| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammed Ahmed Shehata Amin, Hany M A Sonpol, Rehab Hassan Elbanna Gouda, Adel Mohamed Aboregel. Bisphenol A Enhances Apoptosis, Fibrosis, and Biochemical Fluctuations in the Liver of Adult Male Rats with Possible Regression after Recovery. Anatomical record (Hoboken, N.J. : 2007). 2022-07-01. PMID:35773941. |
expression of bcl-2-associated x protein (bax) and transforming growth factor beta 1 (tgfβ1) was prominent, denoting apoptosis and fibrosis. |
2022-07-01 |
2023-08-14 |
human |
| Jibo Li, Yongsong Bai, Kaidi Ma, Zhongshuai Ren, Jianping Li, Jing Zhang, Anshan Sha. Dihydroartemisinin alleviates deoxynivalenol induced liver apoptosis and inflammation in piglets. Ecotoxicology and environmental safety. vol 241. 2022-06-30. PMID:35772362. |
furthermore, don activated death receptor pathway to promote apoptosis by up-regulating the protein expression of fasl and caspase-3, and the mrna expression of fasl, tnfr1, caspase-8, bid, bax, cyc and caspase-3. |
2022-06-30 |
2023-08-14 |
human |
| Sandra S Arango-Varela, Ivan Luzardo-Ocampo, Maria E Maldonado-Celi. Andean berry (Vaccinium meridionale Swartz) juice, in combination with Aspirin, displayed antiproliferative and pro-apoptotic mechanisms in vitro while exhibiting protective effects against AOM-induced colorectal cancer in vivo. Food research international (Ottawa, Ont.). vol 157. 2022-06-28. PMID:35761556. |
the results indicated that aspirin and abj mixtures exhibit antiproliferative and pro-apoptotic effects in sw480 cells inducing mechanisms linked to extrinsic (tnf and trail-mediated apoptosis) and intrinsic (bax and cytochrome c modulation) pathways. |
2022-06-28 |
2023-08-14 |
mouse |
| Francine S Ke, Steven Holloway, Rachel T Uren, Agnes W Wong, Melissa H Little, Ruth M Kluck, Anne K Voss, Andreas Strasse. The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK. The EMBO journal. 2022-06-27. PMID:35758142. |
using mice lacking all known apoptosis effectors, bax, bak and bok, we have previously defined the processes during development that require apoptosis. |
2022-06-27 |
2023-08-14 |
mouse |
| Zinab Mohammadi, Jahanbakhsh Asadi, Seyyed Mehdi Jafar. Synergistic effects of BAY606583 on docetaxel in esophageal cancer through modulation of ERK1/2. Cell biochemistry and function. 2022-06-27. PMID:35758556. |
subsequently, apoptosis was assessed by annexin-v and propidium iodide staining, and bcl-2, bax, and erk1/2 protein-level expressions were evaluated by western blot. |
2022-06-27 |
2023-08-14 |
Not clear |
| Qun Ye, Ziwei Jiang, Ying Xie, Yuanhong Xu, Yiyi Ye, Lei Ma, Lixia Pe. MY11 exerts antitumor effects through activation of the NF-κB/PUMA signaling pathway in breast cancer. Investigational new drugs. 2022-06-27. PMID:35759135. |
our in vitro studies demonstrated that my11 promoted breast cancer cell apoptosis by activating the nf-κb/puma/mitochondrial apoptosis pathway (including bcl-2, bax, and caspase-9). |
2022-06-27 |
2023-08-14 |
mouse |
| Heying Zhou, Fengxia Li, Yanli L. Anti-Cancer Activity of Gedunin by Induction of Apoptosis in Human Gastric Cancer AGS Cells. Applied biochemistry and biotechnology. 2022-06-27. PMID:35759172. |
in the current investigation, the effect of gedunin on the cell viability; reactive oxygen species (ros) generation by dcfh-da staining; mitochondrial membrane potential (mmp) by rh-123 staining; apoptosis by ao/etbr staining; cell migration and wound healing ability by wound scratch assay; and bcl-2, bax, caspase-3, and caspase-9 by elisa techniques were analyzed in the ags cells. |
2022-06-27 |
2023-08-14 |
human |
| Chengtao Sun, Mengzhen Li, Lian Zhang, Feifei Sun, Huimou Chen, Yanjie Xu, Yingxia Lan, Li Zhang, Suying Lu, Jia Zhu, Junting Huang, Juan Wang, Yang Hu, Yanfen Feng, Yizhuo Zhan. IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma. Cell death & disease. vol 13. issue 6. 2022-06-27. PMID:35760783. |
ido1 inhibition induced cell apoptosis coupled with puma and bax upregulation, as well as bcl2 and bcl-xl downregulation. |
2022-06-27 |
2023-08-14 |
Not clear |
| Philipp Wolf, Axel Schoeniger, Frank Edlic. Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane. Biochimica et biophysica acta. Molecular cell research. 2022-06-25. PMID:35752202. |
the bcl-2 protein family controls mitochondrial apoptosis and initiates cell death through the pro-apoptotic activities of bax and bak at the outer mitochondrial membrane (omm). |
2022-06-25 |
2023-08-14 |
Not clear |
| Philipp Wolf, Axel Schoeniger, Frank Edlic. Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane. Biochimica et biophysica acta. Molecular cell research. 2022-06-25. PMID:35752202. |
although it is clear that ultimately complexes of active bax and bak commit the cell to apoptosis, the nature of these complexes is still enigmatic. |
2022-06-25 |
2023-08-14 |
Not clear |
| Yingjie Wang, Fangju Liu, Xin Zhou, Mengru Liu, Haoran Zang, Xiao Liu, Anshan Shan, Xingjun Fen. Alleviation of Oral Exposure to Aflatoxin B1-Induced Renal Dysfunction, Oxidative Stress, and Cell Apoptosis in Mice Kidney by Curcumin. Antioxidants (Basel, Switzerland). vol 11. issue 6. 2022-06-24. PMID:35739979. |
additionally, afb1 was found to increase apoptotic cells percentage in the kidney via the tunel assay, along with increased expression of cyt-c, bax, cleaved-caspase-3, caspase-9, and decreased expression of bcl-2 at the transcriptional and protein levels; in contrast, for mice given curcumin, there was a significant reversal in kidney coefficient, biochemical parameters, pathological changes, and the expression of genes and proteins involved in oxidative stress and apoptosis. |
2022-06-24 |
2023-08-14 |
mouse |
| Monika Morawska-Kochman, Agnieszka Śmieszek, Klaudia Marcinkowska, Krzysztof Mariusz Marycz, Kamil Nelke, Krzysztof Zub, Tomasz Zatoński, Marek Bochni. Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)-Evaluation at mRNA and miRNA Levels. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740420. |
the expression of transcripts was determined by rt-qpcr and included the detection of markers associated with cell survival and apoptosis, i.e., bax, p53, p21, casp3, casp9, c-myc, ccnd1, bric5, and apaf1. |
2022-06-24 |
2023-08-14 |
human |
| Monika Morawska-Kochman, Agnieszka Śmieszek, Klaudia Marcinkowska, Krzysztof Mariusz Marycz, Kamil Nelke, Krzysztof Zub, Tomasz Zatoński, Marek Bochni. Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)-Evaluation at mRNA and miRNA Levels. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740420. |
the obtained results indicated increased apoptosis determined by a tunel assay in csrwnp patients and accompanied by an increased expression of bax, p21, p53, casp3, casp9, c-myc, and apaf-1 transcripts and decreased mrna levels of bcl-2 and birc5. |
2022-06-24 |
2023-08-14 |
human |
| Michael J Viereckl, Kelsey Krutsinger, Aaron Apawu, Jian Gu, Bryana Cardona, Donovan Barratt, Yuyan Ha. Cannabidiol and Cannabigerol Inhibit Cholangiocarcinoma Growth In Vitro via Divergent Cell Death Pathways. Biomolecules. vol 12. issue 6. 2022-06-24. PMID:35740979. |
the expression of proliferation biomarker ki-67, apoptosis biomarker bax, and autophagic flux biomarkers lc3b and lamp1 were evaluated via immunofluorescence. |
2022-06-24 |
2023-08-14 |
Not clear |
| Michael J Viereckl, Kelsey Krutsinger, Aaron Apawu, Jian Gu, Bryana Cardona, Donovan Barratt, Yuyan Ha. Cannabidiol and Cannabigerol Inhibit Cholangiocarcinoma Growth In Vitro via Divergent Cell Death Pathways. Biomolecules. vol 12. issue 6. 2022-06-24. PMID:35740979. |
in addition, the expression of autophagy gene lc3b and apoptosis genes bax, bcl-2, and cleaved caspase-3 were evaluated via western blot. |
2022-06-24 |
2023-08-14 |
Not clear |
| Junhao Huang, Zhiwei Xu, Hongshu Chen, Yiyou Lin, Jiale Wei, Sichen Wang, Hongxia Yu, Shuo Huang, Yehui Zhang, Changyu Li, Xiaojie Zho. Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741643. |
we found that sqw treatment significantly alleviated learning and memory impairment, pathological damage, and apoptosis in rats, as evidenced by an increased level of neun and bcl-2, and decreased phosphorylation of tau, bax, and caspase-3 protein expression. |
2022-06-24 |
2023-08-14 |
rat |
| Haibin Dai, Yan Zhou, Yue Lu, Xiangsheng Zhang, Zong Zhuang, Yongyue Gao, Guangjie Liu, Chunlei Chen, Jin Ma, Wei Li, Chunhua Han. Decreased Expression of CIRP Induced by Therapeutic Hypothermia Correlates with Reduced Early Brain Injury after Subarachnoid Hemorrhage. Journal of clinical medicine. vol 11. issue 12. 2022-06-24. PMID:35743480. |
after treatments, the brain tissues of the three groups were randomly collected after 12 h, 1 d, 3 d, and 7 d, and the expression levels of the cirp and mitochondrial apoptosis pathway-related proteins bax, bcl-2, caspase-9, caspase-3, and cytochrome c measured using western blotting and real-time pcr. |
2022-06-24 |
2023-08-14 |
rat |
| Yibin Yang, Xia Zhu, Ying Huang, Hongyu Zhang, Yongtao Liu, Ning Xu, Guihong Fu, Xiaohui A. RNA-Seq and 16S rRNA Analysis Revealed the Effect of Deltamethrin on Channel Catfish in the Early Stage of Acute Exposure. Frontiers in immunology. vol 13. 2022-06-24. PMID:35747138. |
moreover, the kegg pathway and go enrichment analyses showed that the apoptosis signaling pathway was significantly enriched, and apoptosis-related degs, including cathepsin l, p53, bax, and caspase-3, were also detected. |
2022-06-24 |
2023-08-14 |
Not clear |
| Xinying Zhao, Hailin Xu, Yan Li, Yufan Liu, Xueyan Li, Wei Zhou, Ji Wang, Caixia Guo, Zhiwei Sun, Yanbo L. Silica nanoparticles perturbed mitochondrial dynamics and induced myocardial apoptosis via PKA-DRP1-mitochondrial fission signaling. The Science of the total environment. 2022-06-24. PMID:35750168. |
concomitantly, sinps activated mitochondrial-mediated apoptotic signaling in view of the up-regulated bax, increased caspase-9 cleavage and declined bcl-2, ultimately resulting in myocardial apoptosis. |
2022-06-24 |
2023-08-14 |
Not clear |
| Qi Li, Boyu Xia, Jingjing Wu, Xiaomei Yuan, Xu Lu, Chao Huang, Hongcheng Gu, Koulong Zheng, Qingsheng You, Kun Li. Indole-3-Carbinol (I3C) Protects the Heart From Ischemia/Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Cellular Apoptosis in Mice. Frontiers in pharmacology. vol 13. 2022-06-23. PMID:35734410. |
i3c pretreatment also suppressed cardiac apoptosis in miri mice by increasing the expression levels of the anti-apoptotic protein bcl-2 and decreasing the expression levels of several apoptotic proteins, including bax, caspase-3, and caspase-9. |
2022-06-23 |
2023-08-14 |
mouse |