| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoqin Feng, Xiangying Zhang, Yan Li, Renxiao Wan. Analysis of the Binding Sites on BAX and the Mechanism of BAX Activators through Extensive Molecular Dynamics Simulations. Journal of chemical information and modeling. 2021-05-28. PMID:34047559. |
the bax protein is a pro-apoptotic member of the bcl-2 family, which triggers apoptosis by causing permeabilization of the mitochondrial outer membrane. |
2021-05-28 |
2023-08-13 |
Not clear |
| Yanhui Chu, Luxin Li, Yong Liu, Yan Wu, He Bai, Jieting Liu, Xiaohuan Yuan, Zhen Zhan. FGF1 inhibits H₂O₂-induced mitochondrion-dependent apoptosis in H9c2 cells. Die Pharmazie. vol 75. issue 7. 2021-05-27. PMID:32635976. |
the content of ros, calcium ion, mitochondrial membrane potential and apoptosis were detected by fluorescence probe, the mrna expression of bcl-2, bax and caspase-3 were detected by real-time pcr to evaluate whether fgf1 has ability to resist the apoptosis of cardiomyocytes caused by oxidative damage. |
2021-05-27 |
2023-08-13 |
Not clear |
| Yanhui Chu, Luxin Li, Yong Liu, Yan Wu, He Bai, Jieting Liu, Xiaohuan Yuan, Zhen Zhan. FGF1 inhibits H₂O₂-induced mitochondrion-dependent apoptosis in H9c2 cells. Die Pharmazie. vol 75. issue 7. 2021-05-27. PMID:32635976. |
the results showed that the proliferation of h9c2 cells could be inhibited after being treated with 200 μm h₂o₂ for 12 h, and 100 μg/ml fgf1 could increase the proliferation rate of h9c2 cells, mitochondrial membrane potential and the mrna expression of bcl-2, and reduce the ros accumulation, the level of apoptosis, the content of intracellular calcium and the mrna expression of bax and caspase-3 caused by h₂o₂. |
2021-05-27 |
2023-08-13 |
Not clear |
| Tuan-Tuan Hao, Rui Liao, Deng-Liang Lei, Gang-Li Hu, Fang Lu. Inhibition of B7-H4 promotes hepatocellular carcinoma cell apoptosis and autophagy through the PI3K signaling pathway. International immunopharmacology. vol 88. 2021-05-27. PMID:32805693. |
here, western blotting was used to measure the expression of the related proteins involved in changes in of autophagy and apoptosis, such as lc3, p62, cleaved caspase 3, cleaved parp, bcl-2, and bax in huh7 and hep3b cells. |
2021-05-27 |
2023-08-13 |
Not clear |
| Ilona Kowalczyk-Zieba, Dorota Boruszewska, Katarzyna Suwik, Joanna Staszkiewicz-Chodor, Joanna Jaworska, Izabela Woclawek-Potock. Iloprost affects in vitro maturation and developmental competence of bovine oocytes. Theriogenology. vol 157. 2021-05-27. PMID:32823024. |
moreover, iloprost reduced the occurrence of apoptosis in cocs and promoted an antiapoptotic balance in the transcription of genes involved in apoptosis (bax and bcl2). |
2021-05-27 |
2023-08-13 |
cat |
| Tingxu Yan, Tingting Nian, Fuyuan Li, Bosai He, Ying Jia, Kaishun Bi, Zhenzhong Wan. Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. vol 44. issue 11. 2021-05-26. PMID:32910486. |
furthermore, sal was found to be able to inhibit pa-induced apoptosis that down-regulates cleaved caspase-3 and bax expressions, while up-regulating bcl-2 expression and up-regulates the bcl-2/bax ratio in glucosamine induced insulin resistance model. |
2021-05-26 |
2023-08-13 |
Not clear |
| Xinru Pang, Linlin Shao, Xiaojuan Nie, Haiyue Yan, Chao Li, Abrey J Yeo, Martin F Lavin, Qing Xia, Hua Shao, Gongchang Yu, Qiang Jia, Cheng Pen. Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition. International immunopharmacology. vol 91. 2021-05-26. PMID:33352442. |
in addition, we found that emodin inhibited apoptosis and demonstrated an anti-fibrotic effect by down-regulating the pro-apoptotic protein bax and up-regulating the anti-apoptotic protein bcl-2. |
2021-05-26 |
2023-08-13 |
mouse |
| Hong Yang, Jianxia Chen, Yanghaoyu Chen, Yan Jiang, Baoxue Ge, Ling Hon. Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax. International immunopharmacology. vol 91. 2021-05-26. PMID:33373810. |
sirt1 activation negatively regulates overt apoptosis in mtb-infected macrophage through bax. |
2021-05-26 |
2023-08-13 |
mouse |
| Hong Yang, Jianxia Chen, Yanghaoyu Chen, Yan Jiang, Baoxue Ge, Ling Hon. Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax. International immunopharmacology. vol 91. 2021-05-26. PMID:33373810. |
thus, it seems that sirt1 acts as a novel regulator of apoptosis signaling in m. tuberculosis infection via its effects on bax. |
2021-05-26 |
2023-08-13 |
mouse |
| Lu Yu, Qikang Chen, Xin Chu, Yang Luo, Zizhao Feng, Liqun Lu, Ye Zhang, Dan X. Expression and regulation of ccBAX by miR-124 in the caudal fin cell of C. auratus gibelio upon cyprinid herpesvirus 2 infection. Journal of fish diseases. vol 44. issue 6. 2021-05-26. PMID:33400351. |
bax, the death-promoting protein of bcl2 family, mediated mitochondrial pathway inducing cells' apoptosis in mammal. |
2021-05-26 |
2023-08-13 |
mouse |
| Xiaoguang Gu, Yimeng Wang, Chunlei Zhang, Yongsheng Li. GFI-1 overexpression promotes cell proliferation and apoptosis resistance in mycosis fungoides by repressing Bax and P21. Oncology letters. vol 22. issue 1. 2021-05-26. PMID:34025788. |
gfi-1 overexpression promotes cell proliferation and apoptosis resistance in mycosis fungoides by repressing bax and p21. |
2021-05-26 |
2023-08-13 |
Not clear |
| Peipei Zhou, Lin Zhou, Yingying Shi, Zhuolun Li, Liwei Liu, Lihua Zuo, Jun Zhang, Shuhong Liang, Jian Kang, Shuzhang Du, Jing Yang, Zhi Sun, Xiaojian Zhan. Neuroprotective Effects of Danshen Chuanxiongqin Injection Against Ischemic Stroke: Metabolomic Insights by UHPLC-Q-Orbitrap HRMS Analysis. Frontiers in molecular biosciences. vol 8. 2021-05-26. PMID:34026822. |
results showed that dscxq intervention significantly reduced cerebral infarct size, ameliorated behavioral abnormality, inhibited the expression of sphk1, s1pr1, cd62p, bax, cleaved caspase-3, while increased the level of bcl-2, and prevented neuronal apoptosis. |
2021-05-26 |
2023-08-13 |
Not clear |
| Weiling Li, Kuan Lin, Mei Zhou, Qi Xiong, Chaoying Li, Qin R. Polysaccharides from Opuntia milpa alta alleviate alloxan-induced INS-1 cells apoptosis via reducing oxidative stress and upregulating Nrf2 expression. Nutrition research (New York, N.Y.). vol 77. 2021-05-25. PMID:32422500. |
we found that maps could attenuate alloxan-induced apoptosis by increasing the expression of bcl-2 and decreasing the expression of bax and the activities of caspase-3 and caspase-9. |
2021-05-25 |
2023-08-13 |
Not clear |
| Panpan Liu, Yurun Xue, Bin Zheng, Yingran Liang, Jianping Zhang, Jing Shi, Xi Chu, Xue Han, Li Ch. Crocetin attenuates the oxidative stress, inflammation and apoptosisin arsenic trioxide-induced nephrotoxic rats: Implication of PI3K/AKT pathway. International immunopharmacology. vol 88. 2021-05-25. PMID:32919218. |
further, ato induced apoptosis by significantly enhancing cytc, bax and caspase-3 and inhibiting bcl-2. |
2021-05-25 |
2023-08-13 |
rat |
| Yan Yang, Li Meng, Shun Wu, You Li, Yu Zhong, Feng Xu, Xiao-Cui Zhou, Gui-Qing Li, Gui-Lian Xu, Kan-Fu Pen. LIGHT deficiency aggravates cisplatin-induced acute kidney injury by upregulating mitochondrial apoptosis. International immunopharmacology. vol 89. issue Pt A. 2021-05-25. PMID:33045563. |
moreover, in the renal tissues of light ko mice, cisplatin-induced mitochondrion injury and the levels of the pro-apoptotic molecules bax, cytochrome c (cyt c), cleaved caspase-3, and cleaved caspase-9 were dramatically increased; in contrast, the expression of anti-apoptotic molecule bcl-2 was markedly reduced, compared to those in wt mice, suggesting that light deficiency accelerated cisplatin-induced mitochondrial apoptosis of renal tubular cells in these mice. |
2021-05-25 |
2023-08-13 |
mouse |
| Md Shihabul Islam, Md Sifat Rahi, Chowdhury Arif Jahangir, Israt Jerin, Md Mahmudul Hasan, Kazi Md Faisal Hoque, Md Abu Rez. Deciphering the molecular pathways of apoptosis using purified fractions from leaf extract of Basella alba through studying the regulation of apoptosis related genes. Molecular biology reports. vol 48. issue 1. 2021-05-25. PMID:33454909. |
the polymerase chain reaction amplification of bax, bcl-2 (b-cell lymphoma 2), p53, tumor necrosis factor-α, fas, nf-kβ (nuclear factor-kappa-b), parp-1 (poly (adp-ribose) polymerase), cyt-c cas-8, cas-9 and cas-3 revealed that the experimental sample able to induce apoptosis in both extrinsic and intrinsic pathways through altering the gene expression. |
2021-05-25 |
2023-08-13 |
Not clear |
| Joshua A Grosser, Rachel L Fehrman, Dennis Keefe, Martin Redmon, Robert W Nickell. The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis. BMC research notes. vol 14. issue 1. 2021-05-25. PMID:34022923. |
the effects of a mitochondrial targeted peptide (elamipretide/ss31) on bax recruitment and activation during apoptosis. |
2021-05-25 |
2023-08-13 |
Not clear |
| Joshua A Grosser, Rachel L Fehrman, Dennis Keefe, Martin Redmon, Robert W Nickell. The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis. BMC research notes. vol 14. issue 1. 2021-05-25. PMID:34022923. |
several studies have documented cell protective features of this peptide, including impairment of intrinsic apoptosis by inhibiting the recruitment and activation of the pro-apoptotic bax protein. |
2021-05-25 |
2023-08-13 |
Not clear |
| Surya P Singh, Abhijeet Mishra, Ritis K Shyanti, Rana P Singh, Arbind Achary. Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells. Biological trace element research. vol 199. issue 4. 2021-05-24. PMID:32557113. |
induction of apoptosis (57%) was revealed by ao/eb staining in du145 cells along with induction of bax, cleaved caspase-3, and cleaved parp proteins. |
2021-05-24 |
2023-08-13 |
human |
| Yajing Wang, Aoyun Li, Khalid Mehmood, Riaz Hussain, Rao Zahid Abbas, M Tariq Javed, Yung-Fu Chang, Lianmei Hu, Jiaqiang Pan, Ying Li, Lijun Shi, Zhaoxin Tang, Hui Zhan. Long-term exposure to the fluoride blocks the development of chondrocytes in the ducks: The molecular mechanism of fluoride regulating autophagy and apoptosis. Ecotoxicology and environmental safety. vol 217. 2021-05-21. PMID:33864983. |
more importantly, fluoride exposure induced apoptosis of tibial bone through cytc/bcl-2/p53 pathways via targeting caspase3, caspase9, bak1, and bax expressions. |
2021-05-21 |
2023-08-13 |
Not clear |