| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Osterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrew. The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells. eLife. vol 9. 2021-04-14. PMID:31976859. |
the bcl-2 family bh3 protein bim promotes apoptosis at mitochondria by activating the pore-forming proteins bax and bak and by inhibiting the anti-apoptotic proteins bcl-xl, bcl-2 and mcl-1. |
2021-04-14 |
2023-08-13 |
Not clear |
| Yongjun Wang, Huan Li, Yongsheng Shi, Shuying Wang, Yan Xu, Hanyi Li, Donghai Li. miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway. Bioscience reports. vol 40. issue 7. 2021-04-14. PMID:32597476. |
compared with model group, model mice had up-regulated mir-143-3p expression and decreased myd88 and p-nf-κb p50 protein expressions (all p<0.05); model mice treated with mir-143-3p mimic and tak-242 had reduced interleukin (il)-2 and tumor necrosis factor (tnf)-α contents and protein expressions of myd88, p-nf-κb p50, increased il-10 content, fewer alveolar epithelial cell apoptosis, lower bax expression and higher bcl-2 expression (all p<0.05); however, mice with mir-143-3p inhibitor treatment showed opposite trends in terms of above indicators. |
2021-04-14 |
2023-08-13 |
mouse |
| Youcheng Bian, Hui Zeng, Hong Tao, Lulin Huang, Zhenyun Du, Jiao Wang, Kan Din. A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy. International journal of biological macromolecules. vol 162. 2021-04-13. PMID:32531363. |
mechanism study suggested that rp02-1 induced pancreatic cancer cells apoptosis, which was detected by bcl-2 down-regulation, bax up-regulation and conversion from caspase 3 to cleaved caspase 3. |
2021-04-13 |
2023-08-13 |
human |
| Jianwen Long, Xianming P. Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway. BioMed research international. vol 2020. 2021-04-13. PMID:32733943. |
the outcomes represented that polyphyllin i promoted a375 cell apoptosis via upregulating bax level and cleaved caspase-3 level and downregulating bcl-2 level, inhibited the growth of a375 cells at the g0/g1 phase, and enhanced cell autophagy via regulating the levels of beclin 1, lc3ii, and p62. |
2021-04-13 |
2023-08-13 |
mouse |
| Hyun-Young Lee, Seon-Hee O. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33321290. |
dram and bax levels began to increase post autophagy induction and continued to increase, indicating that autophagy preceded apoptosis. |
2021-04-13 |
2023-08-13 |
human |
| Guiqing Zhou, Jianhui Liu, Xiangyang Li, Yujian Sang, Yue Zhang, Leqiang Gao, Ji Wang, Yang Yu, Wei Ge, Zhiwei Sun, Xianqing Zho. Silica nanoparticles inducing the apoptosis via microRNA-450b-3p targeting MTCH2 in mice and spermatocyte cell. Environmental pollution (Barking, Essex : 1987). vol 277. 2021-04-13. PMID:33652185. |
the results showed that sinps induced the apoptosis of spermatogenic cells, decreased the quantity and quality of the sperm, reduced the expressions of mir-450 b-3p, and increased the protein expressions of the mtch2, bid, bax, cytochrome c, caspase-9, and caspase-3 in the testis. |
2021-04-13 |
2023-08-13 |
mouse |
| Guiqing Zhou, Jianhui Liu, Xiangyang Li, Yujian Sang, Yue Zhang, Leqiang Gao, Ji Wang, Yang Yu, Wei Ge, Zhiwei Sun, Xianqing Zho. Silica nanoparticles inducing the apoptosis via microRNA-450b-3p targeting MTCH2 in mice and spermatocyte cell. Environmental pollution (Barking, Essex : 1987). vol 277. 2021-04-13. PMID:33652185. |
in vitro, the mimic of mirna-450 b-3p reversed the decrease of viability and the increase of apoptosis rate and significantly antagonized the expression enhancements of the mtch2, bid, bax, cytochrome c, caspase-9, caspase-3 induced by sinps, while inhibitor of mirna-450 b-3p further promoted the effects induced by sinps. |
2021-04-13 |
2023-08-13 |
mouse |
| Surinder M Soond, Lyudmila V Savvateeva, Vladimir A Makarov, Neonila V Gorokhovets, Paul A Townsend, Andrey A Zamyatni. Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis. Pharmaceutics. vol 13. issue 3. 2021-04-13. PMID:33807987. |
cathepsin s cleaves bax as a novel and therapeutically important regulatory mechanism for apoptosis. |
2021-04-13 |
2023-08-13 |
Not clear |
| Fanyuan Zhou, Xiaohu Zou, Jing Zhang, Ziwei Wang, Yajun Yang, Dongtao Wan. Jian-Pi-Yi-Shen Formula Ameliorates Oxidative Stress, Inflammation, and Apoptosis by Activating the Nrf2 Signaling in 5/6 Nephrectomized Rats. Frontiers in pharmacology. vol 12. 2021-04-13. PMID:33841151. |
moreover, the jpys formula showed a significant protective effect in suppressing cell apoptosis according to the results of apoptotic indexes, including increased gene expression of bcl-2, decreased gene expression of bax, caspase 3, caspase 9, and the number of tunel-positive cells. |
2021-04-13 |
2023-08-13 |
rat |
| Yunyi Chen, Jiaojiao Liang, Xiao Liang, Jiebiao Chen, Yue Wang, Jinping Cao, Chongde Sun, Jiaming Ye, Qingjun Che. Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity. Food science & nutrition. vol 9. issue 4. 2021-04-13. PMID:33841805. |
western blot results showed that limonin could activate the endogenous apoptosis pathway mediated by mitochondria via up-regulating pro-apoptotic proteins (bax, cytochrome c, caspase3, and caspase9) and down-regulating anti-apoptotic proteins (bcl-2), thus inhibiting the proliferation of hl-60 cells and promoting apoptosis, which further proved the anticancer activity of limonin from the molecular mechanism. |
2021-04-13 |
2023-08-13 |
human |
| Li Dong, David L Vau. Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1. Cell death & disease. vol 11. issue 6. 2021-04-12. PMID:32513923. |
glucocorticoids can induce bim to trigger apoptosis in the absence of bax and bak1. |
2021-04-12 |
2023-08-13 |
Not clear |
| Li Dong, David L Vau. Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1. Cell death & disease. vol 11. issue 6. 2021-04-12. PMID:32513923. |
deletion of bax and bak1 prevented rapid apoptosis, but treatment with dexamethasone for greater 6 days still led to cell death that was characterized by release of cytochrome c into the cytosol, activation of caspases, and loss of cell membrane integrity. |
2021-04-12 |
2023-08-13 |
Not clear |
| Zhaolong Yu, Zecong Xiao, Xintao Shuai, Jiwei Tia. Local delivery of sunitinib and Ce6 via redox-responsive zwitterionic hydrogels effectively prevents osteosarcoma recurrence. Journal of materials chemistry. B. vol 8. issue 30. 2021-04-12. PMID:32578660. |
in vitro study demonstrated that sun/ce6@gel induced 143b human osteosarcoma cell apoptosis via downregulating the expression of bcl-2 and upregulating the expression levels of bax and caspase-3. |
2021-04-12 |
2023-08-13 |
human |
| Ni Li, Linwen Zhu, Hua Zhou, Dawei Zheng, Guodong Xu, Lebo Sun, Jianqing Gao, Guofeng Sha. miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33073840. |
during the compensatory period of rhd, up-regulated mir-1183 destroyed the balance of apoptosis proteins (bax and bak) in bcl-2 family, enhance the apoptosis cascade reaction and reduce the anti apoptosis effect. |
2021-04-12 |
2023-08-13 |
Not clear |
| Hector Flores-Romero, Uris Ros, Ana J Garcia-Sae. Pore formation in regulated cell death. The EMBO journal. vol 39. issue 23. 2021-04-12. PMID:33124082. |
in apoptosis, the permeabilization of the outer mitochondrial membrane by bax and bak releases apoptotic factors that initiate the caspase cascade and is considered the point of no return in cell death commitment. |
2021-04-12 |
2023-08-13 |
Not clear |
| Zhen Zhao, Yan Xing, Yan Liu, Shanghua Jin. Lung cancer‑associated transcript 1 facilitates tumorigenesis in laryngeal squamous cell carcinoma through the targeted inhibition of miR‑493. Molecular medicine reports. vol 23. issue 1. 2021-04-12. PMID:33215214. |
moreover, lucat1 knockdown promoted cell apoptosis and upregulated the expression levels of bax and cleaved caspase‑3, whilst downregulating the expression levels of bcl‑2. |
2021-04-12 |
2023-08-13 |
Not clear |
| Lei Jiang, Cun Wang, Xinyue She. LncRNA GAS5 suppresses ER stress‑induced apoptosis and inflammation by regulating SERCA2b in HG‑treated retinal epithelial cell. Molecular medicine reports. vol 22. issue 2. 2021-04-09. PMID:32467994. |
in addition, hg treatment induced apoptosis by increasing bax, bad and caspase 12, and by decreasing bcl‑2 levels expression levels. |
2021-04-09 |
2023-08-13 |
human |
| Xiaoxiong Xiao, Lei Jiang, Huoli Hu, Yunhe Huang, Lun Yang, Yang Jiao, Guangxia We. Silencing of UAP1L1 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma. Molecular carcinogenesis. vol 60. issue 3. 2021-04-09. PMID:33434300. |
moreover, the apoptosis of escc cells was induced by knockdown of uap1l1 via regulating a variety of apoptosis-related proteins, such as upregulation of bax, cd40, cd40l, fas, fasl, igfbp-6, p21, p27, p53, and smac. |
2021-04-09 |
2023-08-13 |
Not clear |
| Eric J O'Neill, Deborah Termini, Alexandria Albano, Evangelia Tsian. Anti-Cancer Properties of Theaflavins. Molecules (Basel, Switzerland). vol 26. issue 4. 2021-04-09. PMID:33668434. |
treatment with theaflavins has been associated with increased levels of cleaved poly (adp-ribose) polymerase (parp) and cleaved caspases-3, -7, -8, and -9, all markers of apoptosis, and increased expression of the proapoptotic marker bcl-2-associated x protein (bax) and concomitant reduction in the antiapoptotic marker b-cell lymphoma 2 (bcl-2). |
2021-04-09 |
2023-08-13 |
Not clear |
| Hanan Saleh, Haidan M El-Shorbag. Chitosan protects liver against ischemia-reperfusion injury via regulating Bcl-2/Bax, TNF-α and TGF-β expression. International journal of biological macromolecules. vol 164. 2021-04-08. PMID:32735924. |
marked reduction of apoptosis has been indicated by the elevation in bcl2, and decreasing in bax, caspace-3 and cytochrome-c expression levels, which furthermore confirmed by dna fragmentation assay. |
2021-04-08 |
2023-08-13 |
cat |