| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priyal Lnu, Vineet Sehgal, Saniya Kapila, Nihal Gulati, Lucky Bhalla Sehga. Ataxia Telangiectasia Presenting as Cervical Dystonia. Cureus. vol 14. issue 10. 2022-11-28. PMID:36439585. |
the ataxia telangiectasia mutant (atm) protein is a sensor and signal transducer that amplifies and communicates signals of dna damage further to the mediators of cell cycle arrest, apoptosis, and senescence (p16, p19, p21, bax etc.) |
2022-11-28 |
2023-08-14 |
Not clear |
| Shuancheng Zhang, Yucong Ma, Qianqian Zuo, Mengrui Liu, Zhifang Yu, Ying Sun, Cuimiao Song, Hongyan Sun, Guimin Hao, Bulang Gao, Huilan Du, Jingwei Che. Repeated controlled ovarian stimulation-induced ovarian and uterine damage in mice through the PI3K/AKT signaling pathway. Human cell. 2022-11-28. PMID:36441500. |
the morphology of the ovary and endometrium, ovarian apoptosis, and expressions of the vascular endothelial growth factor (vegf), leukemia inhibitory factor (lif), pi3k, akt, bax, and bcl-2 in the ovarian and uterine tissues were tested by hematoxylin-eosin (he) staining, immunohistochemistry, and western blot. |
2022-11-28 |
2023-08-14 |
mouse |
| Jiaqi Jiao, Tianqiao Yong, Longhua Huang, Shaodan Chen, Chun Xiao, Qingping Wu, Huiping Hu, Yizhen Xie, Xiangmin Li, Yuancao Liu, Manjun Cai, Ruifang Zhang, Ting Xie, Rongjie Li. A Ganoderma lucidum polysaccharide F31 alleviates hyperglycemia through kidney protection and adipocyte apoptosis. International journal of biological macromolecules. 2022-11-28. PMID:36442553. |
also, apoptosis was promoted by f31 in epididymal fat through increasing caspase-3, caspase-6 and bax and decreasing bcl-2. |
2022-11-28 |
2023-08-14 |
mouse |
| Hailong Li, Yingying Liu, Jiaming Zhou, Su Liu, Yue Liu, Yiting Yang, Wanting Wang, Yange Che, Muhammad Inam, Lili Gua. The protective mechanism of a novel polysaccharide from Lactobacillus-fermented Nostoc commune Vauch. on attenuating cadmium-induced kidney injury in mice. International journal of biological macromolecules. 2022-11-28. PMID:36442563. |
in addition, ncvp-f effectively inhibited apoptosis proteins (bax, cytochrome c, a-caspase-9 and a-caspase-3) and enhanced anti-apoptotic protein (bcl-2) probably via activating pi3k/akt/mtor pathway in the cd-injury kidney. |
2022-11-28 |
2023-08-14 |
mouse |
| Enming Du, Yueping Jiang, Fangyuan Qin, Yange Wang, Siyu He, Gang Wang, Zongming Song, Junjie Zhang, Ye Ta. Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of UV-B Induced Corneal Damage. Photochemistry and photobiology. 2022-11-27. PMID:36435980. |
moreover, compound 6 reduced bax and cleaved caspase-3 expressions to suppress uv-b mediated the intrinsic apoptosis pathway. |
2022-11-27 |
2023-08-14 |
Not clear |
| Sudjit Luanpitpong, Montira Janan, Juthamas Yosudjai, Jirarat Poohadsuan, Pithi Chanvorachote, Surapol Issaragrisi. Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430955. |
overexpression of antiapoptotic bcl-xl and depletion of proapoptotic bax cooperatively protected mcl cells against btz-induced apoptosis, causing acquired btz resistance, likely by tilting the balance of bcl-2 family proteins toward antiapoptotic signaling. |
2022-11-26 |
2023-08-14 |
human |
| Yu Tang, Yan-Fei Leng, Wei Wang, Jiong Zhang, Tong-Ling Yuan, Jia Wan. Protective effect of Saxagliptin on diabetic rats with renal ischemia reperfusion injury by targeting oxidative stress and mitochondrial apoptosis pathway through activating Nrf-2/HO-1 signaling. Transplant immunology. 2022-11-26. PMID:36435353. |
the results has displayed sax treatment significantly attenuate the cell apoptosis and pathological damage of kidney as well as lessening the expression of cleaved-caspase-9, cleaved-caspase3, bax, cytoplasmic-cytc, mda, bak, and apaf-1 molecules, and the contents of ros, cr, cysc, β2-mg, and bun . |
2022-11-26 |
2023-08-14 |
rat |
| Xipeng Sun, Li Zhou, Yonglong Han, Quanjun Yang, Xingxia Li, Bo Xin, Mengyi Chi, Yaxian Wang, Cheng Gu. Scutellarin Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Myocardial Fibrosis, Apoptosis and Autophagy in Rats. Chemistry & biodiversity. 2022-11-24. PMID:36419360. |
furthermore, scu also prevented against dox-induced apoptosis and autophagy as evidenced by upregulation of bcl-2, downregulation of bax and cleaved caspase-3, inhibited the ampk/mtor pathway. |
2022-11-24 |
2023-08-14 |
rat |
| Hany H Arab, Hayat A Abd El Aal, Shuruq E Alsufyani, Azza A K El-Sheikh, El-Shaimaa A Arafa, Ahmed M Ashour, Ahmed M Kabel, Ahmed H Ei. Topiramate Reprofiling for the Attenuation of Cadmium-Induced Testicular Impairment in Rats: Role of NLRP3 Inflammasome and AMPK/mTOR-Linked Autophagy. Pharmaceuticals (Basel, Switzerland). vol 15. issue 11. 2022-11-24. PMID:36422532. |
moreover, curbing testicular apoptosis was seen by lowered bax expression, decreased caspase-3 activity, and upregulation of bcl-2. |
2022-11-24 |
2023-08-14 |
rat |
| Panpan Zhao, Yan Wang, Qiankun Yang, Guili Yu, Fenfen Ma, Jingquan Don. Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death. Environmental science and pollution research international. 2022-11-23. PMID:36418824. |
tunel staining showed that abamectin triggered cardiac apoptosis via activating p53-mediated mitochondrial apoptosis with elevated bcl2-associated x (bax), reduced b-cell lymphoma-2 (bcl-2), and activated caspase-9 and caspase-3. |
2022-11-23 |
2023-08-14 |
Not clear |
| Yanlu Liu, Shiting Gong, Kejian Li, Gong Wu, Xiaohong Zheng, Jingna Zheng, Xiaowei Lu, Luyao Zhang, Jincan Li, Ziren Su, Yuhong Liu, Jianhui Xie, Jiannan Chen, Yucui L. Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-11-22. PMID:36411660. |
meanwhile, coptisine treatment significantly suppressed hyperuricemia induced oxidant stress, inflammatory injury and apoptosis through promoting superoxide dismutase (sod) activity, restraining reactive oxygen species (ros), malondialdehyde (mda), tumor necrosis factor (tnf)-α, interleukin (il)- 1β, il-18 levels, down-regulating protein expressions of cleaved-caspase 3, apoptosis-inducing factor (aif), cyto-cytc, cleaved poly adp-ribose polymerase (parp) and bcl-2-associated x protein (bax), and up-regulating protein expressions of bcl-2 and p-bad. |
2022-11-22 |
2023-08-14 |
mouse |
| Haoyuan Wu, Jing Yuan, Haixu Yin, Bo Jing, Chang Sun, Ivan Stève Nguepi Tsopmejio, Zhouyu Jin, Hui Son. Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver-blood-ovary axis. Poultry science. vol 102. issue 1. 2022-11-21. PMID:36410067. |
additionally, fvs significantly decreased ovarian apoptosis by regulating bax, bcl-2, and caspase3 mrna and protein expression levels. |
2022-11-21 |
2023-08-14 |
Not clear |
| Hyo Sun Cha, Han Ki Lee, See-Hyoung Park, Myeong Jin Na. Acetylshikonin induces apoptosis of human osteosarcoma U2OS cells by triggering ROS-dependent multiple signal pathways. Toxicology in vitro : an international journal published in association with BIBRA. 2022-11-21. PMID:36410617. |
in terms of the presence of ros, induction of apoptosis was detected by measuring proteins such as cleaved caspase 3, parp, bcl-2 and bax. |
2022-11-21 |
2023-08-14 |
human |
| Lili Wei, Jianping Fu, Li He, Hui Wang, Jiming Ruan, Fugui Li, Huadong W. Microcystin-LR-induced autophagy regulates oxidative stress, inflammation, and apoptosis in grass carp ovary cells in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2022-11-21. PMID:36410616. |
interestingly, the significant decrease of caspase-9, caspase-7, and bax expression and significant increase of bcl-2 and bcl-2/bax ratio in 3-ma + mc-lr group compared to mc-lr group, suggesting that extent of apoptosis were reduced. |
2022-11-21 |
2023-08-14 |
cat |
| Fatemeh Jamshidi-Adegani, Shokoofeh Ghaemi, Sulaiman Al-Hashmi, Saeid Vakilian, Juhaina Al-Kindi, Najeeb Ur Rehman, Khurshid Alam, Khamis Al-Riyami, Rene Csuk, Ehsan Arefian, Ahmed Al-Harras. Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer. Scientific reports. vol 12. issue 1. 2022-11-21. PMID:36411309. |
the expression of p53, bax, and bcl2 genes in cancerous cell lines has affirmed that both akba and aba could induce the maximal apoptosis. |
2022-11-21 |
2023-08-14 |
Not clear |
| Jing Wang, Qing-Guo Jin, Rong-Ping Liu, Xin-Qin Wang, Ying-Hua Li, Nam-Hyung Kim, Yong-Nan X. Dihydromyricetin supplementation during in vitro culture improves porcine oocyte developmental competence by regulating oxidative stress. The Journal of reproduction and development. 2022-11-20. PMID:36403957. |
further, dhm supplementation also improved glutathione levels and mitochondrial membrane potential; reduced natural reactive oxygen species levels in blastomeres and apoptosis rate; upregulated nanog, oct4, sod1, sod2, sirt1, and bcl2 expression; and downregulated beclin1, atg12, and bax expression. |
2022-11-20 |
2023-08-14 |
Not clear |
| Ahmed Ismail, Hamada Ahmed Mokhlis, Marwa Sharaky, Mohamed H Sobhy, Sherif S Hassanein, Ahmed S Doghish, Salama A Salama, Amr D Mariee, Yasmin M Atti. Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase. Pathology, research and practice. vol 240. 2022-11-19. PMID:36401980. |
moreover, apoptosis marker caspase-3 and bax were increased, while the anti-apoptotic bcl2 was decreased. |
2022-11-19 |
2023-08-14 |
Not clear |
| W Yan, Y Feng, Z Lei, W Kuang, C Lon. MicroRNA-214-3p Ameliorates LPS-Induced Cardiomyocyte Injury by Inhibiting Cathepsin B. Folia biologica. vol 68. issue 2. 2022-11-17. PMID:36384265. |
we also found that a mir-214-3p mimic or ctsb silencing could significantly reduce lpsinduced apoptosis, decrease ros, mda, caspase-3, and bax and increase sod and bcl-2. |
2022-11-17 |
2023-08-14 |
Not clear |
| Richard L Jayaraj, Sheikh Azimullah, Khatija A Parekh, Shreesh K Ojha, Rami Beira. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an Heliyon. vol 8. issue 11. 2022-11-17. PMID:36387498. |
further, to understand the effect of citronellol on apoptosis and proteotoxicity, we evaluated apoptotic markers (bax, bcl-2), growth regulator (mtor) and α-synuclein expression. |
2022-11-17 |
2023-08-14 |
rat |
| Mostafa D Mostafa, Magda A ElKomy, Azza I Othman, Maggie E Amer, Mohamed A El-Missir. Epigallocatechin-3-gallate Enhances Cognitive and Memory Performance and Protects Against Brain Injury in Methionine-induced Hyperhomocysteinemia Through Interdependent Molecular Pathways. Neurotoxicity research. 2022-11-17. PMID:36394770. |
the decreases in both oxidative stress and inflammatory cytokines were significantly associated with upregulation of the antiapoptotic bcl-2 protein and downregulation of the proapoptotic protein bax, caspases 3 and 9, and p53 compared with met-treated animals, indicating a diminution of neuronal apoptosis. |
2022-11-17 |
2023-08-14 |
mouse |