| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Sun, Zhe Wang, Min Sun, Weixin Huang, Yimeng Wang, Yuehui Wan. Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. Cell and tissue research. vol 384. issue 3. 2021-06-18. PMID:33502605. |
moreover, the enhanced apoptosis in cells under si/r conditions were reduced after aloin treatment, concomitant with the decrease in pro-apoptotic bax protein levels and increase in anti-apoptotic bcl-2 protein expression. |
2021-06-18 |
2023-08-13 |
Not clear |
| Tomoyuki Yamakawa, Nobuaki Okamatsu, Koji Ishikawa, Shuichi Kiyohara, Kazuaki Handa, Erika Hayashi, Nobuhiro Sakai, Akiko Karakawa, Masahiro Chatani, Mayumi Tsuji, Katsunori Inagaki, Yuji Kiuchi, Takako Negishi-Koga, Masamichi Takam. Novel gene Merlot inhibits differentiation and promotes apoptosis of osteoclasts. Bone. vol 138. 2021-06-17. PMID:32569872. |
merlot-deficient osteoclasts were found to represent suppression of caspase-3-mediated apoptosis and merlot deficiency caused transcriptional downregulation of a proapoptotic cascade, including bax, bak, noxa, and bim, as well as the executor caspase members casp-3, -6, and -7, and upregulation of anti-apoptotic bcl2, resulting in a low apoptotic threshold. |
2021-06-17 |
2023-08-13 |
mouse |
| Amin Bazzazzadeh, Babak Faraji Dizaji, Nazanin Kianinejad, Arezo Nouri, Mohammad Iran. Fabrication of poly(acrylic acid) grafted-chitosan/polyurethane/magnetic MIL-53 metal organic framework composite core-shell nanofibers for co-delivery of temozolomide and paclitaxel against glioblastoma cancer cells. International journal of pharmaceutics. vol 587. 2021-06-17. PMID:32707243. |
the cell viability, flowcytometry and bcl-2, bax expression levels were investigated to obtain the optimum nanofibrous carrier for apoptosis of u-87 mg cells in vitro. |
2021-06-17 |
2023-08-13 |
Not clear |
| Zihao He, Hanjun Li, Xuequan Han, Feng Zhou, Jingke Du, Yiqi Yang, Qi Xu, Shuhong Zhang, Shuangyan Zhang, Ning Zhao, Mengning Yan, Zhifeng Y. Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice. Bone. vol 141. 2021-06-17. PMID:32768686. |
irisin significantly increased the proliferation of osteocytes, protected them from apoptosis, and maintained cellular activity by regulating the expression of bax, bcl-2, and osteoprotegerin/receptor activator of nuclear factor (nf)-kb-ligand (opg/rankl). |
2021-06-17 |
2023-08-13 |
mouse |
| Timur Yagudin, Yue Zhao, Haiyu Gao, Yang Zhang, Ying Yang, Xiaofang Zhang, Wenbo Ma, Tolessa Muleta Daba, Vladimir Ishmetov, Kai Kang, Baofeng Yang, Zhenwei Pa. iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33128543. |
mechanistically, overexpression of iaspp inhibited, while knockdown of iaspp increased the expressions of p53 and bax, the key regulators of apoptosis. |
2021-06-17 |
2023-08-13 |
mouse |
| Jia-Fei Liu, Dong Guo, En-Ming Kang, Yu-Shan Wang, Xiao-Zhong Gao, Hai-Yan Cong, Peng Liu, Nai-Qian Zhang, Ming-Yi Wan. Acute and chronic infection of H. pylori caused the difference in apoptosis of gastric epithelial cells. Microbial pathogenesis. vol 150. 2021-06-17. PMID:33421608. |
apoptosis of these two models were analyzed by flow cytometry compared with the control cells, meanwhile, apoptosis associated markers (bcl-xl, bcl-2, bax, etc) were detected by western blot, additional in clinical h. pylori-positive gastric cancer tissues. |
2021-06-17 |
2023-08-13 |
Not clear |
| Jia-Fei Liu, Dong Guo, En-Ming Kang, Yu-Shan Wang, Xiao-Zhong Gao, Hai-Yan Cong, Peng Liu, Nai-Qian Zhang, Ming-Yi Wan. Acute and chronic infection of H. pylori caused the difference in apoptosis of gastric epithelial cells. Microbial pathogenesis. vol 150. 2021-06-17. PMID:33421608. |
results showed that compared with the control cells, acute infection of h. pylori significantly accelerated the apoptosis of ges-1, increased the expression of bax and cleaved caspase-3, down-regulated expression of bcl-xl and bcl-2. |
2021-06-17 |
2023-08-13 |
Not clear |
| Chawalit Chatupheeraphat, Sittiruk Roytrakul, Narumon Phaonakrop, Kamolchanok Deesrisak, Sucheewin Krobthong, Usanarat Anurathapan, Dalina Tanyon. A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines. Planta medica. vol 87. issue 7. 2021-06-17. PMID:33757145. |
a novel peptide derived from ginger induces apoptosis through the modulation of p53, bax, and bcl2 expression in leukemic cell lines. |
2021-06-17 |
2023-08-13 |
Not clear |
| Fa-Chun Wan, Chen Zhang, Qing Jin, Chen Wei, Hong-Bo Zhao, Xiang-Lun Zhang, Wei You, Xiao-Mu Liu, Gui-Fen Liu, Yi-Fan Liu, Xiu-Wen Ta. Protective effects of astaxanthin on lipopolysaccharide-induced inflammation in bovine endometrial epithelial cells†. Biology of reproduction. vol 102. issue 2. 2021-06-16. PMID:31566218. |
the effects of ast were mediated through the downregulation of b-cell lymphoma 2 (bcl-2) associated x, apoptosis regulator (bax), and cleaved caspase-3 and through the upregulation of bcl-2. |
2021-06-16 |
2023-08-13 |
cattle |
| Javed Ahmad, Rizwan Wahab, Maqsood A Siddiqui, Quaiser Saquib, Naushad Ahmad, Abdulaziz A Al-Khedhair. Strontium-Doped Nickel Oxide Nanoparticles: Synthesis, Characterization, and Cytotoxicity Study in Human Lung Cancer A549 Cells. Biological trace element research. 2021-06-16. PMID:34131861. |
as a result, apoptosis was mediated by the p53, bax, caspase3, and bcl-2 pathways, implying a potential mechanism by which srnionps mediate their toxicity. |
2021-06-16 |
2023-08-13 |
human |
| D Martínez, C Vargas-Lagos, J Saravia, R Oyarzún, C Loncoman, J P Pontigo, L Vargas-Chacof. Cellular stress responses of Eleginops maclovinus fish injected with Piscirickettsia salmonis and submitted to thermal stress. Cell stress & chaperones. vol 25. issue 1. 2021-06-15. PMID:31834618. |
the genes implied in the heat shock response (hsp70, hsc70, hsp90, and grp78), apoptosis pathway (bax and smac/diablo), ubiquitination (e2, e3, ubiquitin, and chip), and 26 proteasome complex (psmb7, psmc1, and psma2) showed expression profiles dependent on time and type of injection applied. |
2021-06-15 |
2023-08-13 |
Not clear |
| Faming Wang, Muhammad Younis, Yao Luo, Le Zhang, Liudi Yua. Iguratimod-encapsulating PLGA-NPs induce human multiple myeloma cell death via reactive oxygen species and Caspase-dependent signalling. International immunopharmacology. vol 95. 2021-06-15. PMID:33756230. |
mechanistically, igu-plga-nps increase apoptosis in mm cells by activating caspase-dependent signalling pathway to increase the levels of bax, cytochrome c (cyt-c), caspase-9 and caspase-3 proteins. |
2021-06-15 |
2023-08-13 |
mouse |
| Chawalit Chatupheeraphat, Sittiruk Roytrakul, Narumon Phaonakrop, Kamolchanok Deesrisak, Sucheewin Krobthong, Usanarat Anurathapan, Dalina Tanyon. Correction: A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines. Planta medica. 2021-06-15. PMID:33784770. |
correction: a novel peptide derived from ginger induces apoptosis through the modulation of p53, bax, and bcl2 expression in leukemic cell lines. |
2021-06-15 |
2023-08-13 |
Not clear |
| Ehraz Anis, Mohd Faraz Zafeer, Fakiha Firdaus, Shireen Naaz Islam, Azka Anees Khan, M Mobarak Hossai. Perillyl Alcohol Mitigates Behavioural Changes and Limits Cell Death and Mitochondrial Changes in Unilateral 6-OHDA Lesion Model of Parkinson's Disease Through Alleviation of Oxidative Stress. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32394056. |
we observed that pa treatment blocked bax and drp1 translocation to mitochondria, an event often associated with the inception of apoptosis. |
2021-06-14 |
2023-08-13 |
rat |
| Yu-Ping Gong, Ya-Wei Zhang, Xiao-Qing Su, Hai-Bo Ga. Inhibition of long noncoding RNA MALAT1 suppresses high glucose-induced apoptosis and inflammation in human umbilical vein endothelial cells by suppressing the NF-κB signaling pathway. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 6. 2021-06-10. PMID:32502356. |
the expression levels of malat1, tnf-α, and il-6 in huvecs were increased in the hg environment; however, when malat1 was silenced in the huvecs, cell proliferation increased significantly, the expression levels of tnf-α, il-6, bax, cleaved-caspase-3, and cleaved-caspase-9 decreased, and the rate of apoptosis also decreased. |
2021-06-10 |
2023-08-13 |
human |
| Negin Mokri, Zahra Sepehri, Farnaz Faninam, Sepideh Khaleghi, Negar Motakef Kazemi, Mehrdad Hashem. Chitosan-coated Zn-metal-organic framework nanocomposites for effective targeted delivery of LNA-antisense miR-224 to colon tumor: in vitro studies. Gene therapy. 2021-06-10. PMID:34108628. |
in these investigations, decreased cell viability (14.22 ± 0.3% after 72 h treatment), increased apoptotic and autophagy-related genes expression level (beclin1: 34-folds, bax: 36-folds, mtorc1: 10-folds, and caspase-9: 9-folds more than control), higher cell cycle arrest in sub-g1 phase (19.53% of cells in sub-g1 phase), and more apoptosis analyses (late apoptosis: 67.7%) were evaluated in colon cancer cells treated with mcfl224 nano-complex. |
2021-06-10 |
2023-08-13 |
Not clear |
| Li Zhang, Lu Wang, Han Xiao, Hui Gan, Hui Chen, Shuyue Zheng, Dan Jian, Xuan Zhai, Ning Jiang, Zhao Jing, Ping Lian. Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling. Journal of molecular medicine (Berlin, Germany). vol 99. issue 3. 2021-06-09. PMID:33409551. |
fyn downregulation reduced apoptosis following ich, as indicated by downregulation of apoptosis-related proteins aif, cyt.c, caspase 3, and bax; upregulation of anti-apoptosis-related protein bcl-2; and decreased tunnel staining. |
2021-06-09 |
2023-08-13 |
human |
| Ruiqi Zhu, Li Li, Bao Nguyen, Jaesung Seo, Min Wu, Tessa Seale, Mark Levis, Amy Duffield, Yu Hu, Donald Smal. FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation. Signal transduction and targeted therapy. vol 6. issue 1. 2021-06-09. PMID:34024909. |
treatment with the drugs together resulted in dissociation of bim from both bcl-2 and mcl-1, with an increased binding of bim to the cell death mediator bax, leading to increased apoptosis. |
2021-06-09 |
2023-08-13 |
Not clear |
| Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Angela Trovato Salinaro, Emanuela Raffone, Tiziana Genovese, Salvatore Cuzzocrea, Roberta Fusco, Rosanna Di Paol. Autophagy and Mitophagy Promotion in a Rat Model of Endometriosis. International journal of molecular sciences. vol 22. issue 10. 2021-06-09. PMID:34064854. |
rapamycin was administered by activating autophagy and mitophagy, which increased apoptosis (assessed by western blot analysis of bcl-2, bax, and cleaved-caspase 3) and reduced angiogenesis (assessed by immunohistochemical analysis of vascular endothelial grow factor (vegf) and cd34) in the lesions. |
2021-06-09 |
2023-08-13 |
rat |
| Dong-Hui Xu, Guo-Nan Chi, Cong-Hai Zhao, Dong-Yuan L. Long noncoding RNA MEG3 inhibits proliferation and migration but induces autophagy by regulation of Sirt7 and PI3K/AKT/mTOR pathway in glioma cells. Journal of cellular biochemistry. 2021-06-08. PMID:30417553. |
cell viability and migration were significantly reduced by meg3 overexpression whereas cell apoptosis as well as bax and cleaved caspase-3/-9 proteins were obviously induced. |
2021-06-08 |
2023-08-13 |
Not clear |