| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahnoush Kolahdouz, Faranak Jafari, Farahnaz Falanji, Samad Nazemi, Mohammad Mohammadzadeh, Mehdi Molavi, Bahareh Ami. Clavulanic Acid Attenuating Effect on the Diabetic Neuropathic Pain in Rats. Neurochemical research. vol 46. issue 7. 2021-10-18. PMID:33846883. |
the expression of the glutamate transport 1 (glt1), genes of oxidative stress including inducible nitric oxide synthase (inos), proinflammatory cytokine, tumor necrosis factor alpha (tnf-α), as well as genes involved in the apoptosis including bcl2, bcl2-associated x (bax) were measured in the spinal cord tissue by real time pcr, on day 42. |
2021-10-18 |
2023-08-13 |
rat |
| Ju-Ha Kim, Ji Hoon Jung, Hyo-Jung Lee, Deok-Yong Sim, Eunji Im, Jieon Park, Woon-Yi Park, Chi-Hoon Ahn, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Ki. UBE2M Drives Hepatocellular Cancer Progression as a p53 Negative Regulator by Binding to MDM2 and Ribosomal Protein L11. Cancers. vol 13. issue 19. 2021-10-16. PMID:34638383. |
herein, ube2m depletion suppressed viability and proliferation and induced cell cycle arrest and apoptosis via cleavages of parp and caspase 3 and upregulation of p53, bax and puma in hepg2, huh7 and hep3b cells. |
2021-10-16 |
2023-08-13 |
mouse |
| Alexander Sirotkin, Zuzana Záhoranska, Adam Tarko, Zuzana Fabova, Saleh Alwasel, Abdel Halim Harrat. Plant polyphenols can directly affect ovarian cell functions and modify toluene effects. Journal of animal physiology and animal nutrition. vol 105. issue 1. 2021-10-15. PMID:33058312. |
the influence of toluene alone and in combination with plant polyphenols apigenin, daidzein or rutin on viability, proliferation (proliferating cell nuclear antigen accumulation), apoptosis (bax accumulation) and release of progesterone (p), testosterone (t) and estradiol (e) in cultured porcine ovarian granulosa cells was evaluated. |
2021-10-15 |
2023-08-13 |
Not clear |
| M M Romi, N Anggorowati, D S Maulida, M W A H Suskalanggeng, W A W Setyaningsih, D C R Sari, N Arfia. Upregulation of Megalin, Cubilin, NGAL mRNA expression in kidney may represent tubular injury and apoptosis in chronic condition of rat diabetic model. The Medical journal of Malaysia. vol 76. issue 1. 2021-10-15. PMID:33510115. |
diabetes mellitus (dm) leads to microvascular injury development and produces diabetes nephropathy (dn) with proteinuria, tubular injury, apoptosis and autophagy with upregulation of bax, basp and mtorc-1. |
2021-10-15 |
2023-08-13 |
rat |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
apoptosis of nucleus pulposus cells was detected by flow cytometry and bcl2, bax and caspase 3. |
2021-10-15 |
2023-08-13 |
human |
| Xingxue Pan, Yu Zhou, Xueqin Duan, Jing Cui, Jia Liu, Xiaoping Song, Wuren Ma, Weimin Zhang, Yingqiu Liu, Yunpeng Fa. The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine. Research in veterinary science. vol 140. 2021-10-15. PMID:34399280. |
the results showed that pcp could significantly reduce the apoptosis rate induced by tgev, reduce the expression of ros, reduce tgev replication, increase the expression levels of bcl-2 and bax genes, increase the expression of bcl-2 protein, decreased the expression of cyto c protein, and reduce the amount of cleaved caspase 3. |
2021-10-15 |
2023-08-13 |
Not clear |
| Hai-Fan Yu, Lian-Wen Zheng, Zhan-Qing Yang, Yu-Si Wang, Ting-Ting Wang, Zhan-Peng Yue, Bin Gu. TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway. Experimental & molecular medicine. vol 53. issue 9. 2021-10-15. PMID:34497345. |
moreover, taz prevented stromal cell apoptosis by upregulating bcl2 expression and inhibiting casp3 activity and bax expression. |
2021-10-15 |
2023-08-13 |
Not clear |
| A P Sklifasovskaya, M L Blagonravov, A Yu Ryabinina, M M Azova, V A Goryache. Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes in Wistar-Kyoto and SHR Rats with Insulin-Dependent Diabetes Mellitus. Bulletin of experimental biology and medicine. vol 171. issue 5. 2021-10-15. PMID:34617183. |
initiation of apoptosis by the mitochondrial pathway depends on the balance between proapoptotic and antiapoptotic factors, in particular, bax and bcl-2. |
2021-10-15 |
2023-08-13 |
rat |
| Eman A Abdelghffar, Wael A Obaid, Abdelbaset M Elgamal, Rachid Daoud, Mansour Sobeh, Mohamed A El Rae. Pea (Pisum sativum) peel extract attenuates DOX-induced oxidative myocardial injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 143. 2021-10-15. PMID:34649330. |
these data show that p. sativum has a cardio-protective impact against dox-induced cardiomyocyte damage in mice via boosting endogenous antioxidants, decreasing inflammation, and regulating bcl-2 and bax apoptosis pathway, which might be related to the presence of flavonoid glycosides. |
2021-10-15 |
2023-08-13 |
mouse |
| Zahra Salemi, Reza Azizi, Faranak Fallahian, Mahmoud Aghae. Integrin α2β1 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial-mesenchymal transition. Journal of cellular physiology. vol 236. issue 7. 2021-10-14. PMID:33305380. |
moreover, inhibition of integrin α2β1 induces apoptosis through the activation of ros, bax protein upregulation, caspase-3 activation, and depletion of ΔΨm. |
2021-10-14 |
2023-08-13 |
Not clear |
| Hui Bai, Tingting Li, Yan Yu, Ningcong Zhou, Huijuan Kou, Yingying Guo, Liang Yang, Peishi Ya. Cytoprotective Effects of Taurine on Heat-Induced Bovine Mammary Epithelial Cells In Vitro. Cells. vol 10. issue 2. 2021-10-14. PMID:33525569. |
taurine also alleviated the rates of cell apoptosis and markedly depressed the mrna expressions of bcl2 associated x, apoptosis regulator (bax) and caspase3. |
2021-10-14 |
2023-08-13 |
cattle |
| Huifeng Cheng, Miaojun Lv, Rulin Mi, Guofang Xu. Amifostine ameliorates cerebral ischaemia-reperfusion injury via p38-mediated oxidative stress and mitochondrial dysfunction. Folia neuropathologica. vol 58. issue 4. 2021-10-13. PMID:33480238. |
furthermore, amifostine suppressed neuronal apoptosis, accompanied by the reduction of bax, cleaved caspase-9, cleaved caspase-3, and bcl-2 upregulation. |
2021-10-13 |
2023-08-13 |
mouse |
| Hadi Tavakkoli, Ahmad Khosravi, Iraj Sharifi, Zohreh Salari, Ehsan Salarkia, Reza Kheirandish, Kazem Dehghantalebi, Maziar Jajarmi, Seyedeh Saedeh Mosallanejad, Shahriar Dabiri, Alireza Keyhan. Partridge and embryonated partridge egg as new preclinical models for candidiasis. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33483560. |
in immunohistochemistry assay, low expression of bcl-2 and increased expression of bax confirmed apoptosis. |
2021-10-13 |
2023-08-13 |
human |
| Chien-Yu Huang, Yu-Jia Chang, Po-Li Wei, Chin-Sheng Hung, Weu Wan. Methyl gallate, gallic acid-derived compound, inhibit cell proliferation through increasing ROS production and apoptosis in hepatocellular carcinoma cells. PloS one. vol 16. issue 3. 2021-10-13. PMID:33725002. |
the western blot analysis showed that mg activated cleavage of caspase-3 and poly (sdp ribose) polymerase (parp), modulated levels of the bcl2, bax, and bad ligands, and induced apoptosis. |
2021-10-13 |
2023-08-13 |
human |
| Yanxiang Zhao, Haiyan Zhou, Wenhui Don. LncRNA RHPN1-AS1 promotes the progression of nasopharyngeal carcinoma by targeting CELF2 expression. Experimental and molecular pathology. vol 122. 2021-10-13. PMID:34358519. |
rhpn1-as1 silencing inhibited cell viability, capacity of proliferation, migration and invasion, promoted apoptosis, decreased protein expression of bcl-2, mmp2/9, increased protein expression of bax, caspase-3, and timp2 of npc cells. |
2021-10-13 |
2023-08-13 |
Not clear |
| Ahmet Yardim, Fatih Mehmet Kandemir, Selcuk Ozdemir, Sefa Kucukler, Selim Comakli, Cihan Gur, Hamit Celi. Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways. Neurotoxicology. vol 81. 2021-10-12. PMID:33038355. |
additionally, vincristine was determined to cause er stress and apoptosis by increasing perk, ire1, atf-6, and grp78 and caspase 3 and bax expressions and by decreasing bcl-2 expressions. |
2021-10-12 |
2023-08-13 |
rat |
| M S Araujo, M D Guastali, F Paulini, A N Silva, M H Tsunemi, P K Fontes, A C S Castilho, F C Landim-Alvareng. Molecular and cellular effects of insulin-like growth factor-1 and LongR3-IGF-1 on in vitro maturation of bovine oocytes: comparative study. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 55. 2021-10-12. PMID:33038561. |
addition effects of insulin-like growth factor-1 (igf-1) and its synthetic analogue insulin-like growth factor-1 recombinant-3 (longr3-igf-1) after in vitro maturation (ivm) of cattle cumulus-oocyte complexes (cocs) were compared and evaluated on meiotic progression, apoptosis and profile genes of oocyte competence (gdf9, bmp15, bax, bcl2, oosp1, igfbp2, igbfp4 and igfbp5), and their respective cumulus cells (areg, egfr, fshr, cox2, bax, bcl2, igfbp2, igfbp4 and igfbp5). |
2021-10-12 |
2023-08-13 |
cattle |
| Meghan E Turnis, Ewa Kaminska, Kaitlyn H Smith, Brittany J Kartchner, Peter Vogel, Jonathan D Laxton, Richard A Ashmun, Paul A Ney, Joseph T Opferma. Requirement for antiapoptotic MCL-1 during early erythropoiesis. Blood. vol 137. issue 14. 2021-10-12. PMID:33512417. |
functionally, mcl-1 relies upon its ability to prevent apoptosis to promote erythroid development because codeletion of the proapoptotic effectors bax and bak can overcome the requirement for mcl-1 expression. |
2021-10-12 |
2023-08-13 |
human |
| Yanhe Lue, Ronald Swerdloff, Yue Jia, Christina Wan. The emerging role of mitochondrial derived peptide humanin in the testis. Biochimica et biophysica acta. General subjects. vol 1865. issue 12. 2021-10-12. PMID:34534645. |
humanin interacting with igfbp-3 and/or bax (pro-apoptotic proteins) prevents the activation of germ cell apoptosis. |
2021-10-12 |
2023-08-13 |
Not clear |
| Linlin Dai, Luyao Wang, Cheng Tan, Jun Cai, Hongsheng Shen, Ting Zhang, Shuang Zhi, Zibo Yang, Yunhui Hu, Xiumei Zhao, Dongdong L. Sophoridine Derivatives Induce Apoptosis and Autophagy to Suppress the Growth of Triple-Negative Breast Cancer through Inhibition of mTOR Signaling. ChemMedChem. 2021-10-12. PMID:34569159. |
cellular functional assays showed that representative compounds could induce g1-phase arrest and trigger apoptosis, evidenced by the alteration of bax, bcl-2, caspase-3 and parp levels. |
2021-10-12 |
2023-08-13 |
mouse |