| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaisen Liao, Jing Chen, Li Fan, Zhangquan Wan. Long noncoding RNA H19 promotes the apoptosis of corpus cavernsum smooth muscle cells after cavernosal nerve injury via JNK signalling pathway. Andrologia. vol 53. issue 8. 2021-08-11. PMID:34137055. |
jnk/ bcl-2/ bax pathway participates in corpus cavernosal smooth muscle cells apoptosis during early period after cavernosal nerve (cn) crush injury (cnci). |
2021-08-11 |
2023-08-13 |
rat |
| Kaisen Liao, Jing Chen, Li Fan, Zhangquan Wan. Long noncoding RNA H19 promotes the apoptosis of corpus cavernsum smooth muscle cells after cavernosal nerve injury via JNK signalling pathway. Andrologia. vol 53. issue 8. 2021-08-11. PMID:34137055. |
lncrna h19 might be involved in regulation of bcl-2, bax via jnk signalling pathway in ccsmcs apoptosis after cn injury. |
2021-08-11 |
2023-08-13 |
rat |
| Dan Liu, Meng Zeng, Jing-Wen Pi, Mei-Jia Liu, Wei-Zhe Ding, Xue-Ying Mei, Jian-Li Liu, Xiang-Yu Ca. Exploring the Potential Mechanism of Costunolide-Induced MCF-7 Cells Apoptosis by Multi-Spectroscopy, Molecular Docking and Cell Experiments. Chemistry & biodiversity. vol 18. issue 5. 2021-08-10. PMID:33855794. |
the apoptosis mechanism relied on regulating the protein expression of bax, bcl-2, p53, caspase-3 and the activation of p38mapk and nuclear factor κb (nf-κb) pathways. |
2021-08-10 |
2023-08-13 |
Not clear |
| Allal Ouhtit, Ishita Gupta, Rajiv L Gaur, Augusta Fernando, Amira O Abd El-Azim, Ali Ei. Deregulation of cell growth and apoptosis in UV-induced melanomagenesis. Frontiers in bioscience (Elite edition). vol 12. 2021-08-09. PMID:32114459. |
more interestingly, p16 mutant cells increased their resistance to apoptosis at high uvb-dose, associated with decreased bax and increased bcl2 expression. |
2021-08-09 |
2023-08-13 |
Not clear |
| Yi-Cheng Chen, Yu-Chi Chou, Yu-Tung Hsieh, Pin-Yu Kuo, Mei-Lin Yang, Hao-Earn Chong, Chao-Liang Wu, Ai-Li Shiau, Chrong-Reen Wan. Targeting Intra-Pulmonary P53-Dependent Long Non-Coding RNA Expression as a Therapeutic Intervention for Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage. International journal of molecular sciences. vol 22. issue 13. 2021-08-09. PMID:34203338. |
intra-pulmonary delivery of shrna targeting lincrna-p21 reduced hemorrhage frequencies and improved anemia status through decreasing bax expression and cell apoptosis. |
2021-08-09 |
2023-08-13 |
mouse |
| Naymel Alejandra Guzmán Mendoza, Kohei Homma, Hideto Osada, Eriko Toda, Norimitsu Ban, Norihiro Nagai, Kazuno Negishi, Kazuo Tsubota, Yoko Ozaw. Neuroprotective Effect of 4-Phenylbutyric Acid against Photo-Stress in the Retina. Antioxidants (Basel, Switzerland). vol 10. issue 7. 2021-08-09. PMID:34356380. |
concurrently, light-induced oxidative stress markers, nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase 1 (ho-1), and mitochondrial apoptotic markers, b-cell lymphoma 2 apoptosis regulator (bcl-2)-associated death promoter (bad), and bcl-2-associated x protein (bax), were suppressed by 4-pba administration. |
2021-08-09 |
2023-08-13 |
mouse |
| Lai Chen, Shaohui Zhang, Xiaoying Liu, Jiong Dai, Zhenguo Yan, Chunlan W. Effects of dendrobium polysaccharides on human brain microvascular endothelial cell injury induced by ox-LDL via regulating the miR-378 expression. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 7. 2021-08-06. PMID:33287924. |
the kit was used to detect the levels of malondialdehyde (mda) and the activities of superoxide dismutase (sod) and catalase (cat); flow cytometry to detect apoptosis; and western blot to detect b-cell lymph tumor/leukemia-2 (bcl-2) and bcl-2 related x (bax) protein expression; real-time fluorescence quantitative pcr (rt-qpcr) was used to detect the expression of mir-378. |
2021-08-06 |
2023-08-13 |
human |
| Lai Chen, Shaohui Zhang, Xiaoying Liu, Jiong Dai, Zhenguo Yan, Chunlan W. Effects of dendrobium polysaccharides on human brain microvascular endothelial cell injury induced by ox-LDL via regulating the miR-378 expression. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 7. 2021-08-06. PMID:33287924. |
results showed that after treatment with different concentrations of dendrobium polysaccharides, mda levels were decreased in ox-ldl-induced human brain microvascular endothelial cells, sod and cat activities were increased, apoptosis rate was decreased, bcl-2 expression was increased, bax expression was decreased, mir-378 expression was increased, in a dose-dependent manner (p<0.05). |
2021-08-06 |
2023-08-13 |
human |
| Kuo Wang, Nan Zhang, Zhanbiao Yu, Ning L. Galactose protects pancreatic acinar cells from cerulein induced damage by regulating FGF21 and Klotho. Pakistan journal of pharmaceutical sciences. vol 33. issue 3(Special). 2021-08-06. PMID:33361031. |
acute pancreatitis cell injury model was established by arbusin-induced pancreatic acinar cell ar42j injury; galactose (25, 50, 100 mmol / l) was used to treat the injured cells, and the optimal concentration was 50 mmol / l; cell counting kit (cck-8), enzyme linked immunosorbent assay (elisa) to detect cell survival rate and necrosis rate; flow cytometry and western blotting (western blot) to detect cell apoptosis and autologous phage-related gene (beclin1) and microtubule-associated protein 1 light chain 3 (lc3), apoptosis-related protein b-cell lymphoma / leukemia-2 (bcl-2), bcl-2-related x gene (bax), and fibroblasts expression of growth factor 21 antibody (fgf21) and anti-aging gene klotho. |
2021-08-06 |
2023-08-13 |
Not clear |
| Qiping Yao, Bei Zh. Effects of miR-532-5p on human brain microvascular endothelial cells damage induced by ox-LDL via down-regulating CLIC4 expression. Pakistan journal of pharmaceutical sciences. vol 33. issue 3(Special). 2021-08-06. PMID:33361034. |
the ox-ldl treatment led to lower expression of mir-532-5p (p<0.05), higher expression of clic4 (p <0.05), enhanced content of mda (p<0.05), decreased activities of sod and cat (p<0.05), increased apoptosis rate (p<0.05), higher protein level of bax (p<0.05), and lower protein level of bcl-2 (p<0.05). |
2021-08-06 |
2023-08-13 |
human |
| Qiping Yao, Bei Zh. Effects of miR-532-5p on human brain microvascular endothelial cells damage induced by ox-LDL via down-regulating CLIC4 expression. Pakistan journal of pharmaceutical sciences. vol 33. issue 3(Special). 2021-08-06. PMID:33361034. |
compared with ox-ldl + mir-nc group and ox-ldl + si-nc group, ox-ldl + mir-532-5p group and ox-ldl + si-clic4 group had decreased content of mda (p<0.05), increased activities of sod and cat (p<0.05), decreased apoptosis rate (p<0.05), lower level of bax (p<0.05), and higher level of bcl-2 (p<0.05). |
2021-08-06 |
2023-08-13 |
human |
| Shuai Bian, Yue Zhao, Fangyu Li, Shuyan Lu, Song Yang, Meichen Liu, Siming Wang, Daqing Zhao, Wei Zhang, Jiawen Wan. Knockdown of p62/sequestosome enhances ginsenoside Rh2-induced apoptosis in cervical cancer HeLa cells with no effect on autophagy. Bioscience, biotechnology, and biochemistry. vol 85. issue 5. 2021-08-06. PMID:33784737. |
silencing of p62 further decreased cell viability while also enhancing cell apoptosis, reactive oxygen species generation, the ratio of bax to bcl-2, and the cleavage of parp. |
2021-08-06 |
2023-08-13 |
Not clear |
| Jie Zeng, Yu Zhao, Kexun Li, Daoling Long, Wei Li, Liang Lian. A coordinated ruthenium-rifampicin complex reprogramming the colon carcinoma micro-environment mediated by modulation of p53/AkT/mTOR/VEGF pathway. Toxicology and applied pharmacology. vol 426. 2021-08-06. PMID:34126112. |
along with that, p53 could be modulated by the ruthenium-rifampicin complex to interfere with apoptosis in colon carcinoma, initiated by the intrinsic apoptotic trail facilitated through bcl2 and bax, thus controlling the akt/mtor/vegf pathway coupled through the wnt/β-catenin trail. |
2021-08-06 |
2023-08-13 |
human |
| Rongjun Gao, Hui Ye, Qingjun Gao, Nanpeng Wang, Yan Zhou, Haisong Dua. Inhibition of circular RNA_0000285 prevents cell proliferation and induces apoptosis in thyroid cancer by sponging microRNA-654-3p. Oncology letters. vol 22. issue 3. 2021-08-06. PMID:34345298. |
functional experiments demonstrated that circrna_0000285-sirna decreased thyroid cancer cell proliferation, promoted cell apoptosis, enhanced bax expression and suppressed bcl-2 expression. |
2021-08-06 |
2023-08-13 |
Not clear |
| Hongwen You, Xinyou Su, Guoying S. Novel thiazole-pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction. Archiv der Pharmazie. vol 353. issue 12. 2021-08-03. PMID:32841430. |
in the western blot analysis, compound 4i prevented mitochondrial apoptosis after mi by downregulating the expression of cleaved caspase-3 and bax, with the upregulation of bcl-2, as compared with the iso group. |
2021-08-03 |
2023-08-13 |
rat |
| Wei-Ni Qin, Kai-Cheng Zhang, Ting Geng, Fang-Fang Cheng, Pei-Dong Chen, Wei-Feng Yao, Li Zhang, Yu-Dan Ca. The toxicity mechanism of toxic compounds from Euphorbiae pekinensis Radix on zebrafish embryos. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-08-03. PMID:34311525. |
also, four compounds could provoke apoptosis by up-regulating the expression level of p53, mdm2, bax, bcl-2 and activating the activity of caspase-3, caspase-9. |
2021-08-03 |
2023-08-13 |
zebrafish |
| Nabil A Alhakamy, Osama A Ahmed, Usama A Fahmy, Hani Z Asfour, Adel F Alghaith, Wael A Mahdi, Sultan Alshehri, Shadab M. Development, Optimization and Evaluation of 2-Methoxy-Estradiol Loaded Nanocarrier for Prostate Cancer. Frontiers in pharmacology. vol 12. 2021-08-03. PMID:34335251. |
this increased apoptosis was further correlated with increased bax expression (11.6 ± 0.7) and decreased bcl-2 expression (0.29 ± 0.05) in 2 me micelles treated cells when compared to the control group. |
2021-08-03 |
2023-08-13 |
Not clear |
| Zhaorigetu, Islam M Farrag, Amany Belal, Manal H Al Badawi, Alsayed A Abdelhady, Fawzy M A Abou Galala, Abdou El-Sharkawy, Asmaa A El-Dahshan, Ahmed B M Mehan. Antiproliferative, Apoptotic Effects and Suppression of Oxidative Stress of Quercetin against Induced Toxicity in Lung Cancer Cells of Rats: Journal of Cancer. vol 12. issue 17. 2021-08-03. PMID:34335941. |
two genes bax and bcl-2 that play an important role in apoptosis pathways were investigated. |
2021-08-03 |
2023-08-13 |
human |
| Li-Juan Wang, Han-Qing Ca. Let-7b downgrades CCND1 to repress osteogenic proliferation and differentiation of MC3T3-E1 cells: An implication in osteoporosis. The Kaohsiung journal of medical sciences. vol 36. issue 10. 2021-08-02. PMID:32533643. |
the expression of let-7b in mc3t3-e1 and its effect on cell viability, apoptosis, and the apoptosis-related proteins (bcl-2, bax, and cleaved caspase-9) were tested by cck-8 assay, flow cytometry and western blot, severally. |
2021-08-02 |
2023-08-13 |
Not clear |
| Xiao-He Zheng, Lin-Lin Wang, Ming-Zhi Zheng, Jin-Jie Zhong, Ying-Ying Chen, Yue-Liang She. RGFP966 inactivation of the YAP pathway attenuates cardiac dysfunction induced by prolonged hypothermic preservation. Journal of Zhejiang University. Science. B. vol 21. issue 9. 2021-08-02. PMID:32893527. |
rgfp966 inhibited hypothermic preservation-induced overexpression of b-cell lymphoma protein 2 (bcl-2)-associated x (bax) and cleaved caspase-3, increased bcl-2 mrna and protein expression, and reduced cardiomyocyte apoptosis. |
2021-08-02 |
2023-08-13 |
rat |