| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dingyu Wang, Li Sun, Guowei Zhang, Yang Liu, Zhaoguang Liang, Jing Zhao, Shuangli Yin, Mengqi Su, Song Zhang, Ying Wei, He Liu, Desen Liang, Yue L. Increased Susceptibility of Atrial Fibrillation Induced by Hyperuricemia in Rats: Mechanisms and Implications. Cardiovascular toxicology. vol 21. issue 3. 2021-06-29. PMID:33099748. |
apoptosis and fibrosis of atria were partly mediated by caspase-3, bax, tgf-β1, and α-smooth muscle actin. |
2021-06-29 |
2023-08-13 |
rat |
| Hui He, Chengqiang Wang, Gen Liu, Haoyue Ma, Mingdong Jiang, Pan Li, Qianwei Lu, Li Li, Hongyi Q. Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation. Phytotherapy research : PTR. vol 35. issue 6. 2021-06-29. PMID:33624885. |
moreover, ibc induced mitochondrial apoptosis evidenced by reduced mitochondrial membrane potential, increased bax level, decreased bcl-2, bcl-xl, and mcl-1 levels, elevated cytochrome c level in the cytosol and increased cleavage of caspase-9, caspase-3, and parp. |
2021-06-29 |
2023-08-13 |
mouse |
| Manar G Helal, Ahmed G Abd Elhamee. Graviola mitigates acetic acid-induced ulcerative colitis in rats: insight on apoptosis and Wnt/Hh signaling crosstalk. Environmental science and pollution research international. vol 28. issue 23. 2021-06-28. PMID:33559079. |
both treatments significantly attenuated aa-induced apoptosis via downregulating the expression of bax and caspase-3 and upregulating the expression of the anti-apoptotic protein, bcl-2. |
2021-06-28 |
2023-08-13 |
rat |
| Ajlaa Sofya Mohd Khalil, Nelli Giribabu, Suseela Yelumalai, Huma Shahzad, Eswar Kumar Kilari, Naguib Salle. Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats. Life sciences. vol 278. 2021-06-28. PMID:33989665. |
ma also prevented increase in testicular inflammation and apoptosis, as indicated by low inflammatory (nf-κb p65, ikkβ, tnf-α, il-1β and inos) and apoptosis (bax and caspase-9), but high anti-apoptosis (bcl-2) markers' levels. |
2021-06-28 |
2023-08-13 |
rat |
| Dan Xu, Chonglin Ran, Lizi Yin, Juchun Lin, Hualin Fu, Xi Peng, Xiaoling Zhao, Gang Sh. Acute and Subchronic Toxicity Studies of Aristolochic Acid A in Tianfu Broilers. Animals : an open access journal from MDPI. vol 11. issue 6. 2021-06-27. PMID:34071750. |
the results of qrt-pcr showed that aa reduced the mrna expressions of ho-1, nqo1, raf-1 and bcl-2, while the expressions of bax and caspase-3 increased, which show that aa aroused oxidative stress and promoted the apoptosis of renal cells. |
2021-06-27 |
2023-08-13 |
Not clear |
| XiaoLi Yang, ZhaoFang Li, RongQiang Zhang, Di Zhang, YongMin Xiong, Chen Wang, XueNa Yang, Qiang L. Dysregulation of Transcription Profile of Selenoprotein in Patients with Kashin-Beck Disease and Its Effect on Se Deficiency-Induced Chondrocyte Apoptosis. Biological trace element research. 2021-06-27. PMID:34176076. |
moreover, in the se deficiency group, the mrna levels of gpx3, dio1, and txnrd1 were downregulated and gpx activity was decreased, but the late apoptosis rate, the mrna levels of bax and p53, and the bax/bcl2 ratio were increased; the opposite trend was observed in the se supplement group. |
2021-06-27 |
2023-08-13 |
Not clear |
| Raed Shalaby, Hector Flores-Romero, Ana J García-Sáe. The Mysteries around the BCL-2 Family Member BOK. Biomolecules. vol 10. issue 12. 2021-06-25. PMID:33291826. |
while some studies propose that bok could replace bak and bax to elicit apoptosis, others attribute to this protein an indirect way of apoptosis regulation. |
2021-06-25 |
2023-08-13 |
Not clear |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
ethanol exposure decreased cell viability and the expression of bdnf and increased the cell apoptosis rate and the expression of bax, cleaved caspase-3, il-1β and il-6. |
2021-06-25 |
2023-08-13 |
mouse |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
glua1 silencing aggravated ethanol-induced changes in cell viability and apoptosis and the expression of bdnf, bax and cleaved caspase-3, and glua1 overexpression attenuated these changes. |
2021-06-25 |
2023-08-13 |
mouse |
| Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Men. Lysionotin induces apoptosis of hepatocellular carcinoma cells via caspase-3 mediated mitochondrial pathway. Chemico-biological interactions. vol 344. 2021-06-25. PMID:33989594. |
additionally, the pre-treatment of ac-devd-cho, an inhibitor of caspase-3, strongly restored the low cell viability, the enhanced apoptosis rate, the dissipation of mmp caused by lysionotin exposure, as well as prevented the lysionotin-caused enhancement on expressions of apoptosis related proteins, especially cleaved poly (adp-ribose) polymerase (parp), fas ligand (fasl), cleaved caspase-3 and bax in both hepg2 and smmc-7721 cells. |
2021-06-25 |
2023-08-13 |
mouse |
| Shanmeng Lin, Yuyong He, Yi Gong, Yueling Zhang, Hongyu Ma, Huaiping Zheng, Shengkang L. SpBOK inhibits WSSV infection by regulating the apoptotic pathway in mud crab (Scylla paramamosain). Developmental and comparative immunology. vol 106. 2021-06-24. PMID:31899307. |
b-cell lymphoma 2 (bcl-2) related ovarian killer (bok) is a member of the bcl-2 family, which has a similar function to bax and bak in the process of apoptosis. |
2021-06-24 |
2023-08-13 |
Not clear |
| Chen-Chu Lin, Wan-Ting Liao, Tsung-Ying Yang, Hsueh-Ju Lu, Shih-Lan Hsu, Chun-Chi W. MicroRNA‑10b modulates cisplatin tolerance by targeting p53 directly in lung cancer cells. Oncology reports. vol 46. issue 2. 2021-06-24. PMID:34165168. |
ectopic expression of mir‑10b‑agomir decreased the expression of p53 and its downstream effectors, such as bax and p53 upregulated modulator of apoptosis. |
2021-06-24 |
2023-08-13 |
Not clear |
| Ying Feng, Bu-Zhen Ta. LncRNA MALAT1 inhibits apoptosis of endometrial stromal cells through miR-126-5p-CREB1 axis by activating PI3K-AKT pathway. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32809092. |
knockdown of malat1 or creb1 restrained proliferation and induced apoptosis as confirmed by upregulating cleaved caspase-3 and bax, and down-regulating bcl-2 in hescs, while inhibition of mir-126-5p presented the opposite results. |
2021-06-23 |
2023-08-13 |
human |
| Yu-Ping Zhou, Qin Xi. Inhibition of miR-103a-3p suppresses lipopolysaccharide-induced sepsis and liver injury by regulating FBXW7 expression. Cell biology international. vol 44. issue 9. 2021-06-22. PMID:32369227. |
then, interfering mir-103a-3p significantly decreased apoptosis by suppressing bax expression and upregulating bcl-2 levels in lps-induced aml12 and lo2 cells, and septic liver of mice. |
2021-06-22 |
2023-08-13 |
mouse |
| Duanya Liu, Jun Yu, Jie Xie, Zhaoyu Zhang, Caoli Tang, Tianmei Yu, Shouni Chen, Zhidan Hong, Chunhong Wan. PbAc Triggers Oxidation and Apoptosis via the PKA Pathway in NRK-52E Cells. Biological trace element research. vol 199. issue 7. 2021-06-22. PMID:32926327. |
under the exposure of 40 and 80 μm pbac, the mrna level of b cell lymphoma-2 (bcl-2) in the cells decreased, the mrna levels of bcl-2-associated x protein (bax) and caspase-3 increased, and apoptosis was obvious. |
2021-06-22 |
2023-08-13 |
Not clear |
| Nitish Kumar, Nidhi Sharma, Rishabh Khera, Ria Gupta, Sidharth Meha. Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain. Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33635478. |
in addition, gst prevented apoptosis, as demonstrated by the reduction of caspase-3 and bax. |
2021-06-22 |
2023-08-13 |
rat |
| Sally A Habib, Ghada M Suddek, Mona Abdel Rahim, Rehab S Abdelrahma. The protective effect of protocatechuic acid on hepatotoxicity induced by cisplatin in mice. Life sciences. vol 277. 2021-06-22. PMID:33864821. |
moreover, proto reduced cisplatin-induced apoptosis in the liver through decreasing caspase-3, annexin-v, and bax. |
2021-06-22 |
2023-08-13 |
mouse |
| Jia-Jia Zhang, Chang-Geng Song, Ji-Min Dai, Xue-Qin Zhang, Peng Lin, Ling Li, Xiang-Min Yang, Zhi-Nan Che. Inhibition of mu-opioid receptor suppresses proliferation of hepatocellular carcinoma cells via CD147-p53-MAPK cascade signaling pathway. American journal of translational research. vol 13. issue 5. 2021-06-22. PMID:34149993. |
the mab against mor also enhanced the cisplatin-induced apoptosis of hcc cells by downregulating p-erk, bcl-2 and upregulating bax. |
2021-06-22 |
2023-08-13 |
Not clear |
| Li Pan, Yan Liu, Hainan Lan, Nan Bao, Yuan Zhao, Hui Sun, Guixin Qin, Mohammed Hamdy Farou. Biological Mechanisms Induced by Soybean Agglutinin Using an Intestinal Cell Model of Monogastric Animals. Frontiers in veterinary science. vol 8. 2021-06-22. PMID:34150879. |
with increasing sba levels, the percentage of the cells at g0/g1 phase, cell apoptosis rates, expressions of bax and p21, and the activities of casp-3 and casp-9 were increased, while cyclin d1 and bcl-2 expressions were declined ( |
2021-06-22 |
2023-08-13 |
Not clear |
| Lei Wang, Wenbin Shi, Xuewei Gao, Nagaraja SreeHarsha, Daisong Zhan. Cardioprotective role of metformin against sodium arsenite-induced oxidative stress, inflammation, and apoptosis. IUBMB life. vol 72. issue 4. 2021-06-21. PMID:31587475. |
in addition, sa provoked the apoptosis by expanding the p53 and bax levels, terminal deoxynucleotidyl transferase dutp nick end labeling, and expression of caspase-3. |
2021-06-21 |
2023-08-13 |
rat |