| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Zhai, Bu-Gu Liu, Xue-Ni Mo, Min Zou, Xiao-Ping Mei, Wei Chen, Guo-Dong Huang, Lin W. Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis. The Kaohsiung journal of medical sciences. 2021-12-28. PMID:34962339. |
inhibition of mir-210 resulted in increased viability and reduced apoptosis along with increased levels of bcl-2, bdnf, and trkb and reduced levels of bax and cleaved caspase 3 after hypoxia/reoxygenation. |
2021-12-28 |
2023-08-13 |
Not clear |
| Kexin Yuan, Pei Zhao, Lili Wan. Molecular mechanism of atrial remodeling in patients with aging atrial fibrillation under the expression of microRNA-1 and microRNA-21. Bioengineered. vol 12. issue 2. 2021-12-27. PMID:34957910. |
the ultrastructure, degree of myocardial fibrosis, apoptosis index (ai), expression of microrna-1, expression of microrna-21, and mrna of timp-1, mmp-9, bcl-2, and bax of patients were compared and analyzed in each group. |
2021-12-27 |
2023-08-13 |
human |
| Zhiruo Miao, Zhiying Miao, Shengchen Wang, Hao Wu, Shiwen X. Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp hepatocytes. Fish & shellfish immunology. 2021-12-26. PMID:34954370. |
we further found that exposure to imi induced apoptosis, which is characterized by promoting release of cytochrome c (cyt-c), and increasing the expression of bcl-2-associated x (bax), cysteinyl aspartate specific proteinases (caspase 9 and 3), decreasing bcl-2 level. |
2021-12-26 |
2023-08-13 |
cat |
| Yen-Po Chen, Po-Chang Shih, Chien-Wei Feng, Chang-Cheng Wu, Kuan-Hao Tsui, You-Hsien Lin, Hsiao-Mei Kuo, Zhi-Hong We. Pardaxin Activates Excessive Mitophagy and Mitochondria-Mediated Apoptosis in Human Ovarian Cancer by Inducing Reactive Oxygen Species. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34942985. |
pardaxin induced apoptosis as determined by mtt and tunel assays, as well as activation of caspases-9/3, bid, t-bid, and bax, whereas bcl-2 was downregulated. |
2021-12-24 |
2023-08-13 |
human |
| Dan Xu, Lizi Yin, Juchun Lin, Hualin Fu, Xi Peng, Lijen Chang, Yilei Zheng, Xiaoling Zhao, Gang Sh. Aristolochic Acid I-Induced Hepatotoxicity in Tianfu Broilers Is Associated with Oxidative-Stress-Mediated Apoptosis and Mitochondrial Damage. Animals : an open access journal from MDPI. vol 11. issue 12. 2021-12-24. PMID:34944214. |
additionally, aa-i elevated the production of reactive oxygen species (ros) and induced oxidative stress, which further led to excessive apoptosis, characterized by mitochondrial depolarization, upregulation of bax, and down-regulation of bcl-2 expression. |
2021-12-24 |
2023-08-13 |
Not clear |
| Li Shan, Haiyong Zhang, Ying Han, Ruijuan Kuan. Expression and mechanism of microRNA 195 in diabetic retinopathy. Endocrine journal. 2021-12-23. PMID:34937832. |
in addition, human retinal endothelial cells and human dermal microvascular endothelial cells were cultured in a high-glucose environment to detect the targeted relationship between mir-195 and sirt1; determine the mrna and protein expression levels of sirt1, bax, and bcl-2 after mir-195 knockdown; and assess the levels of cell proliferation and apoptosis. |
2021-12-23 |
2023-08-13 |
human |
| Li Shan, Haiyong Zhang, Ying Han, Ruijuan Kuan. Expression and mechanism of microRNA 195 in diabetic retinopathy. Endocrine journal. 2021-12-23. PMID:34937832. |
conversely, mir-195 knockdown led to the downregulation of the mrna and protein expression levels of bax and the upregulation of the mrna and protein expression levels of sirt1 and bcl-2 as well as improvement in cell growth and a decrease in the apoptosis rate. |
2021-12-23 |
2023-08-13 |
human |
| Dong Wang, Caiyun Ya. MicroRNA-208a-3p participates in coronary heart disease by regulating the growth of hVSMCs by targeting BTG1. Experimental and therapeutic medicine. vol 23. issue 1. 2021-12-22. PMID:34934442. |
furthermore, this study also suggested that mir-208a-3p served an inhibitory role in the proliferation of hvsmcs, induced cell apoptosis, promoted the protein expression of bax and reduced bcl-2 protein expression; however, these effects were reversed by btg1 silencing. |
2021-12-22 |
2023-08-13 |
human |
| Hector Flores-Romero, Lisa Hohorst, Malina John, Marie-Christine Albert, Louise E King, Laura Beckmann, Tamas Szabo, Vanessa Hertlein, Xu Luo, Andreas Villunger, Lukas P Frenzel, Hamid Kashkar, Ana J Garcia-Sae. BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. The EMBO journal. 2021-12-21. PMID:34931711. |
during apoptosis, the bcl-2-family protein tbid promotes mitochondrial permeabilization by activating bax and bak and by blocking anti-apoptotic bcl-2 members. |
2021-12-21 |
2023-08-13 |
Not clear |
| Hector Flores-Romero, Lisa Hohorst, Malina John, Marie-Christine Albert, Louise E King, Laura Beckmann, Tamas Szabo, Vanessa Hertlein, Xu Luo, Andreas Villunger, Lukas P Frenzel, Hamid Kashkar, Ana J Garcia-Sae. BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. The EMBO journal. 2021-12-21. PMID:34931711. |
here, we report that tbid can also mediate mitochondrial permeabilization by itself, resulting in release of cytochrome c and mitochondrial dna, caspase activation and apoptosis even in absence of bax and bak. |
2021-12-21 |
2023-08-13 |
Not clear |
| Jie Liu, Ya-Qi Wang, Hai-Bo Niu, Chun-Xiao Zhan. PAX9 functions as a tumor suppressor gene for cervical cancer via modulating cell proliferation and apoptosis. The Kaohsiung journal of medical sciences. 2021-12-21. PMID:34931758. |
pax9 inhibits the cc cell proliferation and promotes the apoptosis, with the up-regulations of caspase-3, poly(adp-ribose) polymerase (parp), and bax and the down-regulation of bcl-2. |
2021-12-21 |
2023-08-13 |
mouse |
| Baigang Zhang, Hairong Liang, Ke Huang, Jinliang Li, Dongmei Xu, Chenghui Huang, Yi L. Cardiotoxicity of patulin was found in H9c2 cells. Toxicon : official journal of the International Society on Toxinology. 2021-12-20. PMID:34929212. |
expression level of caspase-3, caspase-9, bax, bcl-2 were quantified to verify the potential mechanism of mitochondrial apoptosis pathway. |
2021-12-20 |
2023-08-13 |
Not clear |
| Ghasem Majdi Yazdi, Gholamhasan Vaezi, Vida Hojati, Mohammad Mohammad-Zade. The Effect of 6-gingerol on Growth Factors and Apoptosis Indices in Rats Exposed to Gold Nanoparticles. Basic and clinical neuroscience. vol 12. issue 3. 2021-12-17. PMID:34917289. |
given the antioxidant properties of gingerol (ging), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), dna oxidative damage, and the amount of bax and bcl2 apoptosis indices of rats exposed to aunps. |
2021-12-17 |
2023-08-13 |
rat |
| Peng Guo, Nan Zhang, Juan Li, Yang Liu, Yi Li, Xuedong Wang, Jingyu Wang, Yupeng Wang, Aiguo Wan. Protective effects of low-temperature plasma on cisplatin-induced nephrotoxicity. Life sciences. 2021-12-17. PMID:34919900. |
it significantly improved clinical indicators such as survival rate, water intake, food intake, body weight, and mobility, as well as physiological indexes such as reduced renal index and levels of serum urea, creatinine, and total bilirubin; pathological indicators such as reduced tubular injury, inflammatory infiltration, tubulointerstitial fibrosis, and apoptosis; cell survival indicators such as decreased protein levels of caspase-3 and bax and increased bcl-2; anti-oxidation status such as reduced malondialdehyde content and increased activities of catalase, superoxide dismutase, and glutathione peroxidase; and reduced inflammatory factors such as tnf-α in kidney tissues. |
2021-12-17 |
2023-08-13 |
mouse |
| Marius Winkler, Juliane Friedrich, Cathinka Boedicker, Nadezda Dolgik. Co-targeting MCL-1 and ERK1/2 kinase induces mitochondrial apoptosis in rhabdomyosarcoma cells. Translational oncology. vol 16. 2021-12-15. PMID:34906889. |
a genetic silencing approach reveals that bim, bmf, bak and bax are all required for ulixertinib/s63845-induced apoptosis. |
2021-12-15 |
2023-08-13 |
Not clear |
| Jitrada Phetfong, Tulyapruek Tawonsawatruk, Witchayapon Kamprom, Pawared Ontong, Dalina Tanyong, Suparerk Borwornpinyo, Aungkura Supokawe. Bone marrow mesenchymal stem cell-derived extracellular vesicles affect proliferation and apoptosis of leukemia cells in vitro. FEBS open bio. 2021-12-15. PMID:34907674. |
msc-evs increased the expression of bid and bax and decreased expression of bcl2, indicating the induction of intrinsic apoptosis in nb4. |
2021-12-15 |
2023-08-13 |
Not clear |
| Marwa A Mahmoud, Tark M Okda, Gamal A Omran, Mohammad M Abd-Alhasee. Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation. Journal of applied biomedicine. vol 19. issue 4. 2021-12-15. PMID:34907739. |
it also triggered apoptosis by restoring the levels of p53, bcl-2, bax, and caspase-3. |
2021-12-15 |
2023-08-13 |
mouse |
| RongXin Xiao, Hong Wang, Biao Yan. MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway. Bioengineered. vol 12. issue 2. 2021-12-13. PMID:34895048. |
reverse transcription quantitative polymerase chain reaction was applied to detect mir-98-5p expression in cc tissues and cell lines; cell counting kit-8 and edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, western blot for proliferation-related proteins ki67 and proliferating cell nuclear antigen expression, apoptosis-related proteins bcl-2 and bax expression, epithelial-mesenchymal transition (emt)-related proteins snail, matrix metalloproteinase-3, e-cadherin and n-cadherin expression, as well as pi3k/akt pathway-related proteins pten, pi3k as well as akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify |
2021-12-13 |
2023-08-13 |
mouse |
| Souvik Roy, Anil Kumar Mondru, Tania Chakraborty, Abhijit Das, Sandipan Dasgupt. Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways. Toxicology and applied pharmacology. 2021-12-13. PMID:34896434. |
ruthenium-phloretin complex could modulate p53 intervene apoptosis in the breast carcinoma, initiated by the trail of intrinsic apoptosis facilitated through bcl2 and bax and at the same time down regulating the pi3k/akt/mtor pathway coupled with mmp9 regulated tumor invasive pathways. |
2021-12-13 |
2023-08-13 |
human |
| Peixian Luan, Haoran Zhang, Xiaofeng Zhang, Guo Hu, Ziwei Zhan. Cadmium regulates FKBP5 through miR-9-5p and induces carp lymphocyte apoptosis. Fish & shellfish immunology. 2021-12-13. PMID:34896595. |
the results showed that cd could increase the expression of bax (bcl-2 associated x protein), caspase9 (cysteinyl aspartate specific proteinase 9) and caspase3 (cysteinyl aspartate specific proteinase 3), inhibit the expression of bcl-2 (b cell lymphoma/leukemia 2), and induce apoptosis of carp head kidney lymphocytes. |
2021-12-13 |
2023-08-13 |
Not clear |