| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beini Sun, Hongce Chen, Xiaoping Wang, Tongsheng Che. Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export. Cell death discovery. vol 9. issue 1. 2023-01-31. PMID:36720853. |
knockdown of bim, bak and bax respectively almost completely inhibited rego-induced apoptosis, demonstrating the key role of bim by directly activating bax/bak. |
2023-01-31 |
2023-08-14 |
Not clear |
| Cai-Wen Fan, Mei-Shan Li, Xi-Xi Song, Li Luo, Jing-Chen Jiang, Jia-Zi Luo, Heng-Shan Wan. Discovery of novel 2-oximino-2-indolylacetamide derivatives as potent anticancer agents capable of inducing cell autophagy and ferroptosis. Bioorganic & medicinal chemistry. vol 80. 2023-01-29. PMID:36709571. |
additionally, 4d significantly induced cell apoptosis, caused mitochondrial dysfunction, promoted bax, cleaved-parp and p53 expression and inhibited bcl-2 expression in 5-8f cells. |
2023-01-29 |
2023-08-14 |
mouse |
| Xueyun Li, Lili Tian, Xinyi Oiao, Lei Ye, Hong Wang, Mengyun Wang, Jianmin Sang, Fuhong Tian, Ren-Shan Ge, Yiyan Wan. Citrinin inhibits the function of Leydig cells in male rats in prepuberty. Ecotoxicology and environmental safety. vol 252. 2023-01-25. PMID:36696728. |
citrinin at 5 mg/kg markedly decreased the ratio of bcl2 to bax, in consistent with the increased apoptosis in leydig cells judged by tunel assay. |
2023-01-25 |
2023-08-14 |
rat |
| Chengli Ni, Gang Wu, Tingting Miao, Jianguang X. Wnt4 prevents apoptosis and inflammation of dental pulp cells induced by LPS by inhibiting the IKK/NF‑κB pathway. Experimental and therapeutic medicine. vol 25. issue 2. 2023-01-23. PMID:36684653. |
overexpression of wnt4 ameliorated cell inflammatory response and apoptosis, presented by reduced expressions of il-8, il-6, tnf-α, il-1β, bax, cleaved-caspase 3 and enhanced bcl-2 expression as well as decreased apoptosis rate. |
2023-01-23 |
2023-08-14 |
human |
| Xueying Zhao, Lina Si, Lin Niu, Meng Wei, Fengxia Wang, Xiaochao Liu, Zhihong Chen, Yuebing Qiao, Luyang Cheng, Songhe Yan. Effects of RFRP‑3 on an ovariectomized estrogen‑primed rat model and HEC‑1A human endometrial carcinoma cells. Experimental and therapeutic medicine. vol 25. issue 2. 2023-01-23. PMID:36684658. |
rfrp-3 treatment (10,000 ng/ml) also suppressed hec-1a cell viability, induced apoptosis, downregulated bcl-2 and upregulated bax protein expression, compared with those in the control group. |
2023-01-23 |
2023-08-14 |
human |
| Junhua Xi, Yang Chen, Junfeng Jing, Wei Qi, Yanbing Zhan. LncRNA LINC01197 inhibited the formation of calcium oxalate-induced kidney stones by regulating miR-516b-5p/SIRT3/FOXO1 signaling pathway. Cell and tissue research. 2023-01-23. PMID:36688989. |
linc01197 knockdown promoted caox-induced cell adherence and cell apoptosis, increased bax, decreased bcl-2 expression. |
2023-01-23 |
2023-08-14 |
Not clear |
| Kamila Boszkiewicz, Helena Moreira, Ewa Sawicka, Anna Szyjka, Agnieszka Piwowa. The Effect of Metalloestrogens on the Effectiveness of Aromatase Inhibitors in a Hormone-Dependent Breast Cancer Cell Model. Cancers. vol 15. issue 2. 2023-01-21. PMID:36672406. |
a cell viability assay, a flow cytometer analysis of apoptosis and cell cycle phases, and protein activity of bax and bcl-2 were performed on two human breast cancer cell lines-mcf-7 and mcf-7/dox. |
2023-01-21 |
2023-08-14 |
human |
| Robert L Fine, Yuehua Mao, Richard Dinnen, Ramon V Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W Brandt-Rau. C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672645. |
the mechanism of apoptosis from 4r-pal-p53p involved the extrinsic and intrinsic pathways (fas, caspase-8, bax, puma) for apoptosis, as well as increasing reactive oxygen species (ros). |
2023-01-21 |
2023-08-14 |
human |
| Dong Hoon Suh, Wook Ha Park, Miseon Kim, Kidong Kim, Jae Hong No, Yong Beom Ki. HOXB9 Overexpression Confers Chemoresistance to Ovarian Cancer Cells by Inducing ERCC-1, MRP-2, and XIAP. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674764. |
cisplatin treatment of skov3 strongly induced ercc-1, mrp-2, and xiap, and apoptosis was strongly induced through the inhibition of bcl-2 and activation of bax. |
2023-01-21 |
2023-08-14 |
mouse |
| Dong Hoon Suh, Wook Ha Park, Miseon Kim, Kidong Kim, Jae Hong No, Yong Beom Ki. HOXB9 Overexpression Confers Chemoresistance to Ovarian Cancer Cells by Inducing ERCC-1, MRP-2, and XIAP. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674764. |
in contrast to skov3, cisplatin treatment alone of hoxb9 oe/skov3 did not affect the expression of bcl-2 and bax, and consequently, there was no increase in apoptosis. |
2023-01-21 |
2023-08-14 |
mouse |
| Dong Hoon Suh, Wook Ha Park, Miseon Kim, Kidong Kim, Jae Hong No, Yong Beom Ki. HOXB9 Overexpression Confers Chemoresistance to Ovarian Cancer Cells by Inducing ERCC-1, MRP-2, and XIAP. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674764. |
treatment of skov3 with both cisplatin and sirna_hoxb9 led to complete suppression of ercc-1, mrp-2, and xiap, and significantly increased apoptosis through inhibition of bcl-2 expression and activation of bax. |
2023-01-21 |
2023-08-14 |
mouse |
| Sohail Hussain, Mohammad Ashafaq, Saeed Alshahrani, Ibrahim A M Bokar, Rahimullah Siddiqui, Mohammad Intakhab Alam, Manal Mohamed Elhassan Taha, Yosif Almoshari, Saad S Alqahtani, Rayan A Ahmed, Abdulmajeed M Jali, Marwa Qadr. Hepatoprotective Effect of Curcumin Nano-Lipid Carrier against Cypermethrin Toxicity by Countering the Oxidative, Inflammatory, and Apoptotic Changes in Wistar Rats. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677938. |
the administration of cur-nlc significantly ameliorates all changes caused by cyp, such as a decrease in the levels of serum liver markers, an increase in antioxidative parameters, a decrease in expression of inflammatory cytokines (il-1β, il-6, tnf-α, and nf-κb), and apoptosis (caspases-3, 9, apaf-1, 4-hne, and bax), according to calorimetric and immunohistochemistry studies. |
2023-01-21 |
2023-08-14 |
rat |
| Zhenwei Zhang, Shan Zhao, Jiying Pei, Linghui Hou, Shenglin Luan, Hongguang Deng, Dan Liu, Min Huang, Linxiang Zha. Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties. European journal of medicinal chemistry. vol 248. 2023-01-21. PMID:36680883. |
direct activation of the pro-apoptotic protein bax represents a potential therapeutic strategy to trigger apoptosis in cancer. |
2023-01-21 |
2023-08-14 |
Not clear |
| Zhenwei Zhang, Shan Zhao, Jiying Pei, Linghui Hou, Shenglin Luan, Hongguang Deng, Dan Liu, Min Huang, Linxiang Zha. Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties. European journal of medicinal chemistry. vol 248. 2023-01-21. PMID:36680883. |
herein, structural optimization of the reported bax trigger site activator btsa1 turned out into a series of pyrazolone derivatives, where compound 6d exhibited significantly enhanced antiproliferative effects and apoptosis induction ability compared to btsa1. |
2023-01-21 |
2023-08-14 |
Not clear |
| Zhenwei Zhang, Shan Zhao, Jiying Pei, Linghui Hou, Shenglin Luan, Hongguang Deng, Dan Liu, Min Huang, Linxiang Zha. Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties. European journal of medicinal chemistry. vol 248. 2023-01-21. PMID:36680883. |
mechanism of action studies revealed that compound 6d could initiate the bax activation cascade, promoting bax insertion into mitochondrial membranes and activating momp, ultimately leading to the release of cytochrome c and apoptosis. |
2023-01-21 |
2023-08-14 |
Not clear |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Zuzana Fabová, Barbora Loncová, Miroslav Bauer, Alexander V Sirotki. Involvement of microRNA miR-125b in the control of porcine ovarian cell functions. General and comparative endocrinology. 2023-01-20. PMID:36669691. |
expression levels of mir-125b, viability, proliferation (expression and accumulation of pcna and cyclin b1), the proportion of proliferative active cells, apoptosis (expression and accumulation of bax and caspase 3), the proportion of cells containing dna fragmentation, steroid hormones, igf-i, oxytocin, and prostaglandin e2 release were analysed by rt-qpcr, trypan blue exclusion test, quantitative immunocytochemistry, xtt and tunel assays, and elisa. |
2023-01-20 |
2023-08-14 |
Not clear |
| Ahmed R Hamed, Shaymaa M M Yahya, Heba K Nabi. Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. Naunyn-Schmiedeberg's archives of pharmacology. 2023-01-18. PMID:36651944. |
additionally, qrt-pcr was used to quantify genes having a role in drug resistance phenotype (abcb1, abcc1, abcc2, abcc3, abcc4, abcc5, and abcg2); apoptosis (caspases-3, and -7, bcl2, bax, and p53); anti-oxidation (nrf2); expression of melatonin receptors (mt1, mt2, and mt3); besides, programmed death receptor pd-1 gene. |
2023-01-18 |
2023-08-14 |
human |
| Suleyman Ilhan, Harika Atmaca, Elif Serel Yilmaz, Esra Korkmaz, Metin Zor. N-Propargylic β-enaminones in breast cancer cells: Cytotoxicity, apoptosis, and cell cycle analyses. Journal of biochemical and molecular toxicology. 2023-01-17. PMID:36647602. |
npes induced apoptosis and caused significant changes in bcl-2 and bax mrna levels. |
2023-01-17 |
2023-08-14 |
human |
| Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Kuo-Hsuan Chang, Guey-Jen Lee-Che. A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment. Biomolecules & therapeutics. 2023-01-16. PMID:36646447. |
treatments with quercetin and apigenin increased trkb tyr516 and tyr817 and downstream camp-response-element binding protein (creb) ser133 to activate transcription of bdnf and bcl2 apoptosis regulator (bcl2), as well as reduced the expression of pro-apoptotic bcl2 associated x protein (bax). |
2023-01-16 |
2023-08-14 |
Not clear |