| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuzana Fabová, Barbora Loncová, Miloš Mlynček, Alexander V Sirotki. Kisspeptin as autocrine/paracrine regulator of human ovarian cell functions: Possible interrelationships with FSH and its receptor. Reproductive biology. vol 22. issue 1. 2021-12-08. PMID:34844165. |
viability, markers of proliferation (pcna and cyclin b1) and apoptosis (bax and caspase 3), as well as accumulation of kp, fshr, and steroid hormones, igf-i, oxytocin (ot), and prostaglandin e2 (pge2) release were analyzed by the trypan blue exclusion test, quantitative immunocytochemistry, and elisa. |
2021-12-08 |
2023-08-13 |
human |
| Halil Sezgin Semis, Fatih Mehmet Kandemir, Ozgur Kaynar, Tuba Dogan, Sefik Murat Arika. The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats. Life sciences. vol 287. 2021-12-07. PMID:34743946. |
it was determined that ptx caused apoptosis in the sciatic nerve by increasing caspase-3 and bax levels and suppressing bcl-2 levels. |
2021-12-07 |
2023-08-13 |
rat |
| Shanshan Li, Yang Li, Hongjian Sun, Yang Jiang, Keming Pan, Yue Su, Nan B. Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation. Bioengineered. vol 12. issue 2. 2021-12-07. PMID:34866538. |
besides, the hepatic apoptosis markers (bcl-2, bax, caspase3, and caspase9), inflammation markers (il-1β, tnf-α, and nf-κb), and mutt homologue gene 1 (mth1) were examined. |
2021-12-07 |
2023-08-13 |
rat |
| Yun-Shi Xia, Yin-Shi Sun, Chang Liu, Zhi-Man Li, Duo-Duo Ren, Rui Mu, Yan-Ting Zhang, Pan-Pan Bo, Li-Juan Zhao, Zi Wan. Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury. Frontiers in nutrition. vol 8. 2021-12-07. PMID:34869537. |
it also enhances the expression of defense factors prostaglandin (e2), epidermal growth factor (egf), and somatostatin (ss), it inhibits apoptosis evidenced by the enhanced of bcl-2 and decreased expression of cleavage of caspase-3 and bax. |
2021-12-07 |
2023-08-13 |
rat |
| Abigail H Cleveland, Alejandra Romero-Morales, Laurent Alfonso Azcona, Melisa Herrero, Viktoriya D Nikolova, Sheryl Moy, Orna Elroy-Stein, Vivian Gama, Timothy R Gersho. Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration. Cell death & disease. vol 12. issue 12. 2021-12-07. PMID:34873168. |
disabling apoptosis through co-deletion of bax or bak rescued white matter degeneration, implicating the intrinsic apoptotic pathway in mcl-1-dependence. |
2021-12-07 |
2023-08-13 |
mouse |
| Arijit Chakraborty, Vertika Singh, Kiran Singh, Singh Rajende. Excess iodine impairs spermatogenesis by inducing oxidative stress and perturbing the blood testis barrier. Reproductive toxicology (Elmsford, N.Y.). vol 96. 2021-12-06. PMID:32593569. |
further investigations showed increased apoptosis evidenced by reduced expression of anti-apoptotic (bcl-2, survivin), increased expression of pro-apoptotic (bid, bax) markers, and increased expression of p53 and other modulators/effectors of apoptosis (cytochrome c, cleaved parp, caspase3 and caspase9). |
2021-12-06 |
2023-08-13 |
rat |
| Xin He, Haizhu Zou, Fengyu Wan. SOX4-induced upregulation of ARHGAP9 promotes the progression of acute myeloid leukemia. Drug development research. vol 82. issue 8. 2021-12-06. PMID:34159626. |
in addition, interference of arhgap9 greatly promoted cell apoptosis, accompanied with the decreased protein expression of bcl-2 and the increased protein expression of bax, cleaved caspase 3 and cleaved caspase 9. |
2021-12-06 |
2023-08-13 |
Not clear |
| Jia Chen, Mingyang Wang, Hanli Wang, Miao Lon. Zearalenone promotes apoptosis of mouse Leydig cells by targeting phosphatase and tensin homolog and thus inhibiting the PI3K/AKT signal pathway. Environmental science and pollution research international. vol 28. issue 47. 2021-12-06. PMID:34264493. |
apoptosis was detected cytometrically and the protein expression levels of pten, akt, p-akt, bax, and bcl-2 were evaluated via western blot analysis. |
2021-12-06 |
2023-08-13 |
mouse |
| Xi-Yu Zhang, Xiao-Fei Jiao, Di Wu, Fan Chen, Zhi-Ming Ding, Yong-Sheng Wang, Fei Meng, Ze-Qun Duan, Jia-Jun Xiong, Cai-Xia Yang, Li-Jun Hu. Benzophenone-3 breaches mouse Sertoli cell barrier and alters F-actin organization without evoking apoptosis. Environmental toxicology. vol 37. issue 1. 2021-12-06. PMID:34558770. |
moreover, although increased dna damage marker γh2a.x was observed in the treatment group, the cell apoptosis rate was changeless which was further confirmed by increased bax and stable bcl-2 (two primary apoptosis regulating proteins). |
2021-12-06 |
2023-08-13 |
mouse |
| Yong Cai, Zhaoying Sheng, Jiying Wan. Xanthorrhizol inhibits non-small cell carcinoma (A549) cell growth and promotes apoptosis through modulation of PI3K/AKT and NF-κB signaling pathway. Environmental toxicology. vol 37. issue 1. 2021-12-06. PMID:34664399. |
in addition, xnt treatment alters the ΔΨm, thereby induces apoptosis was closely coordinated with the induction of pro-apoptotic markers bax, bad, caspase- 3, 9 and cytochrome c, and suppression of anti-apoptotic (bcl-2, bcl-xl) protein expression. |
2021-12-06 |
2023-08-13 |
human |
| Nan Zhang, Yafei Hao, Hansheng Liu, Qianqian Yu, Bi Bo, Jianwei Lian. Combined anti-cancer effects of curcumin and oxaliplatin on colon carcinoma colo205 cells using transplanted nude mice. Pakistan journal of pharmaceutical sciences. vol 34. issue 5(Special). 2021-12-06. PMID:34862868. |
the expression of bcl-2 and bax related to apoptosis was detected. |
2021-12-06 |
2023-08-13 |
mouse |
| Ali Pourgholi, Mehdi Dadashpour, Akram Mousapour, Akram Firouzi Amandi, Nosratollah Zargham. Anticancer Potential of Silibinin Loaded Polymeric Nanoparticles against Breast Cancer Cells: Insight into the Apoptotic Genes Targets. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 8. 2021-12-04. PMID:34452574. |
moreover, the results demonstrated that sil-nps could induce apoptosis in breast cancer cells by upregulation of caspase-3, caspase-7, p53 and bax, along with bcl-2, htert, survivin and cyclin d1 down regulation. |
2021-12-04 |
2023-08-13 |
Not clear |
| A Wnuk, K Przepiórska, B A Pietrzak, M Kajt. Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1. Neurotoxicity research. vol 39. issue 6. 2021-12-04. PMID:34797527. |
the mechanisms of the neuroprotective action of pape-1 also involved apoptosis inhibition demonstrated by normalization of both mitochondrial membrane potential and expression levels of apoptosis-related genes and proteins such as fas, fasl, bcl2, fas, fasl, bcl2, bax, and gsk3β. |
2021-12-04 |
2023-08-13 |
mouse |
| Juan Gong, Luqun Dou, Yang Zho. Positive feedback loop of lncRNA SNHG1/miR‑16‑5p/GATA4 in the regulation of hypoxia/reoxygenation‑induced cardiomyocyte injury. Molecular medicine reports. vol 25. issue 1. 2021-12-04. PMID:34841440. |
cell counting kit‑8, enzyme‑linked immunosorbent assay, terminal deoxynucleotidyl‑transferase‑mediated dutp nick end labeling and western blotting experiments were used to detect cell activity, lactate dehydrogenase release, apoptosis and apoptosis‑related proteins (bcl‑2, bax, cleaved caspase‑3 and cleaved caspase‑9), respectively. |
2021-12-04 |
2023-08-13 |
Not clear |
| Junjiang Liu, Yunxia Zhang, Chunhong Yu, Panying Zhang, Shouyi Gu, Gang Wang, Helong Xiao, Shoubin L. Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway. Drug development research. vol 82. issue 2. 2021-12-03. PMID:33112006. |
apoptosis was induced by bergenin in bladder cancer cells, as evidenced by increased bax and cleaved caspase 3 protein levels and decreased bcl-2 level in bergenin-treated cells. |
2021-12-03 |
2023-08-13 |
Not clear |
| Michael A Dengler, Leonie Gibson, Jerry M Adam. BAX mitochondrial integration is regulated allosterically by its α1-α2 loop. Cell death and differentiation. vol 28. issue 12. 2021-12-03. PMID:34135480. |
the conformational changes converting bax from an inert cytosolic monomer into the homo-oligomers that permeabilize the mitochondrial outer membrane (mom) are crucial steps toward apoptosis. |
2021-12-03 |
2023-08-13 |
Not clear |
| Xiuli Zhang, Ruqing Gao, Huiyu Yan, Zijian Zhao, Jun Zhang, Weiming Yo. Assembling BH3-mimic peptide into a nanocluster to target intracellular Bcl2 towards the apoptosis induction of cancer cell. Nanotechnology. vol 33. issue 8. 2021-12-03. PMID:34261054. |
however, bh3 proteins could directly activate bax via antagonizing bcl-2 to induce apoptosis in response to the stimulation. |
2021-12-03 |
2023-08-13 |
Not clear |
| Himika Wasan, Devendra Singh, Balu Joshi, Uma Sharma, A K Dinda, K H Reet. Post Stroke Safinamide Treatment Attenuates Neurological Damage by Modulating Autophagy and Apoptosis in Experimental Model of Stroke in Rats. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34453687. |
for sub-acute study, the treatment with effective dose was extended for 3 days and effects on neurobehavioral parameters, infarct size (ttc staining and mri), oxidative stress parameters (mda, gsh, sod, nox-2), inflammatory cytokines (tnf-α, il-1β, il-10), apoptosis (bax, bcl-2, cleaved caspase-3 expression, and tunel staining), and autophagy (pampk, beclin-1, lc3-ii expression) were studied. |
2021-12-03 |
2023-08-13 |
rat |
| Hongce Chen, Beini Sun, Han Sun, Lingjun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xuhong Fan, Zihao Mai, Qiling Tang, Xiaoping Wang, Tongsheng Che. Bak instead of Bax plays a key role in metformin-induced apoptosis s in HCT116 cells. Cell death discovery. vol 7. issue 1. 2021-12-03. PMID:34811352. |
bak instead of bax plays a key role in metformin-induced apoptosis s in hct116 cells. |
2021-12-03 |
2023-08-13 |
human |
| Hongce Chen, Beini Sun, Han Sun, Lingjun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xuhong Fan, Zihao Mai, Qiling Tang, Xiaoping Wang, Tongsheng Che. Bak instead of Bax plays a key role in metformin-induced apoptosis s in HCT116 cells. Cell death discovery. vol 7. issue 1. 2021-12-03. PMID:34811352. |
most importantly, silencing bak instead of bax inhibited met-induced loss of mitochondrial membrane potential, indicating the key role of bak in met-induced apoptosis. |
2021-12-03 |
2023-08-13 |
human |