| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Liang, Xiangyong Li, Rongwen Lin, Xin Zhang, Huimin Wang, Ning Tan, Keshen Li, Xudong Tang, Keyuan Zhou, Tao L. Combinatorial gene targeting hTERT and BI-1 in CNE-2 nasopharyngeal carcinoma cell line. Biomedical reports. vol 1. issue 2. 2021-10-21. PMID:24648937. |
in recent studies, we demonstrated that overexpression of the bax inhibitor-1 (bi-1) induces cell transformation in nih3t3 cells and that knockdown of bi-1 and human telomerase reverse transcriptase (htert) gene expression suppresses npc cell proliferation and induces apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| Guangyi Liu, Tao Wang, Tinging Wang, Jinming Song, Zhen Zho. Effects of apoptosis-related proteins caspase-3, Bax and Bcl-2 on cerebral ischemia rats. Biomedical reports. vol 1. issue 6. 2021-10-21. PMID:24649043. |
in conclusion, cerebral ischemia/reperfusion injury may cause neurological impairment and lead to a change of ethology, and neuron apoptosis may be associated with the activation of caspase-3 and bax and the downregulation of bcl-2. |
2021-10-21 |
2023-08-12 |
rat |
| Xue Lu, Chun Li, Yong-Kun Wang, Kun Jiang, Xiao-Dong Ga. Sorbitol induces apoptosis of human colorectal cancer cells via p38 MAPK signal transduction. Oncology letters. vol 7. issue 6. 2021-10-21. PMID:24932277. |
during sorbitol-induced apoptosis, the mitochondrial pathway was activated by a dose-dependent increase in bax expression and cytochrome |
2021-10-21 |
2023-08-13 |
human |
| Heng Zhou, Yuan Yuan, Yuan Liu, Wei Deng, Jing Zong, Zhou-Yan Bian, Jia Dai, Qi-Zhu Tan. Icariin attenuates angiotensin II-induced hypertrophy and apoptosis in H9c2 cardiomyocytes by inhibiting reactive oxygen species-dependent JNK and p38 pathways. Experimental and therapeutic medicine. vol 7. issue 5. 2021-10-21. PMID:24940396. |
furthermore, icariin repressed ang ii-induced cell apoptosis and protein expression levels of bax and cleaved-caspase 3, while the expression of bcl-2 was increased by icariin. |
2021-10-21 |
2023-08-13 |
rat |
| Ling-Yun Zhou, Fang-Yuan Chen, Li-Jing Shen, Hai-Xia Wan, Ji-Hua Zhon. Arsenic trioxide induces apoptosis in the THP1 cell line by downregulating EVI-1. Experimental and therapeutic medicine. vol 8. issue 1. 2021-10-21. PMID:24944602. |
these results indicated that ato inhibited the proliferation and induced apoptosis in thp1 cells partially via blocking the inhibitory effects of evi-1 on the jnk signaling pathway with the involvement of apoptosis-associated proteins, including bax, bcl-2, bcl-xl and caspase-3. |
2021-10-21 |
2023-08-13 |
Not clear |
| Qun Lu, Shaohong Luo, Yongfang We. Effect of ligustilide on Ang II-induced hypertrophy in cardiomyocytes and the potential mechanisms. Experimental and therapeutic medicine. vol 8. issue 1. 2021-10-21. PMID:24944617. |
the cells were then were stimulated by ang ii and lig for 1-3 days, following which the cell surface area, intracellular protein concentration, rate of apoptosis and the expression levels of p53, bcl-2 and bax were determined. |
2021-10-21 |
2023-08-13 |
rat |
| Dejun Zhang, Jie Xiang, Yuming Gu, Wei Xu, Hao Xu, Maoheng Zu, Dongsheng Pei, Junnian Zhen. Inhibition of mammalian target of rapamycin by rapamycin increases the radiosensitivity of esophageal carcinoma Eca109 cells. Oncology letters. vol 8. issue 2. 2021-10-21. PMID:25009644. |
furthermore, the cell apoptosis rate and expression of cleaved caspase-3 and bax in the experimental group were higher than those of the control groups, whereas the expression of bcl-2 was less than that of the control groups. |
2021-10-21 |
2023-08-13 |
Not clear |
| Hai-Yan Song, Xiao-Hui Deng, Xin-Fang Hou, Guo-Yan Yuan, Zhen-Dong Zhu, Ming-Xin Re. Effect of ECRG2 in combination with cisplatin on the proliferation and apoptosis of EC9706 cells. Experimental and therapeutic medicine. vol 8. issue 5. 2021-10-21. PMID:25289046. |
thus, ecrg2 in combination with ddp had an enhanced inhibitory effect on ec9706 cell proliferation compared with that of ecrg2 alone, and an increased inductive effect on ec9706 cell apoptosis, possibly due to the upregulation of the expression of bax. |
2021-10-21 |
2023-08-13 |
Not clear |
| Jianjun Li, Chuan Xiong, Pan Xu, Qiang Luo, Ronggui Zhan. Puerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1/Nrf2/ARE signaling pathway. Bioengineered. vol 12. issue 1. 2021-10-21. PMID:33356808. |
this loss of cell viability in du145 and pc-3 cells by peu was mediated by the induction of apoptosis via up-regulation of bax and cleaved-caspase-3, but downregulation of bcl-2. |
2021-10-21 |
2023-08-13 |
Not clear |
| Rong Li, Wuqiang Che, Naizheng Liang, Shu Deng, Zhijie Song, Lei Yan. Silent FOSL1 Enhances the Radiosensitivity of Glioma Stem Cells by Down-Regulating miR-27a-5p. Neurochemical research. vol 46. issue 12. 2021-10-21. PMID:34420141. |
radiotherapy down-regulated cell viability and the expressions of fosl1 and bcl-2, but up-regulated cell apoptosis and the expressions of cleaved caspase-3 and bax, which could be partially reversed by overexpressed fosl1 or further enhanced by shfosl1. |
2021-10-21 |
2023-08-13 |
Not clear |
| Ping Tan, Hao Cai, Qiang Wei, Xiaodi Tang, Qianfeng Zhang, Michal Kopytynski, Junxiao Yang, Yong Yi, Hu Zhang, Qiyong Gong, Zhongwei Gu, Rongjun Chen, Kui Lu. Enhanced chemo-photodynamic therapy of an enzyme-responsive prodrug in bladder cancer patient-derived xenograft models. Biomaterials. vol 277. 2021-10-21. PMID:34508957. |
western blots analysis confirmed that proteins promoting apoptosis (bax, cleaved caspase-3, cleaved parp) and dna damage (γh2a.x) were up-regulated, while those inhibiting apoptosis (bcl-2) and mitosis (pan-actin and α/β-tubulin) were down-regulated after chemo-pdt treatment. |
2021-10-21 |
2023-08-13 |
human |
| Tasneem H Patwa, Yanfei Wang, Fred R Miller, Steve Goodison, Subramaniam Pennathur, Timothy J Barder, David M Lubma. A novel phosphoprotein analysis scheme for assessing changes in premalignant and malignant breast cell lines using 2D liquid separations, protein microarrays and tandem mass spectrometry. Proteomics. Clinical applications. vol 3. issue 1. 2021-10-20. PMID:19194518. |
three regulators of apoptosis, bad, bax and acinus, were also differentially phosphorylated in the two cell lines. |
2021-10-20 |
2023-08-12 |
human |
| Surajit Karmakar, Subhasree Roy Choudhury, Naren L Banik, Swapan K Ra. N-(4-Hydroxyphenyl) Retinamide Potentiated Anti-tumor Efficacy of Genistein in Human Ewing's Sarcoma Xenografts. World journal of oncology. vol 2. issue 2. 2021-10-20. PMID:21822457. |
combination therapy increased bax:bcl-2 ratio to trigger mitochondrial release of smac/diablo into the cytosol to down regulate the baculovirus inhibitor-of-apoptosis repeat containing (birc) proteins such as birc-2 and birc-3 and thereby promote apoptosis. |
2021-10-20 |
2023-08-12 |
human |
| Kamal A Mohammed, Xiaohong Wang, Eugene P Goldberg, Veena B Antony, Najmunnisa Nasree. Silencing receptor EphA2 induces apoptosis and attenuates tumor growth in malignant mesothelioma. American journal of cancer research. vol 1. issue 3. 2021-10-20. PMID:21968554. |
apoptosis was characterized by fadd expression, activated caspase-8, caspase-3 and induction of bax, bak, and bid as revealed by gearray and protein fractionation assays. |
2021-10-20 |
2023-08-12 |
Not clear |
| Zhiruo Miao, Zhiying Miao, Shengchen Wang, Xu Shi, Shiwen X. Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN/PI3K/AKT in grass carp hepatocytes. Environmental pollution (Barking, Essex : 1987). vol 290. 2021-10-20. PMID:34488159. |
we found that imi exposure enhanced reactive oxygen species (ros) generation, inhibiting the activities of sod, cat and t-aoc, exacerbating the accumulation of mda, aggravating the expression of mitochondrial apoptosis pathway (cyt-c, bax, caspase9 and caspase3) related genes and decreased the expression of anti-apoptosis gene b-cell lymphoma-2 (bcl-2). |
2021-10-20 |
2023-08-13 |
cat |
| Zhiruo Miao, Zhiying Miao, Shengchen Wang, Xu Shi, Shiwen X. Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN/PI3K/AKT in grass carp hepatocytes. Environmental pollution (Barking, Essex : 1987). vol 290. 2021-10-20. PMID:34488159. |
in addition, que and imi co-treatment significantly restored the activity of anti-oxidant enzymes, downregulated ros level and apoptosis rate, thereby alleviating the depletion of mitochondrial membrane potential (ΔΨm) and the expression of cytochrome c (cyt-c), bcl-2-associated x (bax), and cysteinyl aspartate specific proteinases (caspase9 and 3), increasing the bcl-2 level. |
2021-10-20 |
2023-08-13 |
cat |
| Lili Liu, Xiangling Liu, Liangyou Zhao, Yuan Li. 1,8-cineole alleviates bisphenol A-induced apoptosis and necroptosis in bursa of Fabricius in chicken through regulating oxidative stress and PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 226. 2021-10-20. PMID:34634738. |
tunel analysis results, histopathological variations, and the overexpression of proapoptosis biomakers (caspase 3, bax, cyt-c, and p53) and necroptosis pathway-related factors (ripk1, ripk3, mlkl, and fadd) indicated that bpa exposure induced the apoptosis and necroptosis in chicken bf. |
2021-10-20 |
2023-08-13 |
cat |
| Mariam I Gamal El-Din, Fadia S Youssef, Riham S Said, Mohamed L Ashour, Omayma A Eldahshan, Abdel Nasser B Singa. Chemical constituents and gastro-protective potential of Pachira glabra leaves against ethanol-induced gastric ulcer in experimental rat model. Inflammopharmacology. vol 29. issue 1. 2021-10-19. PMID:32914383. |
it also hindered apoptosis through decreasing bax and increasing bcl-2 expression hence decreasing bax/bcl2 ratio with a subsequent reduction in caspase 3 expression. |
2021-10-19 |
2023-08-13 |
rat |
| Yu Luo, Lin-Jie Zeng, Xiao-Qin Liu, Lu Li, Qi-Yan Zen. cDNA cloning of a novel lectin that induce cell apoptosis from Artocarpus hypargyreus. Chinese journal of natural medicines. vol 19. issue 2. 2021-10-19. PMID:33641787. |
ahl inhibits cell proliferation in a time- and dose-dependent manner through apoptosis, evidenced by morphological changes, phosphatidylserine externalization, poly adp-ribose polymerase (parp) cleavage, bad and bax up-regulation, and caspase-3 activation. |
2021-10-19 |
2023-08-13 |
Not clear |
| Umamaheswari Natarajan, Thiagarajan Venkatesan, Sivanesan Dhandayuthapani, Priya Dondapatti, Appu Rathinavel. Differential mechanisms involved in RG-7388 and Nutlin-3 induced cell death in SJSA-1 osteosarcoma cells. Cellular signalling. vol 75. 2021-10-18. PMID:32827690. |
nutlin-3, on the other hand, appears to increase the levels of bax, leading to the inactivation of bcl-2, consequently loss of mitochondrial membrane potential and release of cytochrome c (cyt c) and elevation of apaf-1 triggering apoptosis. |
2021-10-18 |
2023-08-13 |
Not clear |