| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q Gu, H-F We. PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway. Folia biologica. vol 68. issue 1. 2022-10-06. PMID:36201855. |
functional assays showed that silence of plag1 increased viability and suppressed apoptosis in high glucose-induced recs, accompanied with up-regulation of bcl-2 and down-regulation of bax and cleaved caspase-3. |
2022-10-06 |
2023-08-14 |
rat |
| Masaya Tanaka, Hiroshi Endo, Konatsu Sakusa, Mihiro Yan. Hesperetin induces apoptosis in A549 cells via the Hsp70‑mediated activation of Bax. International journal of oncology. vol 61. issue 6. 2022-10-05. PMID:36196892. |
hesperetin induces apoptosis in a549 cells via the hsp70‑mediated activation of bax. |
2022-10-05 |
2023-08-14 |
Not clear |
| Masaya Tanaka, Hiroshi Endo, Konatsu Sakusa, Mihiro Yan. Hesperetin induces apoptosis in A549 cells via the Hsp70‑mediated activation of Bax. International journal of oncology. vol 61. issue 6. 2022-10-05. PMID:36196892. |
the present study highlighted the importance of the bax activation‑triggered mitochondria‑mediated pathway for hesperetin‑induced apoptosis and demonstrated a novel mechanism of how hsp70 played a critical role in the negative regulation of this apoptotic network in cancer cells. |
2022-10-05 |
2023-08-14 |
Not clear |
| Yu Wang, Zhihui Liu, Jun Ma, Qingyang Xv, Hongxin Gao, Hang Yin, Ge Yan, Xiaowen Jiang, Wenhui Y. Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system. Redox biology. vol 57. 2022-10-05. PMID:36198206. |
moreover, lyc was able to up-regulate the expression of bcl-2, down-regulate bax expression and inhibit the activation of cleaved forms of caspase-9 and caspase-3, which finally attenuated the apoptosis of the mitochondrial pathway induced by aai exposure. |
2022-10-05 |
2023-08-14 |
mouse |
| Gajendran Nithya, Rajasekaran Santhanasabapathy, Manickam Kalappan Vanitha, Pandi Anandakumar, Dhanapalan Sakthisekara. Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene-induced experimental lung cancer. Journal of biochemical and molecular toxicology. 2022-10-04. PMID:36193556. |
furthermore, tq administration in b(a)p-induced animals downregulated phosphatidylinositol 3-kinase/protein kinase b signaling pathway and induced apoptosis as evidenced by a decrease in cytochrome c, proapoptotic bax, caspase-3, and p53 with a parallel increase in antiapoptotic bcl-2. |
2022-10-04 |
2023-08-14 |
mouse |
| Jiayang Cai, Zhang Ye, Yuanyuan Hu, Yixuan Wang, Liguo Ye, Lun Gao, Qian Sun, Shiao Tong, Zhiqiang Sun, Ji'an Yang, Qianxue Che. FAIM2 is a potential pan-cancer biomarker for prognosis and immune infiltration. Frontiers in oncology. vol 12. 2022-10-03. PMID:36185230. |
fas apoptosis inhibitory molecule 2 (faim2) is an important member of the transmembrane bax inhibitor motif containing (tmbim) family. |
2022-10-03 |
2023-08-14 |
Not clear |
| Archana Chaudhary, Sadhan Kumar Bhardwaj, Azmi Khan, Amrita Srivastava, Kislay Kumar Sinha, Mehboob Ali, Rizwanul Haqu. Combinatorial Effect of Arsenic and Herbal Compounds in Telomerase-Mediated Apoptosis Induction in Liver Cancer. Biological trace element research. 2022-10-03. PMID:36192614. |
arsenic trioxide in combination with quercetin and aloe-emodin reduced cell viability in cancerous cells compared to normal cells by inducing apoptosis, downregulating telomerase and bcl-2 (anti-apoptotic protein) and upregulating the expression of bax (pro-apoptotic protein). |
2022-10-03 |
2023-08-14 |
human |
| Shuang Chen, You Li, Shuai Fu, Yang Li, Chao Wang, Ping Sun, Hairu Li, Jiawei Tian, Guo-Qing D. Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress. Biochemical pharmacology. 2022-10-02. PMID:36183803. |
in this study, high avp doses were found to induce h9c2 cardiomyoblast apoptosis, demonstrated by increased terminal deoxynucleotidyl transferase dutp nick end labeling (tunel)-positive cells, pro-apoptotic b-cell lymphoma-2 (bcl-2)-associated x protein (bax) up-regulation, and anti-apoptotic bcl-2 downregulation. |
2022-10-02 |
2023-08-14 |
Not clear |
| Nguyen Ngoc Trang, Ting-Wei Lee, Yu-Hsun Kao, Tze-Fan Chao, Ting-I Lee, Yi-Jen Che. Ketogenic diet modulates cardiac metabolic dysregulation in streptozocin-induced diabetic rats. The Journal of nutritional biochemistry. 2022-10-02. PMID:36184012. |
compared with the control rats, nd-fed dm rats had increased phosphorylation of acetyl coa carboxylase and higher expressions of cd-36, carnitine palmitoyltransferase-1β, tumor necrosis factor-α, interleukin (il)-1β, il6, perk, and e-if2α as well as more myocardial fibrosis and apoptosis (assessed by bcl-2, bax, and caspase-3 expression); these increases were attenuated in the kd-fed dm rats. |
2022-10-02 |
2023-08-14 |
rat |
| Hanxue Li, Meng Li, Kuichi Chen, Yueheng Li, Zhengyan Yang, Zhi Zho. The circadian clock gene ARNTL overexpression suppresses oral cancer progression by inducing apoptosis via activating autophagy. Medical oncology (Northwood, London, England). vol 39. issue 12. 2022-09-30. PMID:36180647. |
when the autophagy inhibitor autophinib was used, expressions of elevated bax and decreased bcl-2 were reversed effectively, as were decreased cell proliferation index and increased apoptosis index. |
2022-09-30 |
2023-08-14 |
human |
| Lijuan Zhao, Xiuhua Liu, Chunyan Ren, Hua Zhang, Li Ga. Silencing of LncRNA SNHG6 protects trophoblast cells through regulating miR-101-3p/OTUD3 axis in unexplained recurrent spontaneous abortion. Journal of molecular histology. 2022-09-29. PMID:36173586. |
in addition, both snhg6 silencing and mir-101-3p overexpression could increase cell viability and migration, decrease cell apoptosis, up-regulate ki-67 and bcl-2, and down-regulate bax in htr-8/svneo cells. |
2022-09-29 |
2023-08-14 |
Not clear |
| Fang Pan, Yueping Li, Yujie Ding, Songwei Lv, Rongrong You, Roja Hadianamrei, Mhd Anas Tomeh, Xiubo Zha. Anticancer effect of rationally designed α-helical amphiphilic peptides. Colloids and surfaces. B, Biointerfaces. vol 220. 2022-09-29. PMID:36174494. |
moreover, these peptides were found to induce apoptosis in cancer cells by up-regulating the expression of apoptotic proteins bax and caspase-3, down-regulating the apoptotic protein bcl-2, and activating the caspase enzyme-linked reaction. |
2022-09-29 |
2023-08-14 |
Not clear |
| Marwa A Alsakhawy, Doaa A Abdelmonsif, Medhat Haroun, Sally A Sabr. Naringin-loaded Arabic gum/pectin hydrogel as a potential wound healing material. International journal of biological macromolecules. 2022-09-28. PMID:36170930. |
furthermore, it significantly (p < 0.001) down-regulated the mrna expression of inflammatory mediators (tnf-α) and apoptosis (bax). |
2022-09-28 |
2023-08-14 |
Not clear |
| Xing Liu, Jiahui Dong, Yue Xian, Zongfang Re. [lncRNA-HOTAIR inhibits the proliferation of H9c2 rat cardiomyocytes induced by lipopolysaccharide and promotes inflammation through targeting negative regulation of miR-1-3p]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163622. |
compared with the lps combined with si-nc group, the lps combined with si-hotair treated h9c2 cell proliferation activity, presenting increased ki67 and bcl2 expression, as well as decreased level of p21 expression, apoptosis rate, bax expression, il-6 and tnf-α. |
2022-09-27 |
2023-08-14 |
rat |
| Xing Liu, Jiahui Dong, Yue Xian, Zongfang Re. [lncRNA-HOTAIR inhibits the proliferation of H9c2 rat cardiomyocytes induced by lipopolysaccharide and promotes inflammation through targeting negative regulation of miR-1-3p]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163622. |
compared with the lps combined mir-1-3p group, the proliferation activity, ki67, bcl2 expression of h9c2 cells increased in the lps combined mir-nc group, and the p21 expression, apoptosis rate, bax expression, il-6, and tnf-α levels decreased. |
2022-09-27 |
2023-08-14 |
rat |
| Xing Liu, Jiahui Dong, Yue Xian, Zongfang Re. [lncRNA-HOTAIR inhibits the proliferation of H9c2 rat cardiomyocytes induced by lipopolysaccharide and promotes inflammation through targeting negative regulation of miR-1-3p]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163622. |
compared with the lps combined with si-hotair and anti-mir-nc group, the h9c2 cell proliferation activity in the lps combined with sihotair and anti-mir-1-3p group descended, and the expression of ki67 and bcl2 decreased, while the expression of p21, bax, apoptosis, il-6 and tnf-α levels increased. |
2022-09-27 |
2023-08-14 |
rat |
| Jing-Ru Zheng, Chun-Lian Ji, Liang-Hui Zhan, Jin-Bao Pu, Li Ya. [Effect of Tetrastigma hemsleyanum on sepsis and mechanism based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164882. |
in summary, syq plays an anti-inflammatory role in the treatment of sepsis by acting on the key genes related to inflammation and apoptosis, such as tnf-α, il-6, il-lβ, il-10, bax, bcl2, and cleaved caspase-3. |
2022-09-27 |
2023-08-14 |
Not clear |
| Jing Li, Qun-Jun Duan, Jian She. [Resveratrol pretreatment improves mitochondrial function and alleviates myocardial ischemia-reperfusion injury by up-regulating mi R-20b-5p to inhibit STIM2]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 18. 2022-09-27. PMID:36164909. |
additionally, the ogd/r group had higher h9 c2 cell apoptosis rate, protein levels of bax and cleaved caspase-3, and ros level and lower bcl-2 protein, mmp, and atp levels than the control group(p<0.05) and the ogd/r+res group(p<0.05). |
2022-09-27 |
2023-08-14 |
rat |
| Jing Li, Qun-Jun Duan, Jian She. [Resveratrol pretreatment improves mitochondrial function and alleviates myocardial ischemia-reperfusion injury by up-regulating mi R-20b-5p to inhibit STIM2]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 18. 2022-09-27. PMID:36164909. |
the ogd/r+res+mir-20 b-5 p inhibitor group had higher h9 c2 cell apoptosis rate, protein levels of bax and cleaved-caspase 3, and ros level and lower bcl-2 protein, mmp, and atp levels than the ogd/r+res group(p<0.05). |
2022-09-27 |
2023-08-14 |
rat |
| Xiao Liang, Jun-Hao Zhang, Hao-Tian Bai, Ya-Lan Li, Shu-Hui Sun, Qian-Qian Zhang, Jing Yang, Rui Wan. [Mechanism of Linderae Radix against gastric cancer based on network pharmacology and in vitro experimental validation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 18. 2022-09-27. PMID:36164911. |
finally, in an in vitro experiment, the screened radix linderae active ingredient gemmadone is used for preliminarily verifying the core targets and pathways of the human gastric cancer cell sgc-7901, the results showed that germacrone could significantly inhibit the proliferation of gastric cancer cells and induce the apoptosis of sgc-7901 by regulating the expression of p53, bax, bcl-2 and other key proteins. |
2022-09-27 |
2023-08-14 |
human |