| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Chen, Wenting Luo, Peijun Ji, Zhujuan Li, Yi Yan, Qin Zho. Effects of BMI1 Gene on Regulating Apoptosis, Invasion, and Migration of HEC-1B Cells Induced by Ionizing Radiation. Journal of healthcare engineering. vol 2022. 2022-03-14. PMID:35281533. |
cell proliferation was detected by cell counting kit-8 (cck-8); cell migration and invasion were detected by transwell test; cell apoptosis was detected by flow cytometry; and the expression of mmp2, mmp7, mmp9, rock1, rhoa, p53, p21, and bax protein was detected by the western blot. |
2022-03-14 |
2023-08-13 |
human |
| Hongchao Zhang, Liuli Li, Hao Li, Peng Qu, Mingyang Xiao, Guopei Zhang, Shengwen Wu, Guolian Zhu, Xiaobo L. Corn Embryo Ameliorates Cognitive Dysfunction and Anxiety-like Behaviors in D-galactose-induced Aging Rats via Attenuating Oxidative Stress, Apoptosis and Up-regulating Neurotrophic Factors. Journal of chemical neuroanatomy. 2022-03-14. PMID:35283255. |
besides, histopathological alterations were reflected by hematoxylin-eosin staining and neuronal apoptosis levels were measured by immunohistochemical staining of bax and bcl-2. |
2022-03-14 |
2023-08-13 |
rat |
| Xiuheng Xue, Caiyun Fan, Luping Wang, Lei Gao, Kai Fan, Mengling Peng, Fugui Fang, Jianbo Cheng, Juhua Wan. Ascorbic acid regulates mouse spermatogonial stem cell proliferation in a Wnt/β-catenin/ROS signaling dependent manner. Theriogenology. vol 184. 2022-03-13. PMID:35279534. |
finally, the appropriate ros in the 40 μg/ml aa group further adjust the levels of dvl2 and nrx protein in the wnt/β-catenin pathway to maintain the nuclear intensity of β-catenin, in turn, the expression of apoptosis gene bax decreased, while the expression of bcl2, axin2, lgr5, c-myc and cyclin d1 genes increased. |
2022-03-13 |
2023-08-13 |
mouse |
| Huiling Guo, Ruiming Hu, Gang Huang, Wenjing Pu, Xuesheng Chu, Chenghong Xing, Caiying Zhan. Molybdenum and cadmium co-exposure induces endoplasmic reticulum stress-mediated apoptosis by Th1 polarization in Shaoxing duck (Anas platyrhyncha) spleens. Chemosphere. 2022-03-12. PMID:35278442. |
data confirmed that mo and/or cd strikingly promoted their levels in spleen, caused histological abnormality and trace elements imbalance, and disrupted th1/th2 balance to divert toward th1, then triggered er stress by increasing three branches perk/eif2α/chop, ire1/caspase-12 and traf2/jnk signaling pathways-related genes mrna and proteins levels, which stimulated apoptosis by elevating bak-1, bax, caspase-9, caspase-3 mrna expression, and cleaved-caspase-9/caspase-9, cleaved-caspase-3/caspase-3 proteins expression as well as apoptosis rate, and decreasing bcl-xl, bcl-2 mrna expression and bcl-2/bax ratio. |
2022-03-12 |
2023-08-13 |
Not clear |
| Marwa A Mahmoud, Mona A El-Bana, Sfaa M Morsy, Ehsan A Badawy, Abd-Elrazik Farrag, Ahmed M Badawy, Mosaad A Abdel-Wahhab, Mohamed A El-Dosok. Synthesis and characterization of berberine-loaded chitosan nanoparticles for the protection of urethane-induced lung cancer. International journal of pharmaceutics. 2022-03-12. PMID:35278602. |
co-treatment with bbr-cosnps suppressed lung cancer growth and promoted apoptosis by modulating serum bax and lung caspase 9 gene expressions. |
2022-03-12 |
2023-08-13 |
mouse |
| Cheng Lin Ye, Yang Du, Xi Yu, Zhi Yuan Chen, Lei Wang, Yong Fa Zheng, Xiu Heng Li. STEAP3 Affects Ferroptosis and Progression of Renal Cell Carcinoma Through the p53/xCT Pathway. Technology in cancer research & treatment. vol 21. 2022-03-11. PMID:35275508. |
this mechanism does not require activation of caspase or the participation of other apoptotic effector molecules (such as bax or bak), nor is it accompanied by the morphological characteristics or biochemical processes of apoptosis. |
2022-03-11 |
2023-08-13 |
Not clear |
| Enric Pouso-Vázquez, Xue Bai, Gerard Batallé, Gerard Roch, Olga Po. Effects of Heme Oxygenase 1 in the Molecular Changes and Neuropathy Associated with Type 2 Diabetes in Mice. Biochemical pharmacology. 2022-03-11. PMID:35276215. |
thus, we evaluated the effects of copp on the protein levels of 4-hne (oxidative stress), nrf2, superoxide dismutase 1 (sod1), nad(p)h quinone oxidoreductase 1 (nqo1), ho-1, glutathione s-transferase mu 1 (gstm1) (antioxidant enzymes), phosphatidylinositol 3-kinase/protein kinase b (nociceptive pathway), cd11b/c (microglial activation), and bax (apoptosis) in the amygdala and spinal cord of db/db mice. |
2022-03-11 |
2023-08-13 |
mouse |
| Esmaeel Babaeenezhad, Omid Dezfoulian, Forouzan Hadipour Moradi, Sobhan Rahimi Monfared, Mohammad Davood Fattahi, Maryam Nasri, Abdolhakim Amini, Hassan Ahmadvan. Exogenous glutathione protects against gentamicin-induced acute kidney injury by inhibiting NF-κB pathway, oxidative stress, and apoptosis and regulating PCNA. Drug and chemical toxicology. 2022-03-10. PMID:35266424. |
interestingly, egsh inhibited intrinsic apoptosis by downregulating bax and caspase-3 and upregulating bcl2 in the kidney of rats with aki. |
2022-03-10 |
2023-08-13 |
rat |
| Jin-Yuan Wang, Duo Ma, Min Luo, Yong-Peng Tan, Ou Zhong, Ge Tian, Yong-Ting Lv, Mei-Xiang Li, Xi Chen, Zhi-Han Tang, Lin-Lin Hu, Xiao-Can Le. Effect of spermidine on ameliorating spermatogenic disorders in diabetic mice via regulating glycolysis pathway. Reproductive biology and endocrinology : RB&E. vol 20. issue 1. 2022-03-08. PMID:35255928. |
pro-apoptotic factor (bax) was down-regulated expression with the up-regulated expression of bcl-2 and suppression of apoptosis in the testes. |
2022-03-08 |
2023-08-13 |
mouse |
| Andrea Lopez, Denis E Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathioti. Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nature communications. vol 13. issue 1. 2022-03-08. PMID:35256598. |
co-targeting of bax and bcl-xl proteins broadly overcomes resistance to apoptosis in cancer. |
2022-03-08 |
2023-08-13 |
Not clear |
| Andrea Lopez, Denis E Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathioti. Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nature communications. vol 13. issue 1. 2022-03-08. PMID:35256598. |
here, we find that apoptosis resistance in a diverse panel of solid and hematological malignancies is mediated by both overexpression of bcl-xl and an unprimed apoptotic state, limiting direct and indirect activation mechanisms of pro-apoptotic bax. |
2022-03-08 |
2023-08-13 |
Not clear |
| Qi Zhang, Yanan Li, Chunping Yin, Jiaxu Yu, Juan Zhao, Lirong Yan, Qiujun Wan. Electro-Acupuncture Pretreatment Ameliorates Anesthesia and Surgery-Induced Cognitive Dysfunction Via Inhibiting Mitochondrial Injury and nEuroapoptosis in Aged Rats. Neurochemical research. 2022-03-08. PMID:35258777. |
then hippocampal tissues were stripped and hippocampal neuronal amount, expression level of cleaved caspase-9 level, cytochrome c (cyt c), cleaved caspase-3 level, bcl-2, bax, ros expression level, apoptosis rate, mitochondrial membrane potential (mmp), cytosolic calcium concentration ([ca |
2022-03-08 |
2023-08-13 |
rat |
| Ashrafullah Khan, Adnan Khan, Bushra Shal, Abdul Aziz, Muhammad Naeem Ahmed, Salman Kha. N-(benzylidene)-2-((2-hydroxynaphthalen-1-yl)diazenyl)benzohydrazides (1-2) (NCHDH and NTHDH) attenuates DMBA-induced breast cancer via Nrf2/NF-κB/apoptosis signaling. Fundamental & clinical pharmacology. 2022-03-08. PMID:35259284. |
similarly, the nchdh and nthdh showed marked increase in the apoptosis proteins such as caspase-3, caspase-9, and bcl-2 associated x-protein (bax), while it inhibited the b-cell lymphoma 2 (bcl-2) expression. |
2022-03-08 |
2023-08-13 |
Not clear |
| Kai Li, Changyu Lv, Wencui Zhang, Jia Fan. CircFN1 upregulation initiated oxidative stress-induced apoptosis and inhibition of proliferation and migration in trophoblasts via circFN1-miR-19a/b-3p-ATF2 ceRNA network. Reproductive biology. vol 22. issue 2. 2022-03-08. PMID:35259622. |
functionally, its upregulation decreased sod activity, cell viability, edu incorporation, migration rate, and bcl-2 expression in human trophoblast htr-8/sv-neo cells, but meanwhile increased mda level, apoptosis rate, and bax and cleaved-caspase3 expression. |
2022-03-08 |
2023-08-13 |
human |
| Yun Zhao, Chanlin Fang, Cuiyuan Jin, Zhiwei Bao, Guiling Yang, Yuanxiang Ji. Catechin from green tea had the potential to decrease the chlorpyrifos induced oxidative stress in larval zebrafish (Danio rerio). Pesticide biochemistry and physiology. vol 182. 2022-03-07. PMID:35249660. |
catechin also could reduce the transcription of p53 and bax, which are tightly related to the apoptosis induced by cpf in zebrafish larvae. |
2022-03-07 |
2023-08-13 |
cat |
| Beibei Zhang, Guanggang Qu, Yuchen Nan, En-Min Zho. Ovarian Oxidative Stress Induced Follicle Depletion After Zona Pellucida 3 Vaccination Is Associated With Subfertility in BALB/c Mice. Frontiers in veterinary science. vol 9. 2022-03-07. PMID:35252419. |
meanwhile, activation of caspase-3 and caspase-9 along with increased bax and decreased bcl-2 levels were observed, indicating the ongoing apoptosis of ovarian cells. |
2022-03-07 |
2023-08-13 |
mouse |
| b' Ilias Tsochantaridis, Aglaia Pappa, Egemen Dere, Ferda Ar\\xc4\\xb. Zn(II) 5,5-Diethylbarbiturate complex selectively induces apoptosis in breast cancer and breast cancer stem-like cells. Chemistry & biodiversity. 2022-03-07. PMID:35254725.' |
intrinsic apoptosis pathway in mcf-7 cells and extrinsic apoptosis pathway in mda-mb-231 cells was determined by western blot (parp, cleave parp, bax, cox4, rip, caspase 8, split caspase 8, dr4 and b-actin) and rt-pcr (parp, fas, bcl-2, tnf10a, p53) analysis. |
2022-03-07 |
2023-08-13 |
human |
| Mahmoud Elshal, Marwa E Abdelmagee. Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways. Archives of pharmacal research. 2022-03-04. PMID:35244883. |
diacerein also counteracted acetaminophen-induced hepatocellular apoptosis by increasing bcl-2 and decreasing bax and caspase-3 expression levels. |
2022-03-04 |
2023-08-13 |
mouse |
| Li Zhang, Min-Na Dong, Jun Deng, Chun-Hai Zhang, Ming-Wei Li. Resveratrol exhibits neuroprotection against paraquat-induced PC12 cells via heme oxygenase 1 upregulation by decreasing MiR-136-5p expression. Bioengineered. vol 13. issue 3. 2022-03-03. PMID:35236239. |
results showed that pq dose-dependently increased the expression of mir-136-5p, the apoptosis of pc12 cells, the activities of reactive oxygen species (ros), and the levels of lactate dehydrogenase (ldh), malondialdehyde (mda), caspase-3, and pro-apoptotic protein bax. |
2022-03-03 |
2023-08-13 |
Not clear |
| Yixiao Gu, Yiqing Zhang, Jieyu Li. Mifepristone inhibited tumor progression by disrupting the stability of PD-L1 by miR-127-3p/VAMP2 in ovarian cancer. Pakistan journal of pharmaceutical sciences. vol 35. issue 1(Special). 2022-03-03. PMID:35236654. |
the results showed that mifepristone up-regulated the expression of mir-127-3p and mifepristone could significantly inhibit the proliferation of ovarian cancer skov3 cells and a2780 cells, promote apoptosis, inhibit the expression of pd-l1, down regulate the expression of cyclind1 and up regulate the expression of cl-caspase-3 and bax; silencing mir-127-3p could restore the effects of mifepristone on the proliferation and apoptosis of skov3 cells and a2780 cells, as well as the expression of pd-l1, cyclind1, cl-caspase-3 and bax protein; our study confirmed that mifepristone can regulate the expression of vamp2 and pd-l1 through mir-127-3p and vamp2 can positively regulate the expression of pd-l1; finally, we found that mifepristone can down regulate pd-l1 through mir-127-3p/vamp2 axis, inhibit proliferation and promote apoptosis of ovarian cancer cells. |
2022-03-03 |
2023-08-13 |
Not clear |