| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiong Li, Jing Xie, Yan-Zhen Wang, Yi-Rong Gan, Ling Wei, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xi. Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324. Molecular medicine reports. vol 23. issue 2. 2021-05-04. PMID:33300079. |
tm induced apoptosis, ers and autophagy, as indicated by an increased ratio of apoptotic cells, increased expression levels of bax, cleaved (c)-caspase-3/9, glucose-regulated protein 78 kda (grp78), phosphorylated (p)-inositol-requiring enzyme-1α (ire1α), spliced x-box-binding protein 1 (xbp1s), ire1α, activating transcription factor (atf)6, atf4, beclin 1 and microtubule associated protein 1 light chain 3α (lc3)ii/i, and decreased expression levels of bcl-2, unspliced xbp1 (xbp1u) and p62 in the tm group compared with the control group. |
2021-05-04 |
2023-08-13 |
rat |
| Yanxia Zhao, Jun Shi, Yankun Zhao, Zhifang L. SNHG1/miR-186/FUT8 regulates cell migration and invasion in oral squamous cell carcinoma. Oral diseases. 2021-05-04. PMID:33872442. |
snhg1 silencing prevented cell proliferation and increased the incidence of apoptosis, dna fragments, cleaved-caspase 3, and bax protein levels. |
2021-05-04 |
2023-08-13 |
Not clear |
| Ting Chen, Chunyan Zhu, Chongyang Y. LncRNA CYTOR attenuates sepsis-induced myocardial injury via regulating miR-24/XIAP. Cell biochemistry and function. vol 38. issue 7. 2021-05-03. PMID:32181504. |
western blot was applied to determine the expression level of caspase 3, bax and x-chromosome-linked inhibitor of apoptosis (xiap). |
2021-05-03 |
2023-08-13 |
mouse |
| Yifei Shen, Yin Zhu, Fei Ron. miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN. Molecular medicine reports. vol 22. issue 2. 2021-05-03. PMID:32626945. |
taken together, these data suggested that overexpression of mir‑200c‑3p targets pten to suppress cleaved caspase‑3 and bax expression and activate the pten/akt/mtor signaling pathway, thereby resulting in the promotion of cell proliferation and the inhibition of cell apoptosis. |
2021-05-03 |
2023-08-13 |
human |
| Hongyu Xu, Hui Gao, Hua Li, Dong Li, Weiwei Yuan, Ling Zhang, Peng Cheng, Xiaomei Su, Zhihui Li, Guangjie Wang, Tao Zhan. Downregulated Mucin 1 alleviates paclitaxel resistance in non‑small cell lung cancer cells. Molecular medicine reports. vol 22. issue 4. 2021-05-03. PMID:32945387. |
silence of muc1 could obviously suppress the proliferation and promote apoptosis of a549/pr cells in treatment of paclitaxel through up‑regulating the expression of bax and caspase‑3, and down‑regulating the expression of bcl‑2, suggesting that chemotherapy combined with the modulation of muc1 might be characterized as a promising therapeutic approach to overcome paclitaxel‑resistance in nsclc in the future. |
2021-05-03 |
2023-08-13 |
Not clear |
| Heng Boon Low, Zhen Lim Wong, Bangyuan Wu, Li Ren Kong, Chin Wen Png, Yik-Lam Cho, Chun-Wei Li, Fengchun Xiao, Xuan Xin, Henry Yang, Jia Min Loo, Fiona Yi Xin Lee, Iain Bee Huat Tan, Ramanuj DasGupta, Han-Ming Shen, Herbert Schwarz, Nicholas R J Gascoigne, Boon Cher Goh, Xiaohong Xu, Yongliang Zhan. DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33863904. |
mechanistically, dusp16 inhibits jnk and p38 activation, thereby reducing bax accumulation in mitochondria to reduce apoptosis. |
2021-05-03 |
2023-08-13 |
human |
| Isha Godwin, Nikhil Ponnoor Anto, Smitha V Bava, Mani Shankar Babu, Goodwin G Jines. Targeting K-Ras and apoptosis-driven cellular transformation in cancer. Cell death discovery. vol 7. issue 1. 2021-05-02. PMID:33854056. |
the defects in key apoptosis regulators such as p53, bax, and bak lead to apoptosis evasion, cellular transformation, and genomic instability to further lead to stemness, tumorigenesis, and metastasis via c-myc-dependent transcription. |
2021-05-02 |
2023-08-13 |
Not clear |
| Sze Wei Leong, Suet Lin Chia, Faridah Abas, Khatijah Yusof. Synthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer. Bioorganic & medicinal chemistry letters. vol 30. issue 8. 2021-04-30. PMID:32127259. |
further western blot studies confirmed that 8 has induced intrinsic apoptosis in rko cells through the up-regulations of bad and bax pro-apoptotic proteins and down-regulations of bcl-2 and bcl-xl pro-survival proteins. |
2021-04-30 |
2023-08-13 |
Not clear |
| Fatemeh Safari, Mohammad Bayat, Shima Nasri, Solmaz Karam. Synthesis and evaluation of anti-tumor activity of novel triazolo[1,5-a] pyrimidine on cancer cells by induction of cellular apoptosis and inhibition of epithelial-to-mesenchymal transition process. Bioorganic & medicinal chemistry letters. vol 30. issue 10. 2021-04-30. PMID:32199733. |
apoptosis induction was shown using quantitative real time pcr (qrt-pcr) by evaluating of bax and bcl2 mrna levels. |
2021-04-30 |
2023-08-13 |
human |
| Changwei Zou, Hong Yang, Lanyue Cui, Xinyi Cao, Hong Huang, Tingtao Che. Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury. Molecular medicine reports. vol 22. issue 4. 2021-04-30. PMID:32945461. |
western blot analysis indicated that pm2.5 significantly enhanced expression of phosphorylated (p)‑erk relative to total erk, cyclooxygenase‑2, p‑anti‑nuclear‑factor‑κb (p‑nf‑κb) relative to nf‑κb, transforming growth factor‑β1 and bax relative to bcl‑2 in inflammation (p<0.05), fibrosis and apoptosis signaling pathways. |
2021-04-30 |
2023-08-13 |
mouse |
| Wen-Jie Xie, Guo Hou, Lu Wang, Sha-Sha Wang, Xiao-Xing Xion. Astaxanthin suppresses lipopolysaccharide‑induced myocardial injury by regulating MAPK and PI3K/AKT/mTOR/GSK3β signaling. Molecular medicine reports. vol 22. issue 4. 2021-04-30. PMID:32945516. |
furthermore, the extent of myocardial injury was evaluated using pathological analysis, and cardiomyocyte apoptosis was analyzed using a tunel assay, in addition to determining the expression levels of bcl‑2 and bax. |
2021-04-30 |
2023-08-13 |
mouse |
| Maryam Mohammadlou, Maryam Abdollahi, Maral Hemati, Rasoul Baharlou, Ehsan Manouchehri Doulabi, Mehrnoosh Pashaei, Farahnaz Ghahremanfard, Mohammad Faranoush, Parviz Kokhae. Apoptotic effect of berberine via Bcl-2, ROR1, and mir-21 in patients with B-chronic lymphocytic leukemia. Phytotherapy research : PTR. vol 35. issue 4. 2021-04-30. PMID:33174291. |
although western blot results did not show any change in bax as a pro-apoptotic protein, an increased bax/bcl-2 ratio indicated that mitochondrial pathway is involved in berberine-induced apoptosis of cll cells. |
2021-04-30 |
2023-08-13 |
Not clear |
| Javed Ahmad, Rizwan Wahab, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhair. Cytotoxicity and cell death induced by engineered nanostructures (quantum dots and nanoparticles) in human cell lines. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 25. issue 2. 2021-04-29. PMID:32124101. |
quantitative real-time pcr data showed that the mrna levels of apoptotic marker genes such as p53, bax, and caspase-3 were upregulated, whereas bcl-2, an anti-apoptotic gene, was downregulated; therefore, apoptosis was mediated through the p53, bax, caspase-3, and bcl-2 pathways, suggesting a possible mechanism by which qds and nps of zno mediate their toxicity.graphic abstract. |
2021-04-29 |
2023-08-13 |
human |
| Haiying Liu, Luguang Wang, Linyu Dai, Fumin Feng, Yonghong Xia. CaMK II/Ca2+ dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1. International journal of biological macromolecules. vol 172. 2021-04-29. PMID:33454324. |
in the experiment, we demonstrate that kn-62 and utp can inhibit the proliferation and promote the apoptosis in hscs, increase the level of intracellular ca2+ and the expression of ers protein grp78, and increase the apoptosis protein caspase-12 and bax expression, while decrease the expression of bcl-2 protein. |
2021-04-29 |
2023-08-13 |
rat |
| Mingqi Sun, Junli Yang, Dianming Jiang, Guoyu Ba. Overexpression of hsa_circ_0094742 inhibits IL-1β-induced decline in CHON-001 cell viability by targeting microRNA-127-5p. Histology and histopathology. vol 36. issue 2. 2021-04-29. PMID:33665792. |
furthermore, il-1β-induced alterations in aggrecan, matrix metallopeptidase 13, x-linked inhibitor of apoptosis protein (xiap), bax and active caspase 3 were reversed by hsa_circ_0094742 oe. |
2021-04-29 |
2023-08-13 |
human |
| Xiaohong Gu, Yuechun Li, Kaixin Chen, Xingang Wang, Zhongyu Wang, Hao Lian, Yuanzheng Lin, Xing Rong, Maoping Chu, Jiafeng Lin, Xiaoling Gu. Exosomes derived from umbilical cord mesenchymal stem cells alleviate viral myocarditis through activating AMPK/mTOR-mediated autophagy flux pathway. Journal of cellular and molecular medicine. vol 24. issue 13. 2021-04-28. PMID:32424968. |
moreover, in vitro data showed that hucmsc-exosomes (50 μg/ml) inhibited the apoptosis of cvb3-infected hcm through increasing pampk/ampk ratio and up-regulating autophagy proteins lc3ii/i, beclin-1 and anti-apoptosis protein bcl-2 as well as decreasing pmtor/mtor ratio, promoting the degradation of autophagy flux protein p62 and down-regulating apoptosis protein bax. |
2021-04-28 |
2023-08-13 |
mouse |
| Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhan. Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway. International immunopharmacology. vol 85. 2021-04-28. PMID:32492628. |
meanwhile, que significantly inhibited the level of tumor suppressor p53, bax, cleaved-cas3 expressionl and increased bcl-2 expression to reduce apoptosis in vivo and in vitro. |
2021-04-28 |
2023-08-13 |
rat |
| Senmin Chen, Xiuli Yuan, Huanli Xu, Meng Yi, Sixi Liu, Feiqiu We. WNT974 Inhibits Proliferation, Induces Apoptosis, and Enhances Chemosensitivity to Doxorubicin in Lymphoma Cells by Inhibiting Wnt/β-Catenin Signaling. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-04-28. PMID:32597418. |
treatment with 1 μm wnt974 for 48 h increased the rate of cell apoptosis, inhibited the expression of anti-apoptotic protein bcl-2, and enhanced pro-apoptotic proteins bax, cleaved-caspase3, and cleaved-caspase9 expression in both cell lines. |
2021-04-28 |
2023-08-13 |
human |
| Wusheng Lu, Jinhuang Lin, Dequan Zheng, Chunyong Hong, Laishun Ke, Xinyu Wu, Peineng Che. Overexpression of MicroRNA-133a Inhibits Apoptosis and Autophagy in a Cell Model of Parkinson's Disease by Downregulating Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1). Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-04-28. PMID:32713934. |
after overexpressing mir-133a, cell proliferation increased, and apoptosis (cleaved caspase-3 and bax levels decreased, while bcl2 levels increased) and autophagy was inhibited (lc3ii/i and beclin-1 levels decreased, while p62 levels increased). |
2021-04-28 |
2023-08-13 |
mouse |
| Xiao Geng Zhu, Tie Ning Zhang, Ri Wen, Chun Feng Li. Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression. BioMed research international. vol 2020. 2021-04-28. PMID:32908879. |
furthermore, the expression of mir-150-5p was reduced, and overexpression of mir-150-5p with mimics resulted in a decrease in apoptosis, decreased expression of cleaved caspase3 and bax, and increased expression of bcl-2. |
2021-04-28 |
2023-08-13 |
rat |