| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingjing Gao, Yanjin Fu, Linliang Song, Mengsha Long, Yiyao Zhang, Jiajia Qin, Haiquan Li. Proapoptotic Effect of Icariin on Human Ovarian Cancer Cells via the NF-[Formula: see text]B/PI3K-AKT Signaling Pathway: A Network Pharmacology-Directed Experimental Investigation. The American journal of Chinese medicine. 2022-02-04. PMID:35114909. |
the assay results demonstrated that ica can promote the apoptosis of skov3 cells as indicated by the proapoptotic markers bax, bcl-xl and caspase-3 and the key factors of the nf-[formula: see text]b signaling pathway (nf-[formula: see text]bp65, p-nf-[formula: see text]bp65, p-i[formula: see text]b[formula: see text] and i[formula: see text]b[formula: see text]. |
2022-02-04 |
2023-08-13 |
human |
| Zuzana Fabová, Barbora Loncová, Miloš Mlynček, Alexander V Sirotki. Interrelationships between amphiregulin, kisspeptin, FSH and FSH receptor in promotion of human ovarian cell functions. Reproduction, fertility, and development. 2022-02-03. PMID:35109967. |
viability, markers of proliferation [accumulation ofproliferating cell nuclear antigen (pcna) cyclin b1 and sodium 3'-[1-(phenylaminocarbonyl)-3,4-tetrazolium]-bis(4-methoxy6-nitro)benzene sulfonic acid hydrate (xtt formazan)] and apoptosis (accumulation of bax, caspase 3 and terminal deoxynucleotidyl transferase dutp nick-end labelling), accumulation of kiss, fshr and steroid hormones, and areg release were analysed by trypan blue exclusion test, quantitative immunocytochemistry, xtt, terminal deoxynucleotidyl transferase dutp nick-end labelling assays and enzyme-linked immunosorbent assay. |
2022-02-03 |
2023-08-13 |
human |
| Dedong Li, Jian Sun, Mingdong Yu, Ying Wang, Yuechun Lu, Bo L. The protective effects of miR-128-3p on sevoflurane-induced progressive neurotoxicity in rats by targeting NOVA1. The Journal of toxicological sciences. vol 47. issue 2. 2022-02-03. PMID:35110470. |
overexpressed mir-128-3p partially reversed the role of sevoflurane treatment in triggering cell apoptosis, enhancing the expression of bax and cleaved caspase-3 and inhibiting bcl-2 expression obviously. |
2022-02-03 |
2023-08-13 |
rat |
| Guangzhi Ma, Yunfu Deng, Luxi Qian, Karin A Vallega, Guojing Zhang, Xingming Deng, Taofeek K Owonikoko, Suresh S Ramalingam, Douglas D Fang, Yifan Zhai, Shi-Yong Su. Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both. Oncogene. 2022-02-01. PMID:35102249. |
we found that osimertinib, when combined with mcl-1 inhibition or bax activation, synergistically decreased the survival of different osimertinib-resistant cell lines, enhanced the induction of intrinsic apoptosis, and inhibited the growth of osimertinib-resistant tumor in vivo. |
2022-02-01 |
2023-08-13 |
Not clear |
| Guangzhi Ma, Yunfu Deng, Luxi Qian, Karin A Vallega, Guojing Zhang, Xingming Deng, Taofeek K Owonikoko, Suresh S Ramalingam, Douglas D Fang, Yifan Zhai, Shi-Yong Su. Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both. Oncogene. 2022-02-01. PMID:35102249. |
interestingly, the triple-combination of osimertinib with mcl-1 inhibition and bax activation exhibited the most potent activity in decreasing the survival and inducing apoptosis of osimertinib-resistant cells and in suppressing the growth of osimertinib-resistant tumors. |
2022-02-01 |
2023-08-13 |
Not clear |
| Li Zhang, Bingxin Jia, Periyannan Velu, Hong W. Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine. Environmental toxicology. 2022-02-01. PMID:35103375. |
in western blot analysis showed released higher apoptotic marker of caspase-3, -9, bax while bcl-2 levels were significantly reduced confirming that corilagin triggers apoptosis in gastric cancer. |
2022-02-01 |
2023-08-13 |
rat |
| Xue Rong, Yang Jiang, Feng Li, Dongxiao Sun-Waterhouse, Shancang Zhao, Xuedong Guan, Dapeng L. Close association between the synergistic toxicity of zearalenone-deoxynivalenol combination and microRNA221-mediated PTEN/PI3K/AKT signaling in HepG2 cells. Toxicology. 2022-01-29. PMID:35090964. |
moreover, apoptosis and inflammatory response were promoted after the co-exposure of zea and don, indicated by the increased expression of bax, caspase-3, il-1β and il-6 genes. |
2022-01-29 |
2023-08-13 |
Not clear |
| Haoran Zhang, Jiaqiang Huang, Jie Yang, Jingzeng Cai, Qi Liu, Xintong Zhang, Jun Bao, Ziwei Zhan. Cadmium induces apoptosis and autophagy in swine small intestine by downregulating the PI3K/Akt pathway. Environmental science and pollution research international. 2022-01-29. PMID:35091949. |
cell apoptosis was induced by increasing the expression of apoptosis markers bcl-2 associated x protein (bax), cysteinyl aspartate specific proteinase 9 (caspase9), cleaved caspase9, cysteinyl aspartate specific proteinase 3 (caspase3), and cleaved caspase3, and by reducing the expression of b cell lymphoma/leukemia 2 (bcl-2). |
2022-01-29 |
2023-08-13 |
Not clear |
| Jun Peng, Zheng-Tao Yu, Rong-Jun Xiao, Qing-Song Wang, Ying Xi. LncRNA CEBPA-AS1 knockdown prevents neuronal apoptosis against oxygen glucose deprivation/reoxygenation by regulating the miR-455/GPER1 axis. Metabolic brain disease. 2022-01-28. PMID:35088289. |
neuronal viability and apoptosis were examined using mtt and flow cytometry assays, followed by determination of apoptosis-related factors (caspase 3, caspase 8, caspase 9, bax, and bcl-2). |
2022-01-28 |
2023-08-13 |
Not clear |
| Qingfang Li, Lingling Za. Knockdown of ATG4A inhibits breast cancer progression and promotes tamoxifen chemosensitivity by suppressing autophagy. Molecular medicine reports. vol 25. issue 3. 2022-01-28. PMID:35088889. |
after treatment with 4‑oht, knockdown of atg4a suppressed proliferation, triggered apoptosis, decreased the expression of bcl‑2, β‑catenin, cyclin d1 and c‑myc, and increased the expression of bax and p‑gsk3β in mcf7/r cells. |
2022-01-28 |
2023-08-13 |
Not clear |
| V N Mal'tseva, M V Goltyaev, S V Novoselov, E G Varlamov. [Effects of Sodium Selenite and Dithiothreitol on Expression of Endoplasmic Reticulum Selenoproteins and Apoptosis Markers in MSF7 Breast Adenocarcinoma Cells]. Molekuliarnaia biologiia. vol 56. issue 1. 2022-01-27. PMID:35082262. |
when the ss concentration was increased to 0.1 μm, an increase in expression was observed for key er stress genes and apoptosis markers, including chop, gadd34, puma, bim, atf4, sxbp, uxbp, akt1, bax, and bak. |
2022-01-27 |
2023-08-13 |
Not clear |
| Wei Zhao, Yingyan Zhao, Ling Chen, Yan Sun, Sumei Fa. miR-335-5p Inhibits Progression of Uterine Leiomyoma by Targeting ARGLU1. Computational and mathematical methods in medicine. vol 2022. 2022-01-27. PMID:35082911. |
additionally, upregulation of mir-335-5p promotes the apoptosis of ul cell lines, increases the protein levels of bax, cleaved caspase-3, and cleaved caspase-9, and decreases the protein expression of bcl-2. |
2022-01-27 |
2023-08-13 |
Not clear |
| Yu-Hui Huang, Li-Ping Dong, Yan-Guo Cui, Hong-Yan L. MiR-520h inhibits viability and facilitates apoptosis of KGN cells through modulating IL6R and the JAK/STAT pathway. Reproductive biology. vol 22. issue 1. 2022-01-27. PMID:35085910. |
moreover, downregulation of mir-520h enhanced the cell viability, impeded the cell apoptosis, upregulated the expressions of cdk2, ccnb1, bcl-2, activated jak/stat pathway and downregulated bax expression in kgn cells. |
2022-01-27 |
2023-08-13 |
human |
| Lin Sun, Huangxing Cai, Tengchao Zhou, Hua Xiang, Lin Lon. Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR-101-3p/Wee1 axis. Drug development research. 2022-01-26. PMID:35080031. |
then, cck-8 and flow cytometry assays were used to detect the proliferation and apoptosis of hcc cells after verbascoside and x-ray combined treatment, and the expressions of wee1 and apoptosis-related proteins bax and bcl-2 were detected by western blot. |
2022-01-26 |
2023-08-13 |
human |
| Chengtao Sun, Bing Han, Yufei Zhai, Huan Zhao, Xuan Li, Jun Qian, Xiaolong Hao, Qun Liu, Jiayan Shen, Guoyin Ka. Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation. Free radical biology & medicine. 2022-01-25. PMID:35074488. |
dht induced apoptosis and g2 cell cycle arrest accompanied by reduced expression of bcl-2, caspase-3, and increased bax. |
2022-01-25 |
2023-08-13 |
mouse |
| Ahmad Ghasemi, Amir Salari, Mahboube Kalantarmahdavi, Mohammad Reza Amiryousef. Sodium metabisulfite in dried plum and its cytotoxic effects on K-562 and L-929 normal cell lines. Journal of food science. 2022-01-24. PMID:35067933. |
the expression analysis of apoptosis marker genes (bax, bcl-2, and p53) was also assessed. |
2022-01-24 |
2023-08-13 |
human |
| Yanji Zhu, Min Liu, Wenlong Xun, Keliang Li, Xiangji Ni. P2X7R antagonist protects against renal injury in mice with adriamycin nephropathy. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069842. |
the expression of il-1β, il-18, p2x7r, ox-ldl, cxcl16, bax, caspase-3 and nlrp3, as well as cellular apoptosis in the renal tissues of the adr group, was significantly increased in the adr group compared with the control. |
2022-01-24 |
2023-08-13 |
mouse |
| Yanji Zhu, Min Liu, Wenlong Xun, Keliang Li, Xiangji Ni. P2X7R antagonist protects against renal injury in mice with adriamycin nephropathy. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069842. |
furthermore, activated p2x7r may promote the release of inflammatory cytokines il-1β and il-18 through the downstream p2x7r/nlrp3 pathway and upregulate the expression of bax and caspase-3 to promote apoptosis, which participates in the process of adr nephropathy. |
2022-01-24 |
2023-08-13 |
mouse |
| Yanji Zhu, Min Liu, Wenlong Xun, Keliang Li, Xiangji Ni. P2X7R antagonist protects against renal injury in mice with adriamycin nephropathy. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069842. |
inhibiting p2x7r may also reduce the release of il-1β and il-18 by downregulating the p2x7r/nlrp3 pathway, downregulating the expression of bax and caspase-3, and reducing apoptosis, thereby alleviating kidney injury in mice with adr nephropathy. |
2022-01-24 |
2023-08-13 |
mouse |
| Ling-Ling Xu, Yu-Kui Chen, Qin-Yao Zhang, Li-Jian Chen, Kai-Kai Zhang, Jia-Hao Li, Jia-Li Liu, Qi Wang, Xiao-Li Xi. Gestational exposure to GenX induces hepatic alterations by the gut-liver axis in maternal mice: A similar mechanism as PFOA. The Science of the total environment. 2022-01-23. PMID:35066053. |
overexpression of cleaved parp-1, cleaved caspase 3, bax and decreased bcl-2 proteins indicated activation of apoptosis, whereas overexpression of ulk-1, p62, beclin-1, lc3-ii proteins and downregulation of p-mtor implied that pfoa and genx exposure initiated autophagy. |
2022-01-23 |
2023-08-13 |
mouse |