| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Peng, Jing Liu, Erqun Song, Yang Son. Polychlorinated biphenyl quinone induces immunotoxicity via lymphocytes apoptosis and Th1-Th2 cell imbalance in C57BL/6 mice. The Science of the total environment. 2022-02-17. PMID:35176371. |
the activation of caspase-3, the significant up-regulation of bax and the decrease of bcl-2 indicated occurrence of apoptosis. |
2022-02-17 |
2023-08-13 |
mouse |
| Chunliu Tang, Jiefeng Luo, Xianjia Yan, Qiaojuan Huang, Zhenhua Huang, Qi Luo, Yuan Lan, Dingzhi Chen, Baolin Zhang, Menghua Chen, Deyan Kon. Melanin nanoparticles enhance the neuroprotection of mesenchymal stem cells against hypoxic-ischemic injury by inhibiting apoptosis and upregulating antioxidant defense. Cell biology international. 2022-02-16. PMID:35170135. |
further data demonstrated that mnps enhanced the neuroprotection against hypoxic-ischemic injury of mscs by scavenging reactive oxygen species (ros) and superoxide and attenuating neuronal apoptosis by deactivating caspase-3, downregulating the expression of proapoptotic bax proteins and upregulating the expression of antiapoptotic bcl-2 proteins. |
2022-02-16 |
2023-08-13 |
Not clear |
| Yizhen Wang, Yuting Han, Yanhui Wang, Min Lv, Yifeng Li, Donghong Ni. Expression of p38MAPK and its regulation of apoptosis under high temperature stress in the razor clam Sinonovacula constricta. Fish & shellfish immunology. 2022-02-16. PMID:35172214. |
furthermore, we examined the expression of the apoptosis suppressor gene bcl-2 and pro-apoptosis gene bax by knock-down of p38mapk with dsrna interference in the gill and hepatopancreas tissues. |
2022-02-16 |
2023-08-13 |
Not clear |
| Si Yang, Jie Chen, Bingchun Ma, Jinglei Wang, Jiaxiang Che. Role of Autophagy in Lysophosphatidylcholine-Induced Apoptosis of Mouse Ovarian Granulosa Cells. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163399. |
meanwhile, lpc was shown to induce apoptosis, which is accompanied by an increase in apoptosis-related protein levels, such as cleaved caspase-3, cleaved caspase-8 and bax, as well as a decrease in bcl-2. |
2022-02-15 |
2023-08-13 |
mouse |
| Ya-Li Zhou, Qiang Sun, Lei Zhang, Rui L. Retraction notice to "miR-208b targets Bax to protect H9c2 cells against hypoxia-induced apoptosis" [Biomed. Pharmacother. 106 (2018) 1751-1759]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022-02-15. PMID:35164994. |
retraction notice to "mir-208b targets bax to protect h9c2 cells against hypoxia-induced apoptosis" [biomed. |
2022-02-15 |
2023-08-13 |
Not clear |
| Byung Sik Kim, In-Hwa Park, A-Hyeon Lee, Hyun-Jin Kim, Young-Hyo Lim, Jeong-Hun Shi. Sacubitril/valsartan reduces endoplasmic reticulum stress in a rat model of doxorubicin-induced cardiotoxicity. Archives of toxicology. 2022-02-13. PMID:35152301. |
in addition, sacubitril/valsartan significantly downregulated the expression levels of proteins related to apoptosis and er stress, including bax, caspase 3, grp78, perk, ire-1α, atf-6, eif-2α, atf-4, and chop, in the myocardium of a rat model of doxorubicin-induced cardiotoxicity in vivo and doxorubicin-treated h9c2 cardiomyocytes in vitro. |
2022-02-13 |
2023-08-13 |
rat |
| K P Kravchenko, K L Kozlov, A O Drobintseva, D S Medvedev, V O Polyakov. [Age-associated features of the expression level of apoptosis markers in cardiomyocytes of patients with dilated cardiomyopathy.] Advances in gerontology = Uspekhi gerontologii. vol 34. issue 6. 2022-02-13. PMID:35152605. |
aging of myocardial cells at the molecular level was manifested in an increase in the expression of the bax protein, which is the triggering mechanism of the mitochondrial apoptosis pathway. |
2022-02-13 |
2023-08-13 |
Not clear |
| Quanwei Li, Jianzhao Liao, Kai Zhang, Zhuoying Hu, Hui Zhang, Qingyue Han, Jianying Guo, Lianmei Hu, Jiaqiang Pan, Ying Li, Yuelong Li, Zhaoxin Tan. Toxicological mechanism of large amount of copper supplementation: Effects on endoplasmic reticulum stress and mitochondria-mediated apoptosis by Nrf2/HO-1 pathway-induced oxidative stress in the porcine myocardium. Journal of inorganic biochemistry. vol 230. 2022-02-12. PMID:35151098. |
furthermore, cu exposure could induce apoptosis, evidenced by the increased terminal deoxynucleotidyl transferase biotin-d utp nick end labeling (tunel)-positive staining, the upregulated expression levels of cytoplasm-cytochrome c (cytc), bcl-2-associated x protein (bax), and cleaved-caspase3, and decreased expression level of b-cell lymphoma-2 (bcl-2) and mitochondrial-cytc. |
2022-02-12 |
2023-08-13 |
Not clear |
| Chayanika Gundu, Vijay Kumar Arruri, Bhoomika Sherkhane, Dharmendra Kumar Khatri, Shashi Bala Sing. GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells. Current research in pharmacology and drug discovery. vol 3. 2022-02-11. PMID:35146419. |
additionally, er stress induced neuronal apoptosis was attenuated by gsk2606414 treatment via inhibiting the perk-eif2α-atf4-chop axis that not only curtailed the levels of apoptotic proteins like bax and caspase 3 but also elevated the levels of anti-apoptotic bcl-2. |
2022-02-11 |
2023-08-13 |
Not clear |
| Liping Wu, Fan Yang, Sufei Du, Ting Hu, Shaofeng Wei, Guoze Wang, Qibing Zeng, Peng Lu. Inorganic arsenic promotes apoptosis of human immortal keratinocytes through the TGF-β1/ERK signaling pathway. Environmental toxicology. 2022-02-10. PMID:35142421. |
the relative expressions of the indicators of the tgf-β1/erk signaling pathway, apoptosis-related genes (cytochrome c, caspase-3, caspase-9, cleaved caspase-3, cleaved caspase-9, and bax), the mitochondrial membrane potential, and the total apoptosis rate were significantly increased (p < .05), while the expression of the antiapoptosis gene bcl-2 was significantly decreased (p < .05) in cells of the group exposed to arsenic. |
2022-02-10 |
2023-08-13 |
human |
| Ming Wang, Wenyan Zhang, Yibo Liu, Zhigang Ma, Wei Xiang, Yuqi Wen, Dingkun Zhang, Yanling Li, Yeming Li, Tao Li, Ligang Chen, Jie Zho. PDIA4 promotes glioblastoma progression via the PI3K/AKT/m-TOR pathway. Biochemical and biophysical research communications. vol 597. 2022-02-08. PMID:35131603. |
mechanistically, pdia4 downregulation promoted the apoptosis of gbm cells by increased the expression of apoptosis pathway proteins (caspase 3, caspase 9 and bax). |
2022-02-08 |
2023-08-13 |
Not clear |
| Jian Kang, Yan Gu. Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Promote Neurological Function Recovery in a Rat Spinal Cord Injury Model. Neurochemical research. 2022-02-08. PMID:35132478. |
intravenous administration of huc-msc derived exosomes dramatically improved motor function of sprague-dawley rats after sci, with reduced apoptosis demonstrated by increased expression of b-cell lymphoma 2 (bcl2), decreased bcl2 associated x, apoptosis regulator (bax), and reduced cleaved caspase 9. |
2022-02-08 |
2023-08-13 |
human |
| Mei Yang, Juan-Juan Song, Xin-Chun Yang, Guang-Zhen Zhong, Jiu-Chang Zhon. MiRNA-122-5p inhibitor abolishes angiotensin II-mediated loss of autophagy and promotion of apoptosis in rat cardiofibroblasts by modulation of the apelin-AMPK-mTOR signaling. In vitro cellular & developmental biology. Animal. 2022-02-08. PMID:35133561. |
furthermore, ang ii led to promoted expression of p62, bax, and phosphorylated mtor as well as downregulation of lc3ii, beclin-1, and ampk-phosphorylated levels, thereby contributing to imbalance of autophagy and apoptosis, and cellular injury in cfs, which were significantly ameliorated by treatment with mirna-122-5p inhibitor. |
2022-02-08 |
2023-08-13 |
rat |
| Wei Chen, Haotian Zheng, Xuan Zhang, Yude Xu, Zhibin Fu, Xing Ji, Changhao Wei, Guoyao An, Mingyuan Tan, Mingwang Zho. Columbianetin alleviates lipopolysaccharides (LPS)-induced inflammation and apoptosis in chondrocyte through activation of autophagy by inhibiting serum and glucocorticoid-induced protein kinase 1 (SGK1) expression. Bioengineered. vol 13. issue 2. 2022-02-07. PMID:35129051. |
cell apoptosis was attenuated following cbt adding in atdc5 cells exposed to lps, accompanied by upregulated bcl-2 expression and downregulated bax and cleaved caspase 3 expression. |
2022-02-07 |
2023-08-13 |
mouse |
| Qian Wang, Wenying Chen, Boyang Zhang, Zilu Gao, Qipeng Zhang, Huiqiong Deng, Lingyun Han, Xiao Li She. Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication. Chemico-biological interactions. 2022-02-06. PMID:35123991. |
results indicated that a 24 h-treatment with 64 and 256 μm pfoa could remarkably induce mitochondrial-mediated apoptosis via initiating the vicious cycle between endoplasmic reticulum stress and oxidative stress, thereby increasing the level of calcium ion and decreasing the level of ΔΨm, simultaneously elevating the protein expressions of cyclophilin d (cypd), bcl-2 homologous antagonist/killer (bak), bcl-2-associated x protein (bax), bcl-2-like protein 11 (bim), cytochrome c (cyt-c), 78 kda glucose-regulated protein (grp78), ccaat/enhancer-binding protein (c/ebp) homologous protein (chop), and thioredoxin-interacting protein (txnip), while inhibiting the protein expression of tumor necrosis factor receptor-associated protein 1 (trap1), lon protease 1 (lonp1), pro-caspase-9, b-cell lymphoma-2 (bcl-2), and sigma 1-type opioid receptor (sig-1r) (p < 0.05). |
2022-02-06 |
2023-08-13 |
human |
| Katia Cosentino, Vanessa Hertlein, Andreas Jenner, Timo Dellmann, Milos Gojkovic, Aida Peña-Blanco, Shashank Dadsena, Noel Wajngarten, John S H Danial, Jervis Vermal Thevathasan, Markus Mund, Jonas Ries, Ana J Garcia-Sae. The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. Molecular cell. 2022-02-05. PMID:35120587. |
bax and bak are key apoptosis regulators that mediate the decisive step of mitochondrial outer membrane permeabilization. |
2022-02-05 |
2023-08-13 |
Not clear |
| Katia Cosentino, Vanessa Hertlein, Andreas Jenner, Timo Dellmann, Milos Gojkovic, Aida Peña-Blanco, Shashank Dadsena, Noel Wajngarten, John S H Danial, Jervis Vermal Thevathasan, Markus Mund, Jonas Ries, Ana J Garcia-Sae. The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. Molecular cell. 2022-02-05. PMID:35120587. |
bak recruits and accelerates bax assembly into oligomers that continue to grow during apoptosis. |
2022-02-05 |
2023-08-13 |
Not clear |
| Katarzyna Supruniuk, Robert Czarnomysy, Anna Muszyńska, Iwona Radziejewsk. Anti-cancer effects of pyrazole-platinum(II) complexes combined with anti-MUC1 monoclonal antibody versus monotherapy in DLD-1 and HT-29 colon cancer cells. Translational oncology. vol 18. 2022-02-05. PMID:35121220. |
combined therapy applied in dld-1 cells induced apoptosis, was more effective than monotherapy in relation to p53, bcl-xl, bax, and bim. |
2022-02-05 |
2023-08-13 |
Not clear |
| Xiangyuan Liu, Li Son. Quercetin protects human liver cells from o,p'-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-02-05. PMID:35122929. |
meanwhile, we found o,p'-ddt induced mitochondria-dependent apoptosis, which is characterized by the loss of of mitochondrial membrane potential (Δψm), decreased bcl-2 expression, and increased protein levels of bax, cytochrome c, activated-caspase-9, and activated-caspase-3. |
2022-02-05 |
2023-08-13 |
human |
| Peixian Luan, Haoran Zhang, Xiaoming Chen, Yue Zhu, Guo Hu, Jingzeng Cai, Ziwei Zhan. Melatonin relieves 2,2,4,4-tetrabromodiphenyl ether (BDE-47)-induced apoptosis and mitochondrial dysfunction through the AMPK-Sirt1-PGC-1α axis in fish kidney cells (CIK). Ecotoxicology and environmental safety. vol 232. 2022-02-05. PMID:35123185. |
bde-47 enhanced the mrna and protein levels of mitochondrial-pathway apoptosis related genes (cas 3, cyt-c, and bax). |
2022-02-05 |
2023-08-13 |
cat |