| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gyun Moo Kim, Chan Lee, Tae Chang Jan. Zoletil promotes apoptosis in BV-2 microglial cells via induction of oxidative stress and neural inflammation. Toxicology research. vol 11. issue 1. 2022-03-03. PMID:35237418. |
zol caused apoptosis via phosphorylation of c-jun n-terminal kinase, increased ratio of bax to bcl-2, disruption of mitochondrial membrane potential, activation of caspase-3, and cleavage of poly (adp-ribose) polymerase. |
2022-03-03 |
2023-08-13 |
Not clear |
| Lan Li, Ben Niu, Weihua Zhang, Limin Hou, Yan Zhen. Withaferin A inhibits cell proliferation of U266B1 and IM-9 human myeloma cells by inducing intrinsic apoptosis. Acta biochimica Polonica. 2022-03-02. PMID:35235278. |
the induction of apoptosis in u266b1 and im-9 cells was associated with upregulation of bax and cytochrome c, downregulation of bcl-2 and activation of parp, caspase-3 and capase-9 cleavage. |
2022-03-02 |
2023-08-13 |
human |
| Dong Chen, Xin Jian. Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1. Experimental cell research. 2022-03-01. PMID:35231441. |
n-cesc-exo reduced degenerated nucleus pulposus cells (tbhp-npc) apoptosis, bax, mmp13, and p62 expression, while increased bcl2, acan, lc3-ii/i expression, and the fluorescence intensity of gfp-lc3. |
2022-03-01 |
2023-08-13 |
Not clear |
| Bereket Molla Tanga, Xun Fang, Seonggyu Bang, Gyeonghwan Seong, Mahanama De Zoysa, Islam M Saadeldin, Sanghoon Lee, Jongki Ch. MiRNA-155 inhibition enhances porcine embryo preimplantation developmental competence by upregulating ZEB2 and downregulating ATF4. Theriogenology. vol 183. 2022-03-01. PMID:35231827. |
the relative gene expression level analysis showed downregulation of mrnas related to stress and apoptosis, bax, and the stress-induced autophagy gene atf4, and tnf-ɑ in the mirna-155 inhibitor group. |
2022-03-01 |
2023-08-13 |
Not clear |
| Shaosheng Liu, Yuanyuan Li, Zhaoxia L. Salidroside suppresses the activation of nasopharyngeal carcinoma cells via targeting miR-4262/GRP78 axis. Cell cycle (Georgetown, Tex.). 2022-02-28. PMID:35220889. |
after salidroside treatment, cell proliferation decreased and apoptosis increased, bax protein expression increased and bcl-2 decreased; mir-4262 expression level in nasopharyngeal carcinoma tissues was lower than that in adjacent tissues. |
2022-02-28 |
2023-08-13 |
mouse |
| Dong Young Kang, Nipin Sp, Kyoung-Jin Jang, Eun Seong Jo, Se Won Bae, Young Mok Yan. Antitumor Effects of Natural Bioactive Ursolic Acid in Embryonic Cancer Stem Cells. Journal of oncology. vol 2022. 2022-02-28. PMID:35222644. |
finally, the ua created an internal mechanism of apoptosis in the embryonic csc using bax and cytochrome c regulation as well as the regulation of bcl-xl and bcl-2 proteins. |
2022-02-28 |
2023-08-13 |
Not clear |
| Minyuan Nie, Heng Li, Puhe Liu, Ping Dan. HMBOX1 attenuates LPS-induced periodontal ligament stem cell injury by inhibiting CXCL10 expression through the NF-κB signaling pathway. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-28. PMID:35222701. |
the effects of ov-hmbox1 on cell proliferation, inflammation and apoptosis were subsequently investigated using cell counting kit-8, elisa for analysis of il-6, tnf-α and il-1β levels, tunel and western blotting assays for analysis of bcl-2, bax, cleaved caspase-3 and caspase-3 levels, respectively. |
2022-02-28 |
2023-08-13 |
human |
| Mei-Chou Lai, Wayne-Young Liu, Shorong-Shii Liou, I-Min Li. The Citrus Flavonoid Hesperetin Encounters Diabetes-Mediated Alzheimer-Type Neuropathologic Changes through Relieving Advanced Glycation End-Products Inducing Endoplasmic Reticulum Stress. Nutrients. vol 14. issue 4. 2022-02-26. PMID:35215394. |
hesperetin is able to upregulate bcl-2 protein expression, downregulate bax expression, and decrease caspase-12/-9/-3 activity as well, indicating that it inhibits er stress-mediated neuronal apoptosis. |
2022-02-26 |
2023-08-13 |
Not clear |
| Tarek M Okda, Gamal M K Atwa, Ahmed Fathy Eldehn, Naief Dahran, Khalaf F Alsharif, Ehab Kotb Elmahallaw. A Novel Role of Galectin-3 and Thyroglobulin in Prognosis and Differentiation of Different Stages of Thyroid Cancer and Elucidation of the Potential Contribution of Bcl-2, IL-8 and TNF-α. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203561. |
furthermore, the determination of bax, bcl-2, il-8 and tnf-α levels constitute a major important marker for investigation of the mechanisms of apoptosis and inflammation in thyroid cancer. |
2022-02-25 |
2023-08-13 |
human |
| Junning Pu, Daiwen Chen, Gang Tian, Jun He, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Yuheng Luo, Hui Yan, Bing Y. All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Apoptosis in IPEC-J2 Cells via Inhibiting ROS-Mediated P Antioxidants (Basel, Switzerland). vol 11. issue 2. 2022-02-25. PMID:35204227. |
atra treatment also attenuated tgev-induced apoptosis in ipec-j2 cells by downregulating the expression of caspase-3, which is related to the inhibition of death receptor (fas and caspase-8) and mitochondrial (bax, bcl-2, and caspase-9) pathways. |
2022-02-25 |
2023-08-13 |
Not clear |
| Abhishek Singh, Parul Gupta, Shubhangini Tiwari, Amit Mishra, Sarika Sing. Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer's disease. Cell and tissue research. 2022-02-23. PMID:35195784. |
in conjunction, guanabenz also attenuated the ad-related oxidative stress, impaired mitochondrial functionality (mmp, cytochrome-c translocation, atp level, and mitochondrial complex i activity), endoplasmic reticulum stress (grp78, gadd153, cleaved caspase-12), neuronal apoptosis (bcl-2, bax, cleaved caspase-3), and dna fragmentation. |
2022-02-23 |
2023-08-13 |
rat |
| Fazul Nabi, Weilai Tao, Ruiling Ye, Zhenzhen Li, Qin Lu, Yangfei Shang, Yu Hu, Jiali Fang, Zohaib Ahmed Bhutto, Juan Li. Penthorum Chinense Pursh Extract Alleviates Aflatoxin B1-Induced Liver Injury and Oxidative Stress Through Mitochondrial Pathways in Broilers. Frontiers in veterinary science. vol 9. 2022-02-21. PMID:35187148. |
furthermore, supplementation of pcpe to the afb1 group reversed apoptosis by significantly down-regulating the mrna expression levels of bax, bak, caspase-9, caspase-3, and p53 and up-regulating the expression levels of bcl2 in the liver of broilers. |
2022-02-21 |
2023-08-13 |
Not clear |
| Hui Yao, Dalin Zhang, Hao Yu, Hui Shen, Xinze Lan, Hao Liu, Xiaohuan Chen, Xu Wu, Guohua Zhang, Xiaolong Wan. AMPAkine CX516 alleviated chronic ethanol exposure-induced neurodegeneration and depressive-like behavior in mice. Toxicology and applied pharmacology. 2022-02-19. PMID:35181401. |
in addition, cx516 attenuated the levels of pro-inflammatory (il-6, il-1β), apoptosis (bax, bcl-2), and neurodegeneration (fjc) in the mouse hippocampus induced by cee. |
2022-02-19 |
2023-08-13 |
mouse |
| Monireh Golpour, Mina Alimohammadi, Farshad Sohbatzadeh, Sadegh Fattahi, Sander Bekeschus, Alireza Rafie. Cold atmospheric pressure plasma treatment combined with starvation increases autophagy and apoptosis in melanoma in vitro and in vivo. Experimental dermatology. 2022-02-19. PMID:35181947. |
this was paralleled by increased apoptosis (bax, bcl-2, and caspase-3) and autophagy (lc3 and atg5)-related gene expression. |
2022-02-19 |
2023-08-13 |
Not clear |
| Aljohra M Al-Otaibi, Asma S Al-Gebaly, Rafa Almeer, Gadah Albasher, Wedad S Al-Qahtani, Ahmed E Abdel Monei. Potential of green-synthesized selenium nanoparticles using apigenin in human breast cancer MCF-7 cells. Environmental science and pollution research international. 2022-02-19. PMID:35182347. |
flow cytometric and pcr analyses revealed that senps-apigenin treatment induced apoptosis in mcf-7 cells, demonstrating that senps-apigenin treatment could directly target bcl-2, bax, and caspase-3 and result in the discharge of cytochrome c from mitochondria into the cytosol, accompanied by the initiation of cell death, leading to permanent dna damage and killing of mcf-7 cells. |
2022-02-19 |
2023-08-13 |
human |
| Shi-Chun Zhu, Jun Cai, Cheng-Yu Wu, Chun-Song Chen. [Molecular mechanism of Spatholobi Caulis in treatment of ovarian cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 3. 2022-02-18. PMID:35178962. |
western blot showed that prunetin could induce skov3 cell apoptosis by inhibiting gsk-3β phosphorylation and regulating the expression of downstream bcl-2 and bax proteins. |
2022-02-18 |
2023-08-13 |
human |
| Michael A MacDonald, Craig Barry, Teddy Groves, Verónica S Martínez, Peter P Gray, Kym Baker, Evan Shave, Stephen Mahler, Trent Munro, Esteban Marcellin, Lars K Nielse. Modelling Apoptosis Resistance in CHO cells with CRISPR-Mediated Knock-outs of Bak1, Bax, and Bok. Biotechnology and bioengineering. 2022-02-18. PMID:35180317. |
modelling apoptosis resistance in cho cells with crispr-mediated knock-outs of bak1, bax, and bok. |
2022-02-18 |
2023-08-13 |
Not clear |
| JinFang Ke, MengFei Chen, ShiLan Ma, Liang Zhang, Ling Zhan. Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis. Bioengineered. vol 13. issue 3. 2022-02-17. PMID:35172672. |
a large number of deaths in rats after surgery of 72 h were caused via cecal ligation-perforation surgery, w/d value and bax positive cells were increased, li was caused, cell apoptosis, tumor necrosis factor-α, interleukin (il)-1β and il-6 expression were promoted and bcl-2 positive cells were decreased. |
2022-02-17 |
2023-08-13 |
rat |
| Jing-Jing Xing, Xiao-Jie Mi, Jin-Gang Hou, En-Bo Cai, Si-Wen Zheng, Shi-Han Wang, Zi Wang, Chen Chen, Wei L. Maltol mitigates cisplatin-evoked cardiotoxicity via inhibiting the PI3K/Akt signaling pathway in rodents in vivo and in vitro. Phytotherapy research : PTR. 2022-02-17. PMID:35174550. |
multiple exposure of 3 mg/kg for four times of cisplatin increased cardiac cells apoptosis with increased expression of bax and cleaved-caspase 3, and decreased expression of bcl-2. |
2022-02-17 |
2023-08-13 |
mouse |
| Eman A Fayed, Nirvana A Gohar, Amel M Farrag, Yousry A Amma. Upregulation of BAX and caspase-3, as well as downregulation of Bcl-2 during treatment with indeno[1,2-b]quinoxalin derivatives, mediated apoptosis in human cancer cells. Archiv der Pharmazie. 2022-02-17. PMID:35174895. |
upregulation of bax and caspase-3, as well as downregulation of bcl-2 during treatment with indeno[1,2-b]quinoxalin derivatives, mediated apoptosis in human cancer cells. |
2022-02-17 |
2023-08-13 |
human |