| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Zhang, He Nan, Jialong Guo, Shoujun Yang, Jinyu Li. Periplocin induces apoptosis and inhibits inflammation in rheumatoid arthritis fibroblast-like synoviocytes via nuclear factor kappa B pathway. IUBMB life. vol 72. issue 9. 2021-11-22. PMID:32584515. |
bcl-2 protein, one of the apoptotic regulators, was downregulated, while other regulators of apoptosis, including bax, cleaved caspase-3, and cleaved caspase-9, were upregulated in ra-flss under periplocin treatment. |
2021-11-22 |
2023-08-13 |
Not clear |
| Pu Wang, Xiaolong Li, Yuan Xi. B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo. Technology in cancer research & treatment. vol 19. 2021-11-22. PMID:33287670. |
bax, bcl-2, cleaved caspase-3, beclin-1, and lc3 s may be the downstream target factors of b4galt1 in apoptosis and autophagy, which may provide a new strategy to reduce glioblastoma development by regulating apoptosis and autophagy. |
2021-11-22 |
2023-08-13 |
Not clear |
| Jichun Tong, Jiawei Lu, Yajun Yin, Yeming Wang, Ke Zhan. microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction. Technology in cancer research & treatment. vol 19. 2021-11-22. PMID:33302819. |
further loss of function and enhancement experiments revealed that mirna-195 overexpression could significantly inhibit sclc cell proliferation and promote cell apoptosis by upregulation of bax and down-regulation of bcl-2; luciferase reporter assay demonstrated that mirna-195 could bind to rap2c mrna and inhibit its expression, rap2c overexpression also related to the poorer prognosis of lung patients. |
2021-11-22 |
2023-08-13 |
mouse |
| Joshua A Grosser, Margaret E Maes, Robert W Nickell. Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis. Apoptosis : an international journal on programmed cell death. vol 26. issue 1-2. 2021-11-22. PMID:33426618. |
characteristics of intracellular propagation of mitochondrial bax recruitment during apoptosis. |
2021-11-22 |
2023-08-13 |
Not clear |
| Yun-Jie Wei, Jun-Feng Wang, Fei Cheng, Hai-Jun Xu, Jia-Juan Chen, Jian Xiong, Jing Wan. miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway. Journal of physiology and biochemistry. vol 77. issue 4. 2021-11-22. PMID:34146302. |
moreover, the ami rats in the antagomir-124-3p group presented with a reduction in infarct area with an increase in antioxidant enzyme activity, bcl-2 expression, and activation of the fgf21/creb/pgc1α pathway, as well as a decrease in cell apoptosis rate, bax and caspase-3 expression, and levels of proinflammatory factors, effects that were reversed by si-sirt1. |
2021-11-22 |
2023-08-13 |
rat |
| E A Klimentova, I A Suchkov, A A Egorov, R E Kalini. Apoptosis and Cell Proliferation Markers in Inflammatory-Fibroproliferative Diseases of the Vessel Wall (Review). Sovremennye tekhnologii v meditsine. vol 12. issue 4. 2021-11-20. PMID:34795999. |
the main markers of apoptosis (fas, fas ligand, p53, bcl-2, bax) and cell proliferation (toll receptor) have been considered in the current review. |
2021-11-20 |
2023-08-13 |
rabbit |
| Z Fabová, A V Sirotki. Interrelationships between kisspeptin and FSH in control of porcine ovarian cell functions. Domestic animal endocrinology. vol 74. 2021-11-19. PMID:32738561. |
markers of viability, proliferation (accumulation of proliferating cell nuclear antigen [pcna] and cyclin b1), and apoptosis (accumulation of bax and caspase 3), as well as the release of steroid hormones and igf-i were analyzed using the trypan blue exclusion test, quantitative immunocytochemistry, and elisa. |
2021-11-19 |
2023-08-13 |
Not clear |
| Karunaithas Rasaratnam, Chanin Nantasenamat, Narumon Phaonakrop, Sittiruk Roytrakul, Dalina Tanyon. A novel peptide isolated from garlic shows anticancer effect against leukemic cell lines via interaction with Bcl-2 family proteins. Chemical biology & drug design. vol 97. issue 5. 2021-11-19. PMID:33595876. |
particularly, vs-9 could induce apoptosis and upregulate mrna levels of caspase 3, caspase 8, caspase 9, and bax while downregulating bcl-2, bcl-xl, and bcl-w. molecular docking of vs-9 with the anti-apoptotic bcl-2 protein family suggested that vs-9 could bind the binding groove of the bh3 domain on target proteins. |
2021-11-19 |
2023-08-13 |
Not clear |
| Deming Xu, Changbi Zhou, Juanyun Lin, Wenhui Cai, Wei Li. Dexmedetomidine provides protection to neurons against OGD/R-induced oxidative stress and neuronal apoptosis. Toxicology mechanisms and methods. vol 31. issue 5. 2021-11-19. PMID:33648426. |
western blotting has been routinely used to investigate the protein levels of α-adrenergic receptor (α-ar), apoptosis related proteins (bcl-2, bax and cleaved caspase 3) and a range of proteins associated with the nrf2/are pathway (nrf2, ho-1, nqo-1, sod) in neurons. |
2021-11-19 |
2023-08-13 |
Not clear |
| Qingsong Li, Xi Zhan. Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure in neonatal rats. Synapse (New York, N.Y.). vol 75. issue 1. 2021-11-18. PMID:32639628. |
finally, we found that genistein partially restored proteins associated with apoptosis, including bax, bcl-2, cleaved caspase 3, and phosphorylated gsk-3ß and akt. |
2021-11-18 |
2023-08-13 |
rat |
| Yuelin Guan, Kai Tu, Qiqian Huang, Feiyan Li. Verticillin A increases the BIM Biochemical and biophysical research communications. vol 567. 2021-11-18. PMID:34133998. |
in addition, up-regulation of bim protein levels to activate bax translocation results in apoptosis induction. |
2021-11-18 |
2023-08-13 |
human |
| Yongping Chen, Lin Li, Jiuyan Zhang, Hailin Cui, Jiucheng Wang, Chuqiao Wang, Mingxian Shi, Honggang Fa. Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34363182. |
furthermore, dex and sb203582 diminished lps-induced apoptosis, indicated by decreased bax and tom20 fluorescent double-stained cells, reduced annexin v-fitc/pi apoptosis rate, and reduced protein expression levels of bax, cytochrome c, cleaved caspase-9, and cleaved caspase-3. |
2021-11-18 |
2023-08-13 |
rat |
| Nongyao Nonpanya, Kittipong Sanookpan, Keerati Joyjamras, Duangdao Wichadakul, Boonchoo Sritularak, Chatchai Chaotham, Pithi Chanvorachot. Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells. PloS one. vol 16. issue 8. 2021-11-18. PMID:34383763. |
in addition, norcycloartocarpin activated apoptosis caspase cascade associating with restoration of p53, down-regulated bcl-2 and augmented bax in a549 and h460 cells. |
2021-11-18 |
2023-08-13 |
human |
| Yajie Lu, Min Zhang, Qinjun Wei, Zhibin Chen, Guangqian Xing, Jun Yao, Xin Ca. Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells. Biochemical and biophysical research communications. vol 574. 2021-11-18. PMID:34418635. |
the differential expression of apoptosis molecules (bcl2, bax, caspase-3/cleaved-caspase-3) indicated that gprasp2-ko induced apoptosis in hei-oc1 cells. |
2021-11-18 |
2023-08-13 |
mouse |
| Qian Wang, Yuping Suo, Xiaoni Wang, Yulan Wang, Xiaojuan Tian, Yanxia Gao, Nannan Liu, Rui Li. Study on the mechanism of photodynamic therapy mediated by 5-aminoketovalerate in human ovarian cancer cell line. Lasers in medical science. vol 36. issue 9. 2021-11-17. PMID:33392781. |
5-ala-pdt can significantly inhibit the growth of human ovarian cancer cells, and the mechanism of this effect is related to the tumor cell apoptosis mediated by the downregulation of bcl-2 and caspase-3 and upregulation of bax protein expression. |
2021-11-17 |
2023-08-13 |
human |
| Chien-Lun Hung, Hsin-Ho Chang, Su Wei Lee, Yun-Wei Chian. Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes. Cell death and differentiation. vol 28. issue 6. 2021-11-17. PMID:33462413. |
caspase-8-cleaved bid (cbid) associates with mitochondria and promotes the activation of bax, leading to mitochondria outer membrane permeabilization (momp) and apoptosis. |
2021-11-17 |
2023-08-13 |
Not clear |
| Fujiao Lv, Fei Qi, Zhi Zhang, Maorong Wen, Justin Kale, Alessandro Piai, Lingyu Du, Shuqing Wang, Liujuan Zhou, Yaqing Yang, Bin Wu, Zhijun Liu, Juan Del Rosario, Justin Pogmore, James J Chou, David W Andrews, Jialing Lin, Bo OuYan. An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane. The EMBO journal. vol 40. issue 14. 2021-11-17. PMID:34101209. |
bax proteins form pores in the mitochondrial outer membrane to initiate apoptosis. |
2021-11-17 |
2023-08-13 |
Not clear |
| Hadis Fathizadeh, Mahmood Saffari, Davoud Esmaeili, Rezvan Moniri, Javad Amini Mahabad. Anticancer Effect of Enterocin A-Colicin E1 Fusion Peptide on the Gastric Cancer Cell. Probiotics and antimicrobial proteins. vol 13. issue 5. 2021-11-17. PMID:34131854. |
the results of this study showed that this fusion peptide at a concentration of 60.4 µg/ml and 24 h was able to kill half of the tested cancer cells, and treatment of the cells with this concentration increased the expression of bax and caspase 3 genes and reduced the expression of bacl-2 in 24 h. flow cytometry analysis of annexin v-fitc/propidium iodide results also showed that our peptide was able to induce apoptosis in treated cells compared with control. |
2021-11-17 |
2023-08-13 |
human |
| Tapas Patra, Keith Meyer, Ratna B Ray, Tatsuo Kanda, Ranjit Ra. Akt inhibitor augments anti-proliferative efficacy of a dual mTORC1/2 inhibitor by FOXO3a activation in p53 mutated hepatocarcinoma cells. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34759291. |
mechanistic insights indicate that a combination of azd5363 and azd8055 activated foxo3a to induce bim-associated apoptosis in p53 mutated hcc cells, whereas cells retaining functional p53 enhanced bax. |
2021-11-17 |
2023-08-13 |
Not clear |
| Tapas Patra, Keith Meyer, Ratna B Ray, Tatsuo Kanda, Ranjit Ra. Akt inhibitor augments anti-proliferative efficacy of a dual mTORC1/2 inhibitor by FOXO3a activation in p53 mutated hepatocarcinoma cells. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34759291. |
sirna-mediated knock-down of bim or bax prevented apoptosis in inhibitor-treated cells. |
2021-11-17 |
2023-08-13 |
Not clear |