| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haoyang Zhou, Dafeng Yang, Henry S Cheng, Michael G McCoy, Daniel Pérez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W Feinber. miR-181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 6. 2022-05-20. PMID:35593587. |
in gain- or loss-of-function studies, mir-181b regulated the expression of key apoptosis markers (bcl2, bax, cleaved-caspase3) and senescence markers (p16, p21, γh2ax) and the ratio of apoptotic cells (tunel-positive) and senescent cells (sa-βgal-positive) in h |
2022-05-20 |
2023-08-13 |
Not clear |
| Tie Liu, Zhuang-Qin Zhang, Xia Xiao, Xiao-Qian L. Bioassay-guided isolation of anti-tumor polyprenylphloroglucinols from Calophyllum polyanthum and primary mechanism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-20. PMID:35594705. |
it could significantly up-regulate the expression levels of apoptosis-related genes (bax, caspase-9,) and proteins (bax, cleaved-caspase-9, cleaved-caspase-3) and down-regulated the expression of inhibitor of apoptosis gene (bcl-2) and proteins (bcl-2, phosphorylated akt). |
2022-05-20 |
2023-08-13 |
Not clear |
| Bingzheng Dong, Zhenduo Shi, Yang Dong, Jiangang Chen, Zhuo-Xun Wu, Wei Wu, Zhe-Sheng Chen, Conghui Ha. Quercetin ameliorates oxidative stress‑induced cell apoptosis of seminal vesicles via activating Nrf2 in type 1 diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-20. PMID:35594707. |
biomarkers related to cell apoptosis, such as bcl-2, bax and cleaved -caspase3 were measured by western blotting and immumohistochemical staining. |
2022-05-20 |
2023-08-13 |
rat |
| Wenlong Huang, Jiefeng Xiao, Xiaoling Shi, Shukai Zheng, Haiyi Li, Caixia Liu, Kusheng W. Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental toxicology and pharmacology. 2022-05-20. PMID:35595013. |
meanwhile, behavioral changes were accompanied by increased apoptosis and malondialdehyde (mda) content, decreased superoxide dismutase (sod) activity and dopamine (da) content, and perturbed the expression of genes associated with the synthesis (th), reuptake (dat) and metabolism (mao) of da, with dopamine receptors (drs), and with the apoptosis pathway (p53, bax, bcl2, caspase-3, caspase-8, caspase-9). |
2022-05-20 |
2023-08-13 |
zebrafish |
| Xiaofeng Li, Wen Lu, Tianjiao Zhou, Feng Zhao, Li Yan. Timosaponin AIII Suppresses RAP1 Signaling Pathway to Enhance the Inhibitory Effect of Paclitaxel on Nasopharyngeal Carcinoma. Computational and mathematical methods in medicine. vol 2022. 2022-05-19. PMID:35586672. |
the results showed that tsaiii notably strengthened the inhibitory effect of ptx on the proliferation of npc cells cne-1 and hne-2; upregulated the expression of bax b-cell lymphoma 2 (bcl-2)/bcl-xl-associated death promoter (bad), and ras-associated protein1 (rap1) gtpase activating protein (rap1gap); inhibited the level of bcl-2, rap1, and ras guanine nucleotide releasing protein (rasgrp2); and significantly enhanced the promoting effect of ptx on apoptosis in the cne-1 and hne-2 cells. |
2022-05-19 |
2023-08-13 |
mouse |
| Jingming Ren, Rong Huang, Yanjie Li, Ruiyang Chen, Hongqi Tian, Chenlu Li. Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice. Scientific reports. vol 12. issue 1. 2022-05-19. PMID:35589816. |
furthermore, hl-003 downregulated the expression of p-p53, bax, caspase 3, and caspase 9, and upregulated the expression of bcl-2, suggesting that it could inhibit the activation of p53 to reduce cell apoptosis. |
2022-05-19 |
2023-08-13 |
mouse |
| Esam O Kamel, Wail M Gad-Elrab, Mohammed A Ahmed, Zuhair M Mohammedsaleh, Emad H M Hassanein, Fares E M Al. Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1-7 Signals. Biological trace element research. 2022-05-19. PMID:35590119. |
moreover, candesartan attenuated cd hepatorenal apoptosis by upregulating bcl-2 and downregulating bax and cyt-c proteins. |
2022-05-19 |
2023-08-13 |
Not clear |
| Seung Un Seo, Seon Min Woo, Seul Gi Lee, Min Yeong Kim, Hyun Shik Lee, Yung Hyun Choi, Sang Hyun Kim, Young-Chae Chang, Kyoung-Jin Min, Taeg Kyu Kwo. BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation. Redox biology. vol 53. 2022-05-18. PMID:35584569. |
cathepsin k inhibitor (odanacatib; odn) and cathepsin k knockdown (sirna) enhance oxaliplatin-induced apoptosis through p53-dependent bax upregulation. |
2022-05-18 |
2023-08-13 |
Not clear |
| Min Liang, Chun Ji, Liyao Zhang, Xuan Wang, Cuifang Hu, Juanjuan Zhang, Yiwei Zhu, Jun Q Mo, Min-Xin Gua. Leber's hereditary optic neuropathy (LHON)-associated ND6 14 484 T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy. Human molecular genetics. 2022-05-14. PMID:35567411. |
furthermore, the m.14484 t > c mutation promoted apoptosis, evidenced by elevating annexin v-positive cells, release of cytochrome c into cytosol, levels in apoptotic proteins bax, caspases 3, 7, 9 and decreasing levels in anti-apoptotic protein bcl-xl in the mutant cybrids. |
2022-05-14 |
2023-08-13 |
Not clear |
| Lei Ma, Mengyao Bian, Hui Gao, Zhi Zhou, Wei Y. A novel 3-acyl isoquinolin-1(2H)-one induces G2 phase arrest, apoptosis and GSDME-dependent pyroptosis in breast cancer. PloS one. vol 17. issue 5. 2022-05-13. PMID:35551332. |
additionally, 4f was confirmed to induce the cell apoptosis with the up-regulation of bax, down-regulation of bcl-2, activation of cleaved-caspase3/7/9 and cleaved-parp, together with the inhibition of mek/erk and p38 mapk pathway. |
2022-05-13 |
2023-08-13 |
human |
| Gamal Badr, Leila H Sayed, Hossam El-Din M Omar, Sary Khaleel Abd Elghaffar, Medhat M Menshaw. Bee gomogenat rescues lymphoid organs from degeneration by regulating the crosstalk between apoptosis and autophagy in streptozotocin-induced diabetic mice. Environmental science and pollution research international. 2022-05-13. PMID:35554836. |
moreover, diabetic mice showed alterations in the expression of autophagy markers (lc3, beclin-1, and p62) and apoptosis markers (bcl-2 and bax) in the thymus, spleen, and lymph nodes. |
2022-05-13 |
2023-08-13 |
mouse |
| Gamal Badr, Leila H Sayed, Hossam El-Din M Omar, Sary Khaleel Abd Elghaffar, Medhat M Menshaw. Bee gomogenat rescues lymphoid organs from degeneration by regulating the crosstalk between apoptosis and autophagy in streptozotocin-induced diabetic mice. Environmental science and pollution research international. 2022-05-13. PMID:35554836. |
treatment with bg significantly abrogated apoptosis and autophagy in lymphoid organs in diabetic mice by restoring the expression levels of lc3, beclin-1, p62, bcl-2, and bax; decreasing inflammatory signals by downregulating the expression of mcp-1 and hsp-70; and promoting cell survival by enhancing the phosphorylation of akt. |
2022-05-13 |
2023-08-13 |
mouse |
| Stephen D Willis, Randy Stric. Dissecting the Dual Role of cyclin C in Tumor Suppression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556610. |
in response to reactive oxygen species, cyclin c takes on a mitochondrial role, stimulating mitochondrial fission and apoptosis, through its interactions with drp1 and bax, respectively. |
2022-05-13 |
2023-08-13 |
Not clear |
| Vrutti V Mehta, Kenza E Benzeroua. Cucurbitacin B and Evodiamine imparts anti-neoplastic effects against Glioblastoma Multiforme via PI3-K/AKT signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557445. |
in addition, cells treated with cub and evo showed a decrease in bcl2, an anti-apoptotic factor, and an increase in bax, a pro-apoptotic factor, expression; a hallmark of induction of apoptosis. |
2022-05-13 |
2023-08-13 |
human |
| Kai Wang, Jing Dai, Tao Liu, Qiong Wang, Yingxu Pan. Retracted Article: LncRNA ZEB2-AS1 regulates the drug resistance of acute myeloid leukemia RSC advances. vol 9. issue 67. 2022-05-11. PMID:35540690. |
western blotting was applied to analyze levels of bcl2 apoptosis regulator (bcl-2), bcl2 associated x, apoptosis regulator (bax), cleaved-caspase-3 and inpp4b. |
2022-05-11 |
2023-08-13 |
Not clear |
| Kai Wang, Jing Dai, Tao Liu, Qiong Wang, Yingxu Pan. Retracted Article: LncRNA ZEB2-AS1 regulates the drug resistance of acute myeloid leukemia RSC advances. vol 9. issue 67. 2022-05-11. PMID:35540690. |
zeb2-as1 elevated the ic50 of adr, and suppressed cell apoptosis of aml cells, while zeb2-as1 increased bcl-2 expression and decreased the levels of bax and cleaved-caspase-3. |
2022-05-11 |
2023-08-13 |
Not clear |
| Zuowei Pei, Jiahui Hu, Qianru Bai, Baiting Liu, Dong Cheng, Hainiang Liu, Rongmei Na, Qin Y. Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats. RSC advances. vol 8. issue 26. 2022-05-11. PMID:35540763. |
the addition of thymoquinone inhibited dox-induced cardiac fibrosis (tgf-β, smad3, collagen i, collagen iii, and α-sma) and apoptosis (p53, bcl-2, caspase-3, caspase-9, and bax) in sdr, indicating that thymoquinone may be a potential therapeutic target for cardiac damage caused by dox-induced heart failure. |
2022-05-11 |
2023-08-13 |
rat |
| An-Qi Zhang, Lu Wang, Yi-Xiu Wang, Shan-Shan Hong, Yu-Shan Zhong, Ru-Yi Yu, Xin-Lu Wu, Bing-Bing Zhou, Qi-Min Yu, Hai-Feng Fu, Shuang-Dong Chen, Yun-Chang Mo, Qin-Xue Dai, Jun-Lu Wan. Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis. Neural regeneration research. vol 17. issue 11. 2022-05-10. PMID:35535903. |
in a pc12 cell oxygen-glucose deprivation/reoxygenation model, a mir-324-3p mimic decreased cell viability and expression of the anti-apoptotic protein bcl2 and increased expression of the pro-apoptotic protein bax and rates of cell apoptosis, whereas treatment with a mir-324-3p inhibitor had the opposite effects. |
2022-05-10 |
2023-08-13 |
rat |
| Ronglong Luo, Yingjie Wang, Qiao Guo, Changyong Fan, Guangyang Jiang, Lulu Wang, Mengyun Zou, Tengfei Wang, Yingfei Sun, Xiuli Pen. Andrographolide attenuates Mycoplasma gallisepticum-induced inflammation and apoptosis by the JAK/PI3K/AKT signal pathway in the chicken lungs and primary alveolar type II epithelial cells. International immunopharmacology. vol 109. 2022-05-09. PMID:35533556. |
compared with the model group, terminal deoxynucleotidyl transferase-mediated dutp nick endlabeling (tunel), western blot (wb), quantitative real-time polymerase chain reaction (qrt-pcr) and enzyme-linked immunosorbent assays (elisa) results showed andro treatment significantly reduced apoptosis in the chicken lungs and aec ii, and down-regulated the expression levels of the protein of mg adhesin 1.2 (pmga1.2), il-1β, tnf-α, il-6, bax, caspase 9 and caspase 3, and up-regulated the expression levels of bcl-2 and bcl-xl in the chicken lungs, serum and aec ii (p ≤ 0.05). |
2022-05-09 |
2023-08-13 |
chicken |
| Nataliya Finiuk, Anna Kryshchyshyn-Dylevych, Serhii Holota, Olga Klyuchivska, Andriy Kozytskiy, Olexandr Karpenko, Nazar Manko, Iryna Ivasechko, Rostyslav Stoika, Roman Lesy. Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation. European journal of medicinal chemistry. vol 238. 2022-05-09. PMID:35533562. |
compounds 2a, 2b induced mitochondria-dependent apoptosis in treated jurkat t-cells via increasing the level of proapoptotic bax and endog proteins, and decreasing the level of antiapoptotic bcl-2 protein. |
2022-05-09 |
2023-08-13 |
human |