| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoxiang Xu, Guorong Yan, Juan Chang, Ping Wang, Qingqiang Yin, Chaoqi Liu, Shuo Liu, Qun Zhu, Fushan L. Astilbin ameliorates deoxynivalenol-induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC-J2). Journal of applied toxicology : JAT. vol 40. issue 10. 2021-11-01. PMID:32324309. |
the addition of 20 μg/ml ast significantly increased cell viability, superoxide dismutase and catalase activities, bcl-2 gene expression and the bcl-2/bax ratio (p < .05), and decreased lactate dehydrogenase release, malondialdehyde content and the relative expressions of genes associated with inflammation and apoptosis such as interleukin-6 and -8, tumor necrosis factor-alpha, cyclooxygenase-2, nuclear factor-kappab, bax and caspase-3 (p < .05). |
2021-11-01 |
2023-08-13 |
Not clear |
| Marwa H El-Wakil, Marwa Ahmed Meheissen, Marwa M Abu-Seri. Nitrofurazone repurposing towards design and synthesis of novel apoptotic-dependent anticancer and antimicrobial agents: Biological evaluation, kinetic studies and molecular modeling. Bioorganic chemistry. vol 113. 2021-11-01. PMID:34051413. |
data of the bioactivity studies indicated that the potent anticancer activity of 7 is mainly through increasing intracellular ros levels and induction of apoptosis via significantly down-regulating the expression of bcl-2 while up-regulating bax, p53 and caspase 3 expression levels. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yong Xiang, Yun Yu, Qingbo Li, Zeng Jiang, Jinqun Li, Canxin Liang, Jian Chen, Yu Li, Xiaoyan Chen, Weisheng Ca. Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/β-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells. Veterinary research. vol 52. issue 1. 2021-11-01. PMID:34412690. |
subsequently, we found that chtert not only shortened the cell cycle to promote proliferation but also inhibited apoptosis by downregulating the expression of caspase 3, caspase 9 and bax; upregulating bcl-2 and bcl-x expression; and promoting autophagy. |
2021-11-01 |
2023-08-13 |
chicken |
| Yue Li, Yong Zhou, Miaoran Wang, Xiaojing Lin, Yunqi Zhang, Irakoze Laurent, Ying Zhong, Jibin L. Ampelopsin Inhibits Breast Cancer Cell Growth through Mitochondrial Apoptosis Pathway. Biological & pharmaceutical bulletin. vol 44. issue 11. 2021-11-01. PMID:34470980. |
in conclusion, ampelopsin-induced mitochondria damage leads to loss of mitochondria membrane potential, overproduction of ros and activation of bax, increasing mitochondria membrane permeability and ultimately inducing breast cell apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Nada F Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H Eis. Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34639002. |
moreover, quinacrine significantly blocked cisplatin-induced apoptosis, which was made evident by downregulating renal apoptotic proteins (bax and p53) and upregulating the renal anti-apoptotic protein bcl2, compared with the cisplatin group. |
2021-11-01 |
2023-08-13 |
rat |
| Cheng Wang, Changxi Qi, Mingchao Liu, Lumei Wang, Guodong Cheng, Liping Li, Yuxiao Xing, Xiaona Zhao, Jianzhu Li. Protective effects of agrimonolide on hypoxia-induced H9c2 cell injury by maintaining mitochondrial homeostasis. Journal of cellular biochemistry. 2021-11-01. PMID:34724244. |
am inhibited the rate of apoptosis by regulating the expression of apoptosis-related proteins, reducing the level of cleaved caspase 3 and bax, and increasing the level of bcl2, thereby protecting h9c2 cells from hypoxia-induced apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Chengliang Yuan, Guoping Chen, Chengbao Jing, Mengxue Liu, Bo Liang, Guojin Gong, Mei Y. Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF-7 cells. Journal of biochemical and molecular toxicology. 2021-11-01. PMID:34724282. |
eriocitrin induced apoptosis via suppression of stat3 signaling regulated proteins, activating proapoptotic factors bax, caspase 7, 8, 9 and suppressing bcl-2, bcl-x expression in mcf-7 cells. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yi-Ming Zhang, Li-Ying Zhang, Heng Zhou, Yang-Yang Li, Kong-Xi Wei, Cheng-Hao Li, Ting Zhou, Ju-Fang Wang, Wen-Jun Wei, Jun-Rui Hua, Yun He, Tao Hong, Yong-Qi Li. Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs). Cell cycle (Georgetown, Tex.). vol 19. issue 22. 2021-10-31. PMID:33121344. |
in terms of mechanism, aps up-regulates the proteins bcl-2, bcl-xl, and down-regulates the proteins bax and bak, which induces a decrease in mitochondrial membrane potential, which induces the release of cyt-c and aif, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. |
2021-10-31 |
2023-08-13 |
Not clear |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
in addition, mi not only increased levels of il-1β, bax, and cleaved-caspase 3, but also increased iba-1 and gfap expression in the hippocampus, as compared to those in controls, suggesting a promotion of neuro-inflammation and apoptosis in hippocampus. |
2021-10-29 |
2023-08-13 |
rat |
| Sheng Huang, Changye Zou, Shangyan Xie, Bin Wang, Xitao LingHu, Yixiao Wang, Xiaohong Xu, Shuai Huang, Qingde W. Anticancer Activity of Sweroside Nanoparticles in Prostate Cancer Bone Metastasis in PC-3 Cells Involved in Wnt/ Journal of biomedical nanotechnology. vol 17. issue 10. 2021-10-29. PMID:34706796. |
apoptosis was assessed with flow cytometry using the annexin v/propidium iodide binding assay; proteins, including p53, p21, bcl-2, and bax; and induction of intracellular reactive oxygen species (ros). |
2021-10-29 |
2023-08-13 |
Not clear |
| Xuxu Wang, Jiahao Qiao, Chaoyi Zou, Yutao Zhao, Yefei Huan. Sesamin induces cell cycle arrest and apoptosis through p38/C-Jun N-terminal kinase mitogen-activated protein kinase pathways in human colorectal cancer cells. Anti-cancer drugs. vol 32. issue 3. 2021-10-26. PMID:33534411. |
moreover, sesamin dose-dependently triggered apoptosis of hct116 but not fhc, and promoted the expression levels of proapoptotic biomarkers bax, cleaved caspase-3 and cleaved parp-1 and inhibited the expression of antiapoptotic biomarker bcl-2. |
2021-10-26 |
2023-08-13 |
human |
| Daniel L Morris, Nico Tjandr. Inducible fold-switching as a mechanism to fibrillate pro-apoptotic BCL-2 proteins. Biopolymers. vol 112. issue 10. 2021-10-26. PMID:33764501. |
bax is the central regulatory protein for mitochondrial outer membrane permeabilization (momp), a poration process that commits cells to apoptosis by releasing death-propagating factors from the mitochondria. |
2021-10-26 |
2023-08-13 |
Not clear |
| Mei Zhang, Rong Dong, Jing Yuan, Jingjing Da, Yan Zha, Yanjun Lon. Roxadustat (FG-4592) protects against ischaemia/reperfusion-induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice. Clinical and experimental pharmacology & physiology. 2021-10-26. PMID:34653291. |
furthermore, these results suggest that pretreatment with fg-4592 significantly reduced the tubular cells apoptosis (decreased tunel-positive cells, bax, caspase12 levels), attenuated mitochondrial damage (increased atpβ, pparγ, mitochondrial dna copy number, and decreased cytoplasmic cytochrome c), and alleviated dna damage after iri. |
2021-10-26 |
2023-08-13 |
mouse |
| Xiao-Chun Sun, Yue Wang, Han-Fang Zeng, Yu-Meng Xi, Hong Lin, Zhao-Yu Han, Kun-Lin Che. SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway. Cell death discovery. vol 7. issue 1. 2021-10-26. PMID:34675216. |
sirt3 knockdown significantly increased the expression of hsp70, bax, and cleaved-caspase 3 and inhibited the production of antioxidases, thus promoting ros production and cell apoptosis in bmecs. |
2021-10-26 |
2023-08-13 |
cattle |
| Zhuo Han, Xingming Zhao, E Zhang, Jiahui Ma, Hao Zhang, Jianjiang Li, Weidong Xie, Xia L. Resistomycin Induced Apoptosis and Cycle Arrest in Human Hepatocellular Carcinoma Cells by Activating p38 MAPK Pathway In Vitro and In Vivo. Pharmaceuticals (Basel, Switzerland). vol 14. issue 10. 2021-10-26. PMID:34681182. |
resistomycin treatment induced apoptosis and cell cycle arrest in hepg2 cells, accompanied by changes in the expression of related proteins, including bax, cyclin b1, etc. |
2021-10-26 |
2023-08-13 |
human |
| Iwona Radziejewska, Katarzyna Supruniuk, Robert Czarnomysy, Kamila Buzun, Anna Bielawsk. Anti-Cancer Potential of Afzelin towards AGS Gastric Cancer Cells. Pharmaceuticals (Basel, Switzerland). vol 14. issue 10. 2021-10-26. PMID:34681197. |
our purpose was to assess its influence on apoptosis, bax, caspases, muc1, cancer-related carbohydrate antigens, enzymes participating in their formation, and galectin-3 in ags gastric cancer cells. |
2021-10-26 |
2023-08-13 |
Not clear |
| Magdalena Nowaczyk, Agnieszka Zimna, Tobiasz Deptuła, Katarzyna Fiedorowicz, Natalia Rozwadowska, Marta Podralska, Maciej Kurpis. pNiPAM-Nanoparticle-Based Antiapoptotic Approach for Pro-Regenerative Capacity of Skeletal Myogenic Cells. Nanomaterials (Basel, Switzerland). vol 11. issue 10. 2021-10-26. PMID:34684935. |
skmcs incubated with np loaded with antiapoptotic agent, bcb (bax channel blocker), significantly diminished cell apoptosis ( |
2021-10-26 |
2023-08-13 |
human |
| Gang Cheng, Jiang Shan, Ji Ma, Yu-Ping Sh. [Simvastatin induced apoptosis and its effect on apoptosis-related gene expression in rat vascular smooth muscle cell] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 31. issue 1. 2021-10-25. PMID:12557325. |
methods: the presence of apoptosis was detected by electron microscope and flow cytometry assessment of pi/annexin v stain; the protein levels of bax, bel-2 and activation of caspase-3 were examined using western blot technique. |
2021-10-25 |
2023-08-12 |
rat |
| Gang Cheng, Jiang Shan, Ji Ma, Yu-Ping Sh. [Simvastatin induced apoptosis and its effect on apoptosis-related gene expression in rat vascular smooth muscle cell] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 31. issue 1. 2021-10-25. PMID:12557325. |
western blot analyses revealed that the apoptosis process was associated with upregulation of bax protein and activation of caspase-3, but not with bel-2 expression. |
2021-10-25 |
2023-08-12 |
rat |
| Gang Cheng, Jiang Shan, Ji Ma, Yu-Ping Sh. [Simvastatin induced apoptosis and its effect on apoptosis-related gene expression in rat vascular smooth muscle cell] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 31. issue 1. 2021-10-25. PMID:12557325. |
conclusion: simvastatin can induce apoptosis in vsmc in associated with induction of bax and activation of caspase-3. |
2021-10-25 |
2023-08-12 |
rat |