| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qinhua Gu, Kaizheng Duan, Ronald S Petralia, Ya-Xian Wang, Zheng L. BAX regulates dendritic spine development via mitochondrial fusion. Neuroscience research. 2022-06-10. PMID:35688289. |
bax is a bcl-2 family protein acting on apoptosis. |
2022-06-10 |
2023-08-14 |
mouse |
| Madhu Nath, Patrice Elie For. αA-Crystallin Mediated Neuroprotection in the Retinal Neurons Is Independent of Protein Kinase B. Frontiers in neuroscience. vol 16. 2022-06-07. PMID:35669493. |
among these demonstrated mechanisms, they are well-reported to regulate and inhibit apoptosis by interacting and sequestrating the proapoptotic proteins such as bax and bcl-xs. |
2022-06-07 |
2023-08-14 |
Not clear |
| Ilyas Ali, Chengmin Li, Meqian Kuang, Abid Ullah Shah, Muhammad Shafiq, Muhammad Arslan Ahmad, Dyaaaldin Abdalmegeed, Lian Li, Genlin Wan. Nrf2 Activation and NF-Kb & caspase/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells. Molecular immunology. vol 148. 2022-06-07. PMID:35671559. |
in addition, sb attenuated lps-induced oxidative stress (os) (increased intracellular ros, mda, and decreased sod, gsh-px and cat activity), thereby reduced inflammation (increased expression of il-6, il-iβ, and tnf-α), and apoptosis (increased the expression of caspases and bax and decreased bcl-2) via inhibiting nf-kb and caspase/bax signaling pathways. |
2022-06-07 |
2023-08-14 |
cat |
| Amir Raoofi, Ali Delbari, Davood Nasiry, Rahim Golmohammadi, Sara Sadat Javadinia, Reza Sadrzadeh, Mohammad-Shafi Mojadadi, Auob Rustamzadeh, Amin Mousavi Khaneghah, Vahid Ebrahimi, Mohammad Jafar Rezai. Caffeine modulates apoptosis, oxidative stress, and inflammation damage induced by tramadol in cerebellum of male rats. Journal of chemical neuroanatomy. 2022-06-06. PMID:35660069. |
at the end of study (day 21), after performing rotarod behavioral test, cerebellum tissue samples were removed and prepared for further evaluations including biochemical profile markers (mda, gpx, and sod), immunohistochemistry for caspase-3, as well as the expression of genes involved in cellular processes such as inflammation markers (il-1β, hmgb1, il-6, and tnf), apoptosis markers (caspase-3, caspase-8, bax, and p21), and autophagy markers (lamp2, atg5, becn1, and atg12). |
2022-06-06 |
2023-08-14 |
rat |
| Ya-Qing Tian, Xiao-Li Li, Wan-Jie Wang, Hai-Sheng Hao, Hui-Ying Zou, Yun-Wei Pang, Xue-Ming Zhao, Hua-Bin Zhu, Wei-Hua D. Knockdown of bone morphogenetic protein 4 gene induces apoptosis and inhibits proliferation of bovine cumulus cells. Theriogenology. vol 188. 2022-06-06. PMID:35661480. |
the bmp4 knockdown increased the cell apoptosis rate and upregulated the mrna levels of apoptosis genes caspase-3 and bax with downregulation of the anti-apoptosis gene bcl-2 (p < 0.05). |
2022-06-06 |
2023-08-14 |
cattle |
| Wenting Liu, Liping Cheng, Xuefei Li, Lili Zhao, Xiaorong Hu, Zhaocheng M. Short-term pretreatment of naringin isolated from Citrus wilsonii Tanaka attenuates rat myocardial ischemia/reperfusion injury. Naunyn-Schmiedeberg's archives of pharmacology. 2022-06-06. PMID:35666279. |
additionally, naringin pretreatment exhibited striking decreases in the apoptosis index and downregulation of the protein expression levels of cleaved-caspase3, bcl2 and bax. |
2022-06-06 |
2023-08-14 |
rat |
| Min Ji Gu, Ju-Youg Hyon, Hee-Weon Lee, Eun Hee Han, Yoonsook Kim, Youn-Soo Cha, Sang Keun H. Glycolaldehyde, an Advanced Glycation End Products Precursor, Induces Apoptosis via ROS-Mediated Mitochondrial Dysfunction in Renal Mesangial Cells. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624799. |
immunoblotting results showed that ga (100 μm) caused cytotoxicity in murine renal glomerular mesangial cells (sv40 mes 13) and induced apoptosis via major modulators, decreasing bcl-2 and increasing bax, cytochrome c, and cleaved caspase-3/-9 expression. |
2022-05-28 |
2023-08-13 |
Not clear |
| Te-Yang Huang, Miao-San Chien, Wen-Ta S. Therapeutic Potential of Pretreatment with Exosomes Derived from Stem Cells from the Apical Papilla against Cisplatin-Induced Acute Kidney Injury. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628538. |
further, they increased the gene expression of antiapoptotic factor b-cell lymphoma-2 (bcl-2), whereas they reduced that of proapoptotic factors bcl-2-associated x (bax) and caspase-8 (casp8), casp9, and casp3, thereby reducing the risk of cell apoptosis. |
2022-05-28 |
2023-08-13 |
rat |
| Alima Murtazina, Gloria Ruiz Alcala, Yaiza Jimenez-Martinez, Juan Antonio Marchal, Anel Tarabayeva, Elmira Bitanova, Gordon McDougall, Nazira Bishimbayeva, Houria Boulai. Anti-Cancerous Potential of Polysaccharides Derived from Wheat Cell Culture. Pharmaceutics. vol 14. issue 5. 2022-05-28. PMID:35631686. |
in addition, the wccpss induced an increase in the levels of bax, cytochrome c, and caspases 8 and 3, indicating that cell death progressed through intrinsic and extrinsic pathways of apoptosis. |
2022-05-28 |
2023-08-13 |
Not clear |
| Andi Cahyadi, I Dewa Gede Ugrasena, Mia Ratwita Andarsini, Maria Christina Shanty Larasati, Aryati Aryati, Diah Kusuma Arumsar. Relationship between Bax and Bcl-2 Protein Expression and Outcome of Induction Phase Chemotherapy in Pediatric Acute Lymphoblastic Leukemia. Asian Pacific journal of cancer prevention : APJCP. vol 23. issue 5. 2022-05-28. PMID:35633553. |
overexpression of the antiapoptotic protein bcl-2 causes apoptosis to stop and conversely the increased expression of the proapoptotic protein bax makes lymphoblasts easy to destroy. |
2022-05-28 |
2023-08-13 |
Not clear |
| Xiaofeng Niu, Huixin Song, Xin Xiao, Yajie Yang, Qiuxia Huang, Jinjin Yu, Jiabao Yu, Yang Liu, Tengfei Han, Dezhu Zhang, Weifeng L. Tectoridin ameliorates proliferation and inflammation in TNF-α-induced HFLS-RA cells via suppressing the TLR4/NLRP3/NF-κB signaling pathway. Tissue & cell. vol 77. 2022-05-27. PMID:35623305. |
additionally, tectoridin markedly promoted apoptosis rates of hfsl-ra cells and elevated the expression levels of cleaved caspase-3 and bax, while reduced the expression level of bcl-2. |
2022-05-27 |
2023-08-13 |
human |
| Shijia Su, Jiarui Wang, Jing Wang, Ruili Yu, Likang Sun, Yue Zhang, Lei Song, Weiling Pu, Yi Tang, Yingli Yu, Kun Zho. Cardioprotective effects of gypenoside XVII against ischemia/reperfusion injury: Role of endoplasmic reticulum stress, autophagy, and mitochondrial fusion fission balance. Phytotherapy research : PTR. 2022-05-27. PMID:35624528. |
gp-17 inhibited the expression of atg5, lc3a/b, and bax, illustrating the suppression of autophagy and apoptosis. |
2022-05-27 |
2023-08-13 |
mouse |
| Yi Lou, Zhi-Qing Zhu, Li-Li Xie, Yang-Rong Fen. [Electroacupuncture at "Zusanli"(ST36) protects intestinal mucosal immune barrier by suppre-ssing apoptosis of intestinal lymphocytes and regulating expression of Bcl-2 and Bax in sepsis rats]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 5. 2022-05-26. PMID:35616411. |
[electroacupuncture at "zusanli"(st36) protects intestinal mucosal immune barrier by suppre-ssing apoptosis of intestinal lymphocytes and regulating expression of bcl-2 and bax in sepsis rats]. |
2022-05-26 |
2023-08-13 |
rat |
| Yi Lou, Zhi-Qing Zhu, Li-Li Xie, Yang-Rong Fen. [Electroacupuncture at "Zusanli"(ST36) protects intestinal mucosal immune barrier by suppre-ssing apoptosis of intestinal lymphocytes and regulating expression of Bcl-2 and Bax in sepsis rats]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 5. 2022-05-26. PMID:35616411. |
to observe the effect of electroacupuncture (ea) at "zusanli" (st36) on apoptosis of intestinal t lymphocytes, translocation of intestinal bacteria and expression of intestinal bcl-2 and bax proteins and intestinal mucosal immune barrier in sepsis rats, so as to explore its underlying mechanism in relieving sepsis. |
2022-05-26 |
2023-08-13 |
rat |
| Sevgi Irtegun Kandemir, Hilal Saruhan Fidan, Ismail Yener, Nuriye Mete, Abdulselam Ertas, Gulactı Topcu, Ufuk Kola. Investigation of cytotoxic and apoptotic effects of 63 compounds obtained from Salvia species: Promising anticancer agents. Journal of food biochemistry. 2022-05-24. PMID:35608363. |
acetyl royleanone, 6,7-dehydroroyleanone, carnosic acid, and cryptotanshinone were found to have anticancer potential based on their modulating effects on the expression levels of bax and bcl-2 proteins which play important roles in the regulation of apoptosis. |
2022-05-24 |
2023-08-13 |
Not clear |
| Zhu Tian, Xueru Li, Xixiong Shi, Cheng Che. Effects of nitric oxide synthase inhibitor on mitochondria apoptosis and meat quality in postmortem Gannan yak (Bos grunniens) meat. Journal of food biochemistry. 2022-05-24. PMID:35608959. |
the results indicated that after treatment with l-name, nos activity and no content decreased, causing mitochondrial membrane damage, bax protein, and cyt-c levels increased, and resulted in increased activities of caspase-9 and -3, promoting the occurrence of mitochondrial apoptosis. |
2022-05-24 |
2023-08-13 |
Not clear |
| Roghayeh Rashidi, Ramin Rezaee, Abolfazl Shakeri, A Wallace Hayes, Gholamreza Karim. A review of the protective effects of chlorogenic acid against different chemicals. Journal of food biochemistry. 2022-05-24. PMID:35609009. |
moreover, cga inhibited apoptosis by reducing bax, cytochrome c, and caspase 3 and 9 expression while increasing bcl-2 levels. |
2022-05-24 |
2023-08-13 |
human |
| Tianyu Yang, Osmond Datsomor, Maocheng Jiang, Xiaoyu Ma, Guoqi Zhao, Kang Zha. Protective Roles of Sodium Butyrate in Lipopolysaccharide-Induced Bovine Ruminal Epithelial Cells by Activating G Protein-Coupled Receptors 41. Frontiers in nutrition. vol 9. 2022-05-23. PMID:35600833. |
the lsb group abated lps-induced apoptosis and decreased the expression of bax, caspase 3, and caspase 9 mrna relative to the lps group. |
2022-05-23 |
2023-08-13 |
cattle |
| Liang Gong, Biao Chen, Jingyuan Chen, Yongxin L. Protective Effects of Vitamin C against Neomycin-Induced Apoptosis in HEI-OC1 Auditory Cell. Neural plasticity. vol 2022. 2022-05-23. PMID:35601667. |
vc inhibited neomycin-induced apoptosis, ameliorated neomycin reduced antiapoptotic bcl-2 expression, and suppressed neomycin increased expression of proapoptotic bax, caspase-3 cleavage and caspase-8. |
2022-05-23 |
2023-08-13 |
Not clear |
| Jiangnan Yi, Jianzhao Liao, Tian Bai, Bole Wang, Chamba Yangzom, Zulfiqar Ahmed, Khalid Mehmood, Rao Zahid Abbas, Ying Li, Zhaoxin Tang, Hui Zhan. Battery wastewater induces nephrotoxicity via disordering the mitochondrial dynamics. Chemosphere. 2022-05-23. PMID:35605732. |
moreover, the battery wastewater exposure significantly up-regulated the autophagy (pink, parkin, mtor, atg5, lc3-b, p62) and apoptosis (bax, cytc, apaf1, p53, caspase3, caspase8) related mrna and proteins levels in kidneys. |
2022-05-23 |
2023-08-13 |
mouse |