| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linling Yu, Rongli Sun, Kai Xu, Yunqiu Pu, Jiawei Huang, Manman Liu, Minjian Chen, Juan Zhang, Lihong Yin, Yuepu P. Lipidomic analysis reveals disturbances in glycerophospholipid and sphingolipid metabolic pathways in benzene-exposed mice. Toxicology research. vol 10. issue 4. 2021-09-07. PMID:34484662. |
simultaneously, the levels of proliferation marker (pcna and ki67) and apoptosis regulator (bax and caspase-3) showed clear increases in benzene-exposed group. |
2021-09-07 |
2023-08-13 |
mouse |
| Hayate Javed, M F Nagoor Meeran, Sheikh Azimullah, Lujain Bader Eddin, Vivek Dhar Dwivedi, Niraj Kumar Jha, Shreesh Ojh. α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson's disease. Biomolecules. vol 10. issue 10. 2021-09-06. PMID:33049992. |
in addition to countering oxidative stress and inflammation, bsb also attenuated apoptosis of dopaminergic neurons by attenuating downregulation of anti-apoptotic protein bcl-2 and upregulation of pro-apoptotic proteins bax, cleaved caspases-3 and 9. |
2021-09-06 |
2023-08-13 |
rat |
| Rina Du, Pengwei Zhao, Shikui Wu, Yaoxing Gao, Rina Wu, Minli Yang, Wanying Song, Haining Ga. Sendeng-4 Suppressed Melanoma Growth by Induction of Autophagy and Apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-09-04. PMID:34475961. |
in addition, decreased bcl-2 expression and increased bax expression were observed, suggesting programmed cell death via apoptosis. |
2021-09-04 |
2023-08-13 |
Not clear |
| Yu Gao, Libo Li, Jianbai Yu, Zhanwei Zhan. Rosuvastatin protects PC12 cells from hypoxia/reoxygenation-induced injury by inhibiting endoplasmic reticulum stress-induced apoptosis. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-04. PMID:34475979. |
tunel assay was then used to measure the extent of cell apoptosis, and western blotting was used to analyze the expression levels of the apoptosis-associated proteins bax, bcl-2, cleaved caspase-3 and cleaved caspase-9. |
2021-09-04 |
2023-08-13 |
Not clear |
| Yueyang Wang, Xiaojing Li, Yujie Yao, Xia Zhao, Xu Shi, Yan Ca. Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells. Biological trace element research. 2021-09-04. PMID:34480665. |
in addition, se deficiency led to increased intracellular ros content, p-p38 and p-jnk gene expression levels (p < 0.05), the mitochondrial apoptosis pathway bax, casp9 and cle-casp3 protein expression levels (p < 0.05), and decreased bcl2 protein expression level (p < 0.05), simultaneously, increased necroptosis marker genes rip1, rip3, and mlkl protein expression levels (p < 0.05) with a dose-dependent pattern. |
2021-09-04 |
2023-08-13 |
human |
| Jingyu Zhang, Yandong Xie, Qingling Fan, Cheng Wan. Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 3. 2021-09-03. PMID:32580584. |
colon tissues were investigated using tunel analysis of apoptosis; histopathological assessment including number of aberrant crypt foci (acf); immunohistochemical staining for bcl-2-associated x protein (bax), b-cell lymphoma 2 (bcl2), p53 and proliferating cell nuclear antigen (pcna); and antioxidant assay in vivo. |
2021-09-03 |
2023-08-13 |
rat |
| Min-Hui Zhang, Rong Zhou, Fang Liu, Tzi B N. Purification of a novel protein with cytotoxicity against non-small-cell lung cancer cells from Boletus bicolor. Archiv der Pharmazie. vol 354. issue 9. 2021-09-03. PMID:34076300. |
the western blot analysis results showed that the expression of apoptosis and cell cycle-related proteins of cleaved caspase-3, cytochrome c, bax, p16, and p21 was significantly upregulated, whereas the expression of bcl-2, cdk4, cyclin d, p-rb, and e2f was significantly downregulated after treatment with protein d1. |
2021-09-03 |
2023-08-13 |
human |
| Leen M Eldohaji, Bahgat Fayed, Alshaimaa M Hamoda, Mai Ershaid, Shifaa Abdin, Tasneem B Alhamidi, Mohammad G Mohammad, Hany A Omar, Sameh S M Solima. Potential targeting of Hep3B liver cancer cells by lupeol isolated from Avicennia marina. Archiv der Pharmazie. vol 354. issue 9. 2021-09-03. PMID:34085721. |
lupeol significantly (p < .01) downregulated bcl-2 gene expression in parental and resistant hep3b cells by 33 and 3.5 times, respectively, contributing to the induction of apoptosis in hep3b cells, whereas it caused no effect on bax. |
2021-09-03 |
2023-08-13 |
Not clear |
| Chunqiu Xiong, Bingbing Yan, Suhua Xia, Fei Yu, Jingjing Zhao, Hua Ba. Tilianin inhibits the human ovarian cancer (PA-1) cell proliferation via blocking cell cycle, inducing apoptosis and inhibiting JAK2/STAT3 signaling pathway. Saudi journal of biological sciences. vol 28. issue 9. 2021-09-03. PMID:34466064. |
the tilianin-triggered apoptosis in pa-1 cells was correlated with elevated generation of ros, loss of mitochondrial membrane potential, alterations in pro-apoptotic (upregulated mrna expression of bax) and anti-apoptotic (downregulated mrna expression of bcl2) factors and activation of caspase-8, -9 and -3. |
2021-09-03 |
2023-08-13 |
human |
| Man-Lin Guo, Xiang-Yu Ma, Yu-Qing Gong, Meng-Lin Feng, Yu-Wan Zhao, Leng-Xin Dua. [Protective effect of ethyl acetate extract from Bidens bipinnata on hepatocyte damage induced by endoplasmic reticulum stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472265. |
methyl thiazolyl tetrazolium(mtt) colorimetric assay was used to investigate the survival rate of ethyl acetate extract from b. bipinnata in l02 cells injury induced by endoplasmic reticulum stress; the protein expressions of endoplasmic reticulum stress-related molecule glucose regulated protein 78(grp78), pkr-like er kinase(perk), eukaryotic initiation factor-2(eif2α), activating transcription factor 4(atf4), c/ebp homologous protein(chop), b-cell cll/lymphoma 2(bcl-2), bal-2 associated x apoptosis regulator(bax) were examined by wes-tern blot. |
2021-09-03 |
2023-08-13 |
Not clear |
| F Liang, J Xi, X Chen, J Huang, D Jin, X Zh. Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis. Human & experimental toxicology. vol 40. issue 9. 2021-09-02. PMID:33729022. |
kidney function, oxidative stress biomarkers, and apoptosis factors as well as bcl-2 and bax were investigated. |
2021-09-02 |
2023-08-13 |
mouse |
| Wenbin Dong, Xiaodan Zhu, Xingling Liu, Xu Zhao, Xiaoping Lei, Lan Kang, Li Li. Role of the SENP1-SIRT1 pathway in hyperoxia-induced alveolar epithelial cell injury. Free radical biology & medicine. vol 173. 2021-09-02. PMID:34311030. |
in the hyperoxic alveolar epithelial cell injury model, it seemed that hyperoxia could induce the same variation trend in the senp1-sirt1 pathway as in infants with bpd and then increased the expression of ac-p53 and bax, and cell apoptosis. |
2021-09-02 |
2023-08-13 |
human |
| Aichun Qin, Qiong Liu, Jingfang Wan. Ropivacaine inhibits proliferation, invasion, migration and promotes apoptosis of papillary thyroid cancer cells via regulating ITGA2 expression. Drug development research. vol 81. issue 6. 2021-09-01. PMID:32314406. |
furthermore, apoptosis was promoted, coupled with a decrease of bcl-2 expression and increases of bax, cleaved caspase-3 and cleaved caspase-9 expression, in ropivacaine-treated tpc-1 cells, which was restored following itga2 overexpression. |
2021-09-01 |
2023-08-13 |
human |
| Jiangtao Gu, Lan Huang, Yunxia Zhan. Monensin inhibits proliferation, migration, and promotes apoptosis of breast cancer cells via downregulating UBA2. Drug development research. vol 81. issue 6. 2021-09-01. PMID:32462716. |
in addition, monensin promoted the apoptosis accompanied by the increase of bax, caspase3, caspase7, and caspase9 and the decreased of bcl-2 of breast cancer cells. |
2021-09-01 |
2023-08-13 |
Not clear |
| Lian Zeng, Fuyu Zhang, Zhen Zhang, Min Xu, Yang Xu, Ying Liu, Hongxia Xu, Xiaodong Sun, Ming Sang, Huiyu Lu. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. Journal of biochemical and molecular toxicology. vol 35. issue 8. 2021-09-01. PMID:34091999. |
cell viability and apoptosis detected by cck-8 and a jc-1 apoptosis detection kit, the changes of spinal cord structure observed after hematoxylin and eosin staining, apoptosis of the spinal cord measured by terminal deoxynucleotidyl transferase dutp nick end labeling staining, behavioral assessment of the nerve injury evaluated by the detection of sciatic nerve conduction velocity (sncv) andmechanical withdrawal threshold (mwt), the expression of p53 and many apoptosis-related genes included bax, bcl-2, and caspase-3 detected by quantitative real-time polymerase chain reaction, western blot analysis, immunofluorescence, and immunohistochemistry. |
2021-09-01 |
2023-08-13 |
Not clear |
| Lian Zeng, Fuyu Zhang, Zhen Zhang, Min Xu, Yang Xu, Ying Liu, Hongxia Xu, Xiaodong Sun, Ming Sang, Huiyu Lu. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. Journal of biochemical and molecular toxicology. vol 35. issue 8. 2021-09-01. PMID:34091999. |
apoptosis rate and many proapoptotic genes include p53, bax, caspase-3 messenger rna, and proteins were increased by rop, but pft-α could decrease it. |
2021-09-01 |
2023-08-13 |
Not clear |
| Yun-Xia Wei, Shi-Min Dong, Yuan-Yuan Wang, Pu Zhang, Ming-Yu Sun, Yun-Xiao Wei, Xian-Ce Meng, Yue Wan. Autophagy participates in the protection role of 1,25-dihydroxyvitamin D3 in acute myocardial infarction via PI3K/AKT/mTOR pathway. Cell biology international. vol 45. issue 2. 2021-08-31. PMID:33146448. |
vd3 treatment obviously alleviated ami-induced myocardial apoptosis, along with bcl-2 upregulation and downregulation of caspase-3, caspase-9, and bax. |
2021-08-31 |
2023-08-13 |
mouse |
| Ding Yan, Xiaofen Li, Qianqian Yang, Qingtian Huang, Leyi Yao, Peiquan Zhang, Wenshuang Sun, Shuhui Lin, Q Ping Dou, Jinbao Liu, Xin Che. Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30. Cell death discovery. vol 7. issue 1. 2021-08-31. PMID:34381024. |
here, we report that: (i) aumdubin, a synthetic derivative of auranofin, exhibited stronger dub-inhibiting and apoptosis-inducing activities than auranofin in lung cancer cells; (ii) aumdubin shows high affinity for mitochondrial dub usp30; (iii) aumdubin induces apoptosis by increasing the ubiquitination and mitochondrial location of bax protein; and (iv) usp30 inhibition may contribute to bax-dependent apoptosis induced by aumdubin in lung cancer cells. |
2021-08-31 |
2023-08-13 |
Not clear |
| Mengying Chen, Xiaodong Zhang, Jiaxin Fan, Hong Sun, Qingling Yao, Jinming Shi, Huiyang Qu, Shuang Du, Yuxuan Cheng, Shuyin Ma, Meijuan Zhang, Shuqin Zha. Dynorphin A (1-8) inhibits oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA receptor and κ-opioid receptor channels. Neuropeptides. vol 89. 2021-08-30. PMID:34298371. |
we found that mcao rats under intranasal administration of dynorphin a(1-8) showed better behavioral improvement, higher extent of bcl-2, activity of sod along with much lower level of infarction volume, brain water content, number of cell apoptosis, extent of bax and caspase-3, and concentration of mda compared with those in mcao model group and intravenous dynorphin a(1-8) group. |
2021-08-30 |
2023-08-13 |
rat |
| Jian He, Yaoyun Tang, Yongquan Tia. [Retracted] MicroRNA‑214 promotes proliferation and inhibits apoptosis via targeting Bax in nasopharyngeal carcinoma cells. Molecular medicine reports. vol 24. issue 4. 2021-08-30. PMID:34368856. |
[retracted] microrna‑214 promotes proliferation and inhibits apoptosis via targeting bax in nasopharyngeal carcinoma cells. |
2021-08-30 |
2023-08-13 |
Not clear |