| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abbas Haddadian, Farnoush Falahi Robattorki, Hedieh Dibah, Ali Soheili, Erfan Ghanbarzadeh, Nasrin Sartipnia, Shadi Hajrasouliha, Kamal Pasban, Romina Andalibi, Mojtaba Hedayati Ch, Arezou Azari, Arman Chitgarzadeh, Aliasghar Bagheri Kashtali, Fatemeh Mastali, Hassan Noorbazargan, Amir Mirzai. Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities. Scientific reports. vol 12. issue 1. 2022-12-19. PMID:36536030. |
in addition, niosome-loaded senps can upregulate the expression level of bax, cas3, and cas9 apoptosis genes while the expression of the bcl2 gene is down-regulated in all studied cell lines, significantly. |
2022-12-19 |
2023-08-14 |
human |
| Cristini Escobar Viana, Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Mustafa Munir Mustafa Dahleh, Franciéle Romero Machado, Adson de Souza Pereira, Byanca Pereira Moreira de Oliveira, Fernanda Vitória Leimann, Odinei Hess Gonçalves, Marina Prigol, Gustavo Petri Guerr. Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats. Neurotoxicology. 2022-12-17. PMID:36528186. |
the hippocampus was removed for the determination of oxidative stress indicators (ros; tbars; sod and nrf2) and apoptosis biomarkers (hsp-70; p38-mapk; bax and bcl-2). |
2022-12-17 |
2023-08-14 |
rat |
| Ye Bai, Ning Guo, Zhanwu Xu, Yuxi Chen, Wenjin Zhang, Qinghe Chen, Zhenggang B. S100A1 expression is increased in spinal cord injury and promotes inflammation, oxidative stress and apoptosis of PC12 cells induced by LPS via ERK signaling. Molecular medicine reports. vol 27. issue 2. 2022-12-16. PMID:36524376. |
the protein levels of bax, bcl2 and cleaved caspase‑3 were used for the evaluation of the effects of s100a1 on apoptosis. |
2022-12-16 |
2023-08-14 |
rat |
| A Tarko, A Štochmaľová, A H Harrath, J Kotwica, A Baláži, A V Sirotki. Quercetin can affect porcine ovarian cell functions and to mitigate some of the effects of the environmental contaminant toluene. Research in veterinary science. vol 154. 2022-12-14. PMID:36516587. |
the influence of toluene, quercetin, and their combination on proliferation (accumulation of pcna), apoptosis (accumulation of bax) and release of progesterone, testosterone and insulin-like growth factor i (igfi) by cultured porcine ovarian granulosa cells was investigated. |
2022-12-14 |
2023-08-14 |
Not clear |
| Bin Chen, Jingwei Wu, Sheng Hu, Qingli Liu, Hui Yang, Yong Yo. Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling. Neurochemical research. 2022-12-13. PMID:36512295. |
additionally, neuronal apoptosis was inhibited, and the abundance of apoptosis-related proteins (bax, bcl-2, and cleaved caspase 3) was induced. |
2022-12-13 |
2023-08-14 |
mouse |
| Boxiang Zhang, Shiwen Liu, Yeqing Sun, Dan X. Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells. Toxicology. 2022-12-13. PMID:36513242. |
we found that endosulfan induced apoptosis in hk-2 cells by up-regulating the expression of bax, apaf-1, caspase-3 and mitochondrial cytochrome c was released into the cytosol. |
2022-12-13 |
2023-08-14 |
human |
| Guang-Wei Sun, Tian-Yi Ding, Meng Wang, Chang-Long Hu, Jiang-Jiang Gu, Jie Li, Tao Qi. Honokiol Reduces Mitochondrial Dysfunction and Inhibits Apoptosis of Nerve Cells in Rats with Traumatic Brain Injury by Activating the Mitochondrial Unfolded Protein Response. Journal of molecular neuroscience : MN. 2022-12-12. PMID:36508141. |
based on the experimental results, treatment with hnk was associated with a decrease in the number of tunel-positive cells, downregulated bax expression levels, elevated bcl-2 expression levels, and inhibition of neuronal apoptosis in the brain tissue of tbi rats. |
2022-12-12 |
2023-08-14 |
rat |
| Yu Xia, Qihui Luo, Chao Huang, Liangqin Shi, Asad Jahangir, Ting Pan, Xiaoli Wei, Junbo He, Wentao Liu, Riyi Shi, Yi Geng, Jing Fang, Li Tang, Hongrui Guo, Ping Ouyang, Zhengli Che. Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition. Ecotoxicology and environmental safety. vol 249. 2022-12-12. PMID:36508806. |
exposure to fc was positively associated with the mrna and protein expressions of cysteine-aspartic proteases (caspase)- 9, caspase-3, bcl-2-associated x protein (bax), while negatively associated with b-cell lymphoma 2 (bcl2) in mitochondrial apoptosis signaling pathway. |
2022-12-12 |
2023-08-14 |
mouse |
| Ge Wu, Fangfang Yang, Xuecheng Cheng, Zihao Mai, Xiaoping Wang, Tongsheng Che. Live-cell imaging analysis on the anti-apoptotic function of the Bcl-xL transmembrane carboxyl terminal domain. Biochemical and biophysical research communications. vol 639. 2022-12-08. PMID:36476951. |
fluorescence images of living cells co-expressing cfp-xt and bad-yfp or yfp-bax revealed that xt recruited bad to mitochondria but prevented bax translocation to mitochondria, and also significantly suppressed bad/bax-mediated apoptosis, indicating that xt prevents the pro-apoptotic function of bad and bax. |
2022-12-08 |
2023-08-14 |
Not clear |
| Ning Ding, Yu Zhang, Mengna Huang, Jianfeng Liu, Chonglong Wang, Chun Zhang, Jinkang Cao, Qin Zhang, Li Jian. Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p. Communications biology. vol 5. issue 1. 2022-12-08. PMID:36476986. |
we showed that inhibition of circ-crebbp can reduce the expression of mcl1, creb1 and crebbp and increase the expression of bax and casp3, thus promoting sperm apoptosis. |
2022-12-08 |
2023-08-14 |
Not clear |
| Tiago João da Silva Filho, Denise Hélen Imaculada Pereira de Oliveira, Cassiano Francisco Weege Nonaka, Éricka Janine Dantas da Silveira, Lélia Maria Guedes Queiro. Immunoexpression of proliferation and apoptosis markers in oral vascular anomalies. Brazilian dental journal. vol 33. issue 6. 2022-12-08. PMID:36477966. |
this study evaluated a correlation between the proliferative and apoptotic rates of different oral vascular anomalies (vas) by analyzing the immunoexpression of proliferation (ki-67) and apoptosis (bcl-2 and bax) markers in endothelial cells of 20 cases of glut-1 positive infantile hemangiomas (ihs), 20 cases of pyogenic granulomas (pgs) and 20 cases of vascular malformations (vms). |
2022-12-08 |
2023-08-14 |
Not clear |
| Özge Kılınçarslan Aksoy, Mücahit Seçme, Ramazan Mammado. Antioxidant, Cytotoxicity, Apoptotic Properties of Extracts of Andricus sternlichti galls and Their Phenolic Characterisation by HPLC. Chemistry & biodiversity. 2022-12-08. PMID:36478153. |
expression of some genes ( bax, bcl-2, fas, bid, caspase-3, caspase-8, caspase-9, caspase-10, fadd, tradd ) in the apoptosis pathway was determined to investigate apoptosis inducing activity. |
2022-12-08 |
2023-08-14 |
Not clear |
| Jiang Liu, LiJun Ren, HaoWen Wang, Zuowei L. Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells. Biochemical genetics. 2022-12-08. PMID:36480095. |
isoquercitrin treatment decreased gc cell colony formation in a dose-dependent manner and induced apoptosis accompanied by downregulation of bcl-2 and upregulation of bax, cleaved caspase-3, and caspase-12. |
2022-12-08 |
2023-08-14 |
Not clear |
| Changsheng Wang, Rongsheng Chen, Xitian Zhu, Xiaobo Zhan. Long non-coding RNAs LINC00689 inhibits the apoptosis of human nucleus pulposus cells via miR-3127-5p/ATG7 axis-mediated autophagy. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-12-07. PMID:36475062. |
the proliferation and apoptosis of npcs, and the levels of linc00689, mir-3127-5p, bax, bcl-2, cleaved caspase-3, atg5, atg7, p62, and lc3Ⅱ/lc3i were detected. |
2022-12-07 |
2023-08-14 |
human |
| Yuan Luo, Pu Chen, Li-Ping Yang, Xiao-Hua Dua. [Effect of ethanol extract of Gastrodiae Rhizoma on mitochondrial dysfunction in cerebral ischemia-reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 20. 2022-12-06. PMID:36471974. |
tunel staining was used to observe the apoptosis of brain tissues in each group, and western blot was used to detect the expression of b-cell lymphoma 2(bcl-2) and bcl-2-associated x protein(bax) in brain tissues. |
2022-12-06 |
2023-08-14 |
rat |
| Jingwen Cao, Ran Xu, Fuhan Wang, Yuan Geng, Tianchao Xu, Mengran Zhu, Hongli Lv, Shiwen Xu, Meng-Yao Gu. Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills. Fish & shellfish immunology. 2022-12-05. PMID:36470402. |
the results showed that polyethylene microplastics increased the expression of the nuclear factor-κb (nf-κb) pathway (nf-κb p65, ikkα, ikkβ) and apoptosis biomarkers (p53, caspase-3, caspase-9, and bax). |
2022-12-05 |
2023-08-14 |
Not clear |
| Yi Liu, Jing Guo, Wenjin Liu, Fengjie Yang, Yunyun Deng, Yunlong Meng, Bo Cheng, Jianping Fu, June Zhang, Xinjun Liao, Lili Wei, Huiqiang L. Effects of haloxyfop-p-methyl on the developmental toxicity, neurotoxicity, and immunotoxicity in zebrafish. Fish & shellfish immunology. 2022-12-03. PMID:36462742. |
furthermore, haloxyfop-p-methyl could induce neutrophils apoptosis, accompanied with the upregulation of the expression of proapoptotic protein such as bax and p53 and the downregulation of the expression of antiapoptotic protein bcl-2. |
2022-12-03 |
2023-08-14 |
cat |
| Shiang Sun, Qirun Yin, Bing Li, Yafei Deng, Jing Li, Yongjie Xiong, He Shaoju. Effects of betaine on viability, apoptosis, function protein expression and oxidative status in heat-stressed IEC-6 cells. Journal of thermal biology. vol 110. 2022-12-03. PMID:36462857. |
compared to control group, the rate of apoptosis and the bax and caspase-3 expressions significantly increased in hs group (p < 0.05), however, cell activity, total antioxidative capacity (t-aoc), activities of glutathione peroxidase (gsh-px), superoxide dismutase (sod) and the expression of bcl-2, claudin-1 and occludin decreased significantly (p < 0.05). |
2022-12-03 |
2023-08-14 |
Not clear |
| Mingyue Dong, Yan Ding, Yingying Liu, Zeqiong Xu, Huachang Hong, Hongjie Sun, Xianfeng Huang, Xinwei Yu, Qiang Che. Molecular insights of 2,6-dichlorobenzoquinone-induced cytotoxicity in zebrafish embryo: Activation of ROS-mediated cell cycle arrest and apoptosis. Environmental toxicology. 2022-12-01. PMID:36454668. |
to explore this mechanism, we assessed the levels of reactive oxygen species (ros), acridine orange (ao) staining, and the mrna transcriptions of genes (chk2, cdk2, ccna, ccnb and ccne) involved in cell-cycle and genes (p53, bax, bcl-2 and caspase 3) involved in apoptosis in zebrafish embryo, after exposed to different concentrations (10, 30, 60, 90 and 120 μg/l) of 2,6-dcbq for 72 h. |
2022-12-01 |
2023-08-14 |
zebrafish |
| Filiz Bakar-Ates, Erva Ozka. Atorvastatin induces downregulation of matrix metalloproteinase-2/9 in MDA-MB-231 triple negative breast cancer cells. Medical oncology (Northwood, London, England). vol 40. issue 1. 2022-11-29. PMID:36445561. |
it also induces caspase-dependent apoptosis, alters the expression of bax and bcl-2 in favour of apoptosis and stimulates cell cycle arrest at s phase (p < 0.05). |
2022-11-29 |
2023-08-14 |
Not clear |