| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minke Bekker, Shameemah Abrahams, Ben Loos, Soraya Bardie. Can the interplay between autophagy and apoptosis be targeted as a novel therapy for Parkinson's disease? Neurobiology of aging. vol 100. 2021-11-08. PMID:33516928. |
moreover, besides inhibiting mammalian target of rapamycin, akt is associated with decreased bax expression, thereby acting as both an autophagy inducer and apoptosis inhibitor. |
2021-11-08 |
2023-08-13 |
Not clear |
| Mona Pourbaferani, Sima Modiri, Amir Norouzy, Hadi Maleki, Mohadeseh Heidari, Leila Alidoust, Venus Derakhshan, Hossein Shahbani Zahiri, Kambiz Akbari Noghab. A Newly Characterized Potentially Probiotic Strain, Lactobacillus brevis MK05, and the Toxicity Effects of its Secretory Proteins Against MCF-7 Breast Cancer Cells. Probiotics and antimicrobial proteins. vol 13. issue 4. 2021-11-08. PMID:33687634. |
the changes in expression of the three genes involved in the apoptosis pathway (bax, bcl-2, and bcl2l11) in mcf-7 cells treated with the lb-ppsps confirm its cytotoxic activity and apoptosis induction. |
2021-11-08 |
2023-08-13 |
Not clear |
| Huiqin Cao, Wei Wei, Ruirong Xu, Xing Cu. Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34140535. |
ginsenoside rg1 can restore hematopoietic function by inhibiting bax translocation-mediated mitochondrial apoptosis in aplastic anemia. |
2021-11-08 |
2023-08-13 |
mouse |
| Huiqin Cao, Wei Wei, Ruirong Xu, Xing Cu. Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34140535. |
levels of markers of mitochondrial apoptosis in the rg1-treated group were significantly better than those in the aa model group, implying that rg1 might improve hematopoietic stem cells and thereby restore hematopoietic function in aa by suppressing the mitochondrial apoptosis mediated by bax translocation. |
2021-11-08 |
2023-08-13 |
mouse |
| Xiaohao Xu, Guang Sun, Jianzeng Liu, Jingyuan Zhou, Jing Li, Zhuo Sun, Xiangzhu Li, Hong Chen, Daqing Zhao, Rui Jiang, Liwei Su. Akt activation-dependent protective effect of wild ginseng adventitious root protein against UVA-induced NIH-3T3 cell damage. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 29. issue 6. 2021-11-08. PMID:34448508. |
moreover, arp treatment markedly inhibited uva-induced apoptosis, cell cycle arrest and dna fragmentation, while also significantly reversing uva effects (elevated bax levels, reduced bcl-2 expression) by reducing bax levels and increasing bcl-2 expression. |
2021-11-08 |
2023-08-13 |
Not clear |
| Hui Song Cui, So Young Joo, Yoon Soo Cho, Ji Heon Park, Yu Mi Ro, June-Bum Kim, Cheong Hoon Se. Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34453089. |
keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers (keratin 5 and 14), activation markers (keratin 6 and 17), differentiation markers (keratin 1, 10, and involucrin), apoptosis factors (bax, bcl2, and caspase 14), and proliferation/differentiation regulators (p21 and p27) was investigated to compared with that of those in keratinocytes derived from normal skin tissue. |
2021-11-08 |
2023-08-13 |
human |
| Cihan Gur, Ozge Kandemir, Fatih Mehmet Kandemi. Investigation of the effects of hesperidin administration on abamectin-induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, and JAK2/STAT3 pathways. Environmental toxicology. 2021-11-08. PMID:34748272. |
in addition, bax protected against apoptosis and autophagy by reducing the caspase-3, beclin-1, lc3a, and lc3b expressions, and increasing bcl-2 expression. |
2021-11-08 |
2023-08-13 |
rat |
| Shuang Zhao, Ling Tang, Wangqing Chen, Juan Su, Fangfang Li, Xiang Chen, Lisha W. Resveratrol-induced apoptosis is associated with regulating the miR-492/CD147 pathway in malignant melanoma cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 4. 2021-11-05. PMID:33009925. |
subsequently, we investigated cell apoptosis by flow cytometry, as well as detected apoptotic-associated proteins including parp, caspase-3, bcl-2, and bax by western blotting. |
2021-11-05 |
2023-08-13 |
Not clear |
| Fatemeh Forouzanfar, Elham Asadpour, Hossein Hosseinzadeh, Mohammad Taher Boroushaki, Afrouz Adab, Seyedeh Hoda Dastpeiman, Hamid R Sadeghni. Safranal protects against ischemia-induced PC12 cell injury through inhibiting oxidative stress and apoptosis. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 4. 2021-11-05. PMID:33128592. |
also, propidium iodide (pi) flow cytometry assay and western blotting of bax, bcl-2, and cleaved caspase-3 were performed for assessment of apoptosis. |
2021-11-05 |
2023-08-13 |
Not clear |
| Fang Jiang, Jun Lou, Xi-Ming Zheng, Xi-Yong Yan. LncRNA MIAT regulates autophagy and apoptosis of macrophage infected by Mycobacterium tuberculosis through the miR-665/ULK1 signaling axis. Molecular immunology. vol 139. 2021-11-05. PMID:34454184. |
functionally, disruption of miat effectively facilitated cell viability and restricted apoptosis ability concomitant with the downregulation of bax and cleaved caspase-3 along with an accumulation of bcl-2 in bcg-infected thp-1 cells. |
2021-11-05 |
2023-08-13 |
human |
| Basel A Abdel-Wahab, Hussain Alqhtani, Ismail A Walbi, Hassan A Albarqi, Adel M Aljadaan, Masood M Khateeb, Emad H M Hassanei. Piclamilast mitigates 1,2-dimethylhydrazine induced colon cancer in rats through modulation of Ras/PI3K/Akt/mTOR and NF-κβ signaling. Chemico-biological interactions. vol 350. 2021-11-05. PMID:34627785. |
furthermore, pic promoted crc apoptosis, and increased the gene expression of the apoptotic factors, caspase-3 and bax, and decreased the anti-apoptotic factor bcl-2. |
2021-11-05 |
2023-08-13 |
rat |
| Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Soo Hee Lee, Sung Il Bae, Kyeong-Eon Park, Yeran Hwang, Il-Woo Shin, Sangcheol Yoon, Ju-Tae Soh. Lipid emulsion attenuates extrinsic apoptosis induced by amlodipine toxicity in rat cardiomyoblasts. Human & experimental toxicology. vol 40. issue 4. 2021-11-04. PMID:33030052. |
the effects of amlodipine, lipid emulsion, ly 294002, and glibenclamide, either alone or in combination, on cell viability and count, apoptosis, and expression of cleaved caspase-3 and -8, and bax were examined. |
2021-11-04 |
2023-08-13 |
rat |
| Zhu Wu, Jie Chen, Wei Zhao, Chun-Hua Zhuo, Qiong Che. Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-κB pathways via targeting SIRT1. The Kaohsiung journal of medical sciences. vol 37. issue 3. 2021-11-04. PMID:33058411. |
the expressions of mir-181a and sirt1 were identified by qrt-pcr, the levels of sirt1, nrf2, p-p65, bcl-2 and bax were detected by western blotting, the inflammatory cytokines tnf-α, il-6 and il-1β were detected by elisa, and the apoptosis was measured by flow cytometry. |
2021-11-04 |
2023-08-13 |
mouse |
| Ying Liu, Yun Liu, Hong-Li Zhang, Fen-Fang Yu, Xiao-Rui Yin, Yan-Fang Zhao, Fei Ye, Xiang-Qi W. Amelioratory effect of neoandrographolide on myocardial ischemic-reperfusion injury by its anti-inflammatory and anti-apoptotic activities. Environmental toxicology. vol 36. issue 12. 2021-11-04. PMID:34397165. |
compared to the i/r group, neo significantly suppressed imi, infarct size, inflammatory cell infiltration, cell apoptosis, inflammatory cytokines, bax, cleaved caspase-3, p-ikba, and p-nf-κb protein expressions, and the translocation of nf-kb subunit p65 from the cytoplasm to the nucleus in vivo or in vitro. |
2021-11-04 |
2023-08-13 |
mouse |
| Xiaodan Li, Xiaolei Yao, Haiqiang Xie, Guomin Zhang, Mingtian Deng, Kaiping Deng, Xiaoxiao Gao, Yongjin Bao, Kang Li, Feng Wan. PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells. Theriogenology. vol 176. 2021-11-04. PMID:34619436. |
in contrast to ppp2r2a overexpression, ppp2r2a interference greatly promoted cell apoptosis and the expression of bax, casp3, casp9 and bax/bcl-2. |
2021-11-04 |
2023-08-13 |
Not clear |
| Panpan Dong, Lei Xia, Lanyawen Hu, Kai Yang, Huanhuan Wang, Ping Y. Runjing Decoction alleviated cyclophosphamide-induced oligoasthenospermia rats by inhibiting cell apoptosis via RXFP1/AKT/FOXO1 pathway. Andrologia. vol 53. issue 11. 2021-11-03. PMID:34396564. |
rjd suppressed cell apoptosis, inhibited the expression of rxfp1, foxo1, pi3k, akt and bax, and promoted the expression levels of bcl-2 in testicular tissue of oligoasthenospermia rats. |
2021-11-03 |
2023-08-13 |
rat |
| Elif Erdem Guzel, Nalan Kaya Tektemur, Ahmet Tektemur, Hilal Acay, Ayfer Yildiri. The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats. Andrologia. vol 53. issue 11. 2021-11-03. PMID:34431122. |
there was an increase in the apoptotic index, caspase 3 (casp3), bcl2-associated x apoptosis regulator (bax), dynamin-related protein 1 (drp1) expression and total oxidative status (tos) in the dox group, while mitofusin-2 (mfn2), total antioxidative status (tas) and serum testosterone levels of the dox group reduced when compared with the other groups. |
2021-11-03 |
2023-08-13 |
rat |
| Wen-Yuan Li, Xiu-Mei Fu, Zhen-Dong Wang, Zhi-Gang Li, Duo Ma, Ping Sun, Gui-Bo Liu, Xiao-Feng Zhu, Ying Wan. Krüppel-like factor 7 attenuates hippocampal neuronal injury after traumatic brain injury. Neural regeneration research. vol 17. issue 3. 2021-11-02. PMID:34380908. |
the results revealed that, after stretch injury and oxygen-glucose deprivation, klf7 greatly reduced apoptosis, activated caspase-3 and lactate dehydrogenase, downregulated the expression of the apoptotic markers b-cell lymphoma 2 (bcl-2)-associated x protein (bax) and cleaved caspase-3, and increased the expression of βiii-tubulin and the antiapoptotic marker bcl-2. |
2021-11-02 |
2023-08-13 |
mouse |
| Peifang Cong, Teng Wang, Changci Tong, Ying Liu, Lin Shi, Shun Mao, Xiuyun Shi, Hongxu Jin, Yunen Liu, Mingxiao Ho. Resveratrol ameliorates thoracic blast exposure-induced inflammation, endoplasmic reticulum stress and apoptosis in the brain through the Nrf2/Keap1 and NF-κB signaling pathway. Injury. vol 52. issue 10. 2021-11-02. PMID:34454721. |
we also examined the mice for histopathological changes by hematoxylin-eosin staining; the expressions of inflammatory-related factors by elisa; endoplasmic reticulum stress in brain tissue via the generation of reactive oxygen species (ros) and the expressions of inositol-requiring enzyme-α (ire-α) and c/ebp homologous protein (chop); apoptosis by measuring levels of bax, p53 and bcl-2. |
2021-11-02 |
2023-08-13 |
mouse |
| Refaat A Eid, Mashael Mohammed Bin-Meferij, Attalla Farag El-Kott, Samy M Eleawa, Mohamed Samir Ahmed Zaki, Mubarak Al-Shraim, Fahmy El-Sayed, Muhammad Alaa Eldeen, Mahmoud A Alkhateeb, Samah A Alharbi, Hussain Aldera, Mohammad A Khali. Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK. Journal of cardiovascular translational research. vol 14. issue 4. 2021-11-01. PMID:32239434. |
this results in inhibition of cardiomyocyte apoptosis through increasing bcl-2 levels, activity, and levels of mnsod; decreasing expression of bax; decreasing cytochrome c release; and improving mitochondria biogenesis through upregulation of mfn-2. |
2021-11-01 |
2023-08-13 |
rat |