| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuowei Pei, Chenguang Yang, Ying Guo, Min Dong, Fang Wan. Effect of different exercise training intensities on age-related cardiac damage in male mice. Aging. vol 13. issue 17. 2021-09-24. PMID:34520392. |
metabolic characteristics, cardiac function and morphology, myocardial remodeling, myocardial fibrosis (collagen iii, α-sma, and tgf-β), oxidative stress (nrf2, ho-1, sod, and nox4), and apoptosis (bax, bak, bcl-2, and bcl-xl) were analyzed 24 weeks after the different treatments. |
2021-09-24 |
2023-08-13 |
mouse |
| Si Ying Li, Chen Yi Wang, Jing Jing Zhao, Cai Yun Long, Yun Xia Xiao, Xiao Bing Tang, Zheng Wei Yuan, Yu Zuo Ba. Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats. Experimental cell research. vol 402. issue 2. 2021-09-23. PMID:33794264. |
flow cytometry analysis and cck-8 assay (used to detect apoptosis and proliferation, respectively), as well as western blotting, showed that the levels of pppde1 were positively correlated with the pro-apoptotic molecules bax and cyt c. accordingly, aberrantly high expression of pppde1 caused a spatiotemporal imbalance in foetal rats with arms during hindgut development. |
2021-09-23 |
2023-08-13 |
rat |
| Bashir Ahmad, Yaser Gamallat, Pengyu Su, Akbar Husain, Ata Ur Rehman, Mohamed Y Zaky, Ahmed Musa Hago Bakheet, Naeem Tahir, Yi Xin, Wang Lian. Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway. Chemical biology & drug design. vol 97. issue 2. 2021-09-22. PMID:32780548. |
furthermore, alt induced mitochondrial-dependent apoptosis through a decrease in b-cell lymphoma-2 (bcl-2) and bcl-xl and increase in bax expression, resulting in the release of cytochrome c (cyt-c) from mitochondria. |
2021-09-22 |
2023-08-13 |
Not clear |
| Qian Zhou, Ling Zhan. MicroRNA-183-5p protects human derived cell line SH-SY5Y cells from mepivacaine-induced injury. Bioengineered. vol 12. issue 1. 2021-09-22. PMID:34180760. |
the rate of apoptosis increased visibly, cleaved caspase-3 and bax levels waxed, whereas bcl-2 level waned. |
2021-09-22 |
2023-08-13 |
human |
| Qingqing Li, Yansong Zhang, Yufang Yang, Songqing Huang, Xiaoqin Zou, Congying Wei, Taolin Liang, Xiaobin Zhon. Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34385105. |
cell viability, mitochondrial function, cell apoptosis ratio and the expression of apoptosis-associated proteins (cyt c, bcl2, bax, caspases 3) were determined. |
2021-09-22 |
2023-08-13 |
human |
| Xuejiao An, Taotao Li, Nana Chen, Huihui Wang, Xia Wang, Youji M. PGAM1 regulates the glycolytic metabolism of SCs in tibetan sheep and its influence on the development of SCs. Gene. vol 804. 2021-09-22. PMID:34418471. |
the mrna expression of the cell proliferation-related genes pcna and bcl2 was significantly increased (p < 0.05), and the expression of cell apoptosis related genes bax and caspase3 was significantly decreased (p < 0.05). |
2021-09-22 |
2023-08-13 |
Not clear |
| Chaosheng Li, Changyan Fan, Jilai Zhao, Meiqi Di, Chenyan Sui, Likun Han, Lingling H. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32725513. |
pts inhibited apoptosis of ogd/r cells and was accompanied by decreased expression of apoptotic proteins bax and caspase3 and increased expression of bcl-2. |
2021-09-21 |
2023-08-13 |
Not clear |
| Yan-Jun Zhao, Yue-E Chen, Hong-Jun Zhang, Xing G. LncRNA UCA1 remits LPS-engendered inflammatory damage through deactivation of miR-499b-5p/TLR4 axis. IUBMB life. vol 73. issue 2. 2021-09-21. PMID:33368965. |
in the meanwhile, elimination of uca1 distinctly assuaged cell apoptosis concomitant with declined levels of proapoptotic proteins bax and c-caspase-3, and ascended the expression of antiapoptotic protein bcl-2. |
2021-09-21 |
2023-08-13 |
Not clear |
| Kang-In Lee, Seunga Choi, Han-Gyu Choi, Sintayehu Kebede Gurmessa, Thi Binh Dang, Yong Woo Back, Hye-Soo Park, Hwa-Jung Ki. Recombinant Rv1654 protein of Mycobacterium tuberculosis induces mitochondria-mediated apoptosis in macrophage. Microbiology and immunology. vol 65. issue 4. 2021-09-21. PMID:33565648. |
finally, rv1654-mediated apoptosis was inhibited in macrophages transfected with bax sirna. |
2021-09-21 |
2023-08-13 |
Not clear |
| Bingwu Liu, Xinfeng Yan, Zuojia Hou, Lei Zhang, Duwen Zhan. Impact of Bupivacaine on malignant proliferation, apoptosis and autophagy of human colorectal cancer SW480 cells through regulating NF-κB signaling path. Bioengineered. vol 12. issue 1. 2021-09-21. PMID:34151717. |
our work treated crc cells with bupivacaine, detected cell vitality through mtt assay, apoptosis through flow cytometry, cell migration through wound healing assay, nf-κb activity through immunofluorescence, inflammatory factor level, including tnf-α, il-1β as well as il-6 through eslia, apoptosis factor mrna expression, including bcl-2, bax and caspase-3q through qrt-pcr, and protein expression linking with nf-κb signaling pathway as well as autophagy-related proteins via western blot. |
2021-09-21 |
2023-08-13 |
human |
| Bingwu Liu, Xinfeng Yan, Zuojia Hou, Lei Zhang, Duwen Zhan. Impact of Bupivacaine on malignant proliferation, apoptosis and autophagy of human colorectal cancer SW480 cells through regulating NF-κB signaling path. Bioengineered. vol 12. issue 1. 2021-09-21. PMID:34151717. |
the results showed that 1 mm bupivacaine was available to signally inhibit crc cell vitality, promoted apoptosis rate and apoptosis gene expression, like bax, and caspase-3, inhibited bcl-2 expression, inhibited cancer cell migration, promoted autophagy-related protein lc3b ii/lc3b i ratio and beclin-1 expression, and inhibited p62 expression. |
2021-09-21 |
2023-08-13 |
human |
| Mohammadreza Azimi, Jalil Mehrzad, Armita Ahmadi, Elnaz Ahmadi, Ali Ghorbani Ranjbar. Apoptosis Induced by Ziziphora tenuior Essential Oil in Human Colorectal Cancer Cells. BioMed research international. vol 2021. 2021-09-21. PMID:34337019. |
after mtt assay and determination of the percentage of apoptosis by flow cytometry, rna extraction was performed and the expression levels of bax, bcl-2, caspase 3 (c3), and caspase 9 (c9) were analyzed using newly designed primers by reverse transcription (rt) qpcr method and genix6 software. |
2021-09-21 |
2023-08-13 |
human |
| Piers Blombery, Thomas E Lew, Michael A Dengler, Ella R Thompson, Victor S Lin, Xiangting Chen, Tamia Nguyen, Ashish Panigrahi, Sasanka Mithila Handunnetti, Dennis Carney, David A Westerman, Constantine S Tam, Jerry M Adams, Andrew H Wei, David Ching Siang Huang, John F Seymour, Andrew Roberts, Mary Ann Anderso. Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL. Blood. 2021-09-21. PMID:34469514. |
mutations in the apoptosis effector bax were identified in 32% (13/41). |
2021-09-21 |
2023-08-13 |
Not clear |
| Xiuzhi Zhu, Jialin Li, Huiting Ning, Zhidong Yuan, Yue Zhong, Suzhen Wu, Jin-Zhang Zen. α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway. Frontiers in pharmacology. vol 12. 2021-09-21. PMID:34539418. |
α-mangostin can trigger parp cleavage and induce apoptosis, which may be related to the induction of upregulated bax expression and downregulation of bad and cleaved caspase-3 expression in mda-mb-231 cells through blockade of akt signaling. |
2021-09-21 |
2023-08-13 |
Not clear |
| Rameez Raja, Ganes C Se. The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3. Cell death and differentiation. 2021-09-21. PMID:34545182. |
ripa requires linear polyubiquitination of irf3 by the enzyme complex, lubac; ubiquitinated irf3 binds to bax and translocates it to mitochondria causing the release of cytochrome c, activation of caspases and apoptosis of the infected cell. |
2021-09-21 |
2023-08-13 |
Not clear |
| Zhenzhu Jiang, Jing Yin, Guangyao Peng, Xiaoping Lon. Circ_0074027 contributes to the progression of non-small cell lung cancer via microRNA-362-3p/clathrin heavy chain axis. Anti-cancer drugs. vol 32. issue 1. 2021-09-20. PMID:32932275. |
western blot assay was utilized to measure the levels of clathrin heavy chain (cltc), cyclin d1, bcl2-associated x, apoptosis regulator bax (bax), vimentin and matrix metallopeptidase 9. |
2021-09-20 |
2023-08-13 |
human |
| Cihan Gur, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Kucukler, Ozge Kandemir, Mustafa Ileritur. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environmental science and pollution research international. vol 28. issue 36. 2021-09-20. PMID:33939091. |
biochemical and western blot analyses showed that acr increased malondialdehyde (mda), p38α mitogen-activated protein kinase (p38α mapk), nuclear factor kappa-b (nf-κb), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), p53, caspase-3, bcl-2 associated x protein (bax), beclin-1, light chain 3a (lc3a), and light chain 3b (lc3b) levels and decreased those of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione (gsh), b-cell lymphoma-2 (bcl-2), mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k), and protein kinase b (akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. |
2021-09-20 |
2023-08-13 |
rat |
| Xiaofeng Zhou, Yingting He, Nian Li, Guofeng Bai, Xiangchun Pan, Zhe Zhang, Hao Zhang, Jiaqi Li, Xiaolong Yua. DNA methylation mediated RSPO2 to promote follicular development in mammals. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34175894. |
moreover, rspo2 promoted the proliferation of gcs with increasing the expression level of pcna, cdk1, and ccnd1 and promoted the e2 secretion of gcs with increasing the expression level of cyp19a1 and hsd17b1 and inhibited the apoptosis of gcs with decreasing the expression level of caspase3, cleaved caspase3, cleaved caspase8, cleaved caspase9, cleaved parp, and bax. |
2021-09-20 |
2023-08-13 |
Not clear |
| Yangwei Li, Yingwei Liu, Jiangnan Yi, Yuanliang Li, Bijing Yang, Peng Shang, Khalid Mehmood, Rana Muhammad Bilal, Hui Zhang, Yung-Fu Chang, Zhaoxin Tang, Yajing Wang, Ying L. The potential risks of chronic fluoride exposure on nephrotoxic via altering glucolipid metabolism and activating autophagy and apoptosis in ducks. Toxicology. vol 461. 2021-09-20. PMID:34450209. |
more importantly, autophagy and apoptosis levels of cyt c, lc3, p62, beclin, m-tor, bax and caspase-3 were increased (p < 0.05) in the naf treated group. |
2021-09-20 |
2023-08-13 |
Not clear |
| Zhe Liu, Guangze Mou, Zhiming Liang, Rui Zhao, Chenghao Jin, Rui W. Selenomethionine Alleviates Intestinal Ischemia-Reperfusion Injury in Mice Through the Bax-Caspase Pathway. Biological trace element research. 2021-09-18. PMID:34536204. |
thus, semet inhibited apoptosis and resulted in an increase of bcl-2 levels; downregulated the expression of bax, cyt-c, and caspase-3; and alleviated the intestinal ischemia injury in mice. |
2021-09-18 |
2023-08-13 |
mouse |