| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaobo Yang, Meng Zhang, Meng Wei, Anqi Wang, Yongning Deng, Hongmei Ca. MicroRNA-216a inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax. Metabolic brain disease. vol 35. issue 4. 2021-05-11. PMID:32140823. |
microrna-216a inhibits neuronal apoptosis in a cellular parkinson's disease model by targeting bax. |
2021-05-11 |
2023-08-13 |
Not clear |
| Xiaobo Yang, Meng Zhang, Meng Wei, Anqi Wang, Yongning Deng, Hongmei Ca. MicroRNA-216a inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax. Metabolic brain disease. vol 35. issue 4. 2021-05-11. PMID:32140823. |
bax downstream factors were also involved in mir-216a regulation of mpp + -triggered neuronal apoptosis. |
2021-05-11 |
2023-08-13 |
Not clear |
| Yemei Yang, Shengfang Ma, Zi Ye, Xianyi Zho. MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway. Journal of cellular biochemistry. vol 121. issue 2. 2021-05-10. PMID:31535400. |
to further investigate the regulatory mechanisms of mcm7 in cm progress, the expression of mcm7, akt1, mtor, cyclin d1, as well as autophagy and apoptosis relative factors, such as lc3b, sod2, dj-1, p62, bcl-2, bax, and caspase-3 in melanoma cells was determined. |
2021-05-10 |
2023-08-13 |
Not clear |
| Yemei Yang, Shengfang Ma, Zi Ye, Xianyi Zho. MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway. Journal of cellular biochemistry. vol 121. issue 2. 2021-05-10. PMID:31535400. |
mcm7 silencing contributed to the increased expression of bax, capase-3, and autophagy-related genes (lc3b, sod2, and dj-1), but decreased the expression of bcl-2, which suggested that mcm7 silencing promoted autophagy and cell apoptosis. |
2021-05-10 |
2023-08-13 |
Not clear |
| Jingjing Zhao, Gen Li, Xuan Zhao, Xin Lin, Yunge Gao, Nuno Raimundo, Geng-Lin Li, Wei Shang, Hao Wu, Lei Son. Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. Aging. vol 12. issue 7. 2021-05-10. PMID:32240104. |
to further explore the role of ampk signaling in the auditory phenotype, we used genetically knocked out ampkα1 as a rescue to tg-mttfb1 mice and observed: improved abr wave i, ep and ihc function, normal sgns, ihc synapses morphology and ohc survivals, with decreased ros, reduced pro-apoptotic signaling (bax) and increased anti-apoptotic signaling (bcl-2) in the cochlear tissues, indicating that reduced ampk attenuated apoptosis via ros-ampk-bcl2 pathway in the cochlea. |
2021-05-10 |
2023-08-13 |
mouse |
| María-Aránzazu Martínez, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, Jose-Luis Rodríguez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, Jose-Manuel de la Rosa, Mercedes Cuet. Protective effects of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) against oxidant-induced stress in human colon carcinoma Caco-2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 145. 2021-05-10. PMID:32784000. |
moreover, cb08035-sca and cb08035-syp treatments reduced significantly bax, bnip3, apaf1, erk1, jnk1, mapk1, nfκb1, tnfα, il-6, il-1β and ho-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-booh. |
2021-05-10 |
2023-08-13 |
human |
| Zhangyong Yin, Enguo Chen, Xiaoping Cai, Enhui Gong, Yuling Li, Cunlai Xu, Zaiting Ye, Zhuo Cao, Jiongwei Pa. Baicalin attenuates XRCC1-mediated DNA repair to enhance the sensitivity of lung cancer cells to cisplatin. Journal of receptor and signal transduction research. 2021-05-10. PMID:33719846. |
baicalin enhanced the effect of cisplatin on promoting apoptosis, arresting cell on s stage and triggering dna damage accompanied with the upregulation of bcl-2-associated x protein (bax) and downregulation of b-cell lymphoma 2 (bcl-2) and cyclin d1 in a549/dpp cells. |
2021-05-10 |
2023-08-13 |
Not clear |
| Qian Zhang, Jia Wang, Huili Zhang, Tao Zen. Dihydromyricetin inhibits oxidative stress and apoptosis in oxygen and glucose deprivation/reoxygenation‑induced HT22 cells by activating the Nrf2/HO‑1 pathway. Molecular medicine reports. vol 23. issue 6. 2021-05-10. PMID:33786616. |
dhm also inhibited cell apoptosis induced by ogd/r, and decreased the protein expression levels of bax and caspase‑3, and increased the expression levels of bcl‑2. |
2021-05-10 |
2023-08-13 |
mouse |
| Robert T Flemmer, Sarah P Connolly, Brittany A Geizer, Joseph T Opferman, Jacqueline L Vanderlui. The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis. Frontiers in cell and developmental biology. vol 9. 2021-05-08. PMID:33959612. |
breeding the mcl-1 cko mouse with the bax null mouse rescued the majority of npc from apoptosis except in the dorsomedial brainstem and ventral thoracic spinal cord where only 50% were rescued. |
2021-05-08 |
2023-08-13 |
mouse |
| Robert T Flemmer, Sarah P Connolly, Brittany A Geizer, Joseph T Opferman, Jacqueline L Vanderlui. The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis. Frontiers in cell and developmental biology. vol 9. 2021-05-08. PMID:33959612. |
interestingly, although co-deletion of bax rescued the majority of npc apoptosis, it resulted in embryonic lethality at e13, whereas conditional deletion of both mcl-1 and bax rescued embryonic lethality. |
2021-05-08 |
2023-08-13 |
mouse |
| Jingtian Zhang, Zhizhuang Joe Zhao, Xueqi Fu, Han Niu, Chen Hu, Yunzhou Dong, Mei-Zhen Cui, Fuqiang Zhang, Linlin Zeng, Xuemin X. Proapoptotic Mitochondrial Carrier Homolog Protein PSAP Mediates Death Receptor 6 Induced Apoptosis. Journal of Alzheimer's disease : JAD. vol 74. issue 4. 2021-05-07. PMID:32144986. |
to further elucidate the mechanism by which psap mediates dr6-induced mitochondria-dependent apoptosis, our data demonstrated that knockdown of psap blocked dr6-induced bax translocation and cytochrome c release from the mitochondria. |
2021-05-07 |
2023-08-13 |
Not clear |
| Jingtian Zhang, Zhizhuang Joe Zhao, Xueqi Fu, Han Niu, Chen Hu, Yunzhou Dong, Mei-Zhen Cui, Fuqiang Zhang, Linlin Zeng, Xuemin X. Proapoptotic Mitochondrial Carrier Homolog Protein PSAP Mediates Death Receptor 6 Induced Apoptosis. Journal of Alzheimer's disease : JAD. vol 74. issue 4. 2021-05-07. PMID:32144986. |
the observation that knockdown of dr6 significantly reduced the amount of psap-bax complex detected in mitochondria suggests a possibility that dr6-bound bax is transferred to psap upon interaction with psap at the mitochondria, leading to cytochrome c release and eventually apoptosis. |
2021-05-07 |
2023-08-13 |
Not clear |
| Xiao-Xiao Hou, Jing-Yu Liu, Zhuo-Yu Li, Ming-Chang Chang, Min Guo, Cui-Ping Feng, Jiang-Ying Sh. Fruiting body polysaccharides of Hericium erinaceus induce apoptosis in human colorectal cancer cells via ROS generation mediating caspase-9-dependent signaling pathways. Food & function. vol 11. issue 7. 2021-05-07. PMID:32573644. |
they significantly inhibited the growth of these cells by inducing apoptosis by the modulation of bax and bcl-2 expression, which in turn induced the loss of mitochondrial membrane potential, leading to the activation of cleaved-caspase-9 and cleaved-caspase-3. |
2021-05-07 |
2023-08-13 |
human |
| Fümet Duygu Üstündağ, İsmail Ünal, Derya Cansız, Ünsal Veli Üstündağ, Hülya Kara Subaşat, A Ata Alturfan, Pınar Mega Tiber, Ebru Emekli-Alturfa. 3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos. Drug and chemical toxicology. 2021-05-07. PMID:32693643. |
results of our study showed that mptp induced a p53 dependent and bax mediated apoptosis in zebrafish embryos and 3-pyridinylboronic acid restored the locomotor activity and gene expressions related to mitochondrial dysfunction and oxidative stress due to the deleterious effects of mptp, in a dose-dependent manner. |
2021-05-07 |
2023-08-13 |
zebrafish |
| Alisson Bigolin, Mariana F Maioral, Natália M Stefanes, Gabriele A Zatelli, Ana C Philippus, Miriam de B Falkenberg, Maria C Santos-Silv. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anti-cancer drugs. vol 31. issue 7. 2021-05-06. PMID:32639281. |
the activation of intrinsic apoptosis appears to be related to a decreased bcl-2 expression and increased bax expression. |
2021-05-06 |
2023-08-13 |
Not clear |
| Jiong Zhang, Yang Zou, Yan Cheng-Jing, Lu Xiang-Heng, Xue-Peng Wang, Xiao-Jia Yu, Gui-Sen Li, Jia Wan. Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria-mediated apoptosis via SIRT1/p53 signalling. Journal of cellular and molecular medicine. vol 24. issue 20. 2021-05-06. PMID:32881246. |
pioglitazone also reduced the activation of caspase-3 and caspase-9, lowered the ratio of bax/bcl-2, attenuated kidney pathological damage and dysfunction, down-regulated the expression of acetyl-p53, puma-α and bax and abated cell apoptosis after cisplatin treatment. |
2021-05-06 |
2023-08-13 |
Not clear |
| Betül Kuzu, Gökhan Cüce, İlknur Çınar Ayan, Burcu Gültekin, Halime Tuba Canbaz, Hatice Gül Dursun, Zafer Şahin, İlknur Keskin, Sabiha Serpil Kalka. Evaluation of Apoptosis Pathway of Geraniol on Ishikawa Cells. Nutrition and cancer. 2021-05-06. PMID:33086902. |
a significant increase in the bax, caspase3, caspase-8, cytochrome c and fas genes and a significant decrease in the bcl-2 gene was observed when the ic50 dose group was compared to the cells in the control group based on their mrna expression levels.analysis of expression of genes whose products are involved in apoptosis suggests the involvement of the mitochondrial pathway. |
2021-05-06 |
2023-08-13 |
Not clear |
| Qibing Niu, Wanli Sun, Quan Chen, Yang Long, Wanjun Cao, Shiqi Wen, Anqiang Li, Fang Dong, Hao Sh. Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-05. PMID:32686659. |
liver function, changes of oxidative stress index and inflammation, bcl-2 and bax proteins, and apoptosis were assessed. |
2021-05-05 |
2023-08-13 |
human |
| Chunhong Xi, Yingduan Zhang, Mei Yan, Qing Lv, Huan Lu, Jun Zhou, Yucheng Wang, Jianbo L. Exogenous neuritin treatment improves survivability and functions of Schwann cells with improved outgrowth of neurons in rat diabetic neuropathy. Journal of cellular and molecular medicine. vol 24. issue 17. 2021-05-04. PMID:32667138. |
in contrast, exogenous neuritin treatment reduced apoptosis and improved viability, with elevated bcl-2 levels (not bax) and decreased caspase-3 activities. |
2021-05-04 |
2023-08-13 |
rat |
| Hongjing Zhao, Yu Wang, Mengyao Mu, Menghao Guo, Hongxian Yu, Mingwei Xin. Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp ( Food & function. vol 11. issue 10. 2021-05-04. PMID:33026005. |
mechanistically, indicators in the innate immune system (such as toll like receptors (tlrs), tumor necrosis factor-α (tnf-α), interleukin (il)-1β, il-6 and il-8) and the apoptosis pathway (p53, puma, b-cell lymphoma-2 (bcl-2), bcl2-associated x (bax), and caspase-9/3) disclosed adaptive activation under smz exposure; these anomalies returned to normal or close-to-normal levels after lyc coadministration. |
2021-05-04 |
2023-08-13 |
human |