| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nouf M Alyami, Saba Abdi, Hanadi M Alyami, Rafa Almee. Proanthocyanidins alleviate pentylenetetrazole-induced epileptic seizures in mice via the antioxidant activity. Neurochemical research. 2022-07-15. PMID:35838827. |
moreover, neuronal apoptosis was recorded following the development of epileptic convulsions as confirmed by the elevated bax and caspase-3 and the decreased bcl2 protein. |
2022-07-15 |
2023-08-14 |
mouse |
| Zhihui Li, Danhong Ren, Chen Chen, Leiming Sun, Kun Fan. OSU-T315 and doxorubicin synergistically induce apoptosis via mitochondrial pathway in bladder cancer cells. Cell biology international. 2022-07-13. PMID:35830716. |
mechanically, it was found that osu-t315 and dox synergistically induced activation of bax which is critical for the induction of apoptosis. |
2022-07-13 |
2023-08-14 |
Not clear |
| Gabriel Alves Bonafé, Jéssica Silva Dos Santos, Jussara Vaz Ziegler, Fernando Augusto Lima Marson, Thalita Rocha, Manoela Marques Orteg. Dipotassium Glycyrrhizinate on Melanoma Cell Line: Inhibition of Cerebral Metastases Formation by Targeting NF-kB Genes-Mediating MicroRNA-4443 and MicroRNA-3620-Dipotassium Glycyrrhizinate Effect on Melanoma. International journal of molecular sciences. vol 23. issue 13. 2022-07-12. PMID:35806253. |
dna fragmentation suggested that dpg (ic50) induced cellular apoptosis, which was confirmed by a significant number of tunel-positive cells (p-value = 0.048) and by parp-1 [0.55 vs. 1.02 arbitrary units (aus), p-value = 0.001], bax (1.91 vs. 1.05 aus, p-value = 0.09), and bcl-2 (0.51 vs. 1.07 aus, p-value = 0.0018) mrna compared to control cells. |
2022-07-12 |
2023-08-16 |
Not clear |
| Yuyu Feng, Wei Wang, Conghui Li. Effect of Solanum lyratum Polysaccharide on Malignant Behaviors of Lung Cancer Cells by Regulating the Circ_UHRF1/miR-513b-5p Axis. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 6. 2022-07-12. PMID:35818196. |
results showed that compared with the control group, the proliferation inhibition rate and apoptosis rate of a549 cells that intervened with the solanum lyratum polysaccharide and expression of bax protein in the cells were all increased (p<0.05), but the number of clones, migration and invasion and the protein expression of bcl-2 were all decreased (p<0.05), and were dose-dependent. |
2022-07-12 |
2023-08-14 |
Not clear |
| Yuyu Feng, Wei Wang, Conghui Li. Effect of Solanum lyratum Polysaccharide on Malignant Behaviors of Lung Cancer Cells by Regulating the Circ_UHRF1/miR-513b-5p Axis. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 6. 2022-07-12. PMID:35818196. |
after knocking down circ_uhrf1, the proliferation inhibition rate and apoptosis rate of a549 cells and protein expression of bax in the cells were all increased (p<0.05), but the number of clones, migration and invasion and the protein expression of bcl-2 were all decreased (p<0.05). |
2022-07-12 |
2023-08-14 |
Not clear |
| Mozaffari Nazanin, Javad Tolouei-Azar, Mazdak Raz. Running exercise training-induced impact on oxidative stress and mitochondria-related apoptosis in rat's testicles. Andrologia. 2022-07-12. PMID:35818990. |
additionally, the expression levels of bcl-2, bax, caspase-3, proteins involving in the mitochondria-related apoptosis, and the apoptotic index were analysed. |
2022-07-12 |
2023-08-14 |
rat |
| Mozaffari Nazanin, Javad Tolouei-Azar, Mazdak Raz. Running exercise training-induced impact on oxidative stress and mitochondria-related apoptosis in rat's testicles. Andrologia. 2022-07-12. PMID:35818990. |
accordingly, no significant changes were revealed in bcl-2, bax, and caspase-3 expression levels and apoptosis index compared to sedentary rats. |
2022-07-12 |
2023-08-14 |
rat |
| Yanna Zhu, Huan Jin, Xiaokui Huo, Qiang Meng, Changyuan Wang, Pengyuan Sun, Xiaodong Ma, Huijun Sun, Deshi Dong, Jingjing Wu, Kexin Li. Protective effect of Rhein against vancomycin-induced nephrotoxicity through regulating renal transporters and Nrf2 pathway. Phytotherapy research : PTR. 2022-07-12. PMID:35820659. |
rhein decreased the number of apoptosis cells as well as increased the expression of b-cell lymphoma-2 (bcl-2) and decreased expressions of bcl-2-like protein 4 (bax). |
2022-07-12 |
2023-08-14 |
rat |
| Riming He, Jiahui Liu, Yulian Chen, Yijiao Liao, Yuzhi Wang, Xiaoming Jin, Zhongtang Li, Siqi Liu, Jiandong Lu, Shudong Yan. A Chinese Medicine Compound Alleviates Cisplatin-Induced Acute Kidney Injury via Its Antiapoptosis and Anti-Inflammation Effects in Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-07-11. PMID:35815260. |
mechanistically, jpyst treatment attenuated cddp-induced renal tubular cell apoptosis in aki mice, as manifested by a marked decreased in tunel-positive cell counts, downregulation of the pro-apoptotic proteins bax, bad and caspase 3, and upregulation of the antiapoptotic protein bcl-2 in kidney tissues. |
2022-07-11 |
2023-08-14 |
mouse |
| Zhang Yang, Wang Yaling, Liu Tao, Rao Mingyue, Li Yongju. Cardioprotective effect of NRG-4 gene expression on spontaneous hypertension rats and its mechanism through mediating the activation of ErbB signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 1. 2022-07-09. PMID:35809324. |
while shrna group showed decreased expressions of nrg-4, erbb2, erbb4, mmp2, tgfβ1, α-sma and bcl-2, while increased caspase3 and bax expressions, as well as promoted cell proliferation and cell apoptosis when compared with the shrna nc group (p<0.05); while compared with pcdna3.1(-) nc group, pcdna3.1(-) group had highly increased expressions of nrg-4, erbb2, erbb4, mmp2, tgfβ1, α-sma and bcl-2, while decreased caspase3 and bax expressions, inhibited cell proliferation and cell apoptosis (all p<0.05). |
2022-07-09 |
2023-08-14 |
rat |
| Júlia Companys-Alemany, Andreea L Turcu, Marion Schneider, Christa E Müller, Santiago Vázquez, Christian Griñán-Ferré, Mercè Pallà. NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice. Cellular and molecular life sciences : CMLS. vol 79. issue 8. 2022-07-09. PMID:35810220. |
likewise, treatment with ub-alt-ev recovered a wt mice profile in apoptosis markers bcl-2, bax, and caspase-3. |
2022-07-09 |
2023-08-14 |
mouse |
| Muzi Zhang, Yuwen Fan, Haibo Jiang, Jian Shao, Ming L. Establishment of hyperammonemia mode in yellow catfish and the mitigation of exogenous L-ornithine-L-aspartate. Developmental and comparative immunology. 2022-07-08. PMID:35803415. |
the results showed that ammonia poisoning could induce serum ammonia content elevated, liver damage (serum aminotransferase activity elevated and liver malondialdehyde accumulation), and up-regulation of cytokine (il 1, il 8 and tnfɑ), apoptosis (p53, bax, cytochrome c, caspase 3 and caspase 9) and autophagy (dynein, beclin 1, akt and pten) genes transcription, but lola could mitigate the adverse effect of ammonia poisoning. |
2022-07-08 |
2023-08-14 |
Not clear |
| Riya Sarkar, Dipanwita Mitra, Prabal Ghosh, Debidas Ghos. Antiapoptotic and antioxidative efficacy of rhizomes of Curcuma amada on the management of diabetes-induced male infertility in albino rat: An effective fraction selection study. Journal of food biochemistry. 2022-07-07. PMID:35796441. |
the diabetic rats treated with ethyl-acetate solvent fraction also exhibited the maximum resettlement in flow cytometric analysis of sperm viability (55.84%) and sperm mitochondrial integrity (149.79%), gene expression patterns of key markers for androgenesis (Δ5, 3β-hsd 87.50%, and 17β-hsd 74.66%) and apoptosis (bax 44.63%, bcl-2 54.03%, and caspase-3 35.77%) along with testicular histology. |
2022-07-07 |
2023-08-14 |
rat |
| Hai Duc Nguyen, Min-Sun Ki. The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships : The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships. Biological trace element research. 2022-07-07. PMID:35798913. |
the genes casp3, bax, bcl2, il6, tnf, apoe, hmox1, and igf were found to be mutually affected by the heavy metal mixture studied, suggesting the importance of apoptosis, inflammation, lipid, heme, and glucose metabolism in mets and cognitive impairment, as well as the potentiality of targeting these genes in prospective therapeutic intervention for these diseases. |
2022-07-07 |
2023-08-14 |
Not clear |
| Liu Yang, Jingyun Zhang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yan. [Rat serum containing oxymatrine inhibits the proliferation of LX2 human hepatic stellate cells induced by sodium arsenite via blocking PI3K/AKT pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 7. 2022-07-05. PMID:35786453. |
results after indirect arsenic treatment, the proliferation rate of lx2 cells increased, the proportion of g1 phase decreased, the proportion of apoptosis decreased, the expression of α-sma, pi3k, p-akt, cyclin d1, bcl2 were significantly up-regulated, and the expression of bax decreased. |
2022-07-05 |
2023-08-14 |
human |
| Liu Yang, Jingyun Zhang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yan. [Rat serum containing oxymatrine inhibits the proliferation of LX2 human hepatic stellate cells induced by sodium arsenite via blocking PI3K/AKT pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 7. 2022-07-05. PMID:35786453. |
after om-containing serum treatment, the proportion of cells in g1 phase increased, the proportion of apoptosis increased, the expression of bax protein increased significantly, and the expression of other proteins were significantly down-regulated, especially in the high-dose group. |
2022-07-05 |
2023-08-14 |
human |
| Zuzana Fabová, Adam Tarko, Abdel Halim Harrath, Saleh Alwasel, Jan Kotwica, Alexander V Sirotki. Tribulus terrestris can suppress the adverse effect of toluene on bovine and equine ovarian granulosa cells. Reproduction in domestic animals = Zuchthygiene. 2022-07-05. PMID:35789053. |
viability, markers of proliferation (pcna) and apoptosis (bax), steroid hormones, igf-i, oxytocin, and prostaglandin f (pgf) release were analyzed by trypan blue exclusion test, quantitative immunocytochemistry, and eia/elisa. |
2022-07-05 |
2023-08-14 |
cattle |
| Wang Peipei, Wang Ping, Yin Miaomiao, Wang Shu. Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway. Allergologia et immunopathologia. vol 50. issue 4. 2022-07-05. PMID:35789410. |
our results demonstrated that lps caused decreased cell viability, increased ldh release, improved cell apoptosis along with decreased expression of bcl2 and enhanced expressions of bax, cleaved parp and cleaved caspase, enhanced production, and protein expressions of tnf-α, il-6, and il-1β, increased generation of reactive oxygen species (ros) and malondialdehyde (mda), but contributed to declined activity of superoxide dismutase (sod) and glutathione peroxidase (gsh-px). |
2022-07-05 |
2023-08-14 |
human |
| Elaheh Heydarnia, Farzaneh Taghian, Khosro Jalali Dehkordi, Mehrzad Moghadas. Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti-apoptotic process. Journal of food biochemistry. 2022-07-03. PMID:35780321. |
sirt3/fas/bcl-2/cycs and bax, as a critical network of apoptosis, play an essential role in heart failure induced by hyperglycemia. |
2022-07-03 |
2023-08-14 |
rat |
| Gözde Özge Önder, Gülay Sezer, Saim Özdamar, Arzu Ya. Melatonin has an inhibitory effect on MCF-7 and MDA-MB-231 human breast cancer cell lines by inducing autophagy and apoptosis. Fundamental & clinical pharmacology. 2022-07-02. PMID:35778975. |
the goal of this work was to see how melatonin affected bax and bcl-2 expression, as well as apoptosis and autophagy, in mcf-7 and mda-mb-231 breast cancer cell lines, which have distinct hormonal sensitivities. |
2022-07-02 |
2023-08-14 |
human |