| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuko Fukui, Satoru Hayano, Noriaki Kawanabe, Ziyi Wang, Akira Shimada, Megumu K Saito, Isao Asaka, Hiroshi Kamiok. Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency. Pathology international. 2021-09-29. PMID:34587661. |
increased expression of the pro-apoptotic genes bax and casp9 further indicated that rpl5 haploinsufficiency triggered p53-mediated apoptosis in chondrocytes. |
2021-09-29 |
2023-08-13 |
Not clear |
| Mehmet Emin Erdal, Senay Görücü Yilmaz, Mustafa Ertan Ay, Hale Güler Kara, Aynur Avci Özge, Bahar Tasdele. A Study Investigating the Role of 2 Candidate SNPs in Bax and Bcl-2 Genes in Alzheimer's Disease. Puerto Rico health sciences journal. vol 39. issue 3. 2021-09-28. PMID:33031695. |
the proto-oncogene bax (bcl-2-associated x protein) and related protein bcl-2 (b-cell chronic lymphocytic leukemia/lymphoma-2) genes are triggers of apoptosis in alzheimer's disease (ad). |
2021-09-28 |
2023-08-13 |
Not clear |
| Diba Borzabadi Farahani, Hassan Akrami, Behrouz Moradi, Kiumars Mehdizadeh, Mohammad Reza Fattah. The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells. Biochemical genetics. vol 59. issue 5. 2021-09-28. PMID:33725258. |
first, gastric cancer stem-like cells were transfected by hsa-mir-451b inhibitor then we used real-time rt-pcr to evaluate its effect on the expression of hsa-mir-451b and two of its direct target genes, stemness markers such as klf4, sox2, cd44, oct3/4 and nanog genes and finally akt, pi3k, bcl-2, bax, casp3 and pcna genes involved in apoptosis. |
2021-09-28 |
2023-08-13 |
Not clear |
| Diba Borzabadi Farahani, Hassan Akrami, Behrouz Moradi, Kiumars Mehdizadeh, Mohammad Reza Fattah. The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells. Biochemical genetics. vol 59. issue 5. 2021-09-28. PMID:33725258. |
even, under hsa-mir-451b inhibition, downregulation of akt, pi3k, bcl-2 and pcna as well as upregulation of bax and casp3 revealed a movement towards apoptosis in mkn-45 stem-like cells. |
2021-09-28 |
2023-08-13 |
Not clear |
| Lu Gao, Yun Ji, Lulu Wang, Meixia He, Xiaojing Yang, Yibing Qiu, Xu Sun, Zhenyu Ji, Guanrui Yang, Jianying Zhang, Shanshan Li, Liping Dai, Liguo Zhan. Suppression of Esophageal Squamous Cell Carcinoma Development by Mechanosensitive Protein Piezo1 Downregulation. ACS omega. vol 6. issue 15. 2021-09-28. PMID:34056174. |
the protein levels of p53, downstream factor bax, apoptosis executioner cleaved-caspase3, and caspase3 were significantly upregulated by the downregulation of piezo1. |
2021-09-28 |
2023-08-13 |
mouse |
| Chengyan Xu, Zixia He, Chao Lin, Zhipeng She. MiR-30b-5p inhibits proliferation and promotes apoptosis of medulloblastoma cells via targeting MYB proto-oncogene like 2 (MYBL2). Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 68. issue 6. 2021-09-27. PMID:32690599. |
upregulated mir-30b-5p could inhibit the proliferation and induce apoptosis of mb.moreover, overexpressed mir-30b-5p could increase the expression of bax but decrease that of bcl-2. |
2021-09-27 |
2023-08-13 |
human |
| Lili Tan, Limin Liu, Jian Yao, Chenghao Pia. miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1. Experimental animals. vol 70. issue 3. 2021-09-27. PMID:33658472. |
upregulation of mir-145-5p increased cell viability and reduced apoptosis accompanied by downregulation of bax, cleaved caspase-3, cleaved poly(adp-ribose) polymerase (parp) and upregulation of bcl2. |
2021-09-27 |
2023-08-13 |
rat |
| Muhammad Daniyal, Yongbei Liu, Yupei Yang, Feng Xiao, Jialong Fan, Huanghe Yu, Yixing Qiu, Bin Liu, Wei Wang, Qin Yuhu. Anti-gastric cancer activity and mechanism of natural compound "Heilaohulignan C" isolated from Kadsura coccinea. Phytotherapy research : PTR. vol 35. issue 7. 2021-09-27. PMID:34155704. |
western blot analysis confirmed that (b-6) decrease the level of bcl-2 and increase the level of p53, bax, and cleaved caspase-3, this confirms that the b-6 doing the apoptosis through caspase and cytochrome c apoptotic pathways. |
2021-09-27 |
2023-08-13 |
mouse |
| Mubashir Mintoo, Sameer Khan, Abubakar Wani, Sumera Malik, Deendyal Bhurta, Sandip Bharate, Fayaz Malik, Dilip Mondh. A rohitukine derivative IIIM-290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells. Molecular carcinogenesis. vol 60. issue 10. 2021-09-27. PMID:34324743. |
we found that iiim-290 induced apoptosis through upregulation of different apoptotic proteins like puma, bax, cytochrome c, cleaved (active) caspase-3, and cleaved parp in molt-4 cells. |
2021-09-27 |
2023-08-13 |
Not clear |
| Zhaohui Jia, Wensheng Li, Pan Bian, Liuyang Yang, Hui Liu, Dong Pan, Zhongling Do. Ursolic acid treats renal tubular epithelial cell damage induced by calcium oxalate monohydrate via inhibiting oxidative stress and inflammation. Bioengineered. vol 12. issue 1. 2021-09-27. PMID:34506233. |
the results manifested that high- and low-dose ua reduced com crystals in com rats' kidney, down-regulated urea, creatinine, and neutrophil gelatinase-associated lipocalin (ngal) levels in rat plasma, declined kidney tissue and hk-2 cell apoptosis, inhibited bax expression but elevated bcl-2 expression. |
2021-09-27 |
2023-08-13 |
rat |
| Yanwu Hu, Haitao Li, Ruili Li, Yue Tian, Zijing W. Protective effects of Schisandrin B against D-GalN-induced cell apoptosis in human hepatocyte (L02) cells via modulating Bcl-2 and Bax. Bioengineered. vol 12. issue 1. 2021-09-27. PMID:34546847. |
protective effects of schisandrin b against d-galn-induced cell apoptosis in human hepatocyte (l02) cells via modulating bcl-2 and bax. |
2021-09-27 |
2023-08-13 |
human |
| Mutlu Deger, Bulent Kaya, Nebil Akdogan, Halil Mahir Kaplan, Emine Bagir, Volkan Izol, Ibrahim Atilla Aridoga. Protective effect of dapagliflozin against cyclosporine A-induced nephrotoxicity. Drug and chemical toxicology. 2021-09-27. PMID:34565275. |
oxidative stress and apoptosis were evaluated with caspase-3 activity, total oxidant status (tos), total antioxidant status (tas), malondialdehyde (mda), myeloperoxidase (mpo), b-cell lymphoma-2 (bcl-2), and bcl-2-associated x protein (bax) in the right kidney resection material. |
2021-09-27 |
2023-08-13 |
mouse |
| Xiaodong Han, Jiuqiang Wang, Yang Yang, Shuxiang Qu, Fang Wan, Ziyi Zhang, Ruigang Wang, Guojing Li, Haolong Con. Zika virus infection induced apoptosis by modulating the recruitment and activation of pro-apoptotic protein Bax. Journal of virology. 2021-09-26. PMID:33536166. |
zika virus infection induced apoptosis by modulating the recruitment and activation of pro-apoptotic protein bax. |
2021-09-26 |
2023-08-13 |
Not clear |
| Xiaodong Han, Jiuqiang Wang, Yang Yang, Shuxiang Qu, Fang Wan, Ziyi Zhang, Ruigang Wang, Guojing Li, Haolong Con. Zika virus infection induced apoptosis by modulating the recruitment and activation of pro-apoptotic protein Bax. Journal of virology. 2021-09-26. PMID:33536166. |
cell apoptosis was reduced significantly in sy5y cells subjected to bax knockdown. |
2021-09-26 |
2023-08-13 |
Not clear |
| Xiaodong Han, Jiuqiang Wang, Yang Yang, Shuxiang Qu, Fang Wan, Ziyi Zhang, Ruigang Wang, Guojing Li, Haolong Con. Zika virus infection induced apoptosis by modulating the recruitment and activation of pro-apoptotic protein Bax. Journal of virology. 2021-09-26. PMID:33536166. |
the overexpressed ns4b was localized to the mitochondria and induced cell apoptosis by activating the pro-apoptotic protein bax. |
2021-09-26 |
2023-08-13 |
Not clear |
| Linyan Wang, Juan Zhan. Long intergenic ncRNA 00473 improves the invasion of trophoblastic cells via miR-16-5p. Pregnancy hypertension. vol 23. 2021-09-24. PMID:33422740. |
linc00473 overexpression increased cell viability, migration, invasion, and mmp2, mmp9 and bcl-2 levels, yet decreased the apoptosis rates and bax and c caspase-3 levels in cells; however, linc00473 silencing had the opposite effect. |
2021-09-24 |
2023-08-13 |
human |
| David A Price, Tayler D Hill, Kaitlyn A Hutson, Blaze W Rightnowar, Sean D Mora. Membrane-dependent amyloid aggregation of human BAX α9 (173-192). Protein science : a publication of the Protein Society. vol 30. issue 5. 2021-09-24. PMID:33641228. |
mitochondrial outer membrane permeabilization, which is a critical step in apoptosis, is initiated upon transmembrane insertion of the c-terminal α-helix (α9) of the proapoptotic bcl-2 family protein bax. |
2021-09-24 |
2023-08-13 |
human |
| David A Price, Tayler D Hill, Kaitlyn A Hutson, Blaze W Rightnowar, Sean D Mora. Membrane-dependent amyloid aggregation of human BAX α9 (173-192). Protein science : a publication of the Protein Society. vol 30. issue 5. 2021-09-24. PMID:33641228. |
its inherent amyloidogenicity was predicted by sequence analysis, and 2d ir spectra reveal that vesicles modulate the β-sheet structures of insoluble aggregates, motivating further examination of the formation or suppression of bax amyloids in apoptosis. |
2021-09-24 |
2023-08-13 |
human |
| Qi Yin, Xuelei Pi, Yuanyuan Jiang, Guiping Ren, Zhihang Liu, Han Liu, Mengxia Wang, Wenying Sun, Siyu Li, Zhenqiu Gao, Deshan Li, Jiechao Yi. An immuno-blocking agent targeting IL-1β and IL-17A reduces the lesion of DSS-induced ulcerative colitis in mice. Inflammation. vol 44. issue 5. 2021-09-24. PMID:33877484. |
both fl-bsab1/17 and etanercept could reduce the transcription of bax and increase the transcription of bcl-2 and slow down apoptosis in colitis colon tissue. |
2021-09-24 |
2023-08-13 |
mouse |
| Erika Rimondi, Elisabetta Melloni, Arianna Romani, Veronica Tisato, Fabio Casciano, Gian Matteo Rigolin, Daniela Milani, Claudio Celeghini, Giorgio Zauli, Paola Secchiero, Rebecca Volta. Overcoming of Microenvironment Protection on Primary Chronic Lymphocytic Leukemia Cells after Treatment with BTK and MDM2 Pharmacological Inhibitors. Current oncology (Toronto, Ont.). vol 28. issue 4. 2021-09-24. PMID:34287267. |
moreover, the combination induced high p53 levels and a significant dissipation of the mitochondrial membrane potential, together with bax cleavage in the more active p18 form and phospho-bad down-regulation, that are key components of the mitochondrial apoptotic pathway, enhancing the apoptosis level. |
2021-09-24 |
2023-08-13 |
Not clear |