed after mir-515-5p inhibition. |
2022-12-29 |
2023-08-14 |
Not clear |
| Xinyu Wu, Baoshi Xu, Huizhen Chen, Jingchao Qiang, Huimiao Feng, Xueqing Li, Mingyi Chu, Enzhuang Pan, Jingquan Don. Crosstalk of oxidative stress, inflammation, apoptosis, and autophagy under reactive oxygen stress involved in difenoconazole-induced kidney damage in carp. Fish & shellfish immunology. 2022-12-29. PMID:36581253. |
the tunel test clearly showed that difenoconazole induced apoptosis in the kidney and vastly raised the transcript levels of apoptosis-related genes p53, caspase9, caspase3, and bax while inhibiting the expression of bcl-2, fas, capsase8. |
2022-12-29 |
2023-08-14 |
cat |
| Zuzana Fabová, Barbora Loncová, Alexander V Sirotki. MicroRNA miR-125b can suppress ovarian granulosa cell functions: Interrelationships with FSH. Cell biochemistry and function. 2022-12-28. PMID:36575629. |
expression levels of mir-125b, viability, proliferation (accumulation of pcna and cyclin b1), apoptosis (accumulation of bax and caspase 3), the accumulation of fsh receptors (fshr), steroid hormones, insulin-like growth factor i (igf-i), oxytocin, and prostaglandin e2 release were analysed by reverse transcription-quantitative polymerase chain reaction, trypan blue exclusion test, quantitative immunocytochemistry, and elisa. |
2022-12-28 |
2023-08-14 |
Not clear |
| Hsiang-Ching Tseng, Chan-Yen Kuo, Wei-Ting Liao, Te-Sen Chou, Jong-Kai Hsia. Indocyanine green as a near-infrared theranostic agent for ferroptosis and apoptosis-based, photothermal, and photodynamic cancer therapy. Frontiers in molecular biosciences. vol 9. 2022-12-26. PMID:36567945. |
we observed that the ht-1080-oatp1b3 cells treated with icg and exposed to 808-nm laser irradiation underwent apoptosis, as indicated by a reduction in mitochondrial membrane potential, and upregulation of cleaved caspase-3 and bax but downregulation of bcl-2 expression. |
2022-12-26 |
2023-08-14 |
Not clear |
| Duqiang Gong, Kexin Sun, Kexin Yin, Xu Wan. Selenium mitigates the inhibitory effect of TBBPA on NETs release by regulating ROS/MAPK pathways-induced carp neutrophil apoptosis and necroptosis. Fish & shellfish immunology. 2022-12-25. PMID:36566834. |
the expression of genes related to the mitochondrial apoptosis pathway (bax, cyt-c, bcl-2 and caspase-3) and necroptosis pathway (mlkl, ripk1, ripk3, caspase-8 and fadd) were activated. |
2022-12-25 |
2023-08-14 |
Not clear |
| Huan Deng, Yanqiu Liang, Xiaoyu Xiao, Yingqing Hu, Sufang Chen, Pinjie Huang, Dezhao Li. Culture media from hypoxia conditioned mast cells aggravates hypoxia and reoxygenation injury of human intestinal cells. Tissue & cell. vol 80. 2022-12-24. PMID:36565506. |
the results concluded that caco-2 exposed to h/r insult showed an increase in lactate dehydrogenase (ldh) release, cell apoptosis index, cell permeability, bax expression, phosphorylation of c-jun n-terminal protein kinase (jnk) and p38, and a decrease in cell viability and expression of bcl-2, zo1, and occludin (all p < 0.05). |
2022-12-24 |
2023-08-14 |
human |
| Qian Hao, Jiaxiang Chen, Hua Lu, Xiang Zho. The ARTS of p53-dependent mitochondrial apoptosis. Journal of molecular cell biology. 2022-12-24. PMID:36565718. |
on the one hand, nuclear p53 transcriptionally activates the expression of a myriad of pro-apoptotic bcl-2 family genes, such as noxa, puma, bid, bad, bik, bax, etc., whereas inactivates the expression of anti-apoptotic bcl-2, bcl-xl, and mcl1, leading to mitochondrial apoptosis. |
2022-12-24 |
2023-08-14 |
Not clear |
| Kuang-I Cheng, Yu-Chin Chang, Li-Wen Chu, Su-Ling Hsieh, Li-Mei An, Zen-Kong Dai, Bin-Nan W. The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555516. |
loganin also attenuated the cci-increased apoptosis protein bax and cleaved caspase-3. |
2022-12-23 |
2023-08-14 |
rat |
| Fen Xing, Mengyao Wang, Zhiming Ding, Junhui Zhang, Simin Ding, Lingge Shi, Qinge Xie, Muhammad Jamil Ahmad, Zhaolian Wei, Liang Tang, Dan Liang, Yunxia Cao, Yajing Li. Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice. Journal of clinical medicine. vol 11. issue 24. 2022-12-23. PMID:36555999. |
furthermore, cp caused ovarian apoptosis, as indicated by up-regulated bax expression. |
2022-12-23 |
2023-08-14 |
mouse |
| F A Dain Md Opo, Mohammed Moulay, Ghadeer I Alrefaei, Nouf H Alsubhi, Saleh Alkarim, Mohammed M Rahma. Effect of Co-culturing both placenta-derived mesenchymal stem cells and their condition medium in the cancer cell (HepG2) migration, damage through apoptosis and cell cycle arrest. Saudi journal of biological sciences. vol 30. issue 2. 2022-12-23. PMID:36561333. |
flow cytometry, caspase 9 immunofluorescence, qpcr (detection of bax, bcl-2, and β-catenin genes), western blot, and immunophenotyping revealed that treatment with hpmscs or hpmscs-cm caused hepg2 cell death through apoptosis (detection of caspase 9, caspase 3 protein). |
2022-12-23 |
2023-08-14 |
human |
| Mei-Chi Chang, Jen-Hao Chen, Hui-Na Lee, Shyuan-Yow Chen, Bor-Hao Zhong, Kunaal Dhingra, Yu-Hwa Pan, Hsiao-Hua Chang, Yi-Jane Chen, Jiiang-Huei Jen. Inducing cathepsin L expression/production, lysosomal activation, and autophagy of human dental pulp cells by dentin bonding agents, camphorquinone and BisGMA and the related mechanisms. Biomaterials advances. vol 145. 2022-12-23. PMID:36563508. |
cq and bisgma stimulated lysosomal activity, autophagy, and apoptosis, possibly via induction of beclin 1, atg12, lc-3b, bax, and p53 expression. |
2022-12-23 |
2023-08-14 |
human |
| Chaoyang Liu, Zehua Liu, Yanyan Fang, Zizhuo Liao, Zhibing Zhang, Xin Yuan, Ting Yu, Yunying Yang, Min Xiong, Xingyu Zhang, Guoxin Zhang, Lanxia Meng, Zhentao Zhan. Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms. Environment international. vol 171. 2022-12-23. PMID:36563597. |
furthermore, western blot analysis found that the mitochondrial apoptosis pathway (bcl-2, bax, cytochrome c, activated caspase-3) and the pka/creb signaling pathway (pka, pde10a, creb, p-creb) were changed by maneb both in vitro and in vivo. |
2022-12-23 |
2023-08-14 |
mouse |
| Huan Hou, Ying Xu, Meilin Xie, Rong Che. Exploring the potential molecular mechanism of trastuzumab-induced cardiotoxicity based on RNA sequencing and bioinformatics analysis. Biochemical pharmacology. 2022-12-23. PMID:36563885. |
in addition, an increased expressions of bax, caspase-3, ifn-γ and tnf-α and a decreased expression of bcl-2 were observe in western blot, indicating the apoptosis and inflammation levels were increased. |
2022-12-23 |
2023-08-14 |
mouse |
| Jingwen Wang, Zhijia Fang, Yongbin Li, Lijun Sun, Ying Liu, Qi Deng, Saiyi Zhon. Ameliorative Effects of Oyster Protein Hydrolysates on Cadmium-Induced Hepatic Injury in Mice. Marine drugs. vol 20. issue 12. 2022-12-22. PMID:36547905. |
ops suppressed the development of hepatocyte apoptosis (bax, caspase-3, and blc-2) and the activation of the pi3k/akt signaling pathway in cd-exposed mice. |
2022-12-22 |
2023-08-14 |
mouse |
| Peter Vandenabeele, Geert Bultynck, Savvas N Savvide. Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nature reviews. Molecular cell biology. 2022-12-21. PMID:36543934. |
regulated cell death (rcd) relies on activation and recruitment of pore-forming proteins (pfps) that function as executioners of specific cell death pathways: apoptosis regulator bax (bax), bcl-2 homologous antagonist/killer (bak) and bcl-2-related ovarian killer protein (bok) for apoptosis, gasdermins (gsdms) for pyroptosis and mixed lineage kinase domain-like protein (mlkl) for necroptosis. |
2022-12-21 |
2023-08-14 |
Not clear |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
further studies showed that inhibiting sirt1 blocked bergenin's beneficial impact against apoptosis following si/r injury through excessive oxidative stress and depression of the bcl2 to bax ratio. |
2022-12-20 |
2023-08-14 |
mouse |
| Zhewei Zhang, Ke Xiao, Sheng Wang, Abdur Rahman Ansari, Xiaoyu Niu, Wenjie Yang, Mengqi Lu, Zhi Yang, Zia Ur Rehman, Weihua Zou, Weicheng Bei, Hui Son. Visfatin is a multifaceted molecule that exerts regulation effects on inflammation and apoptosis in RAW264.7 cells and mice immune organs. Frontiers in immunology. vol 13. 2022-12-19. PMID:36532047. |
additionally, endogenous visfatin promotes the apoptosis in mice immune organs by regulating the expression levels of bcl2l1, fas, caspase 3, bcl2a1a, and bax. |
2022-12-19 |
2023-08-14 |
mouse |
| Zhenchao Zhang, Fakun Li, Yangyang Deng, Yuhua Li, Wanxin Sheng, Xiaowei Tian, Zhenke Yang, Shuai Wang, Lihua Guo, Lixia Hao, Xuefang Me. Trichomonas vaginalis excretory secretory proteins reduce semen quality and male fertility. Acta tropica. 2022-12-19. PMID:36535511. |
via semi-quantitative analysis, we found that the apoptosis-related p27, smac, p53, bax, bcl-2, xiap, and bcl-w molecules were down-regulated in mouse sperm cells after interaction between the sperms and tvesps, which played an important role in regulating sperm apoptosis. |
2022-12-19 |
2023-08-14 |
mouse |