| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rasha R Radwan, Hussein E Al. Radiation-synthesis of chitosan/poly (acrylic acid) nanogel for improving the antitumor potential of rutin in hepatocellular carcinoma. Drug delivery and translational research. vol 11. issue 1. 2021-11-25. PMID:32488816. |
the following parameters were measured: aspartate and alanine aminotransferase, alkaline phosphatase, gamma glutamyltransferase, and total bilirubin as liver function test; vascular endothelial growth factor as an angiogenesis marker; α-fetoprotein as a tumor marker; and p53, caspase-3, bax, and bcl-2 as apoptosis markers. |
2021-11-25 |
2023-08-13 |
rat |
| Xiaochen Guo, Wenying Sun, Lan Wei, Xiangxiang Wang, Yimeng Zou, Yingying Zhang, Shuai Li, Nan Wang, Ming Jiang, Han Zhao, Enbo Qu, Yuqing Pang, Jiechao Yin, Guiping Re. Development and evaluation of a recombinant VP2 neutralizing epitope antigen vaccine candidate for infectious bursal disease virus. Transboundary and emerging diseases. vol 68. issue 6. 2021-11-25. PMID:33406318. |
furthermore, ibdv rna was not measured, and there appeared to be little apoptosis in the bursa of fabricius based on tunel histology and the expression of bax and bcl-2 in the oea, cfa and gm-csf adjuvant groups. |
2021-11-25 |
2023-08-13 |
Not clear |
| Wenyue Wei, Yuyin Wang, Jing Zhang, Qingfang Gu, Xiaoqin Liu, Lijuan Song, Zhi Chai, Minfang Guo, Jiezhong Yu, Cungen M. Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK/MAPK and activating Nrf2 signalling pathways in APP/PS1 mice. Folia neuropathologica. vol 59. issue 1. 2021-11-25. PMID:33969676. |
the results showed that the administration of fasudil improved learning and memory ability, elevated the concentration of antioxidative substances and decreased lipid peroxides, as well as inhibited neuronal apoptosis by increasing the expression of b-cell lymphoma-2 (bcl-2) (p < 0.05), reducing bcl-2 associated x (bax) (p < 0.05) and cleaved caspase-3 (p < 0.05) of app/ps1 mice. |
2021-11-25 |
2023-08-13 |
mouse |
| J Y Lee, H M Lim, C M Lee, S-H Park, M J Na. Indole-3-carbinol inhibits the proliferation of colorectal carcinoma LoVo cells through activation of the apoptotic signaling pathway. Human & experimental toxicology. vol 40. issue 12. 2021-11-25. PMID:34085558. |
these results indicate that i3c induces apoptosis in lovo cells by upregulating p53, leading to the activation of bax and caspases. |
2021-11-25 |
2023-08-13 |
human |
| L Zhou, S Li, J Su. Ginkgolic acid induces apoptosis and autophagy of endometrial carcinoma cells via inhibiting PI3K/Akt/mTOR pathway in vivo and in vitro. Human & experimental toxicology. vol 40. issue 12. 2021-11-25. PMID:34132136. |
flow cytometry assay and western blot assay were applied to examine the apoptosis and apoptosis related protein bcl-2, bax, cleaved caspase-3 expression levels of ishikawa and hec-1-b cells after treatment with ga. next, we applied western blot assay to analyze the autophagy associated proteins lc3i, lc3ii, p62 and beclin-1 in ga treated ishikawa and hec-1-b cells. |
2021-11-25 |
2023-08-13 |
Not clear |
| Jeerati Prompipak, Thanaset Senawong, Banchob Sripa, Albert J Ketterman, Suppawit Utaiwat, Khanutsanan Woranam, Jarckrit Jeeunngoi, Gulsiri Senawon. Anticancer effects of the combined Thai noni juice ethanolic extracts and 5-fluorouracil against cholangiocarcinoma cells in vitro and in vivo. Scientific reports. vol 11. issue 1. 2021-11-25. PMID:34290264. |
the mechanism underlying a combination treatment was apoptosis induction through an activation of p53 and bax proteins. |
2021-11-25 |
2023-08-13 |
mouse |
| Deming Xu, Changbi Zhou, Juanyun Lin, Wenhui Cai, Wei Li. MicroRNA-367-3p suppresses sevoflurane-induced adult rat astrocyte apoptosis by targeting BCL2L11. Experimental and therapeutic medicine. vol 23. issue 1. 2021-11-25. PMID:34815761. |
various methods, including reverse transcription-quantitative (rt-q)pcr, western blotting and tunel staining, were used to determine the expression levels of bax, bcl-2 and bcl-2-like protein 11 (bcl2l11), as well as the level of apoptosis. |
2021-11-25 |
2023-08-13 |
rat |
| Yun Dai, Guangming Yang, Lie Yang, Li Jiang, Guohua Zheng, Shuyin Pan, Chuming Zh. Expression of FOXA1 gene regulates the proliferation and invasion of human gastric cancer cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 2. 2021-11-25. PMID:34817322. |
the induction of apoptosis was associated with upregulation of bax and downregulation of bcl-2. |
2021-11-25 |
2023-08-13 |
human |
| Qin Yang, Zhiyi Fei, Chunyan Huan. Betulin terpenoid targets OVCAR-3 human ovarian carcinoma cells by inducing mitochondrial mediated apoptosis, G2/M phase cell cycle arrest, inhibition of cell migration and invasion and modulating mTOR/PI3K/AKT signalling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 2. 2021-11-25. PMID:34817343. |
betulin prompted mitochondrial apoptosis which was also associated with alteration in the apoptosis-related protein expression (bax, bad and bcl-2 and bcl-xl). |
2021-11-25 |
2023-08-13 |
human |
| Gao-Bo Lv, Ting-Ting Wang, Hai-Lin Zhu, Hong-Ke Wang, Wen Sun, Li-Feng Zha. Vortioxetine induces apoptosis and autophagy of gastric cancer AGS cells via the PI3K/AKT pathway. FEBS open bio. vol 10. issue 10. 2021-11-23. PMID:32750222. |
additionally, vortioxetine could induce apoptosis and autophagy by increasing the levels of bax, active caspase-3/-9, beclin-1 and light chain 3, as well as by downregulating bcl-2 and p62. |
2021-11-23 |
2023-08-13 |
Not clear |
| Jinfeng Zhan. Targeting mTOR by CZ415 Suppresses Cell Proliferation and Promotes Apoptosis via Lipin-1 in Cervical Cancer In Vitro and In Vivo. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 2. 2021-11-23. PMID:32944878. |
further studies showed that the anti-cancer effects of cz415 were due to an induction of apoptosis, which was accompanied by an upregulation of bax and downregulation of bcl-2 through lipin-1. |
2021-11-23 |
2023-08-13 |
mouse |
| Guangtao Bai, Liang Jiang, Pingping Meng, Jiang Li, Chao Han, Yuyang Wang, Qiang Wan. LncRNA Neat1 Promotes Regeneration after Spinal Cord Injury by Targeting miR-29b. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33175349. |
in addition, the tunel assay was employed to study neuronal apoptosis in the anterior horn, and the expression of the apoptotic proteins bcl-2 and bax was analysed by western blotting. |
2021-11-23 |
2023-08-13 |
rat |
| Bo Chu, Xiyu Mo, Zilu Chen, Mingling Zhang, Yuning Liang, Huancheng Hu, Dongcheng Liu, Fupei Lian. Synthesis and anticancer activity of mixed ligand 3d metal complexes. Metallomics : integrated biometal science. vol 13. issue 4. 2021-11-23. PMID:33755727. |
it revealed from the mechanistic studies that complex 1 mainly induces apoptosis through the mitochondrial pathway by increasing intracellular reactive oxygen species, releasing ca2+, and activating caspase 9 and proapoptotic gene bax. |
2021-11-23 |
2023-08-13 |
Not clear |
| Bao-Li Fei, Chun-Nuan Hui, Zuzhuang Wei, Ling-Yan Kong, Jian-Ying Long, Chunhua Qiao, Zhen-Feng Che. Copper(II) and iron(III) complexes of chiral dehydroabietic acid derived from natural rosin: metal effect on structure and cytotoxicity. Metallomics : integrated biometal science. vol 13. issue 4. 2021-11-23. PMID:33765148. |
the up-regulated bax and down-regulated bcl-2 expression levels, caspase-9/caspase-3 activation, and the release of cyt c demonstrate that 1 triggered mitochondria-mediated intrinsic apoptosis in mcf-7 cells. |
2021-11-23 |
2023-08-13 |
Not clear |
| Xiaoyu Liu, Bingyan Guo, Wei Zhang, Bocong Ma, Yongjun L. MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-κB signalling pathway. Journal of biochemistry. vol 170. issue 3. 2021-11-23. PMID:33837411. |
mir-20a-5p prevented cardiomyocyte apoptosis, along with the upregulated c-caspase-3, bax and downregulated bcl-2. |
2021-11-23 |
2023-08-13 |
mouse |
| Yu Zhang, Jingjing Xiang, Ni Zhu, Hangping Ge, Xianfu Sheng, Shu Deng, Junfa Chen, Lihong Yu, Yan Zhou, Jianping She. Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-β/Smad3 signaling pathway. Aging. vol 13. issue 14. 2021-11-23. PMID:34324434. |
in addition, the combination treatment markedly increased apoptosis of raji cells as evidenced by increased bax, cleaved caspase 3, and cleaved caspase 9 expression. |
2021-11-23 |
2023-08-13 |
Not clear |
| Rajesh Kumar Manne, Yashika Agrawal, Sunil K Malonia, Shahid Banday, Sarathkumar Edachery, Asha Patel, Avinash Kumar, Praveenkumar Shetty, Manas Kumar Santr. FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX. The Journal of biological chemistry. vol 297. issue 4. 2021-11-23. PMID:34587475. |
fbxl20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of puma and bax. |
2021-11-23 |
2023-08-13 |
Not clear |
| Rajesh Kumar Manne, Yashika Agrawal, Sunil K Malonia, Shahid Banday, Sarathkumar Edachery, Asha Patel, Avinash Kumar, Praveenkumar Shetty, Manas Kumar Santr. FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX. The Journal of biological chemistry. vol 297. issue 4. 2021-11-23. PMID:34587475. |
puma (p53 upregulated modulator of apoptosis) and bax (bcl2-associated x protein) are among the most well-known inducers of apoptosis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Jiajie Feng, Jiachen Zhan, Shuangshuang M. LRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating hypoxia-inducible factor-1α. Bioengineered. vol 12. issue 1. 2021-11-23. PMID:34643170. |
in this study, western blot was applied to detect the protein expression of bax, bcl2, lc3, p62, lrg1 and hypoxia-inducible factor-1α (hif-1α); cck-8 assay was employed to detect cell viability; annexin v-fitc/pi staining was adopted to evaluate apoptosis, and immunofluorescence assay was applied to detect autophagy. |
2021-11-23 |
2023-08-13 |
Not clear |
| Yilin Sun, Nan Ma, Junjie Yi, Linyan Zhou, Shengbao Ca. Gastroprotective effect and mechanisms of Chinese sumac fruits ( Food & function. 2021-11-23. PMID:34813638. |
in addition, the fraction remarkably prevented gastric mucous cell apoptosis by upregulating bcl-2 and downregulating bax and cleaved caspase3. |
2021-11-23 |
2023-08-13 |
mouse |