| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tingting Wang, Limin Wu, Qiuying Chen, Kuiyu Chen, Fang Tan, Jiabo Liu, Xiang Liu, Hui Ha. Copper deposition in Wilson's disease causes male fertility decline by impairing reproductive hormone release through inducing apoptosis and inhibiting ERK signal in hypothalamic-pituitary of mice. Frontiers in endocrinology. vol 13. 2022-08-22. PMID:35992126. |
after dmsa intervention, the hypothalamus tissue copper content decreased, the hypothalamus and pituitary tissue morphology and ultrastructure were improved, cell apoptosis was alleviated, the expression of bax and caspase-3 was significantly decreased, the expression of bcl-2 was significantly increased, and the reproductive hormone level, phosphorylation level, and fertility were increased. |
2022-08-22 |
2023-08-14 |
mouse |
| Chunjiao Lu, Yuhang Lv, Guanhua Kou, Yao Liu, Yi Liu, Yang Chen, Xuewei Wu, Fan Yang, Juanjuan Luo, Xiaojun Yan. Silver nanoparticles induce developmental toxicity via oxidative stress and mitochondrial dysfunction in zebrafish (Danio rerio). Ecotoxicology and environmental safety. vol 243. 2022-08-22. PMID:35994909. |
moreover, the expression of mitochondrion-mediated apoptosis signaling pathway-related genes, such as bax, bcl2, caspase-3, and caspase-9, was significantly regulated after agnps exposure in zebrafish. |
2022-08-22 |
2023-08-14 |
human |
| Manjiang Hu, Yizhou Zhong, Jun Liu, Shaozhen Zheng, Li Lin, Xi Lin, Boxuan Liang, Yuji Huang, Hongyi Xian, Zhiming Li, Bingli Zhang, Bo Wang, Hao Meng, Jiaxin Du, Rongyi Ye, Zhi Lu, Xifei Yang, Xingfen Yang, Zhenlie Huan. An adverse outcome pathway-based approach to assess aurantio-obtusin-induced hepatotoxicity. Toxicology. 2022-08-22. PMID:35995123. |
furthermore, ao elevated reactive oxygen species (ros), followed by mitochondrial dysfunction (decreases in mitochondrial membrane potential and adenosine triphosphate) and apoptosis (increased caspase-3, cleaved caspase-3, cytochrome c and bax expression, and decreased bcl-2 expression). |
2022-08-22 |
2023-08-14 |
Not clear |
| Gabriela Kniphoff da Silva Lawisch, Vanderlei Biolchi, Gabriela Kaufmann, Gabriela Nicolai, Eduarda Capitaneo, Thais Regina Rosembach, Janaina Zang, Ilma Simoni Brum, José Artur Bogo Chie. The role of FASL, BCL-2 and BAX polymorphisms in brazilian patients with prostate cancer and benign prostatic hyperplasia. Molecular biology reports. 2022-08-21. PMID:35988104. |
the fasl, bcl-2 and bax genes are involved in cell apoptosis regulation and can be related to the development of both cancer and hyperplasia. |
2022-08-21 |
2023-08-14 |
Not clear |
| Robert F Gah. Expanding the Biological Importance of Protein Structures: Insight into Dynamic Biological Function from Protein Folding Theory Analyses. The journal of physical chemistry. B. 2022-08-19. PMID:35984908. |
this study investigates the dynamic behavior of bax, a member of the bcl-2 family of proteins, during the regulation of apoptosis in the context of its published three-dimensional structure. |
2022-08-19 |
2023-08-14 |
Not clear |
| Carlos Alfredo Silva-Islas, Ricardo Alberto Santana-Martínez, Juan Carlos León-Contreras, Diana Barrera-Oviedo, Jose Pedraza-Chaverri, Rogelio Hernández-Pando, Perla D Maldonad. Quinolinic Acid Induces Alterations in Neuronal Subcellular Compartments, Blocks Autophagy Flux and Activates Necroptosis and Apoptosis in Rat Striatum. Molecular neurobiology. 2022-08-18. PMID:35980566. |
additionally, quin administration increased tumor necrosis factor alpha (tnfα) and receptor-interacting protein kinase 3 (ripk3) levels and its phosphorylation (p-ripk3), as well as decreased b-cell lymphoma 2 (bcl-2) and increased bcl-2-associated x protein (bax) levels and c-jun n-terminal kinase (jnk) phosphorylation, suggesting an activation of necroptosis and apoptosis, respectively. |
2022-08-18 |
2023-08-14 |
rat |
| Yousong Li, Qin Ding, Jinsheng Gao, Chunxia Li, Pengxiao Hou, Jie Xu, Kaiqi Cao, Min Hu, Lin Cheng, Xixing Wang, Xiaoling Yan. Novel mechanisms underlying inhibition of inflammation-induced angiogenesis by dexamethasone and gentamicin via PI3K/AKT/NF-κB/VEGF pathways in acute radiation proctitis. Scientific reports. vol 12. issue 1. 2022-08-18. PMID:35982137. |
moreover, dxm + gm enema induced apoptosis by increasing bax and suppressing bcl-2. |
2022-08-18 |
2023-08-14 |
mouse |
| Pengxiao Li, Xiaoyuan Guo, Ting Liu, Qing Liu, Jie Yang, Guoyun Li. Evaluation of Hepatoprotective Effects of Piperlongumine Derivative PL 1-3-Loaded Albumin Nanoparticles on Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Mice. Molecular pharmaceutics. 2022-08-16. PMID:35971845. |
1-3 nps treatment can inhibit inflammation, oxidative stress, and apoptosis via the downregulation of nf-κb signaling pathways, the activation of nrf2/ho-1 signaling pathways, and the inhibition of expression of bax and caspase 3 proteins. |
2022-08-16 |
2023-08-14 |
mouse |
| Rubina Kousar, Muhammad Naeem, Mohamad Ikhwan Jamaludin, Ammara Arshad, Aisyah Nazirah Shamsuri, Nelofar Ansari, Samreen Akhtar, Abu Hazafa, Jalal Uddin, Ajmal Khan, Ahmed Al-Harras. Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives. American journal of cancer research. vol 12. issue 7. 2022-08-15. PMID:35968347. |
the emerging evidence suggested that bioactive compounds isolated from endophytic fungi showed their anti-cancer activities by revealing the disturbance of the microtubule network caused by increased levels of bax and bcl-2 proteins that triggers cell cycle arrest at the g2-m phase, by inhibiting the dna replication via binding with topoisomerase ii, by regulating the activity of extracellular signal-regulated kinase and nf-kb, by evaluating the levels of p21, p27, and cyclins b/d1/e that led to cell death by apoptosis and cell cycle arrest. |
2022-08-15 |
2023-08-14 |
human |
| Mattie Garaikoetxea, Ernesto Martín-Núñez, Adela Navarro, Lara Matilla, Amaya Fernández-Celis, Vanessa Arrieta, Amaia García-Peña, Alicia Gainza, Virginia Álvarez, Rafael Sádaba, Eva Jover, Natalia López-André. Targeting Fatty Acid-Binding Protein 4 Improves Pathologic Features of Aortic Stenosis. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955575. |
male avs exhibited higher levels of fabp4 compared to females, correlating with markers of inflammation (il-6, rantes), apoptosis (bax, caspase-3, bcl-2), and calcification (il-8, bmp-2 and bmp-4). |
2022-08-12 |
2023-08-14 |
human |
| Omer H M Ibrahim, Magdi A A Mousa, Khalid A Asiry, Nabil A Alhakamy, Kamal A M Abo-Elyous. Plants (Basel, Switzerland). vol 11. issue 15. 2022-08-12. PMID:35956468. |
the cytotoxicity of neem mesocarp extract is strongly correlated with the induction of apoptosis, where it caused downregulation of the antiapoptotic bcl2 gene but upregulation of the proapoptotic p53 and bax genes. |
2022-08-12 |
2023-08-14 |
Not clear |
| Lin He, Yanbo Wang, Jin Lu. Epigenetic modification mechanism of histone demethylase KDM1A in regulating cardiomyocyte apoptosis after myocardial ischemia-reperfusion injury. PeerJ. vol 10. 2022-08-12. PMID:35959481. |
the cell viability, markers of myocardial injury (ldh, ast, and ck-mb) and apoptosis (bax and bcl-2), and caspase-3 and caspase-9 protein activities were detected, respectively. |
2022-08-12 |
2023-08-14 |
Not clear |
| Yuhan Qu, Yue Shen, Li Teng, Yuehui Huang, Yuting Yang, Xi Jian, Shengli Fan, Ping Wu, Qiang F. Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model. International immunopharmacology. vol 111. 2022-08-12. PMID:35961266. |
additionally, ca treatment inhibited apoptosis in c28/i2 cells by upregulating of bcl-2 levels, downregulating bax and ros levels, and activating the nrf2/ho-1 pathway. |
2022-08-12 |
2023-08-14 |
human |
| Shilu Luo, Ming Yang, Yachun Han, Hao Zhao, Na Jiang, Li Li, Wei Chen, Chenrui Li, Jinfei Yang, Yan Liu, Chongbin Liu, Chanyue Zhao, Lin Su. β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress. International immunopharmacology. vol 111. 2022-08-08. PMID:35940076. |
compared to the control, cisplatin-treated mice exhibited high level of serum creatinine, blood urea nitrogen and severe tubular injury, which accompanied with significantly increased expression level of nlrp3, il-1β, il-18, bax, cleaved-caspase 3, as well as aggravated oxidative stress and renal tubular cell apoptosis. |
2022-08-08 |
2023-08-14 |
mouse |
| Ewa Jablonska, Agnieszka Iwaniuk, Wioletta Ratajczak-Wrona, Kamil Grubczak, Dorota Dziemianczyk-Pakiela, Marcin Moniuszko, Karolina Nowak, Jan Borys, Marzena Garle. The promoting effect of neutrophil-derived BAFF molecule on the proliferation and life span of CAL-27 oral squamous carcinoma cells. Immunobiology. vol 227. issue 5. 2022-08-07. PMID:35933760. |
lower intensity of apoptosis in cal-27 cells was associated with the increased expression of anti-apoptotic bcl-2, mcl-1 and activated form of pi3k kinase (ppi3k) and simultaneously reduced expression of pro-apoptotic bax protein in the presence of rhbaff, as well as of supernatants of neutrophils derived from oscc patients. |
2022-08-07 |
2023-08-14 |
Not clear |
| Laya Naderbar, Yaghub Pazhang, Jafar Rezai. Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. Journal of biochemical and molecular toxicology. 2022-08-03. PMID:35920412. |
to determine the pathway of apoptosis induction, the expression of bcl2 associated x (bax) and b-cell lymphoma-2 (bcl-2) apoptotic genes and caspases activity were evaluated. |
2022-08-03 |
2023-08-14 |
Not clear |
| Yue-E Chen, Han Yang, Hu-Bo Pang, Fen-Qing Shan. Circ-CBFB exacerbates hypoxia/reoxygenation-triggered cardiomyocyte injury via regulating miR-495-3p in a VDAC1-dependent manner. Journal of biochemical and molecular toxicology. 2022-08-03. PMID:35920438. |
functionally, deletion of circ-cbfb obviously potentiated cell viability and restrained cell apoptosis, which was accompanied by a remarkable elevation of antiapoptotic bcl-2 but the repression of proapoptotic bax and cleaved caspase-3 in response to h/r. |
2022-08-03 |
2023-08-14 |
cat |
| Shubhangini Tiwari, Parul Gupta, Abhishek Singh, Swati Chaturvedi, M Wahajuddin, Amit Mishra, Sarika Sing. 4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation. Neurochemical research. 2022-08-03. PMID:35922743. |
inhibited neuronal apoptosis and restored neuronal morphology were also observed with 4pba treatment as measured by level of pro-apoptotic proteins t-bid, bax and cleaved caspase-3 along with cresyl violet staining in both substantia nigra and striatal regions. |
2022-08-03 |
2023-08-14 |
rat |
| Ying Xing, Yuqian Zhang, Congqin Li, Lu Luo, Yan Hua, Jian Hu, Yulong Ba. Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models. Cellular and molecular neurobiology. 2022-08-02. PMID:35917043. |
rtms can prompt synaptic plasticity by increasing nmdar, ampar and bdnf expression; rtms can inhibit pro-inflammatory cytokines tnf and facilitate the expression of anti-inflammatory cytokines il-10 by shifting astrocytic phenotypes from a1 to a2, and shifting microglial phenotypes from m1 to m2; rtms facilitated the release of angiogenesis-related factors tgfβ and vegf in a2 astrocytes, which can contribute to vasculogenesis and angiogenesis; rtms can suppress apoptosis by increasing bcl-2 expression and inhibiting bax, caspase-3 expression; rtms can also suppress pyroptosis by decreasing caspase-1, il-1β, asc, gsdmd and nlrp1 expression. |
2022-08-02 |
2023-08-14 |
Not clear |
| Xiao-Ming Liu, Fang Chen, Fan Zhang, Hai-Tao Xi, Jun-Zhao Zha. Knockdown of Chk1 inhibits proliferation and promotes apoptosis in mouse granulosa cells and its regulation mechanism by miR-15a and miR-16. In vitro cellular & developmental biology. Animal. 2022-08-01. PMID:35915338. |
further qrt-pcr results showed that cell cycle factors (cyclin b1 and cyclin d 1) and a marker gene of proliferation (pcna) were downregulated (p < 0.001), while apoptotic factors (p53b, p21, caspase-3, and bax) were upregulated (p < 0.01), which suggested that knockdown of chk1 may inhibit proliferation, regulate cell cycle, and promote apoptosis at the transcriptional level in gcs. |
2022-08-01 |
2023-08-14 |
mouse |