| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qifang Niu, Yang Yang, Delong Li, Wenwen Guo, Chong Wang, Haoyue Xu, Zhien Feng, Zhengxue Ha. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Ischemia-Reperfusion Injury and Promote Survival of Skin Flaps in Rats. Life (Basel, Switzerland). vol 12. issue 10. 2022-10-27. PMID:36295004. |
apoptosis was evaluated via the terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel) assay and western blot analysis of bax, bcl-2. |
2022-10-27 |
2023-08-14 |
human |
| Chunyan Liu, Wenli Zhao, Ligang Zhang, Huamin Sun, Xi Chen, Ning Den. Preparation of DSPE-PEG-cRGD Modified Cationic Liposomes for Delivery of OC-2 shRNA and The Antitumor Effects on Breast Cancer. Pharmaceutics. vol 14. issue 10. 2022-10-27. PMID:36297592. |
in mcf-7 cells, the pshoc-2 could down-regulate expression of oc-2 and result in cell apoptosis, inhibition of the wound healing, migration and cell colony formation, in which the signal pathways of bcl-xl, bcl-2 were inhibited and the signal pathways of bax and cleaved caspase-3 were promoted. |
2022-10-27 |
2023-08-14 |
mouse |
| Hao Yue, Yingying Tian, Zifang Zhao, Yuying Bo, Yao Guo, Jingfeng Wan. Comparative Study of Docosahexaenoic Acid with Different Molecular Forms for Promoting Apoptosis of the 95D Non-Small-Cell Lung Cancer Cells in a PPARγ-Dependent Manner. Marine drugs. vol 20. issue 10. 2022-10-26. PMID:36286423. |
mechanistically, dha-pc and dha-tg treatment up-regulated the pparγ and rxrα signal, inhibited the expression of nf-κb and bcl-2, and enhanced the expression of bax and caspase-3, thereby promoting cell apoptosis. |
2022-10-26 |
2023-08-14 |
Not clear |
| Parvin Ghasemi, Gholamreza Shafiee, Nasrin Ziamajidi, Roghayeh Abbasalipourkabi. Copper Nanoparticles Induce Apoptosis and Oxidative Stress in SW480 Human Colon Cancer Cell Line. Biological trace element research. 2022-10-24. PMID:36274109. |
to investigate the effect of nps on cellular apoptosis, hoechst33258 staining was performed, and the expression of bax, bcl-2, and p53 was evaluated by qrt-pcr. |
2022-10-24 |
2023-08-14 |
human |
| Wen Yu, Huang Sun, Yang Tan, Wei Zhan. Paeoniflorin Protects H9c2 Cardiomyocytes against Hypoxia/Reoxygenation Induced Injury via Regulating the AMPK/Nrf2 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-10-24. PMID:36276847. |
furthermore, pf protected h9c2 cells against h/r-induced apoptosis, as demonstrated by increased bcl-2 expression, decreased bax expression, and decreased caspase-3 activity. |
2022-10-24 |
2023-08-14 |
Not clear |
| Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huan. Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways. Cell biology international. 2022-10-23. PMID:36273427. |
the downregulation of sk4 by a specific inhibitor tram-34 markedly ameliorated cardiac hypertrophy (reflected by the mrna levels of atrial natriuretic peptide, brain natriuretic peptide, and β-myosin heavy chain) and apoptosis (reflected by the level of caspase 3, bax, and bcl-2) induced by ang ii treatment. |
2022-10-23 |
2023-08-14 |
Not clear |
| Akandé Rouchidane Eyitayo, Marie-France Giraud, Laetitia Daury, Olivier Lambert, Cécile Gonzalez, Stéphen Mano. Cell-free synthesis and reconstitution of Bax in nanodiscs: Comparison between wild-type Bax and a constitutively active mutant. Biochimica et biophysica acta. Biomembranes. 2022-10-23. PMID:36273540. |
bax is a major player in the mitochondrial pathway of apoptosis, by making the outer mitochondrial membrane (omm) permeable to various apoptogenic factors, including cytochrome c. in order to get further insight into the structure and function of bax when it is inserted in the omm, we attempted to reconstitute bax in nanodiscs. |
2022-10-23 |
2023-08-14 |
human |
| Feng Jiang, Tieming Zhu, Chunfeng Yang, Yang Chen, Zhidong Fu, Lihui Jiang, Yongzhi Li. Pachymic acid inhibits growth and metastatic potential in liver cancer HepG2 and Huh7 cells. Biological & pharmaceutical bulletin. 2022-10-23. PMID:36273899. |
mechanistically, we revealed that pachymic acid triggered cell apoptosis by increasing caspase 3 and caspase 9 cleavage, upregulating bax and cytochrome c expression, while reducing the expression of bcl2. |
2022-10-23 |
2023-08-14 |
Not clear |
| Larissa Akemi Kido, Isabela Maria Urra Rossetto, Andressa Mara Baseggio, Gabriela Bortolanza Chiarotto, Letícia Ferreira Alves, Felipe Rabelo Santos, Celina de Almeida Lamas, Mário Roberto Maróstica Jr, Valéria Helena Alves Cagno. Brazilian Berry Extract Differentially Induces Inflammatory and Immune Responses in Androgen Dependent and Independent Prostate Cancer Cells. Journal of cancer prevention. vol 27. issue 3. 2022-10-19. PMID:36258714. |
mechanisms related to cell death by apoptosis were stimulated after the jpe treatment, modulating b-cell lymphoma 2 and bax for lncap and pc-3. |
2022-10-19 |
2023-08-14 |
Not clear |
| Tao Feng, Chunyu Song, Zhiyong Wu, Ke Zhao, Shenglan Y. Role of lncRNA MIAT/miR-361-3p/CCAR2 in prostate cancer cells. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-10-17. PMID:36245704. |
downregulating lncrna miat decreased the cell viability, induced the cell apoptosis, increased bax expression, and decreased bcl-2 expression in du145 cells, while the effects were reversed by downregulating mir-361-3p or ccar2 upregulation. |
2022-10-17 |
2023-08-14 |
Not clear |
| Sajedeh Daei, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir, Zeynab Aminzadeh, Mohammad Vahabira. Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression. Chonnam medical journal. vol 58. issue 3. 2022-10-17. PMID:36245767. |
consistent with this, the induction of apoptosis was revealed by the overexpression of bax, accompanied by a reduction in bcl-2 expression compared to the control. |
2022-10-17 |
2023-08-14 |
Not clear |
| Junjie Lu, Bo Shuai, Zhexing Shou, Weina Guo, Cong Zhou, Xiaohu Ouyang, Haifeng Zhou, Junyi Li, Jing Cui, Feng Jiang, Kim Yun Jin, Alexey Sarapultsev, Fangfei Li, Ge Zhang, Shanshan Luo, Desheng H. Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer. Cancers. vol 14. issue 19. 2022-10-14. PMID:36230568. |
further in vitro experiments showed that tax could significantly induce cancer cell apoptosis as verified by increased pro-apoptotic molecules including bax, caspase-9, and parp1 downregulated anti-apoptotic protein bcl-2; and decreased mitochondrial potential. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
this review delineates how in in vivo models mhdis suppress aβ deposition by downregulating β- and γ-secretase activities; inhibit oxidative stress by enhancing the antioxidant activities and reducing lipid peroxidation; prevent tau hyperphosphorylation by upregulating protein phosphatase 2a expression and downregulating glycogen synthase kinase-3β expression; reduce inflammatory mediators partly by upregulating brain-derived neurotrophic factor/extracellular signal-regulated protein kinase 1/2-mediated signaling and downregulating p38 mitogen-activated protein kinase (p38 mapk)/c-jun n-terminal kinase (jnk)-mediated signaling; attenuate synaptic dysfunction by increasing presynaptic protein, postsynaptic protein, and acetylcholine levels and preventing acetylcholinesterase activity; and protect against neuronal apoptosis mainly by upregulating akt/cyclic amp response element-binding protein/b-cell lymphoma 2 (bcl-2)-mediated anti-apoptotic signaling and downregulating p38 mapk/jnk/bcl-2-associated x protein (bax)/caspase-3-, bax/apoptosis-inducing factor-, c/ebp homologous protein/glucose-regulated protein 78-, and autophagy-mediated apoptotic signaling. |
2022-10-14 |
2023-08-14 |
Not clear |
| Monika Kadela-Tomanek, Maria Jastrzębska, Elwira Chrobak, Ewa Bębenek, Małgorzata Latoch. Hybrids of 1,4-Quinone with Quinoline Derivatives: Synthesis, Biological Activity, and Molecular Docking with DT-Diaphorase (NQO1). Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36234741. |
selected hybrids were tested for the transcriptional activity of the gene encoding a proliferation marker (h3 histone), cell cycle regulators (p53 and p21) and the apoptosis pathway (bcl-2 and bax). |
2022-10-14 |
2023-08-14 |
human |
| Xiaoqin Xu, Dandan Luo, Qiuhui Xuan, Peng Lu, Chunxiao Yu, Qingbo Gua. Atlas of metabolism reveals palmitic acid results in mitochondrial dysfunction and cell apoptosis by inhibiting fatty acid β-oxidation in Sertoli cells. Frontiers in endocrinology. vol 13. 2022-10-14. PMID:36237186. |
the increased apoptosis rate of scs was verified by elevated protein expression levels of cleaved caspase-3 and bax as well as decreased bcl-2 protein expression level. |
2022-10-14 |
2023-08-14 |
Not clear |
| Kejun Dong, Wei Zhang, Hao Hu, Shuangshuang Cheng, Yaoqin Mu, Bei Yan, Wan Shu, Longjie Li, Hongbo Wang, Xianjin Xia. A sensitive and specific nano-vehicle based on self-amplified dual-input synthetic gene circuit for intracellular imaging and treatment. Biosensors & bioelectronics. vol 218. 2022-10-14. PMID:36240629. |
we also changed the output fluorescent signal to output effectors such as apoptosis regulator (bax) and proliferation-inhibiting protein (p21) and demonstrated the application range. |
2022-10-14 |
2023-08-14 |
Not clear |
| Zhen Liu, Xinran Li, Junling Gao, Panpan Yin, Yuou Teng, Peng Y. The therapeutic inhibition of topoisomerase inhibitor and crizotinib combination in EGFR wild and mutant lung cancer cells. Biochemical pharmacology. 2022-10-14. PMID:36241099. |
the combination group significantly inhibited the lung cancer growth with combination index (ci) < 1, and they synergistically induced the cell apoptosis by disrupting the balance of bax and bcl-xl, loss of mitochondrial membrane potential (mmp), and accumulation of reactive oxygen species (ros). |
2022-10-14 |
2023-08-14 |
Not clear |
| Xiaohua Guo, Yong Gu, Chao Guo, Liang Pei, Chuan Ha. LINC01146/F11R facilitates growth and metastasis of prostate cancer under the regulation of TGF-β. The Journal of steroid biochemistry and molecular biology. vol 225. 2022-10-11. PMID:36162632. |
linc01146 overexpression impeded apoptosis, facilitated viability, proliferation, migration and invasion in pca cells in vitro, promoted tumor growth in vivo, downregulated e-cadherin, bax and cleaved caspase-3, and upregulated n-cadherin, vimentin and pcna, but linc01146 silencing did the opposite. |
2022-10-11 |
2023-08-16 |
Not clear |
| Donia M Moujalled, Fiona C Brown, Chong Chyn Chua, Michael A Dengler, Giovanna Pomilio, Natasha S Anstee, Veronique Litalien, Ella R Thompson, Thomas David Morley, Sarah MacRaild, Ing Soo Tiong, Rhiannon Morris, Karen Dun, Adrian Carl Zordan, Jaynish S Shah, Sébastien Banquet, Ensar Halilovic, Erick J Morris, Marco J Herold, Guillaume L Lessene, Jerry M Adams, David Ching Siang Huang, Andrew W Roberts, Piers Blombery, Andrew H We. Acquired mutations in BAX confer resistance to BH3-mimetic therapy in Acute Myeloid Leukemia. Blood. 2022-10-11. PMID:36219880. |
we find that 17% of patients relapsing after venetoclax-based therapy for aml have acquired inactivating missense or frameshift/nonsense mutations in the apoptosis effector gene bax. |
2022-10-11 |
2023-08-14 |
Not clear |
| Xiaolan Tang, Ling Liu, Shichun Liu, Shengfang Song, Hua L. MicroRNA-29a inhibits collagen expression and induces apoptosis in human fetal scleral fibroblasts by targeting the Hsp47/Smad3 signaling pathway. Experimental eye research. 2022-10-07. PMID:36206860. |
in contrast, mir-29a suppression led to the upregulation of bcl-2 and downregulation of bax expression and reduced the rate of apoptosis. |
2022-10-07 |
2023-08-14 |
human |