| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanjie Mou, Qinguo Su. The long non-coding RNA ASMTL-AS1 promotes hepatocellular carcinoma progression by sponging miR-1343-3p that suppresses LAMC1 (laminin subunit gamma 1). Bioengineered. 2021-12-03. PMID:34859735. |
cell apoptosis was identified by detecting bax and bcl-2 protein expression using western blotting, and a xenograft assay was performed to investigate tumor growth |
2021-12-03 |
2023-08-13 |
Not clear |
| Yan Zhang, Linchao Zhang, Jialu Bao, Liantao Liu, Xiaodan Wan. Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in mice uterus and liver. Environmental science and pollution research international. vol 28. issue 46. 2021-12-02. PMID:34331232. |
we also determined the expressions of fas, fasl, bax, bcl-2, and caspase-3 in decidual cells by immunohistochemistry and the tunel assay to detect apoptosis uterine cells. |
2021-12-02 |
2023-08-13 |
mouse |
| Faezeh Poursoltani, Vahid Nejati, Yaghub Pazhang, Jafar Rezai. Sulindac and vitamin D3 synergically inhibit proliferation of MCF-7 breast cancer cell through AMPK/Akt/β-catenin axis in vitro. Cell biochemistry and function. vol 39. issue 8. 2021-12-02. PMID:34472641. |
hochst staining was used to evaluate apoptosis, whereas quantitative pcr (qpcr) was performed to measure mrna levels of bcl-2 and bax genes. |
2021-12-02 |
2023-08-13 |
human |
| Zhi Chen, Xiaomei Ye, Kangrui Yuan, Wei Liu, Kun Liu, Yuyun Li, Chaobo Huang, Zhiqiang Yu, Dudu W. Lycorine nanoparticles induce apoptosis through mitochondrial intrinsic pathway and inhibit migration and invasion in HepG2 cells. IEEE transactions on nanobioscience. vol PP. 2021-12-02. PMID:34851831. |
moreover, the up-regulated expression of cleaved caspases-3 and bax, and decrease of mitochondrial membrane potential and the bcl-2 expression were involved in lyc-nps apoptosis, implying that lyc-nps induced apoptosis via the mitochondrial-mediated apoptosis pathway. |
2021-12-02 |
2023-08-13 |
Not clear |
| Heri Suroto, Asyumaredha Asriel, Brigita De Vega, Steven K Samij. Early and late apoptosis protein expression (Bcl-2, BAX and p53) in traumatic brachial plexus injury. Journal of musculoskeletal & neuronal interactions. vol 21. issue 4. 2021-12-02. PMID:34854392. |
early and late apoptosis protein expression (bcl-2, bax and p53) in traumatic brachial plexus injury. |
2021-12-02 |
2023-08-13 |
Not clear |
| Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Günther Jahreis, Ralf M Zerbes, Katelyn O'Neill, Martin van der Laan, Xu Luo, Frank Edlic. Hexokinases inhibit death receptor-dependent apoptosis on the mitochondria. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 33. 2021-12-01. PMID:34385311. |
bax and bak are inhibited by prosurvival bcl-2 proteins through retrotranslocation from the mitochondria into the cytosol, but a specific resistance mechanism to truncated bid-dependent apoptosis is unknown. |
2021-12-01 |
2023-08-13 |
Not clear |
| Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Günther Jahreis, Ralf M Zerbes, Katelyn O'Neill, Martin van der Laan, Xu Luo, Frank Edlic. Hexokinases inhibit death receptor-dependent apoptosis on the mitochondria. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 33. 2021-12-01. PMID:34385311. |
here, we report that hexokinase 1 and hexokinase 2 inhibit the apoptosis activator truncated bid as well as the effectors bax and bak by retrotranslocation from the mitochondria into the cytosol. |
2021-12-01 |
2023-08-13 |
Not clear |
| Emir Bozkurt, Heiko Düssmann, Manuela Salvucci, Brenton L Cavanagh, Sandra Van Schaeybroeck, Daniel B Longley, Seamus J Martin, Jochen H M Preh. TRAIL signaling promotes entosis in colorectal cancer. The Journal of cell biology. vol 220. issue 11. 2021-11-30. PMID:34546352. |
although apoptosis and entosis are morphologically and biochemically distinct, knockout of bax and bak, or inhibition of caspases, also inhibits entotic cell death and promotes survival and release of inner cells. |
2021-11-30 |
2023-08-13 |
Not clear |
| Jia-Ning Syu, Der-Yen Lee, Hung-Chang Hung, Chia-Ying Li, Hung-Yu Lin, En-Pei Isabel Chiang, Yi-Heng Chen, Shu-Ming Huang, Feng-Yao Tan. Docosahexaenoic Acid Inhibits Cell Proliferation through a Suppression of c-Myc Protein in Pancreatic Ductal Adenocarcinoma Cells. Antioxidants (Basel, Switzerland). vol 10. issue 11. 2021-11-30. PMID:34829591. |
dha induced cell apoptosis through increased expression of bax, c-caspase 3 and c-parp proteins in hpaf-ii cells. |
2021-11-30 |
2023-08-13 |
human |
| Baskaran Stephen Inbaraj, Leng-Huei Hua, Bing-Huei Che. Comparative Study on Inhibition of Pancreatic Cancer Cells by Resveratrol Gold Nanoparticles and a Resveratrol Nanoemulsion Prepared from Grape Skin. Pharmaceutics. vol 13. issue 11. 2021-11-30. PMID:34834286. |
western blot analysis implied that both can down-regulate expressions of cyclin a, cyclin b, cdk1, and cdk2 and up-regulate expressions of p53 and p21, accompanied by enhancing cytochrome c expression, decreasing bcl-2 expression, increasing bax expression, and leading to the elevation of caspase-8, caspase-9, and caspase-3 activities for cell apoptosis execution. |
2021-11-30 |
2023-08-13 |
Not clear |
| Jun-Xiu Lu, Yue Qiu, Li-Juan Guo, Ping Song, Jian Xu, Guang-Rui Wan, Shuang-Xi Wang, Ya-Ling Yin, Peng L. Potential Therapeutic Effect of Citronellal on Diabetic Cardiomyopathy in Experimental Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-30. PMID:34840590. |
moreover, this condition was concurrent with metabolic disorders, the degradation of sod activity in myocardial tissues, the increase in mda content, the abnormal activation of sodium-hydrogen exchanger 1 (nhe1), and the aggravation of cell apoptosis (bax levels were elevated, whereas bcl-2 levels decreased). |
2021-11-30 |
2023-08-13 |
rat |
| Yanel A Volonté, Victoria B Ayala-Peña, Harmonie Vallese-Maurizi, Andrés Garelli, Nora P Rotstein, Luis E Politi, Olga L Germa. Retinoid X receptor activation promotes photoreceptor survival and modulates the inflammatory response in a mouse model of retinitis pigmentosa. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 11. 2021-11-29. PMID:34271041. |
pa024 decreased phr death in rd1 mixed cultures; it reduced the amount of non-viable neurons, delayed the onset of phr apoptosis, and decreased bax mrna levels. |
2021-11-29 |
2023-08-13 |
mouse |
| Andrew W Roberts, Andrew H Wei, David C S Huan. BCL2 and MCL1 inhibitors for hematologic malignancies. Blood. vol 138. issue 13. 2021-11-29. PMID:34320168. |
bh3 mimetics act by inhibiting the prosurvival bcl2 proteins to enable the activation of bax and bak, apoptosis effectors that permeabilize the outer mitochondrial membrane, triggering apoptosis directly in many cells and sensitizing others to cell death when combined with other antineoplastic drugs. |
2021-11-29 |
2023-08-13 |
Not clear |
| Apurva Patel, Mital Bhatt, Anjali Soni, Preeti Sharm. Identification of steroidal saponins from Tribulus terrestris and their in silico docking studies. Journal of cellular biochemistry. vol 122. issue 11. 2021-11-29. PMID:34337761. |
docking studies revealed the high binding affinity of nuatigenin at significant sites with apoptotic proteins bcl-2, bax, caspase-3, caspase-8, p53 and apoptosis inducing factor along with cell surface receptors estrogen receptor, projesterone receptor, epidermal growth factor receptor, and human epidermal growth factor receptor-2. |
2021-11-29 |
2023-08-13 |
human |
| Kyung-Sook Chung, Chae-Bin Yoo, Jeong-Hun Lee, Hwi-Ho Lee, Sang-Eun Park, Hee-Soo Han, Su-Yeon Lee, Byoung-Mok Kwon, Jung-Hye Choi, Kyung-Tae Le. Regulation of ROS-Dependent JNK Pathway by 2'-Hydroxycinnamaldehyde Inducing Apoptosis in Human Promyelocytic HL-60 Leukemia Cells. Pharmaceutics. vol 13. issue 11. 2021-11-29. PMID:34834209. |
the present study demonstrated that 2'-hydroxycinnamaldehyde (2'-hca) induced apoptosis in human promyelocytic leukemia hl-60 cells through the activation of mitochondrial pathways including (1) translocation of bim and bax from the cytosol to mitochondria, (2) downregulation of bcl-2 protein expression, (3) cytochrome |
2021-11-29 |
2023-08-13 |
human |
| Yan Cao, Maiying Fan, Yanfang Pei, Lei Su, Weiwei Xiao, Fang Chen, Jie Huang, Xiehong Liu, Zhengtao Gu, Zhongwei Zhang, Fangfang Yuan, Yu Jiang, Xiaotong Ha. CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury. Inflammation. 2021-11-29. PMID:34841454. |
we observed the role of chop in apoptosis-mediated intestinal epithelial cell injury secondary to hs by evaluating cell viability, lactate dehydrogenase release, apoptosis levels, and grp78, perk, atf4, chop, bcl-2, and bax mrna and protein expression. |
2021-11-29 |
2023-08-13 |
mouse |
| Yan Cao, Maiying Fan, Yanfang Pei, Lei Su, Weiwei Xiao, Fang Chen, Jie Huang, Xiehong Liu, Zhengtao Gu, Zhongwei Zhang, Fangfang Yuan, Yu Jiang, Xiaotong Ha. CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury. Inflammation. 2021-11-29. PMID:34841454. |
hs activated the perk-chop pathway and promoted apoptosis by upregulating bax and downregulating bcl-2; these effects were prevented by chop silencing. |
2021-11-29 |
2023-08-13 |
mouse |
| Zahra Yazdani, Pooyan Mehrabanjoubani, Alireza Rafiei, Pourya Biparva, Mostafa Karda. Combined Effect of Cold Atmospheric Plasma and Curcumin in Melanoma Cancer. BioMed research international. vol 2021. 2021-11-27. PMID:34825002. |
in addition, the activation of apoptosis pathways was evaluated using bcl2, bax, and caspase-3 (casp3) gene expression and ratio of bax to bcl2 (bax/bcl2). |
2021-11-27 |
2023-08-13 |
Not clear |
| Liulan Zhao, Ji Liang, Fukai Chen, Xiaohong Tang, Lei Liao, Qiao Liu, Jie Luo, Zongjun Du, Zhiqiong Li, Wei Luo, Song Yang, Samad Rahimneja. High carbohydrate diet induced endoplasmic reticulum stress and oxidative stress, promoted inflammation and apoptosis, impaired intestinal barrier of juvenile largemouth bass (Micropterus salmoides). Fish & shellfish immunology. vol 119. 2021-11-26. PMID:34662728. |
in addition, hcd induced the up-regulated expression of inflammatory (il-8, il-1β, tnfα and cox2) and apoptosis (traf2, bax, casepase3, caspase8 and casepase9) related genes in fish intestine. |
2021-11-26 |
2023-08-13 |
Not clear |
| Lei Tian, Shui Sun, Wei Li, Lin Yuan, Xianquan Wan. Down-regulated microRNA-141 facilitates osteoblast activity and inhibits osteoclast activity to ameliorate osteonecrosis of the femoral head via up-regulating TGF-β2. Cell cycle (Georgetown, Tex.). vol 19. issue 7. 2021-11-25. PMID:32089067. |
depressed mir-141 or overexpressed tgf-β2 inhibited the apoptosis of bone cells of rats with onfh and induced elevated opg, bcl-2, bmp2, runx2 and declined opgl, bax and rank expression in the femoral head tissues of rats with onfh.altogether, we find that down-regulated mir-141 promotes osteoblast activity and inhibits osteoclast activity to ameliorate onfh via up-regulated tgf-β2 expression. |
2021-11-25 |
2023-08-13 |
rat |