| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guibin Li, Jiali Jin, Shengxin Liu, Kejun Ding, Caizhen Qia. Inhibition of miR-1224 suppresses hypoxia/reoxygenation-induced oxidative stress and apoptosis in cardiomyocytes through targeting GPX4. Experimental and molecular pathology. vol 121. 2021-11-12. PMID:33989616. |
in addition, mir-1224 mimic or gpx4 sirna plasmids dramatically enhanced h/r-mediated apoptosis, bax expression and caspase-3 activity, with a concomitant reduction in bcl-2 expression. |
2021-11-12 |
2023-08-13 |
rat |
| Yishu Luo, Wei Liu, Yinmei Zhu, Yongshen Tian, Ke Wu, Linghua Ji, Li Ding, Wenwen Zhang, Tingting Gao, Xiaoqin Liu, Jun Zha. KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor. Pediatric hematology and oncology. 2021-11-12. PMID:34378481. |
we further confirmed that downregulated expression of kif11 promoted cell apoptosis and significantly increased bcl-2 and bax expression. |
2021-11-12 |
2023-08-13 |
human |
| Kun Ma, Chuan Zhang, Wuyin L. Fascin1 mediated release of pro-inflammatory cytokines and invasion/migration in rheumatoid arthritis via the STAT3 pathway. Cell cycle (Georgetown, Tex.). vol 20. issue 21. 2021-11-12. PMID:34499588. |
we also observed a significant positive correlation between fascin1 and stat3 mrna levels in ra- flss.fascin1 silencing attenuated the expression of pro-inflammatory cytokines; reduced fls proliferation in vitro; and increased apoptosis ratio and bax, cleaved parp, and caspase-3 expression. |
2021-11-12 |
2023-08-13 |
Not clear |
| Qinrui Han, Chun Zhang, Yongbin Zhang, Yuan Li, Liyi Wu, Xuegang Su. Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation. Pharmacology research & perspectives. vol 9. issue 1. 2021-11-11. PMID:33421322. |
bufarenogin induces intrinsic apoptosis via bax and ant cooperation. |
2021-11-11 |
2023-08-13 |
mouse |
| Qinrui Han, Chun Zhang, Yongbin Zhang, Yuan Li, Liyi Wu, Xuegang Su. Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation. Pharmacology research & perspectives. vol 9. issue 1. 2021-11-11. PMID:33421322. |
bufarenogin induced b-cell lymphoma 2-associated x protein (bax)-dependent intrinsic apoptosis, as demonstrated by mitochondrial translocation of bax and cytoplasm release of hct116 wild-type cells and cytochrome c (soluble pro-apoptotic factors). |
2021-11-11 |
2023-08-13 |
mouse |
| Qinrui Han, Chun Zhang, Yongbin Zhang, Yuan Li, Liyi Wu, Xuegang Su. Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation. Pharmacology research & perspectives. vol 9. issue 1. 2021-11-11. PMID:33421322. |
bufarenogin induced intrinsic apoptosis through the cooperation of bax and adenine-nucleotide translocator and inhibited the metastasis and growth of orthotopical crc cells. |
2021-11-11 |
2023-08-13 |
mouse |
| Yonggang Yuan, Bing Li, Wanzhong Peng, Zesheng X. Protective effect of glycyrrhizin on coronary microembolization-induced myocardial dysfunction in rats. Pharmacology research & perspectives. vol 9. issue 1. 2021-11-11. PMID:33507583. |
glycyrrhizin inhibited cme-induced cardiomyocyte apoptosis and the expression of cleaved caspase-3 and bax, while enhanced the expression of bcl-2. |
2021-11-11 |
2023-08-13 |
rat |
| Gui-Rong Huang, Feng-Guan Ha. Dexmedetomidine Inhibits Inflammation to Alleviate Early Neuronal Injury via TLR4/NF-κB Pathway in Rats with Traumatic Brain Injury. Critical reviews in eukaryotic gene expression. vol 31. issue 1. 2021-11-11. PMID:33639054. |
results - tbi-challenged rats exhibited significant neuronal apoptosis, which was characterized via the wet-to-dry weight ratio, neurobehavioral functions, tunel assay results, and the levels of cleaved caspase-3, bax upregulation, and bcl-2, which were attenuated by dex. |
2021-11-11 |
2023-08-13 |
rat |
| Kalishwaralal Kalimuthu, Jin Hong Kim, Yong Seok Park, Xu Luo, Lin Zhang, Ja-Lok Ku, M Haroon A Choudry, Yong J Le. Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. Journal of cellular physiology. vol 236. issue 9. 2021-11-10. PMID:33586156. |
moreover, the combined treatment-induced apoptosis was completely suppressed in bh3 interacting-domain death agonist (bid)- or bcl-2-associated x protein (bax)-deficient hct116 cells, but not bak-deficient hct116 cells. |
2021-11-10 |
2023-08-13 |
mouse |
| Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhan. Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558536. |
the results revealed that baicalin greatly increased the basso, beattie, bresnahan locomotor rating scale score, reduced blood-spinal cord barrier permeability, decreased the expression of bax, caspase-3, and nuclear factor κb, increased the expression of bcl-2, and reduced neuronal apoptosis and pathological spinal cord injury. |
2021-11-10 |
2023-08-13 |
rat |
| Wengeng Lu, Zheng-Mei Xu, Qing Liu, Nan-Nan Yu, Jia-Bin Yu, Wei-Long Li, Ying-Ying Mao, Zhenzhen Du, Linqing Si, Siqi Yuan, Jidong Jin, Shixin Fu, Dongbo Sun, Ying-Hao Ha. Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows. Frontiers in veterinary science. vol 8. 2021-11-10. PMID:34746277. |
furthermore, our results showed that bad-msc treatments could also significantly downregulate lps induced p38, ikb-a, and jak1 phosphorylation and bax protein expression levels, which are closely related to inflammatory progress and cellular apoptosis in beecs. |
2021-11-10 |
2023-08-13 |
cattle |
| G F Bomfim, G K F Merighe, S A de Oliveira, J A Negra. Acute and chronic effects of cortisol on milk yield, the expression of key receptors, and apoptosis of mammary epithelial cells in Saanen goats. Journal of dairy science. 2021-11-10. PMID:34756435. |
the objective of this study was to investigate the relationship between cort, insulin, prolactin, growth hormone, and insulin-like growth factor-1 in milk as well as the effect of cort on the expression of receptors of insulin (insr), prolactin (prlr), growth hormone (ghr); we also studied the insulin-like growth factor-1 (igf1r), glucocorticoid (nr3c1), mineralocorticoid (nr3c2), b-cell lymphoma 2 (bcl2), bcl-2-like protein x (bax) genes, and the apoptosis rate of mammary epithelial cells of lactating saanen goats in vivo and in vitro. |
2021-11-10 |
2023-08-13 |
Not clear |
| G F Bomfim, G K F Merighe, S A de Oliveira, J A Negra. Acute and chronic effects of cortisol on milk yield, the expression of key receptors, and apoptosis of mammary epithelial cells in Saanen goats. Journal of dairy science. 2021-11-10. PMID:34756435. |
however, a higher amount of cort added in vitro upregulated the nr3c1, ghr, prlr, and bax genes and downregulated the igf1r and insr genes, which could negatively modulate the apoptosis of mammary epithelial cells. |
2021-11-10 |
2023-08-13 |
Not clear |
| Xuan Ma, Yang Liu, Hao Tian, Bo Zhang, Meiling Wang, Xia Ga. LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer. Journal of microbiology and biotechnology. vol 31. issue 7. 2021-11-09. PMID:34099597. |
mir-7-5p reversed the effect of linc01272 on viability, multiplication, apoptosis and expression of mir-7-5p and crls1 as well as apoptosis-related factors (bcl-2, bax and cleaved caspase-3). |
2021-11-09 |
2023-08-13 |
Not clear |
| Donia E Hafez, Eman Hafez, Islam Eddiasty, Shou-Ping Shih, Leng-Chiang Chien, Yi-Jia Hong, Hung-Yu Lin, Adam B Keeton, Gary A Piazza, Mohammad Abdel-Halim, Ashraf H Abad. Novel thiazolidine derivatives as potent selective pro-apoptotic agents. Bioorganic chemistry. vol 114. 2021-11-09. PMID:34328854. |
mechanistic studies of the anticancer effect of compound 2e in prostate cancer pc-3 and colorectal cancer dld-1 cells revealed that 2e could prevent the cell cycle in the g0/g1 phase by up-regulating the expression of p21 and reducing the expression of cdk2 and cyclin e. it increased the pro-apoptotic protein bax and cleaved caspase 3, and down-regulated the expression of anti-apoptotic protein bcl-2 to induce apoptosis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Nazende Nur Bayram, Gizem Tuğçe Ulu, Murat Topuzoğulları, Yusuf Baran, Sevil Dinçer İşoğl. HER2-Targeted, Degradable Core Cross-Linked Micelles for Specific and Dual pH-Sensitive DOX Release. Macromolecular bioscience. 2021-11-09. PMID:34708562. |
formulations cause apoptosis depending on bax and caspase-3 and cell cycle arrest in g2 phase. |
2021-11-09 |
2023-08-13 |
Not clear |
| Jiayin Deng, Lucía G Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer, Laura Senovill. Paradoxical implication of BAX/BAK in the persistence of tetraploid cells. Cell death & disease. vol 12. issue 11. 2021-11-09. PMID:34725331. |
pro-apoptotic multi-domain proteins of the bcl2 family such as bax and bak are well known for their important role in the induction of mitochondrial outer membrane permeabilization (momp), which is the rate-limiting step of the intrinsic pathway of apoptosis. |
2021-11-09 |
2023-08-13 |
mouse |
| Chaoyi Zhong, Qingwen Nong, Wenyu Feng, Yugu Pan, Yajun Wu, Xianmin Zeng, Hanwen Li, Xueran Zhong, Feicui Li, Zhiwei Luan, Xing Huang, Kai Luo, Daen Liu, Jun Ya. Polyphyllin VII induces fibroblasts apoptosis via the ERK/JNK pathway. Burns : journal of the International Society for Burn Injuries. vol 47. issue 1. 2021-11-08. PMID:33279335. |
our data show that the pp7-induced hsfs cell apoptosis was mainly due to the enhanced expression of apoptotic genes (bax, caspase-3, caspase-9) and decreased expression of bcl-2. |
2021-11-08 |
2023-08-13 |
Not clear |
| Zhiguo Miao, Fanggeng Wu, Haiyun Wei, Zhipeng Luo, Kun Wu, Jiangnan Zhan. Enhancer of zeste homolog 2-mediated paired box 8 methylation promotes gastrointestinal stromal tumor progression through Wnt4 downregulation. Cancer gene therapy. vol 28. issue 10-11. 2021-11-08. PMID:33479444. |
overexpression of pax8 or suppression of pax8 methylation using dna methyltransferase inhibitor 5-aza-dc inhibited the proliferation, migration, and invasion of gist cells while promoting their apoptosis (diminished pcna, ki67 and bcl-2, elevated bax, and cleaved caspase-3). |
2021-11-08 |
2023-08-13 |
mouse |
| Minke Bekker, Shameemah Abrahams, Ben Loos, Soraya Bardie. Can the interplay between autophagy and apoptosis be targeted as a novel therapy for Parkinson's disease? Neurobiology of aging. vol 100. 2021-11-08. PMID:33516928. |
bcl-2 was identified as an important protein with the ability to suppress autophagy and apoptosis through inhibiting beclin-1 and bax, respectively. |
2021-11-08 |
2023-08-13 |
Not clear |