| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Na Pang, Xiaowei Huang, Hui Zhou, Xiangxiang Xia, Xiufang Liu, Yibo Wang, Wen Meng, Tianyuan Bian, Long Meng, Lisheng Xu, Lili Ni. Transcranial Ultrasound Stimulation of Hypothalamus in Aging Mice. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. vol 68. issue 1. 2021-10-25. PMID:31985418. |
furthermore, the level of inflammation (tnf- α : sham: 0.69 ± 0.084; us1: 0.39 ± 0.054; us2: 0.49 ± 0.1, p = 0.021 ) and apoptosis (bax: sham: 0.47 ± 0.049; us1: 0.42 ± 0.054; us2: 0.18 ± 0.055, p = 0.001 ) was significantly reduced after tus in this stage. |
2021-10-25 |
2023-08-13 |
mouse |
| Hatef Talebi, Mohammad Reza Farahpour, Hamed Hamishehka. The effectiveness of Rutin for prevention of surgical induced endometriosis development in a rat model. Scientific reports. vol 11. issue 1. 2021-10-25. PMID:33785814. |
rutin induces apoptosis by the expression of bcl-2, bax and caspase and also antioxidant activity by increasing antioxidants concentrations. |
2021-10-25 |
2023-08-13 |
rat |
| Fernanda Isabel Della Via, Rodrigo Naoto Shiraishi, Irene Santos, Karla Priscila Ferro, Myriam Janeth Salazar-Terreros, Gilberto Carlos Franchi Junior, Eduardo Magalhães Rego, Sara Teresinha Olalla Saad, Cristiane Okuda Torell. (-)-Epigallocatechin-3-gallate induces apoptosis and differentiation in leukaemia by targeting reactive oxygen species and PIN1. Scientific reports. vol 11. issue 1. 2021-10-25. PMID:33907248. |
furthermore, apoptosis of spleen cells was supported by increasing expression of bad and bax, parallel to bcl-2 and c-myc decrease. |
2021-10-25 |
2023-08-13 |
mouse |
| Mehmet Kadir Erdogan, Ibrahim Halil Gecibesler, Yakup Yapar, Ramazan Gundogdu, Mahinur Kirici, Lutfi Behcet, Parham Taslim. Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE. Bioorganic chemistry. vol 113. 2021-10-25. PMID:34089947. |
in addition, human vegf elisa method was used to determine the anti-angiogenic effect, and the quantitative real-time pcr (qrt-pcr) method on p53, bax and bcl-2 mrna levels were used to evaluate apoptosis. |
2021-10-25 |
2023-08-13 |
human |
| Yu Feng, Hantao Wang, Zhi Chen, Bin Che. High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration. Bone. vol 153. 2021-10-25. PMID:34461288. |
using a microarray assay to detect the dysregulated genes in idd patients with obesity, we identified 33 differentially expressed genes and verified only two proapoptotic genes, including puma (p53 upregulated modulator of apoptosis) and bax (bcl2 associated x) responded to glucose. |
2021-10-25 |
2023-08-13 |
rat |
| Yu Feng, Hantao Wang, Zhi Chen, Bin Che. High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration. Bone. vol 153. 2021-10-25. PMID:34461288. |
the accumulation of puma and bax triggered mitochondrial dysfunction and caspase activation, resulting in apoptosis. |
2021-10-25 |
2023-08-13 |
rat |
| Yu Feng, Hantao Wang, Zhi Chen, Bin Che. High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration. Bone. vol 153. 2021-10-25. PMID:34461288. |
our in vitro and in vivo data support a model in which high glucose activates the chrebp/p300 transcriptional complex to bind to the promoters of puma and bax, causing apoptosis and idd pathogenesis. |
2021-10-25 |
2023-08-13 |
rat |
| Jinbing Xue, Gang Wu, Umer Ejaz, Fahad Akhtar, Xinyu Wan, Yong Zhu, Aixing Geng, Yadong Chen, Shuying H. A novel histone deacetylase inhibitor LT-548-133-1 induces apoptosis by inhibiting HDAC and interfering with microtubule assembly in MCF-7 cells. Investigational new drugs. vol 39. issue 5. 2021-10-23. PMID:33788074. |
the decreased expression of bcl-2 and the increased expression of bax, p53, p21, and cleaved-caspase3 indicated the occurrence of apoptosis. |
2021-10-23 |
2023-08-13 |
Not clear |
| Xinxin Hu, Dongli Zhuang, Rong Zhang, Xinghuai Sun, Qinkang Lu, Yi Da. The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity. Neuroreport. vol 31. issue 16. 2021-10-22. PMID:32991521. |
we show here that in the presence of glutamate-induced excitotoxicity, pr-619 stabilized the mitochondrial membrane potential of rgcs, decreased cytotoxicity and apoptosis, attenuated the expression of bax. |
2021-10-22 |
2023-08-13 |
Not clear |
| Mohammed M Alanazi, Hazem A Mahdy, Nawaf A Alsaif, Ahmad J Obaidullah, Hamad M Alkahtani, Abdulrahman A Al-Mehizia, Sultan M Alsubaie, Mohammed A Dahab, Ibrahim H Eiss. New bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer evaluation. Bioorganic chemistry. vol 112. 2021-10-22. PMID:34023640. |
the most cytotoxic compound 20 h was subjected to further biological investigations including cell cycle, apoptosis, caspase-3, caspase-9, bax, and bcl-2 analyses. |
2021-10-22 |
2023-08-13 |
human |
| Jacky Bhagat, Liqing Zang, Hiroko Nakayama, Norihiro Nishimura, Yasuhito Shimad. Effects of nanoplastic on toxicity of azole fungicides (ketoconazole and fluconazole) in zebrafish embryos. The Science of the total environment. vol 800. 2021-10-22. PMID:34399343. |
we investigated the effects of polystyrene (ps) np on the toxicity of ketoconazole (kcz) and fluconazole (fcz) in zebrafish embryos using the developmental toxicity, oxidative-stress-related biochemical parameters, and expression of genes related to neurotoxicity (ache), cardiotoxicity (gata4, bmp4), inflammation (il1b), oxidative stress (sod1, sod2, cyp1a), and apoptosis (bax, bcl2). |
2021-10-22 |
2023-08-13 |
zebrafish |
| Jing Chen, Cunmin Zhou, Juan Yi, Jingjing Sun, Bei Xie, Zhewen Zhang, Qunfeng Wang, Gang Chen, Suya Jin, Jinxia Hou, Miao Qin, Lina Wang, Hulai We. Metformin and arsenic trioxide synergize to trigger Parkin/pink1-dependent mitophagic cell death in human cervical cancer HeLa cells. Journal of Cancer. vol 12. issue 21. 2021-10-22. PMID:34659521. |
both met and ato effectively inhibited the proliferative activity of hela cells and induced apoptosis by activating bax and inhibiting bcl-2. |
2021-10-22 |
2023-08-13 |
human |
| Masumeh Sanaei, Fraidoon Kavoos. Effects of trichostatin A on the intrinsic and extrinsic apoptotic pathway, cell viability, and apoptosis induction in hepatocellular carcinoma cell lines. Gastroenterology and hepatology from bed to bench. vol 14. issue 4. 2021-10-22. PMID:34659660. |
the current study investigated the effect of trichostatin a (tsa) on mitochondrial/intrinsic [pro- (bax, bak, and bim) and anti- (bcl-2, bcl-xl, and mcl-1) apoptotic genes] and cytoplasmic/extrinsic (dr4, dr5, fas, fas-l, and trail genes) pathways, histone deacetylase 1, 2, and 3, p53, p73, cell viability, and apoptosis in hepatocellular carcinoma (hcc) hcclm3, mhcc97h, and mhcc97l cell lines. |
2021-10-22 |
2023-08-13 |
Not clear |
| Jian Li, Chengqiang Wang, Lixin Xue, Fan Zhang, Jianqiang Li. Melatonin Suppresses Apoptosis of Nucleus Pulposus Cells through Inhibiting Autophagy via the PI3K/Akt Pathway in a High-Glucose Culture. BioMed research international. vol 2021. 2021-10-22. PMID:34660789. |
compared with the control np cells, high glucose significantly increased cell apoptosis ratio and caspase-3/caspase-9 activity and decreased mrna expression of bcl-2, whereas it increased mrna or protein expression of bax, caspase-3, cleaved caspase-3, cleaved parp, and autophagy-related molecules (atg3, atg5, beclin-1, and lc3-ii) and decreased protein expression of p-akt compared with the control cells. |
2021-10-22 |
2023-08-13 |
Not clear |
| Yan Li, Xiaolin Zhang, Yuanyuan Wei, Shujuan Wen, Xing Lin, Quanfang Huan. [Tormentic acid inhibits proliferation and promotes apoptosis of LX-2 human hepatic stellate cells via blocking NF-κB signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 10. 2021-10-22. PMID:34670666. |
ta significantly induced lx-2 cells apoptosis by down-regulating the expression of the anti-apoptotic protein bcl2 and up-regulating the expression of the pro-apoptotic protein bax. |
2021-10-22 |
2023-08-13 |
human |
| Daohong He, Yongnan Xu, Lina Hou, Jing Wang, Shaoying Yang, Yu Wang, Shurui Zhang, Qingguo Jin, Qingshan Ga. Toxic effects of methomyl on mouse oocytes and its possible mechanisms. Zygote (Cambridge, England). 2021-10-22. PMID:34676817. |
mrna expression of the pro-apoptotic genes bax and caspase-3 in methomyl-treated oocytes increased, which confirmed the apoptosis. |
2021-10-22 |
2023-08-13 |
mouse |
| Hayati Arda, Oğuzhan Doğanla. Stress-induced miRNAs isolated from wheat have a unique therapeutic potential in ultraviolet-stressed human keratinocyte cells. Environmental science and pollution research international. 2021-10-22. PMID:34677776. |
moreover, si-wmirs inhibited pro-apoptotic bax, caspase 3 and caspase 8 gene expression and protein levels to prevent apoptosis of uv-stressed hacat cells. |
2021-10-22 |
2023-08-13 |
human |
| Rina A Anvekar, James J Asciolla, Derek J Missert, Jerry E Chipu. Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment. Frontiers in oncology. vol 1. issue 34. 2021-10-21. PMID:22268005. |
chemotherapeutic agents target melanoma tumor cells by inducing a form of cell death called apoptosis, which is governed by the bcl-2 family of proteins.the bcl-2 family is comprised of anti-apoptotic proteins (e.g., bcl-2, bcl-xl, and mcl-1) and pro-apoptotic proteins (e.g., bak, bax, and bim), and their coordinated regulation and function are essential for optimal responses to chemotherapeutics. |
2021-10-21 |
2023-08-12 |
Not clear |
| Serge Carreau, Helene Bouraima-Lelong, Christelle Delaland. Estrogens in male germ cells. Spermatogenesis. vol 1. issue 2. 2021-10-21. PMID:22319655. |
moreover, it is noteworthy that gpr 30 (a transmembrane er) induces rapid responses after estradiol binding, which, in turn, modulates cyclins and proapoptotic factors (e.g., bax) to affect germ cell cycle progression and apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Giuliana Cássia Morrone Taromaru, Vilmar Marques DE Oliveira, Maria Antonieta Longo Galvão Silva, Wagner Ricardo Montor, Fabio Bagnoli, José Francisco Rinaldi, Tsutomu Aok. Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. Oncology letters. vol 3. issue 3. 2021-10-21. PMID:22740976. |
the objective of this study was to evaluate the correlation between cyclooxygenase-2 (cox-2) and markers of cell proliferation and apoptosis, including, bcl-2, bax, ki-67 and the type i insulin-like growth factor (igf) receptor (igf1-r) in ductal carcinoma in situ (dcis) and infiltrating ductal carcinoma (idc), present in the same surgical specimen. |
2021-10-21 |
2023-08-12 |
Not clear |