| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ziteng Deng, Jiao Li, Xiaoquan Tang, Dan Li, Yazhou Wang, Shengxi Wu, Kai Fan, Yunfei M. Leonurine Reduces Oxidative Stress and Provides Neuroprotection against Ischemic Injury via Modulating Oxidative and NO/NOS Pathway. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077582. |
furthermore, leo reduced no/nos production and cell apoptosis, decreased bax expression and increased bcl-2 levels in ogd-treated pc12 cells. |
2022-09-09 |
2023-08-14 |
rat |
| Yuzhen Jie, Ning Ding, Lin Xie, Kun Liu, Bianping Liang, Fei Ma, Shengchao Ma, Yideng Jiang, Guanjun L. [Homocysteine induces glomerular podocyte apoptosis via up-regulation of miR-488-3p expression in MPC-5 mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 9. 2022-09-09. PMID:36082710. |
on the contrary, podocyte showed an decreased apoptosis rate, expression levels of bax and caspase-3 decreased after cells were transfected with mir-488-3p inhibitor. |
2022-09-09 |
2023-08-14 |
mouse |
| Qin Zhang, Li Chen, Mengxi Gao, Shubin Wang, Lingzhen Meng, Liru Gu. Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN. Molecular and cellular biochemistry. 2022-09-09. PMID:36083512. |
molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human hepg2 cell proliferation by targeting bax, cdk1, and jun. |
2022-09-09 |
2023-08-14 |
human |
| Qin Zhang, Li Chen, Mengxi Gao, Shubin Wang, Lingzhen Meng, Liru Gu. Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN. Molecular and cellular biochemistry. 2022-09-09. PMID:36083512. |
thus, kaempferol can promote hepg2 cell apoptosis, and the regulatory mechanism may be related to the regulation of the expression levels of the apoptosis-related proteins bax, cdk1, and jun. |
2022-09-09 |
2023-08-14 |
human |
| Xusheng Zhang, Zhanjun Huang, Xiaorong Fan, Xiaoqing Tan, Chengzhi Lu, Jianshe Yan. Molecular mechanism and effects of urocortin II on rat adventitial fibroblast calcification induced by calcified medium. Vascular biology (Bristol, England). 2022-09-09. PMID:36083783. |
finally we successfully constructed the calcified cell model, found that uii was an endogenous substance regulating vascular calcification, regulated the vascular calcification by promoting apoptosis and inhibiting autophagy through up- and down-regulated bax and bcl-2/beclin-1 level, and the wnt/β-catenin signaling pathway was involved. |
2022-09-09 |
2023-08-14 |
rat |
| Rajalakshmi Ramachandran, Ramya Parthasarathy, Sangeetha Dhayala. Silver nanoparticles synthesized by Euphorbia hirta exhibited antibacterial activity and induced apoptosis through downregulation of PI3Kγ mediated PI3K/Akt/mTOR/p70S6K in human lung adenocarcinoma A549 cells. Environmental toxicology. 2022-09-08. PMID:36073799. |
the obtained results demonstrated that the eh-agnps induce reactive oxygen species-mediated apoptosis by expressing p53, bax, and inhibiting pi3k/akt/mtor/p70s6k signaling pathway. |
2022-09-08 |
2023-08-14 |
human |
| Xiaosu Huang, Pei Yan, Wenqing Ding, Chang Zhou, Qiuxiang Xu, Ming Li, Lianbao Ye, Weiqiang Che. α-Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR-34a-5p/Bcl-2 signaling axis. Drug development research. 2022-09-08. PMID:36074793. |
the results investigated that α-pinene induced hela cells apoptosis along with up-regulating the expression of bax, bid, caspase-9, caspase-3, mir-34a-5p, and down-regulating the expression of bcl-2 in vitro. |
2022-09-08 |
2023-08-14 |
Not clear |
| Ehsan Arabzadeh, Mirzahossein Norouzi Kamareh, Rodrigo Ramirez-Campillo, Reza Mirnejad, Yousef Masti, Hossein Shirvan. Twelve weeks of treadmill exercise training with green tea extract reduces myocardial oxidative stress and alleviates cardiomyocyte apoptosis in aging rat: The emerging role of BNIP3 and HIF-1α/IGFBP3 pathway. Journal of food biochemistry. 2022-09-07. PMID:36069470. |
in this study, we consider the effect of treadmill exercise training, green tea extract, and combination of exercise training with green tea extract, in aging rat cardiac myocytes apoptosis markers (i.e., hif-1α, bnip3, bax, igfbp3, bcl-2, caspase-3, mda, gpx, bax/bcl-2 ratio, and hematoxylin and eosin). |
2022-09-07 |
2023-08-14 |
rat |
| Run Tian, Aiping Deng, Xiaocong Pang, Yunli Chen, Yufei Gao, Hai Liu, Zhulin H. VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: identification of VR-10 as putative novel therapeutic agent for choroid neovascularization (CNV) treatment. Peptides. 2022-09-06. PMID:36067926. |
in addition, we evidenced that vr-10 downregulated cdk2, cdk4, cdk6, cyclin d1 and cyclin d2 to induce cell cycle arrest, upregulated cleaved caspase-3, bax and downregulated bcl-2 to promote cell apoptosis, and increased lc3b-ii/i ratio and facilitate p62 degradation to promote cell autophagy in rf/6a cells, which were all reversed by knocking down cd36. |
2022-09-06 |
2023-08-14 |
rat |
| Franziska Walter, Beatrice D'Orsi, Anagha Jagannathan, Heiko Dussmann, Jochen H M Preh. BOK controls ER proteostasis and physiological ER stress responses in neurons. Frontiers in cell and developmental biology. vol 10. 2022-09-05. PMID:36060797. |
the bcl-2 family proteins bak and bax control the crucial step of pore formation in the mitochondrial outer membrane during intrinsic apoptosis. |
2022-09-05 |
2023-08-14 |
Not clear |
| Mateo Ruiz-Conca, Jaume Gardela, Teresa Mogas, Manel López-Béjar, Manuel Álvarez-Rodrígue. Apoptosis and glucocorticoid-related genes mRNA expression is modulated by coenzyme Q10 supplementation during in vitro maturation and vitrification of bovine oocytes and cumulus cells. Theriogenology. vol 192. 2022-09-05. PMID:36063671. |
we also studied the mrna expression of nr3c1-related genes belonging to the gc regulation pathway, such as hydroxysteroid dehydrogenases (hsd11b1; hsd11b2), immunophilins (fkbp4; fkbp5), signal transducers and activators of transcription (stat3; stat5a), the mineralocorticoid receptor (nr3c2), and to the apoptosis pathway, such as the anti- (bcl2) and pro-apoptotic (bax) mrna transcripts in oocytes and cumulus cells 1) after ivm, and 2) after vitrification, both in presence or absence of q10 supplementation during ivm. |
2022-09-05 |
2023-08-14 |
cattle |
| Shuai Jiang, Shuai Liu, Yuxuan Hou, Chenxi Lu, Wenwen Yang, Ting Ji, Yang Yang, Zhibin Yu, Zhenxiao Ji. Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-04. PMID:36058416. |
moreover, cldn5 overexpression attenuated myocardial oxidative stress (dhe and protein levels of nrf2, ho-1, and nqo1), inflammatory response (levels of mpo, f4/80, ly6c, and circulating inflammatory cells), mitochondrial dysfunction (protein levels of pgc-1α, nrf1, and tfam), endoplasmic reticulum stress (protein levels of grp78, atf6, and chop and p-perk), energy metabolism disorder (p-ampk and acc), and apoptosis (tunel assay and protein levels of bax and bcl2) in mice subjected to myocardial ir. |
2022-09-04 |
2023-08-14 |
mouse |
| Huan Wang, Mei-Lin Liu, Chu Chu, Shi-Jiao Yu, Jing Li, Hai-Chuan Shen, Qian Meng, Teng Zhan. Paeonol alleviates placental inflammation and apoptosis in preeclampsia by inhibiting the JAK2/STAT3 signaling pathway. The Kaohsiung journal of medical sciences. 2022-09-02. PMID:36054229. |
the mrna levels of inflammatory cytokines (tnf-α, il-6, ifn-γ, and il-4) and apoptosis markers (bax, bcl-2, and caspase-3) were tested using quantitative reverse transcription-polymerase chain reaction (qrt-pcr). |
2022-09-02 |
2023-08-14 |
mouse |
| Huan Wang, Mei-Lin Liu, Chu Chu, Shi-Jiao Yu, Jing Li, Hai-Chuan Shen, Qian Meng, Teng Zhan. Paeonol alleviates placental inflammation and apoptosis in preeclampsia by inhibiting the JAK2/STAT3 signaling pathway. The Kaohsiung journal of medical sciences. 2022-09-02. PMID:36054229. |
apoptosis in the placentas of pe-like mouse models was attenuated by pae, as manifested by the downregulated mrna and protein levels of bax and cleaved-caspase-3 and the upregulated bcl-2. |
2022-09-02 |
2023-08-14 |
mouse |
| Yue Xie, Zhao-Wei Zheng, Hao-Ting He, Zhi-Bo Chan. LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer. The Kaohsiung journal of medical sciences. 2022-09-02. PMID:36054559. |
apoptosis and autophagy-related proteins bax, cleaved caspase-3, cleaved caspase-9, bcl-2, lc3, beclin-1, and p62 were analyzed by western blotting. |
2022-09-02 |
2023-08-14 |
mouse |
| Mansoor-Ali Vaali-Mohammed, Maha-Hamadien Abdulla, Sabine Matou-Nasri, Wagdy M Eldehna, M Meeramaideen, Eslam B Elkaeed, Mohammed El-Watidy, Noura S Alhassan, Khayal Alkhaya, Omar Al Obee. The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines. Frontiers in pharmacology. vol 13. 2022-09-01. PMID:36046830. |
furthermore, compound 5a-induced apoptosis was associated with the downregulation of the anti-apoptotic bcl-xl marker, upregulation of pro-apoptotic bax and cytochrome c markers, and increased mitochondrial outer membrane permeability, suggesting the involvement of mitochondria-dependent apoptosis pathway. |
2022-09-01 |
2023-08-14 |
Not clear |
| X Liu, C Cheng, B Deng, M Li. Ellagic acid attenuates muscle atrophy in STZ-induced diabetic mice. Physiological research. 2022-09-01. PMID:36047725. |
lastly, ea inhibited bax expressions and enhanced bcl-2 expressions to mitigate apoptosis. |
2022-09-01 |
2023-08-14 |
mouse |
| Guihao Wu, Xin Li, Yongtong Zhan, Xuhong Fan, Lingjun Xu, Tongsheng Chen, Xiaoping Wan. BID- and BAX-mediated mitochondrial pathway dominates A-1331852-induced apoptosis in senescent A549 cells. Biochemical and biophysical research communications. vol 627. 2022-08-30. PMID:36041325. |
most importantly, a-1331852 upregulated the expression of bid and bax indicating their role in mediating a-1331852-induced apoptosis in senescent a549 cells. |
2022-08-30 |
2023-08-14 |
Not clear |
| Guihao Wu, Xin Li, Yongtong Zhan, Xuhong Fan, Lingjun Xu, Tongsheng Chen, Xiaoping Wan. BID- and BAX-mediated mitochondrial pathway dominates A-1331852-induced apoptosis in senescent A549 cells. Biochemical and biophysical research communications. vol 627. 2022-08-30. PMID:36041325. |
in addition, a-1331852 also dissociated the binding between bcl-xl and bax, eventually leading to bax oligomerization in the mitochondria, and resulting in apoptosis via the mitochondrial pathway. |
2022-08-30 |
2023-08-14 |
Not clear |
| Guihao Wu, Xin Li, Yongtong Zhan, Xuhong Fan, Lingjun Xu, Tongsheng Chen, Xiaoping Wan. BID- and BAX-mediated mitochondrial pathway dominates A-1331852-induced apoptosis in senescent A549 cells. Biochemical and biophysical research communications. vol 627. 2022-08-30. PMID:36041325. |
in conclusion, our data demonstrate for the first time that a-1331852 promotes apoptosis of senescent a549 cells by influencing the interaction between bcl-xl and tbid and that between bcl-xl and bax. |
2022-08-30 |
2023-08-14 |
Not clear |