| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Young-Seuk Bae, Sang Hyun Kim, Seung-Soon Im, Ji Hae Seo, Kyoung-Jin Min, Taeg Kyu Kwo. Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo. Oncogene. 2021-11-17. PMID:34785775. |
here, cathepsin k inhibitor (odanacatib; odn) and knockdown of cathepsin k (sirna) enhanced oxaliplatin-induced apoptosis in multiple cancer cells through bax upregulation. |
2021-11-17 |
2023-08-13 |
mouse |
| Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Young-Seuk Bae, Sang Hyun Kim, Seung-Soon Im, Ji Hae Seo, Kyoung-Jin Min, Taeg Kyu Kwo. Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo. Oncogene. 2021-11-17. PMID:34785775. |
our results demonstrate that cathepsin k inhibition enhances oxaliplatin-induced apoptosis by increasing otub1 phosphorylation via ck2 activation, thereby promoting p53 stabilization, and hence upregulating bax. |
2021-11-17 |
2023-08-13 |
mouse |
| Li Guo, Yi Yang, YongJia Sheng, Jin Wang, Shuiliang Ruan, Chenyang Ha. Mechanism of piperine in affecting apoptosis and proliferation of gastric cancer cells via ROS-mitochondria-associated signalling pathway. Journal of cellular and molecular medicine. vol 25. issue 20. 2021-11-16. PMID:34464498. |
the mechanism of pip was associated with ros increase and mitochondrial damage, simultaneously, the expression of key proteins of apoptosis was affected, including bcl-2, bax, cyt-c, caspase-9 and caspase-3. |
2021-11-16 |
2023-08-13 |
human |
| Qian Li, Mingming Zhang, Ying Zhao, Maolong Don. Irisin Protects Against LPS-Stressed Cardiac Damage Through Inhibiting Inflammation, Apoptosis, and Pyroptosis. Shock (Augusta, Ga.). vol 56. issue 6. 2021-11-16. PMID:34779800. |
after stimuli of lps, the function of myocardium was distinctly impaired, which was closely related to increased level of apoptosis (decreased expression of bcl-2 and elevated expression of caspase-3 and bax), pyroptosis (increased expression of caspase1, nlr family pyrin domain containing 3 (nlrp3), and gasdermin d) and inflammatory mediators (increased level of il-1β, tnf-α, and il-6). |
2021-11-16 |
2023-08-13 |
mouse |
| Xuliang Zhang, Qi Wang, Jian Zhang, Miao Song, Bing Shao, Yanfei Han, Xu Yang, Yanfei L. The Protective Effect of Selenium on T-2-Induced Nephrotoxicity Is Related to the Inhibition of ROS-Mediated Apoptosis in Mice Kidney. Biological trace element research. vol 200. issue 1. 2021-11-15. PMID:33547999. |
in addition, inhibition of renal cell apoptosis by se was associated with blocking the mitochondrial pathway in t-2 toxin-treated mice, presenting as decreasing the protein expression of cytochrome-c, activities of caspase-3/9, as well as regulating the protein and mrna expressions of bax and bcl-2. |
2021-11-15 |
2023-08-13 |
mouse |
| Stephanie McKenna, Lucía García-Gutiérrez, David Matallanas, Dirk Fe. BAX and SMAC regulate bistable properties of the apoptotic caspase system. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33558564. |
in summary, we present an experimentally validated dynamic model that summarises our current knowledge of how bax and smac regulate the bistable properties of irreversible caspase activation during apoptosis. |
2021-11-15 |
2023-08-13 |
Not clear |
| Yu Wei Xing, Kuan Zhi Li. Azithromycin inhibited oxidative stress and apoptosis of high glucose-induced podocytes by inhibiting STAT1 pathway. Drug development research. vol 82. issue 7. 2021-11-15. PMID:33655586. |
apoptosis was detected by flow cytometry and apoptosis-related proteins bcl-2, bax, caspase-3, 6, 9, and cleaved caspase-3, 6, 9 were detected by western blot. |
2021-11-15 |
2023-08-13 |
Not clear |
| Yu Wei Xing, Kuan Zhi Li. Azithromycin inhibited oxidative stress and apoptosis of high glucose-induced podocytes by inhibiting STAT1 pathway. Drug development research. vol 82. issue 7. 2021-11-15. PMID:33655586. |
azm can inhibit apoptosis and the expression of bax and cleaved caspase-3, 6, 9, and promote the expression of bcl-2 (p < .001). |
2021-11-15 |
2023-08-13 |
Not clear |
| Chen Li, Hongxu Peng, Y James Kan. Cardiomyocyte-Specific COMMD1 Deletion Suppresses Ischemia-Induced Myocardial Apoptosis. Cardiovascular toxicology. vol 21. issue 7. 2021-11-15. PMID:33900545. |
because commd1 is critically involved in rela ubiquitination and degradation, the data obtained here demonstrate that commd1 deletion leads to rela preservation in ischemic myocardium, promoting the bcl-2 anti-apoptotic pathway and suppressing the bax pro-apoptotic pathway, and in combination, leading to protection of cardiomyocytes from ischemia-induced apoptosis. |
2021-11-15 |
2023-08-13 |
Not clear |
| Liu Xiaoyu, Zhang Wei, Zhao Ming, Jia Guowe. Anti-apoptotic Effect of MiR-223-3p Suppressing PIK3C2A in Cardiomyocytes from Myocardial Infarction Rat Through Regulating PI3K/Akt Signaling Pathway. Cardiovascular toxicology. vol 21. issue 8. 2021-11-15. PMID:33999393. |
four weeks after transfection, the expression levels of mir-223-3p and pik3c2a in tissues as well as pi3k, akt, bax, and bcl-2 mrna in cells were detected by qrt-pcr and western blot, in combination with the detection of apoptosis rate by flow cytometry. |
2021-11-15 |
2023-08-13 |
rat |
| b' Gizem Ece Derici, Sibel \\xc3\\x96zda\\xc5\\x9f, \\xc4\\xb0pek Canatar, Murat Ko\\xc3\\xa. Antidiabetic activities of Bolanthus spergulifolius (Caryophyllaceae) extracts on insulin-resistant 3T3-L1 adipocytes. PloS one. vol 16. issue 6. 2021-11-15. PMID:34133443.' |
moreover, effect of extracts on apoptosis regulated by the bax and bcl-2 was investigated by quantitative reverse transcription polymerase chain reaction (qrt-pcr). |
2021-11-15 |
2023-08-13 |
Not clear |
| b' Gizem Ece Derici, Sibel \\xc3\\x96zda\\xc5\\x9f, \\xc4\\xb0pek Canatar, Murat Ko\\xc3\\xa. Antidiabetic activities of Bolanthus spergulifolius (Caryophyllaceae) extracts on insulin-resistant 3T3-L1 adipocytes. PloS one. vol 16. issue 6. 2021-11-15. PMID:34133443.' |
the extracts significantly induced apoptosis by up-regulating pro-apoptotic bax expression but down-regulated anti-apoptotic bcl-2 gene expression compared to untreated adipocytes (for all p< 0.05). |
2021-11-15 |
2023-08-13 |
Not clear |
| Haiyun Huang, Yu Ren, Hongyu Liang, Xiaojia Liu, Jisangmo Nan, Hui Zhao, Xiaoling Li. Mechanism of TCONS_00147848 regulating apoptosis of nasal mucosa cells and alleviating allergic rhinitis through FOSL2-mediated JAK/STAT3 signaling pathway. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34362948. |
and in this study, we used hematoxylin-eosin (he) staining and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) to detect the histological changes of nasal mucosa and apoptosis of nasal mucosa epithelial cells in mice, cell counting kit-8 (cck-8) assay, transwell and annexin v/pi to detect proliferation, migration and apoptosis of nasal mucosa cells of mice, respectively, enzyme-linked immunosorbent assay (elisa) to detect the expression of inflammatory factors, qrt-pcr to detect tcons_00147848 expression, western blot assay to detect the expressions of fosl2, jak-2, stat3, p-stat3, bax and bcl-2, rna-binding protein immunoprecipitation (rip) assay, rna pull down assay and co-immunoprecipitation (coip) assay to identify tcons_00147848 targeting fosl2. |
2021-11-15 |
2023-08-13 |
mouse |
| Yiqiu Cao, Zhu Dong, Dongpeng Yang, Ximiao Ma, Xiaowu Wan. Alleviation of glucolipotoxicity-incurred cardiomyocyte dysfunction by Z-ligustilide involves in the suppression of oxidative insult, inflammation and fibrosis. Chemistry and physics of lipids. vol 241. 2021-11-15. PMID:34547276. |
here, z-ligustilide elevated high glucose/high palmitic acid (hg/p)-inhibited cell viability and attenuated hg/p-induced cell apoptosis, caspase-3 activity, pro-apoptotic bax and anti-apoptotic bcl-2 protein expression. |
2021-11-15 |
2023-08-13 |
Not clear |
| Masoumeh Hajizadeh, Salar Hafez Ghoran, Hewa Jalal Azeez, Mohammad Ali Hosseinpour Feizi, Esmaeil Babae. Apoptotic Effect of Gemini Curcumin on MDA-MB-468 Breast Cancer Cell Line. Anti-cancer agents in medicinal chemistry. 2021-11-14. PMID:34773965. |
furthermore, the data revealed that curcumin nanoformulation induces apoptosis in mda-mb-468 cells through modulation of the expression of bax, bcl-2, survivin, and caspase-3. |
2021-11-14 |
2023-08-13 |
Not clear |
| Yanina Bellizzi, Juan Manuel Anselmi Relats, Patricia G Cornier, Carina M L Delpiccolo, Ernesto G Mata, Florencia Cayrol, Graciela A Cremaschi, Viviana C Blank, Leonor P Rogui. Contribution of endoplasmic reticulum stress, MAPK and PI3K/Akt pathways to the apoptotic death induced by a penicillin derivative in melanoma cells. Apoptosis : an international journal on programmed cell death. 2021-11-13. PMID:34773171. |
pharmacological inhibition of p38 and jnk, or blockage of pi3k-i/akt cascade with a dominant negative pi3k-i mutant diminished bax expression levels and parp-1 cleavage, indicating the involvement of these pathways in apoptosis. |
2021-11-13 |
2023-08-13 |
human |
| Wang Manli, Qiao Hu. Effect of miR-506-3p on Proliferation and Apoptosis of Airway Smooth Muscle Cells in Asthmatic Mice by Regulating CCL2 Gene Expression and Mediating TLR4/NF-κB Signaling Pathway Activation. Molecular biotechnology. vol 63. issue 5. 2021-11-12. PMID:33638773. |
in mir-506-3p mimic group or sirna-ccl2 group, the expression of ccl2, tlr4, nf-κb (p65) and bcl-2 decreased obviously, while that of bax increased, cell proliferation decreased, g1 phase prolonged, g2 & s phases shortened, and apoptosis rate increased significantly (all p < 0.05), whereas the opposite trends were found in mir-506-3p inhibitor group (all p < 0.05). |
2021-11-12 |
2023-08-13 |
mouse |
| Ying Huang, Xiangping Liao, Huaiwei Wang, Jianghong Luo, Shanquan Zhong, Ziliang Zhang, Fang Zhang, Jianping Chen, Fuhua Xi. Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:33883654. |
molecular analysis revealed that imp inhibited apoptosis through the down regulation of bax, caspase-3 and upregulation of bcl-2. |
2021-11-12 |
2023-08-13 |
rat |
| Taojie Zhang, Wang-Dui BaSang, Weihua Chang, Shengdong Huo, Xingbin Ma, Xianghong Ju, Sijiu Yu, Sheng Cu. Dynamics of apoptosis-related gene expression during follicular development in yak. Journal of animal physiology and animal nutrition. vol 105. issue 6. 2021-11-12. PMID:33899975. |
p53, caspase-9 (casp9), bax, bcl-2 and fas play a crucial role in the ovarian mitochondrion-dependent apoptosis and death receptor pathway. |
2021-11-12 |
2023-08-13 |
Not clear |
| Taojie Zhang, Wang-Dui BaSang, Weihua Chang, Shengdong Huo, Xingbin Ma, Xianghong Ju, Sijiu Yu, Sheng Cu. Dynamics of apoptosis-related gene expression during follicular development in yak. Journal of animal physiology and animal nutrition. vol 105. issue 6. 2021-11-12. PMID:33899975. |
overall, p53 and fas play an essential role in inducing gc apoptosis, and bax, bcl-2, casp9 and p53 are involved in oviduct epithelial regeneration in yak. |
2021-11-12 |
2023-08-13 |
Not clear |