| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zun-Wen Lin, Wei Zhang, Si-Ding Jiang, Wen-Bo Wei, Xiao-Feng L. Inhibition of microRNA-940 suppresses the migration and invasion of human osteosarcoma cells through the secreted frizzled-related protein 1-mediated Wnt/β-catenin signaling pathway. Journal of cellular biochemistry. 2021-07-21. PMID:30324663. |
with the treatment of mir-940 mimic, licl, or sirna-sfrp1, os cells showed promoted proliferation, migration, invasion, tumor formation, and impeded apoptosis (further reflected by elevated bcl-2 expression and reduced fas and bax expression). |
2021-07-21 |
2023-08-13 |
mouse |
| Lijie Wang, Lu Wang, Qi Wan. Constitutive activation of the NEAT1/miR-22-3p/Ltb4r1 signaling pathway in mice with myocardial injury following acute myocardial infarction. Aging. vol 13. issue 11. 2021-07-21. PMID:34081624. |
furthermore, silencing of neat1 also inhibited apoptosis by decreasing levels of cleaved caspase-3 and bax, and increasing bcl-2 level through sponging mir-22-3p, resulting in reduced myocardial injury in chd. |
2021-07-21 |
2023-08-13 |
mouse |
| Yanan Shen, Lihai Chen, Yuan Zhang, Jiayue Du, Jing Hu, Hongguang Bao, Yan Xing, Yanna S. Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder. Neuroscience. vol 468. 2021-07-21. PMID:34166762. |
surgically treated mice had increased expression of pten, ampk, bax, il-1β, and tnf-α, as well as increasing number of activated microglia and apoptosis neurons in the hippocampus. |
2021-07-21 |
2023-08-13 |
mouse |
| Rong H Yin, Zhong B Guo, Yuan Y Zhou, Chao Wang, Rong L Yin, Wen L Ba. LncRNA-MEG3 Regulates the Inflammatory Responses and Apoptosis in Porcine Alveolar Macrophages Infected with Haemophilus parasuis Through Modulating the miR-210/TLR4 Axis. Current microbiology. vol 78. issue 8. 2021-07-21. PMID:34191053. |
the gain- and loss-of-function analysis confirmed that lncrna-meg3 participated in the inflammatory responses and apoptosis in hps-infected pams, which was assessed via several inflammatory cytokine genes (tnf-α, il-1β, and il-6) and apoptotic factors (bcl-2, bax, and c-caspase-3). |
2021-07-21 |
2023-08-13 |
Not clear |
| Jian Wei Xu, Ye Yan, Lei Wang, Dong Wu, Nai Kuan Ye, Shi Hong Chen, Feng L. Marine bioactive compound dieckol induces apoptosis and inhibits the growth of human pancreatic cancer cells PANC-1. Journal of biochemical and molecular toxicology. vol 35. issue 2. 2021-07-20. PMID:33051972. |
the induction of apoptosis was further evaluated with different staining techniques such as rhodamine 123 staining, acridine orange/ethidium bromide staining, dapi staining, propidium iodide staining and was confirmed by estimating the protein expression of apoptotic genes, bax and bcl2. |
2021-07-20 |
2023-08-13 |
human |
| Zahra Changizi, Azam Moslehi, Ali Haeri Rohani, Akram Eid. Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice. Journal of biochemical and molecular toxicology. vol 35. issue 2. 2021-07-20. PMID:33058431. |
chlorogenic acid induces 4t1 breast cancer tumor's apoptosis via p53, bax, bcl-2, and caspase-3 signaling pathways in balb/c mice. |
2021-07-20 |
2023-08-13 |
mouse |
| Zhuo Peng, Rui Zhang, Longfei Pan, Honghong Pei, Zequn Niu, Hai Wang, Junhua Lv, Xiaoyan Dan. Glaucocalyxin A Protects H9c2 Cells Against Hypoxia/Reoxygenation-Induced Injury Through the Activation of Akt/Nrf2/HO-1 Pathway. Cell transplantation. vol 29. 2021-07-19. PMID:33172292. |
moreover, gla prevented h/r-stimulated cell apoptosis in h9c2 cells, as evidenced by increased bcl-2 expression, decreased bax expression, as well as reduced caspase-3 activity. |
2021-07-19 |
2023-08-13 |
mouse |
| Tongtong Wang, Yaoxing Dou, Guoshu Lin, Qiaoping Li, Juan Nie, Baoyi Chen, Jianhui Xie, Ziren Su, Huifang Zeng, Jiannan Chen, Youliang Xi. The anti-hepatocellular carcinoma effect of Brucea javanica oil in ascitic tumor-bearing mice: The detection of brusatol and its role. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 134. 2021-07-19. PMID:33341052. |
furthermore, bjo and be-bjo treatment substantially downregulated bcl-2 and mitochondrial cytochrome c protein expression, and upregulated expression levels of bax, bad, cytosol cytochrome c, caspase-3 (cleaved), caspase‑9 (cleaved), parp and parp (cleaved) to induce h22 cells apoptosis. |
2021-07-19 |
2023-08-13 |
mouse |
| Hongyan Ma, Ying Liu, Zhengtian Li, Lu Yu, Yang Gao, Xiangmei Ye, Baoyi Yang, Hulun Li, Jinghui Sh. Propofol Protects Against Hepatic Ischemia Reperfusion Injury via Inhibiting Bnip3-Mediated Oxidative Stress. Inflammation. vol 44. issue 4. 2021-07-19. PMID:33496895. |
pro ameliorated the abnormal histopathology, reduced cell apoptosis and the levels of ast, alt, bnip3, cleaved caspase-3, and bax, but upregulated the bcl-2 level in the liver tissues of i/r mice. |
2021-07-19 |
2023-08-13 |
mouse |
| So-Ra Jeong, Kwang-Won Le. Methylglyoxal-Derived Advanced Glycation End Product (AGE4)-Induced Apoptosis Leads to Mitochondrial Dysfunction and Endoplasmic Reticulum Stress through the RAGE/JNK Pathway in Kidney Cells. International journal of molecular sciences. vol 22. issue 12. 2021-07-19. PMID:34207084. |
moreover, our results showed that age4 induced the expression of apoptosis markers, such as bax, p53, and kidney injury molecule-1, but downregulated bcl-2 and cyclin d1 levels. |
2021-07-19 |
2023-08-13 |
human |
| Gang Zhang, Samuel Kim, Xiaohuan Gu, Shan Ping Yu, Ling We. DPP-4 Inhibitor Linagliptin is Neuroprotective in Hyperglycemic Mice with Stroke via the AKT/mTOR Pathway and Anti-apoptotic Effects. Neuroscience bulletin. vol 36. issue 4. 2021-07-16. PMID:31808042. |
linagliptin up-regulated the expression of p-akt and p-mtor and regulated the apoptosis factors bcl-2, bax, and caspase 9. |
2021-07-16 |
2023-08-13 |
mouse |
| Qichao Hu, Wenwen Zhang, Zhao Wu, Xin Tian, Junbao Xiang, Longxuan Li, Zhihao Li, Xi Peng, Shizhang Wei, Xiao Ma, Yanling Zha. Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects. Pharmacological research. vol 165. 2021-07-16. PMID:33493657. |
regarding the apoptosis pathway, bax, bcl-2, caspase-3 and caspase-9 are key factors related to the suppression of hepatocellular carcinoma and attenuation of liver injury and colorectal cancer. |
2021-07-16 |
2023-08-13 |
Not clear |
| Yunsheng Liu, Xiangping Xu, Han Tang, Yuchen Pan, Bing Hu, Guodong Huan. Rosmarinic acid inhibits cell proliferation, migration, and invasion and induces apoptosis in human glioma cells. International journal of molecular medicine. vol 47. issue 5. 2021-07-16. PMID:33649774. |
in line with this finding, the expression of apoptosis suppressor protein bcl‑2 was downregulated and that of the pro‑apoptotic proteins bax and cleaved caspase‑3 was increased. |
2021-07-16 |
2023-08-13 |
human |
| Sha Zeng, Li Chen, Qiang Sun, Hui Zhao, Han Yang, Shan Ren, Maolun Liu, Xianli Meng, Haibo X. Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade. European journal of pharmacology. vol 906. 2021-07-16. PMID:34118224. |
in crc ht-29 cells, scutellarin retarded the proliferation and migration, induced apoptosis, with boosted bax expression and decreased bcl-2 level, which may be attributed to its repression of wnt/β-catenin signals in ht-29 cells. |
2021-07-16 |
2023-08-13 |
mouse |
| Pin Lv, Yi-Fan Luo, Wen-Yi Zhou, Ben Liu, Zheng Zhou, Yong-Zhong Shi, Ren Huang, Chuang Peng, Zi-Li He, Jun Wang, Hong-Hui Zhang, Sheng-Dan Ni. miR-373 inhibits autophagy and further promotes apoptosis of cholangiocarcinoma cells by targeting ULK1. The Kaohsiung journal of medical sciences. vol 36. issue 6. 2021-07-15. PMID:32125086. |
overexpression of mir-373 reduced proliferation, enhanced apoptosis, and raised expression levels of pro-apoptosis proteins including bcl2 associated x (bax), caspase-3, and caspase-9. |
2021-07-15 |
2023-08-13 |
human |
| Bin Han, Yanhui Zhang, Yuxia Xiao, Bohong Shi, Hong Wu, Desheng Li. Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis. Stem cells international. vol 2021. 2021-07-15. PMID:34257670. |
after evs-mir-375 treatment or foxf1 overexpression, fbmf cell proliferation, migration, invasion, and apoptosis were evaluated, and levels of apoptosis-related proteins (cleaved-caspase-3, bax, and bcl-2) and fibrosis markers ( |
2021-07-15 |
2023-08-13 |
Not clear |
| Claire Baldauf, Monica Sondhi, Bo-Chul Shin, Young Eun Ko, Xin Ye, Kuk-Wha Lee, Sherin U Devaska. Murine maternal dietary restriction affects neural Humanin expression and cellular profile. Journal of neuroscience research. vol 98. issue 5. 2021-07-14. PMID:31840315. |
no difference was found in bcl-2 or bax (apoptosis) between controls and iugr, though qualitatively, immunoreactivity of doublecortin (migration) and ki67 (proliferation) was decreased. |
2021-07-14 |
2023-08-13 |
mouse |
| Ken-Ichiro Tanaka, Ippei Kanazawa, J Brent Richards, David Goltzman, Toshitsugu Sugimot. Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts. Calcified tissue international. vol 106. issue 5. 2021-07-14. PMID:31980842. |
on the other hand, fam210a sirna did not affect mrna encoding the apoptotic factors bcl-2 and bax and the extent of apoptosis as measured by elisa in c2c12 cells. |
2021-07-14 |
2023-08-13 |
mouse |
| Yameng Fan, Jiaqiao Li, Yuxuan Yang, Xiaodan Zhao, Yamei Liu, Yude Jiang, Long Zhou, Yang Feng, Yan Yu, Yilong Chen. Resveratrol modulates the apoptosis and autophagic death of human lung adenocarcinoma A549 cells via a p53‑dependent pathway: Integrated bioinformatics analysis and experimental validation. International journal of oncology. vol 57. issue 4. 2021-07-14. PMID:32945383. |
in validation experiments, rsv significantly reduced cell viability and initiated apoptosis, with an increase in the number of apoptotic cells; it also upregulated cleaved caspase‑3 expression and bax expression, and downregulated the bcl‑2 expression levels. |
2021-07-14 |
2023-08-13 |
human |
| Qinhan Hou, Hongmou Chen, Quan Liu, Xianlei Ya. FGF10 Attenuates Experimental Traumatic Brain Injury through TLR4/MyD88/NF-κB Pathway. Cells, tissues, organs. vol 209. issue 4-6. 2021-07-14. PMID:33440393. |
overexpression of fgf10 increased protein expression of bcl-2, while it decreased bax and cleaved caspase-3/parp, and improved neuronal apoptosis in tbi mice. |
2021-07-14 |
2023-08-13 |
mouse |