| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Li, Jiang Qian, Junfeng Li, Jia Wang, Wenhong Liu, Qinfei Li, Dan W. Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway. The Journal of toxicological sciences. vol 47. issue 5. 2022-05-08. PMID:35527005. |
dex attenuated the increase in the levels of ne, alt, ast, mda, ros, apoptosis, sod2, cox-2, cytochrome c, cleaved caspase 3, bax, and p-jnk, p-p38, c-amp, p-pka and mir-34a-5p, and the decrease in the levels of sod, gpx, gsh and bcl-2 in model rats. |
2022-05-08 |
2023-08-13 |
rat |
| Dingmei Deng, Xian Ye, Xiyue Wang, Guangning H. Retracted Article: Gemcitabine aggravates miR-199a-5p-mediated breast cancer cell apoptosis by promoting VEGFA downregulation RSC advances. vol 9. issue 35. 2022-05-06. PMID:35514680. |
functional experiments were performed to explore cell viability, apoptosis rate, and expressions of apoptosis-related genes: cell viability was assessed by mtt staining, apoptosis rate was recorded by flow cytometry, and western blot was used to evaluate the expressions of bcl-2, bax and cleaved caspase 3. |
2022-05-06 |
2023-08-13 |
Not clear |
| Ye Cao, Jiajia Zheng, Chentao L. Retracted Article: miR-199a-3p knockdown inhibits dedifferentiated liposarcoma (DDLPS) cell viability and enhances apoptosis through targeting casein kinase-1 alpha (CK1α). RSC advances. vol 9. issue 39. 2022-05-06. PMID:35519458. |
functionally, mtt assay, flow cytometry and western blot results demonstrated that knockdown of mir-199a-3p inhibited ddlps cell viability, enhanced apoptosis rate, and decreased expression of apoptosis-related genes bax and cleaved caspase 3, as well as increased bcl-2 expression |
2022-05-06 |
2023-08-13 |
Not clear |
| Na Wei, Ya-Ping Liu, Rui-Rui Wang, Zhen-Juan Zhong, Xiao-Liang Wang, Yan Yang, Ting He, Si-Jia Zhao, Huan Wang, Yao-Qing Y. Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture. Neurochemical research. 2022-05-06. PMID:35522367. |
bax, annexinv, and propidium iodide (pi) staining results showed that nb medium caused cell death and apoptosis. |
2022-05-06 |
2023-08-13 |
Not clear |
| Yuyan Fan, Hongyu Fan, Ping Li, Qingshan Liu, Lixia Huang, Yilun Zho. Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis. Bioengineered. vol 13. issue 5. 2022-05-05. PMID:35510516. |
map4k3 silencing reduced the apoptosis of nrk-52e cells under hg condition, as evidenced by decreased cleaved caspase 3 and bax (pro-apoptotic factors), and increased bcl-2 and bcl-xl (anti-apoptotic factors). |
2022-05-05 |
2023-08-13 |
mouse |
| Rachel J Carter, Mateus Milani, Alison J Beckett, Shiyu Liu, Ian A Prior, Gerald M Cohen, Shankar Varadaraja. Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis. Cell death & disease. vol 13. issue 5. 2022-05-04. PMID:35508606. |
further mechanistic studies reveal that climp-63 is required for cristae remodeling (opa1 proteolysis) and drp1-mediated mitochondrial fission, whereas both rtn4 and climp-63 regulate the recruitment of bax to er and mitochondrial membranes to enable cytochrome c release and apoptosis, thereby performing novel and distinct roles in the regulation of mitochondrial structure and function. |
2022-05-04 |
2023-08-13 |
Not clear |
| Xingyao Li, Peng An, Yanhong Zhao, Zimo Cai, Bingyu Ye, Yafeng Wang, Wenfang Wang, Qi Gao, Liuyun Li, Tao Zhang, Xili W. Aqueous Extract and Polysaccharide of Aconiti Lateralis Radix Induce Apoptosis and G0/G1 Phase Cell Cycle Arrest by PI3K/AKT/mTOR Signaling Pathway in Mesangial Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-05-02. PMID:35497917. |
alr and palr inhibit the proliferation of the mesangial cells through the pi3k/akt/mtor pathway, induce the g0/g1 phase of block and apoptosis, inhibit the activity of cyclin e and cdk2, increase the expression of bax, cleaved caspase-8/caspase-8, and cleaved caspase-3/caspase-3 proteins, and effectively inhibit the growth of the mesangial cells. |
2022-05-02 |
2023-08-13 |
Not clear |
| Yuning Zhang, Jiancao Gao, Zhijuan Nie, Haojun Zhu, Jinliang Du, Liping Cao, Nailin Shao, Yi Sun, Shengyan Su, Gangchun Xu, Pao X. Microcystin-LR induces apoptosis in Juvenile Eriocheir sinensis via the mitochondrial pathway. Ecotoxicology and environmental safety. vol 238. 2022-05-02. PMID:35500400. |
to further reveal the toxicity of mc-lr, oxidative stress parameters (sod, cat, gsh-px and mda), apoptosis genes (caspase 3, bcl-2 and bax) and apoptotic cells were detected. |
2022-05-02 |
2023-08-13 |
cat |
| E A Klimov, V V Sobolev, N A Batashkov, Z G Kokaeva, A V Tretiakov, Z A Nevozinskaya, I M Korsunskaya, T N Sukhova, O E Evina, A Z Khashukoev. Transcriptional Activity of Some Genes Involved in Apoptosis in Patients with Vulvar Lichen Sclerosus. Bulletin of experimental biology and medicine. 2022-05-02. PMID:35501640. |
we assessed the level of transcriptional activity of apaf1, bax, bcl2, birc5, ccnd1, dapk1, mcl1, and myc genes encoding products that control apoptosis in the samples of tissues affected by vulvar lichen sclerosus and adjacent control tissues (n=24). |
2022-05-02 |
2023-08-13 |
Not clear |
| Feixue Liu, Xueqing Li, Babatunde Kazeem Bello, Tianmeng Zhang, Haitao Yang, Kun Wang, Jingquan Don. Difenoconazole causes spleen tissue damage and immune dysfunction of carp through oxidative stress and apoptosis. Ecotoxicology and environmental safety. vol 237. 2022-04-29. PMID:35487176. |
in addition, we found that dfz caused excessive apoptosis in spleen tissue by tunel staining and expression levels of apoptosis-related genes (caspase3, caspase8, caspase9, fas, bax, bcl-2, and p53). |
2022-04-29 |
2023-08-13 |
cat |
| Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vette. Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. eLife. vol 11. 2022-04-28. PMID:35481836. |
using early postnatal mouse retina, a cns region undergoing significant developmental remodeling, we performed scrnaseq on microglia from mice that are wild-type, lack neuronal apoptosis (bax ko), or are treated with csf1r inhibitor (plx3397). |
2022-04-28 |
2023-08-13 |
mouse |
| Melanie Gil, Marina R Hanna, Vivian Gam. A taste of the early steps in BAX activation with FLAMBE. Cell reports methods. vol 2. issue 3. 2022-04-27. PMID:35475223. |
the activation of bax through intricate intramolecular changes is critical for apoptosis. |
2022-04-27 |
2023-08-13 |
Not clear |
| Yu Pei, Yi Lui, Shengxuan Cai, Chunxia Zhou, Pengzhi Hong, Zhong-Ji Qia. A Novel Peptide Isolated from Microalgae Isochrysis zhanjiangensis Exhibits Anti-apoptosis and Anti-inflammation in Ox-LDL Induced HUVEC to Improve Atherosclerosis. Plant foods for human nutrition (Dordrecht, Netherlands). 2022-04-27. PMID:35476173. |
but down-regulated the expression of p-p65, p-iκb-α, p-p38, p-erk, p-jnk, bax, and cleaved caspase-9/-3 (c-c-9/-3), thereby inhibited ox-ldl induction inflammation and apoptosis of atherosclerosis. |
2022-04-27 |
2023-08-13 |
human |
| Chao Liang, Xiaoli Zhou, Meiling Li, Zhengpeng Song, Jinyan La. Effects of Treadmill Exercise on Mitochondrial DNA Damage and Cardiomyocyte Telomerase Activity in Aging Model Rats Based on Classical Apoptosis Signaling Pathway. BioMed research international. vol 2022. 2022-04-25. PMID:35463973. |
after the rats of each group are modeled, the myocardial tissue and cells are collected, the apoptosis of myocardial cells is detected by tunel method, and the protein expressions of bax and bcl-2 in myocardial tissue are detected by western blotting. |
2022-04-25 |
2023-08-13 |
rat |
| Chih-Hung Lin, Jiunn-Sheng Wu, Po-Chun Hsieh, Valeria Chiu, Chou-Chin Lan, Chan-Yen Ku. Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-04-22. PMID:35449822. |
moreover, wbm alleviated hypoxia-induced apoptosis via the regulation of cleaved-caspase 3, bax, and bcl-2. |
2022-04-22 |
2023-08-13 |
Not clear |
| Sandra Weller, Astrid Toennießen, Benjamin Schaefer, Tobias Beigl, Alina Muenchow, Kathrin Böpple, Ute Hofmann, Bernhard F Gillissen, Walter E Aulitzky, Hans-Georg Kopp, Frank Essman. The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA. Cell death discovery. vol 8. issue 1. 2022-04-21. PMID:35443750. |
synergistic apoptosis induction relies on the pore-forming effector bax and expression of the pro-apoptotic bh3-only protein noxa. |
2022-04-21 |
2023-08-13 |
Not clear |
| Won Hoon Song, Hye-Yoon Kim, Ye Seon Lim, Seon Yeong Hwang, Changyong Lee, Do Young Lee, Yuseok Moon, Yong Jung Song, Sik Yoo. Fish Collagen Peptides Protect against Cisplatin-Induced Cytotoxicity and Oxidative Injury by Inhibiting MAPK Signaling Pathways in Mouse Thymic Epithelial Cells. Marine drugs. vol 20. issue 4. 2022-04-21. PMID:35447905. |
the present study demonstrated that fish collagen peptides (fcp) increase cell viability, reduce intracellular levels of reactive oxygen species (ros), and impede apoptosis by repressing the expression of bax and bad and the release of cytochrome c, and by upregulating the expression of bcl-2 and bcl-xl in cisplatin-treated tecs. |
2022-04-21 |
2023-08-13 |
mouse |
| Yasmin A Ebedy, Mohamed O Elshazly, Neven H Hassan, Marwa A Ibrahim, Eman I Hassane. Novel insights into the potential mechanisms underlying carbendazim-induced hepatorenal toxicity in rats. Journal of biochemical and molecular toxicology. 2022-04-19. PMID:35437878. |
furthermore, cbz-induced apoptosis, as indicated by the observed bax gene upregulation and bcl-2 gene downregulation in both organs. |
2022-04-19 |
2023-08-13 |
human |
| Congcong Wang, Lei Wang, Chengmeng Huang, Yungang Liu, Jian Liu, Hongxuan Kuang, Qihua Pang, Hongyu Han, Ruifang Fa. Involvement of NLRP3/Caspase-1/GSDMD-Dependent Pyroptosis in BPA-Induced Apoptosis of Human Neuroblastoma Cells. Biochemical pharmacology. 2022-04-19. PMID:35439536. |
besides, bpa significantly increased reactive oxygen species production, ldh leakage and apoptosis, with reduced cell viability and mitochondrial membrane potential, in both cell lines, whereas z-yvad-fmk and ici182.780 significantly alleviated the induction of bak1, bax, bcl-2 and caspase-3 proteins by bpa. |
2022-04-19 |
2023-08-13 |
human |
| Maryam Aghaei, Hossein Khanahmad, Akram Jalali, Shahrzad Aghaei, Manizheh Narimani, Sayed Mohsen Hosseini, Fatemeh Namdar, Seyed Hossein Hejaz. Effect of transgenic Iranian journal of basic medical sciences. vol 24. issue 12. 2022-04-18. PMID:35432807. |
transgenic expression of proteins involved in macrophage apoptosis-like bax through the parasite itself accelerates infected macrophage apoptosis and prevents |
2022-04-18 |
2023-08-13 |
Not clear |