| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhuoying Hu, Nandar Linn, Quanwei Li, Kai Zhang, Jianzhao Liao, Qingyue Han, Hui Zhang, Jianying Guo, Lianmei Hu, Jiaqiang Pan, Ying Li, Zhaoxin Tan. MitomiR-504 alleviates the copper-induced mitochondria-mediated apoptosis by suppressing Bak1 expression in porcine jejunal epithelial cells. The Science of the total environment. 2022-11-15. PMID:36379340. |
the mir-504 mimic notably enhanced the mrna and protein expressions of bak1, bax, cleaved-caspase3 and caspase-9, and significantly decreased the apoptosis rate and bcl-2 mrna and protein levels, indicating that overexpression of mitomir-504 attenuated the cu-induced mitochondria-mediated apoptosis. |
2022-11-15 |
2023-08-14 |
Not clear |
| Fengqin Yan, Hong Zhu, Yingxia He, Qinqin Wu, Xiaoyu Dua. Combination of tolvaptan and valsartan improves cardiac and renal functions in doxorubicin-induced heart failure in mice. European journal of histochemistry : EJH. vol 66. issue 4. 2022-11-14. PMID:36373350. |
meanwhile, tolvaptan/valsartan combination notably inhibited the myocardial and renal cell apoptosis in dox-treated mice via upregulation of bcl-2 and downregulation of bax and cleaved caspase 3, compared to the single drug treatment. |
2022-11-14 |
2023-08-14 |
mouse |
| b' Sema Bilgin, Secil Erden Tayhan, Asl\\xc4\\xb1 Y\\xc4\\xb1ld\\xc4\\xb1r\\xc4\\xb1m, Esra Ko\\xc3\\xa. Investigation of the effects of isoeugenol-based phenolic compounds on migration and proliferation of HT29 colon cancer cells at cellular and molecular level. Bioorganic chemistry. vol 130. 2022-11-14. PMID:36375352.' |
in addition, mrna expression levels of apoptosis and metastasis-related genes (p53, bcl2, bax, caspase 3, caspase7, caspase8, caspase9, hif1-α, vegf, mmp-2, mmp-9) were examined by quantitative real-time pcr. |
2022-11-14 |
2023-08-14 |
Not clear |
| Haiming Dai, Kevin L Peterson, Karen S Flatten, X Wei Meng, Annapoorna Venkatachalam, Cristina Correia, Marina Ramirez-Alvarado, Yuan-Ping Pang, Scott H Kaufman. A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C. Cell death and differentiation. 2022-11-14. PMID:36376382. |
a bak subdomain that binds mitochondrial lipids selectively and releases cytochrome c. how bak and bax induce mitochondrial outer membrane (mom) permeabilization (momp) during apoptosis is incompletely understood. |
2022-11-14 |
2023-08-14 |
Not clear |
| Mosaab Salah El-Din El-Agawy, Alaa Mohamed Mohamed Badawy, Mohammed R Rabei, Mohamed Mahmoud Abdelraheem Elshaer, Eman Mohamad El Nashar, Mansour A Alghamdi, Mohammed A Alshehri, Hassan Reda Hassan Elsaye. Methotrexate-Induced Alteration of Renal Aquaporins 1 and 2, Oxidative Stress and Tubular Apoptosis Can Be Attenuated by Omega-3 Fatty Acids Supplementation. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361584. |
then, h&e staining and immunohistochemical staining for the anti-apoptosis marker b-cell lymphoma 2 (bcl-2), the apoptosis marker bcl2-associated x protein (bax), the proinflammatory marker nuclear factor kappa b (nf-kb), aqps 1 and 2 were performed in kidney sections with an assessment of renal oxidative stress. |
2022-11-11 |
2023-08-14 |
rat |
| Hae-Seul Choi, Eun-Su Lim, Kwang-Hyun Bae. Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361894. |
the bax protein is a pro-apoptotic protein belonging to the bcl-2 family, involved in inducing apoptosis at the mitochondrial level. |
2022-11-11 |
2023-08-14 |
Not clear |
| Hae-Seul Choi, Eun-Su Lim, Kwang-Hyun Bae. Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361894. |
regulating the protein levels of bax is essential to enhancing apoptosis. |
2022-11-11 |
2023-08-14 |
Not clear |
| Maqusood Ahamed, Rashid Lateef, Mohd Javed Akhtar, Pavan Rajanahall. Dietary Antioxidant Curcumin Mitigates CuO Nanoparticle-Induced Cytotoxicity through the Oxidative Stress Pathway in Human Placental Cells. Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364205. |
the apoptosis data also exhibited that cuo nps modulate the expression of several genes (p53, bax, bcl-2, casp3, and casp9), the activity of enzymes (caspase-3 and -9), and mitochondrial membrane potential loss, which was successfully reverted by co-treatment with curcumin. |
2022-11-11 |
2023-08-14 |
human |
| Seenipandi Arunachalam, Mohamed Fizur Nagoor Meeran, Sheikh Azimullah, Niraj Kumar Jha, Dhanya Saraswathiamma, Alia Albawardi, Rami Beiram, Shreesh Ojh. α-Bisabolol Attenuates NF-κB/MAPK Signaling Activation and ER-Stress-Mediated Apoptosis by Invoking Nrf2-Mediated Antioxidant Defense Systems against Doxorubicin-Induced Testicular Toxicity in Rats. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364909. |
dox triggered apoptosis, manifested by an increment in the expression levels of pro-apoptotic markers (bax, bcl2, cleaved caspase-3 and -9, and cytochrome-c) and a decline in the expression levels of anti-apoptotic markers (bcl-xl and bcl2) in the testis. |
2022-11-11 |
2023-08-14 |
rat |
| Ayman Alzu'bi, Mazhar Salim Al Zoubi, Bahaa Al-Trad, Manal Isam AbuAlArjah, Malek Shehab, Hiba Alzoubi, Dima Albals, Gamal T Abdelhady, Waseem El-Huneid. Acute Hepatic Injury Associated with Acute Administration of Synthetic Cannabinoid XLR-11 in Mouse Animal Model. Toxics. vol 10. issue 11. 2022-11-10. PMID:36355959. |
using real-time quantitative rt-pcr, mda assay, and tunel assay, we found consistent up-regulation of a variety of genes involved in oxidative stress (nox2, nox4, and inos), inflammation (tnf-α, il-1β, il-6), and apoptosis (bax) in the liver of xlr-11 treated mice compared to control mice. |
2022-11-10 |
2023-08-14 |
mouse |
| Lu Yang, Chunya Ma, Shengfei Tai, Mingzi Ma, Bin Fan, Xiaoxing Liang, Liping Sun, Xiaolong Zhong, Yang Yu, Deqing Wan. Mechanism of selective induction of apoptosis of HCT116 tumor cells in circulating blood by riboflavin photochemistry. Journal of photochemistry and photobiology. B, Biology. vol 237. 2022-11-05. PMID:36334509. |
besides, rpt treatment reduced the expression of long non﹣coding rna (lncrna) neat1, an effector gene of hct116 cells, which further down-regulated the expression of target gene pax2 and promoted the expression of bax, leading to mitochondrial outer membrane permeabilization (momp), and consequently increased the release of pro-apoptotic factors such as cytochrome c(cyt c), high-temperature requirement protein a2(htra2), apoptosis-inducing factor (aif), endonuclease g(endog), finally leading to apoptosis of hct116 cells. |
2022-11-05 |
2023-08-14 |
Not clear |
| Dalong Wang, Jing Liu, Xiaodong Chen, Jing Chen, Tingting Zhao, Jie Du, Changyuan Wang, Qiang Meng, Huijun Sun, Fangjun Wang, Kexin Liu, Jingjing W. Renal transporter OAT1 and PPAR-α pathway co-contribute to icaritin-induced nephrotoxicity. Phytotherapy research : PTR. 2022-11-04. PMID:36331006. |
first, icaritin showed a significant cytotoxic effect on hk-2 cells, which was accompanied by increased ldh and tnf-α in the supernatant, decreased protein expressions of bcl-2 and increased bax and enhanced apoptosis of hk-2 cells as measured by tunel staining. |
2022-11-04 |
2023-08-14 |
mouse |
| Yanxia Xiong, Chengyuan Wang, Mengyi Dong, Meifeng Li, Chengyu Hu, Xiaowen X. Chlorphoxim induces neurotoxicity in zebrafish embryo through activation of oxidative stress. Environmental toxicology. 2022-11-04. PMID:36331003. |
as expected, chlorphoxim exposure induces apoptosis by enhancing the expression of apoptotic genes (bax, bcl2, and p53). |
2022-11-04 |
2023-08-14 |
cat |
| Xue-Min Chen, Yu-Hui Liu, Shuai-Fei Ji, Xin-Miao Xue, Lin-Lin Wang, Min Zhang, Yao-Ming Chang, Xiao-Cheng Wan. Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage in guinea pigs. Environmental science and pollution research international. 2022-11-04. PMID:36331733. |
gsrd treatment markedly mitigated hearing threshold shifts, ameliorated outer hair cell loss and lodging or loss of cilia, and improved apoptosis through decreasing bcl-2 associated x protein (bax) expression and increasing bcl-2 expression. |
2022-11-04 |
2023-08-14 |
Not clear |
| Shijie Lyu, Yaying Zhai, Xiaoting Zhu, Qiaoting Shi, Fuying Chen, Geyang Zhang, Zijing Zhang, Eryao Wan. Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle. Theriogenology. vol 195. 2022-11-04. PMID:36332375. |
overexpression of bta-mir-200b upregulated the expression of proapoptotic gene bcl2 associated x, apoptosis regulator (bax) and endometrial receptivity marker gene osteopontin (opn) at mrna and protein level in bovine endometrial epithelial cells. |
2022-11-04 |
2023-08-14 |
cattle |
| Amal T Abou-Elghait, Dalia A Elgamal, Nessren M Abd El-Rady, Ahmed Hosny, El Zahraa Abd Allah Abd El-Samie, Fares E M Al. Novel protective effect of diosmin against cisplatin-induced prostate and seminal vesicle damage: Role of oxidative stress and apoptosis. Tissue & cell. vol 79. 2022-11-03. PMID:36327569. |
cis significantly induced tissue apoptosis concomitant with suppression of cellular proliferation and stem cell expression as indicated by up-regulation of activated caspase-3 and bax expression along with down-regulation of bcl-2, ki67, and cd44 expression. |
2022-11-03 |
2023-08-14 |
human |
| Xu He, Dayu Wang, Fuquan Zhu, Yuan Jiang, Jiaying Bi, Xinyue Lu, Mingyue Zhao, Weidong Wu, Juan L. Astaxanthin alleviates palmitic acid-induced hindrance of porcine oocyte maturation. Reproduction in domestic animals = Zuchthygiene. vol 57. issue 11. 2022-11-01. PMID:36317481. |
in addition, the rate of ccs with apoptosis decreased in pa0.5 + axe, and the expression level of caspase 3 and bax was lower than pa0.5 group. |
2022-11-01 |
2023-08-14 |
Not clear |
| Gahyun Lim, Yunsook Li. Effects of Whey Peptide Supplementation on Sarcopenic Obesity in High-Fat Diet-Fed Mice. Nutrients. vol 14. issue 20. 2022-10-31. PMID:36297085. |
in skeletal muscle, wp supplementation regardless of re alleviated energy metabolism dysregulation and resulted in down-regulated protein degradation (atrogin-1 (p = 0.003), murf1 (p = 0.006)) and apoptosis (bax) (p = 0.004). |
2022-10-31 |
2023-08-16 |
mouse |
| Bo Li, Ying Lu, Rong Wang, Tao Xu, Xiaolu Lei, Huan Jin, Xiaohong Gao, Ye Xie, Xiaohong Liu, Junwei Zen. MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line. Neurochemical research. 2022-10-30. PMID:36309937. |
the expression of key mrna/proteins (tnfr1, bcl-2, bax, tradd, fadd, caspase-3, -8 and -9) in the apoptosis pathway was detected by pcr or wb. |
2022-10-30 |
2023-08-14 |
mouse |
| Xinxu Zhang, Min Li, Hao Wu, Weiyang Fan, Jiashuo Zhang, Weiwei Su, Yonggang Wang, Peibo L. Naringenin attenuates inflammation, apoptosis and ferroptosis in silver nanoparticle-induced lung injury through a mechanism associated with Nrf2/HO-1 axis: In vitro and in vivo studies. Life sciences. 2022-10-28. PMID:36306867. |
moreover, naringenin attenuated agnps-induced apoptosis with modulated low bax, cytc, cleaved caspase9, cleaved caspase3 but high bcl2. |
2022-10-28 |
2023-08-14 |
mouse |