| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Cimini, Giorgio Giaccone, Fabrizio Tagliavini, Matteo Costantino, Paola Perego, Giacomina Ross. P301L tau mutation leads to alterations of cell cycle, DNA damage response and apoptosis: evidence for a role of tau in cancer. Biochemical pharmacology. 2022-04-18. PMID:35436464. |
such cells also exhibited lower levels of bax and cleaved caspase-3, and increased levels of cdc25a, upon oxidative stress, accounting for diminished apoptosis. |
2022-04-18 |
2023-08-13 |
Not clear |
| Magdalena Delgado, Randall R Rainwater, Billie Heflin, Alicja Urbaniak, Kaitlynn Butler, Mari Davidson, Reine M Protacio, Giulia Baldini, Andrea Edwards, Megan R Reed, Kevin D Raney, Timothy C Chamber. Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways. The Journal of biological chemistry. 2022-04-18. PMID:35436470. |
we found death of m phase cells was associated with established features of mitochondrial-mediated apoptosis, including bax activation, loss of mitochondrial transmembrane potential, caspase-3 activation, and nucleosomal dna fragmentation. |
2022-04-18 |
2023-08-13 |
Not clear |
| Guang-Liang Hong, Ya-Hui Tang, Wen-Wen Li, Kai-Qiang Cao, Jia-Ping Tan, Lu-Feng Hu, Long-Wang Chen, Guang-Ju Zhao, Zhong-Qiu L. Vesicle transport related protein Synaptotagmin-1 mediates paraquat transport to antagonize paraquat toxicity. Toxicology. 2022-04-17. PMID:35430322. |
after inhibiting syt1 expression in a549/pq cells, cell viability, intracellular pq concentration and the expression of bcl-2, snap25 and rab26 were significantly reduced, while the mortality, early apoptosis rate and bax expression were significantly increased. |
2022-04-17 |
2023-08-13 |
mouse |
| Rui Feng, Xue Qin, Qi Li, Samson Olugbenga Adeniran, Fushuo Huang, Yulong Li, Qian Zhao, Peng Zhen. Progesterone regulates inflammation and receptivity of cells via the NF-κB and LIF/STAT3 pathways. Theriogenology. vol 186. 2022-04-17. PMID:35430548. |
the results showed that ammonia decreased the viability of beec, upregulated the ros level and apoptosis rate, and upregulated the expressions of bax, bcl-2, p53, cyt-c, caspase-3, caspase-8 and caspase-9. |
2022-04-17 |
2023-08-13 |
cattle |
| Jiequn Li, Chunli Chen, Chenchen Li, Zhiping Hu, Jieqiong Tan, Liuwang Zen. Genome-Wide Knockout Screen Identifies EGLN3 Involving in Ammonia Neurotoxicity. Frontiers in cell and developmental biology. vol 10. 2022-04-15. PMID:35425766. |
we also demonstrated that egln3 knockdown ameliorated ammonia induced decreased expression of bcl-2, increased expression of bax and inhibited release of cytochrome c into the cytosol in neurons, suggesting that egln3 inhibition protected against ammonia induced apoptosis through mitochondrial dependent apoptosis pathway. |
2022-04-15 |
2023-08-13 |
Not clear |
| Wei Cheng, Dan Liu, Min Guo, Honglei Li, Qiang Wan. Sophoraflavanone G suppresses the progression of triple-negative breast cancer via the inactivation of EGFR-PI3K-AKT signaling. Drug development research. 2022-04-15. PMID:35426453. |
moreover, sg administration promoted cell apoptosis by affecting bax, bcl-2, and cleaved caspase-3 expression. |
2022-04-15 |
2023-08-13 |
mouse |
| Yongli Nie, Xiong Mei, Fengjun Cao, Xueni Zh. BDH2 promotes apoptosis and autophagy of lung adenocarcinoma cells via Akt/mTOR pathway. General physiology and biophysics. vol 41. issue 2. 2022-04-13. PMID:35416174. |
cell apoptosis of lung adenocarcinoma was promoted by bdh2 over-expression with up-regulation of bax and cleaved caspase-3. |
2022-04-13 |
2023-08-13 |
human |
| Hengfang Tang, Zhiming Zheng, Han Wang, Li Wang, Genhai Zhao, Peng Wan. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients. vol 14. issue 7. 2022-04-12. PMID:35406117. |
vitamin k2 played a significant part in apoptosis by upregulating and downregulating bcl-2 and bax protein expressions, respectively, which inhibited mitochondrial depolarization, and ros accumulation to maintain mitochondrial structure and functional stabilities. |
2022-04-12 |
2023-08-13 |
Not clear |
| Xiao-Zhen Cui, Ming-Xue Zheng, Shi-Yu Yang, Rui Bai, Li Zhan. Roles of calpain in the apoptosis of Eimeria tenella host cells at the middle and late developmental stages. Parasitology research. 2022-04-12. PMID:35412077. |
the results demonstrated that bax, bid, and calpain levels were upregulated and apoptosis was increased following e. tenella infection at 24-120 h. |
2022-04-12 |
2023-08-13 |
chicken |
| Gaolong Zhong, Gan Rao, Lixuan Tang, Shaofeng Wu, Zhaoxin Tang, Riming Huang, Zhiyan Ruan, Lianmei H. Combined effect of arsenic and polystyrene-nanoplastics at environmentally relevant concentrations in mice liver: Activation of apoptosis, pyroptosis and excessive autophagy. Chemosphere. 2022-04-12. PMID:35413363. |
meanwhile, co-treatment with as and psnps induced apoptosis in the liver, which was confirmed by ultrastructure observation and changes in the expression of apoptosis indicators (p53, bax, bcl-2, caspase-3, caspase-9, cleaved-caspase-3 and cytc). |
2022-04-12 |
2023-08-13 |
mouse |
| Mustafa Onur Yıldız, Hamit Çelik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gür, İbrahim Bayav, Aydın Genç, Özge Kandemi. Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy. Neurotoxicology. 2022-04-12. PMID:35413380. |
moreover, hesperidin was able to down-regulate the mrna transcript levels of apoptosis and endoplasmic reticulum stress markers such as caspase-3, bax, bcl-2, perk, ire1, atf6, and grp78 in naf-induced neurotoxicity. |
2022-04-12 |
2023-08-13 |
rat |
| Yan Li, Jia Xu, Lingxia Li, Lu Bai, Yunping Wang, Jianfang Zhang, Haixu Wan. Inhibition of Nicotinamide adenine dinucleotide phosphate oxidase 4 attenuates cell apoptosis and oxidative stress in a rat model of polycystic ovary syndrome through the activation of Nrf-2/HO-1 signaling pathway. Molecular and cellular endocrinology. 2022-04-12. PMID:35413388. |
nox4 deficiency increased bcl-2 levels and decreased bax, cleaved caspase-3 and cleaved caspase-9 levels and dhea-induced cell apoptosis in rat ovaries. |
2022-04-12 |
2023-08-13 |
rat |
| Razie Mirjalili, Elahe Shokouh, Niloufar Sayah Dehkordi, Reza Afsari, Sakineh Shafia, Ali Rashidy-Pou. Prior short-term exercise prevents behavioral and biochemical abnormalities induced by single prolonged stress in a rat model of posttraumatic stress disorder. Behavioural brain research. 2022-04-11. PMID:35405172. |
after testing anxiety-like behaviours in the elevated plus maze, the levels of corticosterone and bdnf in serum and bdnf and apoptosis markers (bax, bcl-2, and caspase) in hippocampus were measured. |
2022-04-11 |
2023-08-13 |
rat |
| Collins Waguia Kontchou, Ian E Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich, Georg Häcke. Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak. Cell death and differentiation. 2022-04-10. PMID:35397654. |
chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins bax and bak. |
2022-04-10 |
2023-08-13 |
human |
| Collins Waguia Kontchou, Ian E Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich, Georg Häcke. Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak. Cell death and differentiation. 2022-04-10. PMID:35397654. |
we here provide a molecular analysis of chlamydial apoptosis-inhibition in infected human cells and demonstrate that the block of apoptosis occurs during the activation of the effectors of mitochondrial apoptosis, bak and bax. |
2022-04-10 |
2023-08-13 |
human |
| Hui Luo, Yizuo Song, Jian-An Zhang, Yi Liu, Fengyun Chen, Zhiwei Wang, Xueqiong Zh. MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer. Cell death discovery. vol 8. issue 1. 2022-04-09. PMID:35396512. |
apoptosis related protein level of bcl-2, bax and caspase-3 was also analyzed in cells with pdcd6 k90 methylation mutation. |
2022-04-09 |
2023-08-13 |
Not clear |
| Gioia Boncompagni, Alessia Varone, Vanessa Tatangelo, Nagaja Capitani, Federica Frezzato, Andrea Visentin, Livio Trentin, Daniela Corda, Cosima T Baldari, Laura Patruss. Glycerophosphoinositol Promotes Apoptosis of Chronic Lymphocytic Leukemia Cells by Enhancing Bax Expression and Activation. Frontiers in oncology. vol 12. 2022-04-08. PMID:35392232. |
glycerophosphoinositol promotes apoptosis of chronic lymphocytic leukemia cells by enhancing bax expression and activation. |
2022-04-08 |
2023-08-13 |
Not clear |
| Xuewei Yin, Zonghong Li, Chunyi Lyu, Yan Wang, Shumin Ding, Chenchen Ma, Jingyi Wang, Siyuan Cui, Jinxin Wang, Dadong Guo, Ruirong X. Induced Effect of Zinc oxide nanoparticles on human acute myeloid leukemia cell apoptosis by regulating mitochondrial division. IUBMB life. 2022-04-06. PMID:35383422. |
next, the expression of drp-1, bcl-2, bax mrna and protein was detected, and the effects of zno nps on the levels of reactive oxygen species (ros), mitochondrial membrane potential (Δψm), apoptosis and atp generation in thp-1 cells were measured. |
2022-04-06 |
2023-08-13 |
human |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
in addition, this overexpression increased the viability, inhibited apoptosis, and reduced the expression of p53, bax, and cytochrome c, while increasing the expression of bcl-xl in cultured neurons. |
2022-04-06 |
2023-08-13 |
rat |
| Yunbing Tang, Yingfen Ying, Cheng Zou, Haoni Yan, Yiyan Wang, Huitao Li, Xiaoheng Li, Zhangye Xu, Jieqiang Lv, Ren-Shan G. Leydig cell function in adult male rats is disrupted by perfluorotetradecanoic acid through increasing oxidative stress and apoptosis. Environmental toxicology. 2022-04-06. PMID:35385208. |
pfteda markedly increased testicular malondialdehyde level, while inhibiting antioxidants (sod1, sod2, and cat), triggering oxidative stress, thereby further inducing bax and casp3 while inhibiting bcl2, which led to cell apoptosis. |
2022-04-06 |
2023-08-13 |
rat |