| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vendidandala Nagarjuna Reddy, Shaik Nyamathulla, Khomaizon Abdul Kadir Pahirulzaman, Seri Intan Mokhtar, Nelli Giribabu, Visweswara Rao Pasupulet. Gallocatechin-silver nanoparticles embedded in cotton gauze patches accelerated wound healing in diabetic rats by promoting proliferation and inhibiting apoptosis through the Wnt/β-catenin signaling pathway. PloS one. vol 17. issue 6. 2022-06-23. PMID:35737691. |
furthermore, apoptosis markers such as caspase-3, caspase-9, and bax levels were reduced, whereas anti-apoptosis maker (bcl-2) and proliferation marker (pcna) levels were increased in diabetic rats dressed with cgp2 and cgp3 as compared with diabetic rats dressed with dc+cgp1. |
2022-06-23 |
2023-08-14 |
rat |
| Michael A MacDonald, Matthias Nöbel, Verónica S Martínez, Kym Baker, Evan Shave, Peter P Gray, Stephen Mahler, Trent Munro, Lars K Nielsen, Esteban Marcelli. Engineering death resistance in CHO cells for improved perfusion culture. mAbs. vol 14. issue 1. 2022-06-23. PMID:35737825. |
to combat this limitation, death-resistant chinese hamster ovary cell lines were developed by simultaneously knocking out the apoptosis effector proteins bak1, bax, and bok with crispr technology. |
2022-06-23 |
2023-08-14 |
Not clear |
| Na Qu, Ruizhe Wang, Yiming Meng, Ning Liu, Jingbo Zhai, Fengping Sha. Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor. International immunopharmacology. vol 110. 2022-06-23. PMID:35738090. |
in these studies methionine enkephalin (menk) is shown to inhibit cervical tumor cell proliferation in vitro in association with an increase in the expression of apoptosis markers and mediators, including an increase in fas, caspase 8, and caspase 3 expression and intrinsic expression of the signaling pathway mediator bax. |
2022-06-23 |
2023-08-14 |
mouse |
| Shiv Govind Rawat, Rajan Kumar Tiwari, Pradip Kumar Jaiswara, Vishal Kumar Gupta, Pratishtha Sonker, Naveen Kumar Vishvakarma, Santosh Kumar, Chandramani Pathak, Vibhav Gautam, Ajay Kuma. Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism. Apoptosis : an international journal on programmed cell death. 2022-06-21. PMID:35725975. |
the experimental findings of this study showed that sildenafil enhances the cytotoxic ability of cisplatin by apoptosis induction through altering the levels of apoptosis regulatory molecules: bcl-2, bax, cytochrome c (cyt c), cleaved caspase-3, and poly (adp-ribose) polymerase (parp). |
2022-06-21 |
2023-08-14 |
Not clear |
| Yanghui Huang, Guangyu Zhen. Circ_UBE2D2 Attenuates the Progression of Septic Acute Kidney Injury in Rats by Targeting miR-370-3p/NR4A3 Axis. Journal of microbiology and biotechnology. vol 32. issue 6. 2022-06-20. PMID:35722711. |
after sh-circ_ube2d2 was transfected into cells, the transfection efficiency was detected by qrt-pcr, cell viability and apoptosis were determined by mtt assay and flow cytometry, and expressions of bcl-2, bax and cleaved-caspase 3 were quantified by western blot. |
2022-06-20 |
2023-08-14 |
rat |
| Eric Gyimah, Xian Zhu, Ziqi Zhang, Mengyuan Guo, Hai Xu, John Kenneth Mensah, Xing Dong, Zhen Zhang, Godfred Nana Wireko Gyima. Oxidative Stress and Apoptosis in Bisphenol AF-induced Neurotoxicity in Zebrafish Embryos. Environmental toxicology and chemistry. 2022-06-20. PMID:35723417. |
consistently, the induced apoptosis significantly upregulated caspase 3 in 0.3 μm (1.95 fold) and 1.0 μm (2.26 fold); and bax in folds of 1.60- and 1.78 in 0.3 μm and 1.0 μm, respectively; while bcl-2 expression was significantly decreased in 0.3 μm (0.72-fold) and 1.0 μm (0.53-fold). |
2022-06-20 |
2023-08-14 |
cat |
| Huaxiang Shi, Pengfei Li, Hu Zhou, Zhiyong Nie, Jingxin Zhang, Xin Sui, Jiabin Guo, Yongan Wang, Liyun Wan. Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice. Brain research. 2022-06-20. PMID:35724762. |
similarly, western blot assays revealed upregulation of foxo1a, foxo3a, caspase-3 and bax, and downregulation of bcl-2, indicating a temporal influence of ahh on mitochondrial function and neuronal apoptosis. |
2022-06-20 |
2023-08-14 |
mouse |
| Guang-Chen Zhang, Yi-Hao Wang, Pan-Pan Ruan, Zu-Qi Zhang, Ning-Ning Shen, Yu-Fu Liu, Yu-Guang Wang, Yue Ga. [Protective effect of ophiopogonin D against isoproterenol-induced cardiomyocyte injury and targets]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718492. |
cell count kit-8(cck-8) assay was used to detect viability of cells treated with opd and iso, western blot to examine the effect of opd and iso on the expression of endoplasmic reticulum stress-related bip, bax, perk, atf4, caspase-12, and chop, flow cytometry to determine cell apoptosis rate, and hoechst 33258 and tunel staining to observe cell apoptosis and morphological changes. |
2022-06-19 |
2023-08-14 |
rat |
| Woo Yong Park, Gahee Song, Ja Yeon Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jinbong Park, Jun Hee Lee, Jae-Young U. Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3. Cell death & disease. vol 13. issue 6. 2022-06-17. PMID:35715415. |
it also induced apoptosis by regulating bax, bcl_xl, cytochrome c, caspase 9, and caspase 3 with increasing mitochondrial dynamics. |
2022-06-17 |
2023-08-14 |
human |
| Hecheng Wang, Shusen Lin, Yujie Yang, Mingyu Zhao, Xichun Li, Lanli Zhan. Significant role of long non-coding RNA MALAT1 in deep vein thrombosis via the regulation of vascular endothelial cell physiology through the microRNA-383-5p/BCL2L11 axis. Bioengineered. vol 13. issue 5. 2022-06-16. PMID:35706417. |
compared to the control vector group, malat1-plasmid suppressed the viability and induced apoptosis of huvecs, while improving bcl-2-associated x protein (bax) expression and decreasing bcl-2 expression. |
2022-06-16 |
2023-08-14 |
human |
| Hecheng Wang, Shusen Lin, Yujie Yang, Mingyu Zhao, Xichun Li, Lanli Zhan. Significant role of long non-coding RNA MALAT1 in deep vein thrombosis via the regulation of vascular endothelial cell physiology through the microRNA-383-5p/BCL2L11 axis. Bioengineered. vol 13. issue 5. 2022-06-16. PMID:35706417. |
compared to the control sirna group, malat1-sirna increased the cell viability, reduced cell apoptosis, upregulated bcl-2 expression, and suppressed bax expression. |
2022-06-16 |
2023-08-14 |
human |
| Daniel Thomalla, Laura Beckmann, Christina Grimm, Matteo Oliverio, Lydia Meder, Carmen Diana Herling, Pascal Nieper, Thorsten Feldmann, Olaf Merkel, Eva Lorsy, Alexandra da Palma Guerreiro, Jana von Jan, Ilmars Kisis, Elena Wasserburger, Julia Claasen, Elena Faitschuk-Meyer, Janine Altmüller, Peter Nürnberg, Tsun-Po Yang, Matthias Lienhard, Ralf Herwig, Karl-Anton Kreuzer, Christian P Pallasch, Reinhard Buettner, Stephan Christian Schäfer, Jordan Hartley, Hinrich Abken, Martin Peifer, Hamid Kashkar, Gero Knittel, Barbara Eichhorst, Roland T Ullrich, Marco Herling, Hans Christian Reinhardt, Michael Hallek, Michal R Schweiger, Lukas P Frenze. Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies. Blood. 2022-06-15. PMID:35704690. |
as we found loss of bax in richter's syndrome patients after venetoclax failure, we defined bax-mediated apoptosis to be critical for drug resistance but not for disease progression of cll into aggressive dlbcl in vivo. |
2022-06-15 |
2023-08-14 |
Not clear |
| Daniel Thomalla, Laura Beckmann, Christina Grimm, Matteo Oliverio, Lydia Meder, Carmen Diana Herling, Pascal Nieper, Thorsten Feldmann, Olaf Merkel, Eva Lorsy, Alexandra da Palma Guerreiro, Jana von Jan, Ilmars Kisis, Elena Wasserburger, Julia Claasen, Elena Faitschuk-Meyer, Janine Altmüller, Peter Nürnberg, Tsun-Po Yang, Matthias Lienhard, Ralf Herwig, Karl-Anton Kreuzer, Christian P Pallasch, Reinhard Buettner, Stephan Christian Schäfer, Jordan Hartley, Hinrich Abken, Martin Peifer, Hamid Kashkar, Gero Knittel, Barbara Eichhorst, Roland T Ullrich, Marco Herling, Hans Christian Reinhardt, Michael Hallek, Michal R Schweiger, Lukas P Frenze. Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies. Blood. 2022-06-15. PMID:35704690. |
a compound screen revealed trail-mediated apoptosis as a target to overcome bax deficiency. |
2022-06-15 |
2023-08-14 |
Not clear |
| Xueli Tong, Chunqin Lao, Di Li, Junxi Du, Jingmian Chen, Weijie Xu, Lu Li, Huiling Ye, Xiaofeng Guo, Jiejing L. An acetylated mannan isolated from Aloe vera induce colorectal cancer cells apoptosis via mitochondrial pathway. Carbohydrate polymers. vol 291. 2022-06-14. PMID:35698319. |
our study elucidated the mechanism by which the polysaccharide abpa1 induces apoptosis in colorectal cancer cells through the regulation of bax and cytochrome-c mediated mitochondrial pathway, indicating that abpa1 may be developed as a mitochondrial-targeting anti-cancer drug. |
2022-06-14 |
2023-08-14 |
Not clear |
| Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Cihan Gür, Sefa Küçükler, Ekrem Darendelioğl. Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway. Metabolic brain disease. 2022-06-14. PMID:35699857. |
bpa supplementation caused apoptosis in the brain by up-regulating caspase-3 and bax levels and down-regulating bcl-2. |
2022-06-14 |
2023-08-14 |
rat |
| Liang Chen, Liu Cao, Mengsi Zhan, Jin Li, Dayuan Wang, Régis Laurent, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Sh. Engineered Stable Bioactive Per Se Amphiphilic Phosphorus Dendron Nanomicelles as a Highly Efficient Drug Delivery System To Take Down Breast Cancer In Vivo. Biomacromolecules. 2022-06-13. PMID:35694854. |
strikingly, we show that the drug-free micelles possess good intrinsic anticancer activity and act collectively with dox to take down breast cancer cells in vitro and the xenografted tumor model in vivo through upregulation of bax, pten, and p53 proteins for enhanced cell apoptosis. |
2022-06-13 |
2023-08-14 |
Not clear |
| Lei Huang, Xinyu He, Wen Peng, Xueqing He, Bei Xu, Hu Xu, Yaoxing Wang, Wenjun Xu, Wentong Chen, Sheng Wang, Lanlan Zhou, Ning Liu, Youzhi Xu, Wenjie L. Hyperuricemia induces liver injury by upregulating HIF-1α and inhibiting arginine biosynthesis pathway in mouse liver and human L02 hepatocytes. Biochemical and biophysical research communications. vol 617. issue Pt 2. 2022-06-13. PMID:35696777. |
ua directly activated the hepatic nlrp3 inflammasome and bax apoptosis pathway invivo and invitro. |
2022-06-13 |
2023-08-14 |
mouse |
| Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fa. Amygdalin Induced Mitochondria-Mediated Apoptosis of Lung Cancer Cells via Regulating NF[Formula: see text]B-1/NF[Formula: see text]B Signaling Cascade The American journal of Chinese medicine. 2022-06-10. PMID:35681261. |
the results of immunofluorescence staining, western blotting and sirna knockdown indicated that amygdalin induced mitochondria-mediated apoptosis of lung cancer cells via enhancing the expression of nf[formula: see text]b-1 and inactivating nf[formula: see text]b signaling cascade and further changing the expressions of proteins (bax, bcl-2, cytochrome c, caspase 9, caspase 3 and parp) related to apoptosis, which were further checked by |
2022-06-10 |
2023-08-14 |
Not clear |
| Jian Li, Yan Li, Ruifeng Chai, Xiangyou Yu, Zhaoxia Y. PTX3 Protects Intestinal Mucosal Barrier Damage in Sepsis Through Toll-Like Receptor Signaling Pathway. Inflammation. 2022-06-10. PMID:35687213. |
moreover, compared with the lps group, downregulation of ptx3 increased cell apoptosis and the levels of bcl2-associated x (bax), myeloperoxidase (mpo), tumor necrosis factor-alfa (tnf-α), interleukin 1 beta (il-1β), and interferon-gamma (ifn-γ), and decreased the levels of b-cell lymphoma-2 (bcl-2), zona occludens (zo)-1, and occludin. |
2022-06-10 |
2023-08-14 |
mouse |
| Jian Li, Yan Li, Ruifeng Chai, Xiangyou Yu, Zhaoxia Y. PTX3 Protects Intestinal Mucosal Barrier Damage in Sepsis Through Toll-Like Receptor Signaling Pathway. Inflammation. 2022-06-10. PMID:35687213. |
on the contrary, overexpression of ptx3 reduced cell apoptosis and the levels of bax, mpo, tnf-α, il-1β, and ifn-γ. |
2022-06-10 |
2023-08-14 |
mouse |