All Relations between apoptosis and bax
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. | in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. | 2023-01-14 | 2023-08-14 | human |
| Jin-Guo Wang, Da-Lei Li, Rong Fan, Meng-Jun Ya. Zerumbone combined with gefitinib alleviates lung cancer cell growth through the AKT/STAT3/SLC7A11 axis. Neoplasma. 2023-01-13. PMID:36637083. | the expression of bcl-2, bax, and p53 proteins confirmed the cell apoptosis. | 2023-01-13 | 2023-08-14 | mouse |
| Xiaorong Niu, Peng Han, Junsong Liu, Zichen Chen, Ting Zhang, Baiya Li, Xiaoyan Ma, Qun Wu, Xudong M. Regulation of PPARγ/CPT-1 expression ameliorates cochlear hair cell injury by regulating cellular lipid metabolism and oxidative stress. Molecular genetics and genomics : MGG. 2023-01-13. PMID:36639590. | as a result, cisplatin with varying concentrations (5, 10, 30 μm) suppressed the viability, promoted the apoptosis and hindered the mitochondrial function of hei-oc1 cells, accompanied with up-regulated expressions of bax and cleaved caspase-3 and down-regulated expression of bcl-2. | 2023-01-13 | 2023-08-14 | cat |
| Yu-Xi Liu, Yan Ke, Pin Qiu, Jie Gao, Gao-Pi Den. LncRNA NEAT1 inhibits apoptosis and autophagy of ovarian granulosa cells through miR-654/STC2-mediated MAPK signaling pathway. Experimental cell research. 2023-01-12. PMID:36634743. | overexpression of neat1 reduced apoptosis and autophagy in cyclophosphamide (ctx)-treated ovarian granulosa cells (ogcs), and bax, cleaved-caspase3, lc3b, lc3ii/lc3i ratio were decreased and bcl-2 and p62 were raised. | 2023-01-12 | 2023-08-14 | mouse |
| Wenying Sun, Huanyi Liu, Huijun Zhu, Meichen Gao, Shiwen X. Eucalyptol antagonized the apoptosis and immune dysfunction of grass carp hepatocytes induced by tetrabromobisphenol A by regulating ROS/ASK1/JNK pathway. Environmental toxicology. 2023-01-11. PMID:36629057. | the experiment results suggested that tbbpa exposure induced elevated levels of reactive oxygen species (ros), led to oxidative stress, decreased sod and cat activities, decreased gsh and t-aoc contents, exacerbated mda accumulation, activated ask1/jnk signaling pathway, and further increased the contents of mitochondrial dependent apoptosis pathway related indicators (cyt-c, bax, caspase 9, caspase 3), while bcl-2 expression decreased. | 2023-01-11 | 2023-08-14 | cat |
| Liyun Guan, Shifa Yuan, Jing Ma, Hong Liu, Lizhen Huang, Fengzhen Zhan. Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis. European journal of histochemistry : EJH. vol 67. issue 1. 2023-01-11. PMID:36629320. | furthermore, by using nk1r antagonist we demonstrated that nk1r antagonist inhibited the viability and induced the apoptosis of cervical cancer cells in a dose-dependent manner, and the mechanism may be related to the inhibition of erk activation and the regulation of apoptosis proteins bcl-2 and bax. | 2023-01-11 | 2023-08-14 | Not clear |
| Hana Yamamoto, Nanami Shimomura, Kazuma Oura, Yasushi Hasegaw. Nacre Extract from Pearl Oyster Shell Prevents D-Galactose-Induced Brain and Skin Aging. Marine biotechnology (New York, N.Y.). 2023-01-11. PMID:36629944. | a histological study showed that nacre extract suppressed d-galactose-induced neuronal cell death and the expression of b cell lymphoma 2 (bcl-2)-associated x protein (bax), which causes apoptosis in the hippocampus. | 2023-01-11 | 2023-08-14 | mouse |
| Pankul Kotwal, Parul Khajuria, Sumit Dhiman, Dilpreet Kour, Shakti Kumar Dhiman, Ajay Kumar, Utpal Nand. Molecular mechanism for the involvement of CYP2E1/NF-κB axis in bedaquiline-induced hepatotoxicity. Life sciences. 2023-01-09. PMID:36621541. | induction of liver injury situation was further evaluated by western blotting for various protein expressions linked to oxidative stress (sod, nrf2, and keap1), inflammation (nf-ĸb and ikkβ), apoptosis (bax, bcl-2, and caspase-3) and drug metabolism enzymes (cyp3a4 and cyp2e1). | 2023-01-09 | 2023-08-14 | mouse |
| Jian Li, Cheng-Hsun Chen, Katelyn L O'Neill, Valerie J Fousek-Schuller, Adrian R Black, Jennifer D Black, Jingjing Zhang, Xu Lu. Combined inhibition of Aurora Kinases and Bcl-xL induces apoptosis through select BH3-only proteins. The Journal of biological chemistry. 2023-01-09. PMID:36621626. | we demonstrate that combination of a bh3-mimetic inhibitor (abt-737), a selective inhibitor of bcl-xl, bcl-2, and bcl-w, with alisertib or danusertib potently induces apoptosis through the bcl-2 family effector protein bax. | 2023-01-09 | 2023-08-14 | Not clear |
| Immacolata Maietta, Francesca Del Peschio, Preziosa Buonocore, Eleonora Viscusi, Stefano Laudati, Giuseppe Iannaci, Michele Minopoli, Maria Letizia Motti, Valentina De Falc. p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors. Cancers. vol 15. issue 1. 2023-01-08. PMID:36612117. | a pharmacological inhibitor of p90rsk, bi-d1870, decreases mdm2 phosphorylation, and restores p53 function, which in turn transcriptionally increases the expression of cell cycle inhibitor p21 and of pro-apoptotic protein bax and downregulates the anti-apoptotic protein bcl-2, causing a block of cell proliferation, measured by a brdu assay and growth curve, and promoting apoptosis, measured by a tunel assay. | 2023-01-08 | 2023-08-14 | Not clear |
| Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Don. Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia-Reperfusion Injury via the PERK-ATF4-CHOP Pathway. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613992. | geraniol effectively attenuated cerebral infarction and pathological injury after ciri, had a protective effect against ciri, significantly reduced the expression of the er-stress-related proteins p-perk, atf4, chop, and grp78 and the pro-apoptotic protein bax, increased the expression of the anti-apoptotic protein bcl-2, and reduced the occurrence of apoptosis. | 2023-01-08 | 2023-08-14 | rat |
| Eslam R El-Sawy, Zeinab A El-Shahid, Ahmed A F Soliman, Amr Nassrallah, Ahmed B Abdelwahab, Gilbert Kirsch, Heba Abdelmegee. Synthetic Analogs of Marine Alkaloid Aplysinopsin Suppress Anti-Apoptotic Protein BCL2 in Prostate Cancer. Molecules (Basel, Switzerland). vol 28. issue 1. 2023-01-08. PMID:36615305. | the inhibition of bcl2 led to the activation of bax, which in turn activated caspase 3, leading to apoptosis. | 2023-01-08 | 2023-08-14 | Not clear |
| Sepideh Ebrahimi, Mohammad Soukhtanloo, Zohreh Mostafavi-Pou. Anti-tumor effects of Auraptene through induction of apoptosis and oxidative stress in a mouse model of colorectal cancer. Tissue & cell. vol 81. 2023-01-05. PMID:36603499. | the administration of auraptene induced apoptosis and the cell cycle arrest by modulating bax, bcl-2, nrf2, cyclin d1, and survivin mrna levels. | 2023-01-05 | 2023-08-14 | mouse |
| Jin Song, Xiaolong Xu, Shasha He, Ning Wang, Yunjing Bai, Zhaoxia Chen, Bo Li, Shengsheng Zhan. Myristicin Suppresses Gastric Cancer Growth via Targeting the EGFR/ERK Signaling Pathway. Current molecular pharmacology. 2023-01-04. PMID:36597605. | results: myristicin retarded proliferation and induced er stress and apoptosis in gastric cancer cells, with decreased expression of cyclins, increased bax expression, activated caspases, and enhanced cytochrome c release and mitochondrial ros. |
2023-01-04 | 2023-08-14 | human |
| Yu Cao, Hong-Bo Wang, Chun-Jue Ni, Shun-Li Chen, Wan-Tie Wang, Liang-Rong Wan. Necrostatin-1 prevents skeletal muscle ischemia reperfusion injury by regulating Bok-mediated apoptosis. Journal of the Chinese Medical Association : JCMA. vol 86. issue 1. 2023-01-04. PMID:36599139. | receptor interacting serine/threonine kinase 1 (ripk1) mediates apoptosis by regulating the classic proapoptotic effectors bcl-2-associated x protein (bax) and bcl-2 homologous antagonist/killer (bak). | 2023-01-04 | 2023-08-14 | Not clear |
| Yu Cao, Hong-Bo Wang, Chun-Jue Ni, Shun-Li Chen, Wan-Tie Wang, Liang-Rong Wan. Necrostatin-1 prevents skeletal muscle ischemia reperfusion injury by regulating Bok-mediated apoptosis. Journal of the Chinese Medical Association : JCMA. vol 86. issue 1. 2023-01-04. PMID:36599139. | although bcl-2-related ovarian killer (bok) is structurally similar to bak and bax, it is unclear whether it mediates apoptosis in skeletal muscle ischemia reperfusion (ir) injury. | 2023-01-04 | 2023-08-14 | Not clear |
| Jie Bai, Ganggang Jiang, Mengdan Zhao, Shan Wan. Ghrelin Mitigates High-Glucose-Induced Oxidative Damage and Apoptosis in Lens Epithelial Cells. Journal of diabetes research. vol 2022. 2023-01-02. PMID:36589628. | ghrelin inhibited apoptosis through the downregulation of bax and the upregulation of bcl-2. | 2023-01-02 | 2023-08-14 | human |
| Qipeng Zhang, Wenying Chen, Boyang Zhang, Yiwen Zhang, Yuqing Xiao, Yichen An, Lingyun Han, Huiqiong Deng, Song Yao, Hongwei Wang, Xiao Li She. Lonp1 and Sig-1R contribute to the counteraction of ursolic acid against ochratoxin A-induced mitochondrial apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-01-01. PMID:36587836. | results indicated that a 24 h-treatment of 5 μm ota could significantly induce mitochondrial-mediated apoptosis via repressing lonp1 and sig-1r, thereby enhancing the protein expressions of grp78, p-perk, p-eif2α, chop, ire1α, and bax, and inhibiting the protein expression of bcl-2 in hk-2 cells, which could be remarkably relieved by a 2 h-pre-treatment of 4 μm ua (p < 0.05). | 2023-01-01 | 2023-08-14 | human |
| Yu-Hai Lu, Dong-Sheng He, Ying Li, Hong Wang, Rui-Dong M. LncRNA BBOX1-AS1 Contributes to the Progression of Esophageal Carcinoma by Targeting the miR-361-3p/COL5A1 Axis. Biochemical genetics. 2022-12-31. PMID:36586008. | the colony formation assay (cfa) and cell counting kit-8 (cck-8) were employed to identify ec cell proliferation, while western blotting was used to examine ec cell apoptosis and bax and bcl-2 expression levels. | 2022-12-31 | 2023-08-14 | Not clear |
| Wan Xie, Yang Xue, Xiaokun Song, Hongzhu Zhang, Guangjun Chang, Xiangzhen She. Forkhead box protein A2 alleviates toll-like receptor 4-mediated inflammation, endoplasmic reticulum stress, autophagy, and apoptosis induced by lipopolysaccharide in bovine hepatocytes. Journal of dairy science. 2022-12-31. PMID:36586798. | in addition, foxa2 enhanced mitochondrial membrane potential via reducing pro-apoptotic protein bax, caspase3, and cleaved caspase3 expression and elevating anti-apoptotic protein bcl-2 expression to mitigate lps-induced apoptosis. | 2022-12-31 | 2023-08-14 | cattle |