| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Damilare D Akintade, Bhabatosh Chaudhur. Identification of proteins involved in transcription/translation (eEF 1A1) as an inhibitor of Bax induced apoptosis. Molecular biology reports. vol 47. issue 9. 2021-06-03. PMID:32875432. |
the part eef1a1 plays in apoptosis has been contentious, amidst the pro and anti-apoptotic properties of eef1a1, it was shown clearly, in this study that eef1a1 portrays only anti-apoptotic property in the presence of pro-apoptotic protein, bax. |
2021-06-03 |
2023-08-13 |
human |
| Xinrong Pan, Lingling H. LncRNA MEG3 expression in sepsis and its effect on LPS-induced macrophage function. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 5. 2021-06-03. PMID:33040826. |
compared with the nc group, the macrophage apoptosis rate in the lps group was increased (p <0.05), the levels of bax and p-p65 protein were significantly increased (p <0.05), and the level of bcl-2 protein was decreased (p <0.05), the levels of il-1β and tnf-α were increased (p <0.05). |
2021-06-03 |
2023-08-13 |
human |
| Xinrong Pan, Lingling H. LncRNA MEG3 expression in sepsis and its effect on LPS-induced macrophage function. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 5. 2021-06-03. PMID:33040826. |
compared with the lps + pcdna group, the apoptosis rate of the lps + pcdna-meg3 group was significantly reduced (p <0.05), the levels of bax and p-p65 protein were reduced (p <0.05), and the level of bcl-2 protein was significantly increased (p <0.05), the levels of il-1β and tnf-α were reduced (p <0.05). |
2021-06-03 |
2023-08-13 |
human |
| Xiaolin Xia, Junlian Wang, Qifang Li. Effect of total flavones of Clematis filamentosa Dunn on the oxLDL-induced injury of vascular smooth muscle cells by regulating miR-455-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 5. 2021-06-03. PMID:33040830. |
the expressions of inflammatory factors il-1β and tnf-α were analyzed by elisa, the apoptosis was evaluated by flow cytometry, the expression of bcl-2 and bax was determined by western blot, and the real-time fluorescence quantitative pcr (qrt-pcr) was applied to detect mir-455-5p expression. |
2021-06-03 |
2023-08-13 |
Not clear |
| Xiaolin Xia, Junlian Wang, Qifang Li. Effect of total flavones of Clematis filamentosa Dunn on the oxLDL-induced injury of vascular smooth muscle cells by regulating miR-455-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 5. 2021-06-03. PMID:33040830. |
the total flavones of clematis filamentosa dunn significantly inhibited the expression of il-1β, tnf-α, apoptosis rate, bax protein expression of oxldl induced vascular smooth muscle cells, and remarkably promoted the expression of bcl-2 protein and mir-455-5p, which all showed concentration dependence (p<0.05). |
2021-06-03 |
2023-08-13 |
Not clear |
| Xiaolin Xia, Junlian Wang, Qifang Li. Effect of total flavones of Clematis filamentosa Dunn on the oxLDL-induced injury of vascular smooth muscle cells by regulating miR-455-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 5. 2021-06-03. PMID:33040830. |
overexpression of mir-455-5p reduced il-1β, tnf-α expression, apoptosis rate, bax protein expression, and greatly increased bcl-2 protein expression in oxldl injured vascular smooth muscle cells (p<0.05). |
2021-06-03 |
2023-08-13 |
Not clear |
| Xiaolin Xia, Junlian Wang, Qifang Li. Effect of total flavones of Clematis filamentosa Dunn on the oxLDL-induced injury of vascular smooth muscle cells by regulating miR-455-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 5. 2021-06-03. PMID:33040830. |
after interfering with the expression of mir-455-5p, the inhibitory effect of total flavones of clematis filamentosa dunn on the expression of il-1β, tnf-α, apoptosis, bax protein expression of oxldl-induced vascular smooth muscle cells was reversed, and its promotion effect on bcl-2 protein expression was also reversed. |
2021-06-03 |
2023-08-13 |
Not clear |
| Chuanlei Li, Zhihuang Zheng, Yun Xie, Nan Zhu, Jinfang Bao, Qing Yu, Zhigang Zhou, Jun Li. Protective effect of taraxasterol on ischemia/reperfusion-induced acute kidney injury via inhibition of oxidative stress, inflammation, and apoptosis. International immunopharmacology. vol 89. issue Pt A. 2021-06-03. PMID:33183976. |
moreover, taraxasterol treatment remarkably ameliorated apoptosis in the kidney by decreasing bax expression and conserving bcl2. |
2021-06-03 |
2023-08-13 |
mouse |
| Hasan Bagherpour Shamloo, Arman Shahabi, Zahra Aghazadeh, Ahmad Yari Khosroushah. Pichia fermentans originates apoptosis in human oral squamous cell carcinoma by over-expressing BAX and CASP 9 genes. Cytotechnology. vol 72. issue 3. 2021-06-02. PMID:32253629. |
pichia fermentans originates apoptosis in human oral squamous cell carcinoma by over-expressing bax and casp 9 genes. |
2021-06-02 |
2023-08-13 |
human |
| DingWei Zhang, Yuan Wang, YuMin Xia, Jia Huo, YanFei Zhang, PeiWen Yang, YuHui Zhang, XiaoXue Wan. Repression of miR-142-3p alleviates psoriasis-like inflammation by repressing proliferation and promoting apoptosis of keratinocytes via targeting Sema3A. Molecular and cellular probes. vol 52. 2021-06-02. PMID:32325105. |
in addition, inhibition of mir-142-3p dramatically restricted cell proliferation and enhanced apoptosis in hacat cells exposed to m5, as exemplified by a decrease in the antiapoptotic bcl-2 protein, concomitant with an increase in the proapoptotic proteins bax. |
2021-06-02 |
2023-08-13 |
human |
| Ankita Kaushik, Sandhya Anand, Deepa Bhartiy. Altered Biology of Testicular VSELs and SSCs by Neonatal Endocrine Disruption Results in Defective Spermatogenesis, Reduced Fertility and Tumor Initiation in Adult Mice. Stem cell reviews and reports. vol 16. issue 5. 2021-06-02. PMID:32592162. |
transcripts specific for apoptosis (bcl2, bax) remained unaffected but tumor suppressor (p53) and epigenetic regulator (np95) transcripts showed marked disruption. |
2021-06-02 |
2023-08-13 |
mouse |
| Haihua Zhang, Wuying Lang, Shiyong Wang, Binru Li, Guangyu Li, Qiumei Sh. Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway. International immunopharmacology. vol 88. 2021-06-02. PMID:33182056. |
ep suppressed lps-induced apoptosis along with down-regulation of bcl2-associated x (bax) and cleaved caspase-3 (cc3), and elevated b-cell lymphoma-2 (bcl-2). |
2021-06-02 |
2023-08-13 |
Not clear |
| Weiguo Wang, Jian Xin, Wenming Chen, Lizhong Jing, Peng Zhan. Icariin alleviates hypoxia-induced damage in MC3T3-E1 cells by downregulating TALNEC2. Biotechnology and applied biochemistry. vol 67. issue 6. 2021-06-01. PMID:31845407. |
it also promoted apoptosis by increasing apoptotic cells, bax, and cleaved-poly adp-ribose polymerase but decreasing bcl-2. |
2021-06-01 |
2023-08-13 |
Not clear |
| D V Novikov, S G Selivanova, N V Krasnogorova, E N Gorshkova, S N Pleskova, V V Novikov, A V Karaulo. Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell. Bulletin of experimental biology and medicine. vol 169. issue 1. 2021-06-01. PMID:32495165. |
we studied changes in the transcription of genes encoding cytokines (tnf, il-6, il-10, and il-32), cell activation markers (icam1, cd38, fas, and fcgriii), ros production catalyst (nox2), autophagy (beclin 1, lc3b, and p62) and apoptosis (bax, bcl2) regulators in peripheral blood mononuclear cells upon contact with quantum dots cdse/zns-mpa and cdse/cdsezns/zns-ptvp. |
2021-06-01 |
2023-08-13 |
human |
| Firas Khathayer, Swapan K Ra. Diosgenin as a Novel Alternative Therapy for Inhibition of Growth, Invasion, and Angiogenesis Abilities of Different Glioblastoma Cell Lines. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32683533. |
it also induced apoptosis in c6 and t98g cell lines and the molecular mechanisms involved in the induction of apoptosis included increase in pro-apoptotic bax protein and decrease in anti-apoptotic bcl-2 protein. |
2021-06-01 |
2023-08-13 |
human |
| Hongxu Sheng, Wang Lv, Linhai Zhu, Luming Wang, Zhitian Wang, Jia Han, Jian H. Liriopesides B induces apoptosis and cell cycle arrest in human non‑small cell lung cancer cells. International journal of molecular medicine. vol 46. issue 3. 2021-06-01. PMID:32705266. |
flow cytometry revealed that lpb significantly induced apoptosis of nsclc cells, along with changes in the expression of apoptosis‑associated proteins, including an increase in bax, caspase‑3, and caspase‑8 expression, and a decrease in bcl‑2 and bcl‑xl expression. |
2021-06-01 |
2023-08-13 |
human |
| Mohd Firdaus Che Mat, Ezanee Azlina Mohamad Hanif, Nor Azian Abdul Murad, Kamariah Ibrahim, Roslan Harun, Rahman Jama. Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells. Molecular biology reports. vol 48. issue 2. 2021-06-01. PMID:33590411. |
silencing of zfp36l2 increases sensitivity to temozolomide through g2/m cell cycle arrest and bax mediated apoptosis in gbm cells. |
2021-06-01 |
2023-08-13 |
human |
| Mohd Firdaus Che Mat, Ezanee Azlina Mohamad Hanif, Nor Azian Abdul Murad, Kamariah Ibrahim, Roslan Harun, Rahman Jama. Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells. Molecular biology reports. vol 48. issue 2. 2021-06-01. PMID:33590411. |
downstream analysis showed that the sub-lethal dose of temozolomide and sizfp26l2 caused major upregulation of bcl2-associated x, apoptosis regulator (bax). |
2021-06-01 |
2023-08-13 |
human |
| Yin-Gi Jang, Eul-Bee Ko, Kyung-Chul Cho. Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression. The Journal of nutritional biochemistry. vol 84. 2021-05-31. PMID:32615369. |
western blot analysis revealed down-regulated expression of hdac1 and 2, leading to up-regulation of acetyl-p53 expression at the protein level, subsequent to down-regulating the expression of cell-cycle-related genes, i.e., proliferating cell nuclear antigen (pcna), cyclin d1 and e1, up-regulating the expression of cell cycle arrest gene p21 and regulating the expression of apoptosis intrinsic pathway-related genes, such as bax, bcl-2, cleaved caspase-3 and poly (adp-ribose) polymerase 1 in both pca cell lines. |
2021-05-31 |
2023-08-13 |
mouse |
| Jingmin Che, Huanhuan Lv, Jiancheng Yang, Bin Zhao, Sibo Zhou, Tongyao Yu, Peng Shan. Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro. Cellular signalling. vol 84. 2021-05-31. PMID:33901579. |
moreover, fac dose-dependently decreased mitochondrial membrane potential (mmp) and enhanced the expression of apoptosis related proteins (bax, cyto-c and c-caspase3). |
2021-05-31 |
2023-08-13 |
Not clear |